Article
Nutrition & Dietetics
Xiaoming Liu, Xuejiao Zeng, Jinli Mahe, Kai Guo, Panpan He, Qianwen Yang, Zhiwei Zhang, Zhongxia Li, Di Wang, Zheqing Zhang, Lei Wang, Lipeng Jing
Summary: The study found that nattokinase monascus supplements (NMSs) can improve lipid levels, but have no significant effect on serum TG, HDL-C, and CIMT.
Article
Clinical Neurology
Chin-Hsien Lin, Chin-Hao Chang, Chun-Hwei Tai, Mei-Fang Cheng, Yi-Chieh Chen, Ying-Ting Chao, Tse-Le Huang, Ruoh-Fang Yen, Ruey-Meei Wu
Summary: Evidence suggests that lovastatin may slow the progression of motor symptoms in patients with early-stage PD, especially in the striatal region. The treatment was generally well tolerated, indicating the potential benefits of lovastatin in PD management.
MOVEMENT DISORDERS
(2021)
Editorial Material
Clinical Neurology
Tanya N. Turan, Marios-Nikos Psychogios
Summary: The CASSISS trial, published in JAMA, adds to the growing body of evidence that percutaneous angioplasty and stenting does not provide a benefit over medical therapy for preventing stroke due to intracranial atherosclerotic stenosis. Current guidelines recommend against routine use of this intervention for stroke prevention in these patients. The trial may offer valuable insights for future trial design.
Article
Immunology
Leyi Lin, Michael A. Koren, Kristopher M. Paolino, Kenneth H. Eckels, Rafael De La Barrera, Heather Friberg, Jeffrey R. Currier, Gregory D. Gromowski, Naomi E. Aronson, Paul B. Keiser, Marvin J. Sklar, Erica L. Sondergaard, Louis E. Jasper, Timothy P. Endy, Richard G. Jarman, Stephen J. Thomas
Summary: The study demonstrates that the heterologous prime-boost vaccination strategy can induce higher levels of immune response and may be superior to homologous strategies in maintaining durable tetravalent immunity.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Teresa A. Hillier, Kathryn L. Pedula, Keith K. Ogasawara, Kimberly K. Vesco, Caryn E. S. Oshiro, Suzanne L. Lubarsky, Jan Van Marter
Summary: In this study comparing one-step screening with two-step screening for gestational diabetes mellitus, the one-step approach resulted in more diagnoses of gestational diabetes mellitus but did not have a significant impact on the incidence of adverse perinatal and maternal outcomes.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Nancy A. Rigotti, Neal L. Benowitz, Judith Prochaska, Scott Leischow, Mitchell Nides, Brent Blumenstein, Anthony Clarke, Daniel Cain, Cindy Jacobs
Summary: This study evaluated the efficacy and tolerability of cytisinicline in smoking cessation. The results showed that cytisinicline, when administered for 6 or 12 weeks with behavioral support, demonstrated good effectiveness and tolerability in quitting smoking, offering new treatment options for nicotine dependence.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Sivaneswari Selvarajoo, Jonathan Wee Kent Liew, Tock H. Chua, Wing Tan, Rafdzah Ahmad Zaki, Romano Ngui, Wan Yusoff Wan Sulaiman, Poo Soon Ong, Indra Vythilingam
Summary: This study found that using a combination of gravid oviposition sticky (GOS) traps and dengue non-structural 1 (NS1) antigen testing can effectively reduce the occurrence of dengue cases by early surveillance of Aedes mosquitoes. The study also showed that this surveillance method significantly improved participants' knowledge, attitude, and practice towards dengue control.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Fidelma Dunne, Christine Newman, Alberto Alvarez-Iglesias, John Ferguson, Andrew Smyth, Marie Browne, Paula O'Shea, Declan Devane, Paddy Gillespie, Delia Bogdanet, Oratile Kgosidialwa, Aoife Egan, Yvonne Finn, Geraldine Gaffney, Aftab Khattak, Derek O'Keeffe, Aaron Liew, Martin O'Donnell
Summary: Early initiation of metformin is not superior to placebo for the primary outcome of gestational diabetes. Further investigation of metformin in larger clinical trials is supported by the prespecified secondary outcome data.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, Research & Experimental
Nikolai H. Jung, Silvia Egert-Schwender, Beate Schossow, Victoria Kehl, Ute Wahllaender, Louisa Brich, Viktoria Janke, Christiane Blankenstein, Martin Zenker, Volker Mall
Summary: This is a clinical trial that aims to investigate the effect of lovastatin and lamotrigine on synaptic plasticity and cognitive function in patients with RASopathies, such as NF1 and NS. The study is based on previous animal studies that showed positive results. Attention and synaptic plasticity will be evaluated using TAP and qTBS, respectively.
Article
Multidisciplinary Sciences
Nicky Solomonidi, Panayiotis G. Vlachoyiannopoulos, Maria Pappa, Georgia Liantinioti, Sofia Ktena, Evangelos Theotikos, Antonia Elezoglou, Mihai G. Netea, Evangelos J. Giamarellos-Bourboulis
Summary: This study found that increased concentrations of IL-1 alpha are present in SSc patients. Treatment with the IL-1 alpha blocking antibody, bermekimab, effectively inhibits disease progression and reduces inflammation.
Article
Public, Environmental & Occupational Health
Betzana Zambrano, Fernando Noriega, Gustavo H. Dayan, Doris Maribel Rivera, Jose Luis Arredondo, Humberto Reynales, Kleber Luz, Carmen Deseda, Matthew Bonaparte, Edith Langevin, Yukun Wu, Margarita Cortes, Stephen Savarino, Carlos A. DiazGranados
Summary: In the study, the dengue vaccine showed a protective effect against Zika virus infection caused by dengue virus infection, but the protective effect against serologically suspected Zika was not significant. Similarly, after the Zika epidemic, dengue antibody titers increased, and the impact of the Zika epidemic on the infected population depended on their baseline dengue serostatus.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Medicine, General & Internal
Jennifer L. Grasch, Maged M. Costantine, Devra D. Doan Mast, Baylee Klopfenstein, Jessica R. Russo, Taryn L. Summerfield, Kara M. Rood
Summary: This randomized clinical trial investigated the use of a noninvasive high-frequency electrical stimulation device for pain control and opioid reduction after cesarean delivery. The results showed that the device effectively decreased opioid use in the immediate postoperative period without compromising pain control.
Article
Biochemistry & Molecular Biology
Konstantinos D. Rizas, Luisa Freyer, Nikolay Sappler, Lukas von Stuelpnagel, Peter Spielbichler, Aresa Krasniqi, Michael Schreinlechner, Felix N. Wenner, Fabian Theurl, Amira Behroz, Elodie Eiffener, Mathias P. Klemm, Annika Schneidewind, Martin Zens, Theresa Dolejsi, Ulrich Mansmann, Steffen Massberg, Axel Bauer
Summary: The study compared the efficacy of digital smart devices in detecting atrial fibrillation (AF) and found that digital screening technology more than doubled the detection rate of treatment-relevant AF compared to usual care. This technology has the potential for broad applicability and further studies are needed to assess if digital screening for AF leads to better treatment outcomes.
Article
Dentistry, Oral Surgery & Medicine
K. J. Chen, S. S. Gao, D. Duangthip, E. C. M. Lo, C. H. Chu
Summary: The study found that applying a varnish with fTCP semiannually was more effective in arresting dentine caries in primary teeth compared to without fTCP, particularly on buccal/lingual surfaces, anterior teeth, with dental plaque coverage, and in children from low-income families.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Surgery
Fariba Abbassi, Sascha A. Mueller, Thomas Steffen, Bruno M. Schmied, Rene Warschkow, Ulrich Beutner, Ignazio Tarantino
Summary: This study aimed to evaluate whether caffeine could shorten the time to first bowel movement after laparoscopic colectomy. The results showed that caffeine was not associated with reduced time to first bowel movement.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Immunology
Nguyen Lam Vuong, Nguyen Than Ha Quyen, Nguyen Thi Hanh Tien, Nguyen Minh Tuan, Duong Thi Hue Kien, Phung Khanh Lam, Dong Thi Hoai Tam, Tran Van Ngoc, Sophie Yacoub, Thomas Jaenisch, Ronald B. Geskus, Cameron P. Simmons, Bridget A. Wills
Summary: Higher plasma viremia is associated with increased dengue severity, regardless of serotype or immune status, with effect sizes being modest compared to the effects of a secondary immune response. The association remains consistent across different age, serotype, and immune status groups, indicating a potential role of plasma viremia in predicting dengue severity.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Marcus J. Schultz, Jacqueline Deen, Lorenz von Seidlein, Chaisith Sivakorn, Alex Kumar, Neill K. J. Adhikari, Bridget Wills, Alexander S. Kekule, Nicholas P. J. Day, Ben Cooper, Nicholas J. White, Alex P. Salam, Peter Horby, Piero Olliaro, Arjen M. Dondorp
Summary: Viral hemorrhagic fevers often lead to circulatory shock, requiring optimized fluid therapy for management. However, there is a lack of data and guidelines in this area. An innovative monitoring approach proposes remote-controlled and pulse pressure-guided fluid resuscitation to enhance supportive care capacity and reduce the risk of virus transmission.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Letter
Infectious Diseases
William L. Hamilton, Tom Fieldman, Aminu Jahun, Ben Warne, Christopher J. R. Illingworth, Chris Jackson, Beth Blane, Elinor Moore, Michael P. Weekes, Sharon J. Peacock, Daniela De Angelis, Ian Goodfellow, Theodore Gouliouris, M. Estee Torok
LANCET INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Ivonne Morales, Kerstin D. Rosenberger, Tereza Magalhaes, Clarice N. L. Morais, Cynthia Braga, Ernesto T. A. Marques, Guilherme Amaral Calvet, Luana Damasceno, Patricia Brasil, Ana Maria Bispo de Filippis, Sarah Bethencourt, Adriana Tami, Mayling Alvarez, Pedro A. Martinez, Maria G. Guzman, Bruno Souza Benevides, Andrea Caprara, Nguyen Thanh Ha Quyen, Cameron Simmons, Bridget Wills, Xavier de Lamballerie, Jan Felix Drexler, Thomas Jaenisch
Summary: This study evaluated three commercially available immunoassays for detecting ZIKV antibodies, with the IgAM test showing the best performance in detecting infections. The study was conducted in two different American countries with endemic arboviruses, and sequential blood samples allowed for evaluation of test performance over time. The IgAM assay exhibited superior sensitivity in detecting ZIKV infections compared to IgG and IgM assays, making it a promising candidate for serological monitoring in future ZIKV outbreaks.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Medicine, General & Internal
A. Utarini, C. Indriani, R. A. Ahmad, W. Tantowijoyo, E. Arguni, M. R. Ansari, E. Supriyati, D. S. Wardana, Y. Meitika, I. Ernesia, I. Nurhayati, E. Prabowo, B. Andari, B. R. Green, L. Hodgson, Z. Cutcher, E. Rances, P. A. Ryan, S. L. O'Neill, S. M. Dufault, S. K. Tanamas, N. P. Jewell, K. L. Anders, C. P. Simmons
Summary: The cluster-randomized trial in Indonesia showed that deploying mosquitoes infected with the wMel strain of Wolbachia pipientis led to a reduction in symptomatic, virologically confirmed dengue infections and hospitalizations among residents.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Infectious Diseases
Sofia B. Pinto, Thais I. S. Riback, Gabriel Sylvestre, Guilherme Costa, Julia Peixoto, Fernando B. S. Dias, Stephanie K. Tanamas, Cameron P. Simmons, Suzanne M. Dufault, Peter A. Ryan, Scott L. O'Neill, Frederico C. Muzzi, Simon Kutcher, Jacqui Montgomery, Benjamin R. Green, Ruth Smithyman, Ana Eppinghaus, Valeria Saraceni, Betina Durovni, Katherine L. Anders, Luciano A. Moreira
Summary: The introduction of the wMel strain of the bacterium Wolbachia into Aedes aegypti mosquitoes has been shown to significantly reduce the transmission of dengue, chikungunya, and Zika viruses. In a study conducted in Niteroi, Brazil, it was found that after three years of releases, there was a significant reduction in dengue, chikungunya, and Zika incidence in areas where the wMel-infected mosquitoes were deployed. This approach proved effective in reducing Aedes-borne diseases, even in environments with moderate and spatially heterogeneous prevalence of the wMel bacteria.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Biology
Nguyen Lam Vuong, Phung Khanh Lam, Damien Keng Yen Ming, Huynh Thi Le Duyen, Nguyet Minh Nguyen, Dong Thi Hoai Tam, Kien Duong Thi Hue, Nguyen V. V. Chau, Ngoun Chanpheaktra, Lucy Chai See Lum, Ernesto Pleites, Cameron P. Simmons, Kerstin D. Rosenberger, Thomas Jaenisch, David Bell, Nathalie Acestor, Christine Halleux, Piero L. Olliaro, Bridget A. Wills, Ronald B. Geskus, Sophie Yacoub
Summary: Early identification of severe dengue patients is crucial for patient management and resource allocation. Higher levels of any biomarker on days 1-3 from symptom onset increase the risk of developing severe/moderate dengue. The best biomarker combinations associated with S/MD differ between children and adults.
Article
Public, Environmental & Occupational Health
A. S. M. Nawshad Uddin Ahmed, Abdellatif Maamri, Adegoke G. Falade, Adejumoke Idowu Ayede, Adnan Bhutta, Ajay Gambhir, Alfredo Tagarro, Ali Abdelmegeid, Ali Reza Ahmadi, Aluisio J. D. Barros, Amha Mekasha, Anantha Kumar Srinivasaiyer, Andre Ricardo Araujo da Silva, Andreas Schultz, Batool Fatima, Bishnupada Dhar, Brian Magowan, Bridget Wills, Camille Raynes-Greenow, Caroline Homer, Carolyn Maclennan, Catherine Ward, Daniel Martinez Garcia, David Ross, David Murdoch, Deborah Joy Wilson, Ebun Adejuyigbe, Ecaterina Stasii, Elaine Scudder, Emma Sacks, Eric D. McCollum, Fernando Althabe, Fiona Russell, G. S. Kumar, Halvor Sommerfelt, Hamish Graham, Hannah Blencowe, Hannah Tappis, Haroon Saloojee, Hesham Abdussalam Ben Masaud, Hiresh Tiwary, Ifeyinwa Asiodu, James B. Newton, Jessica Bourdaire, Joel Amwe Adze, Jose Martines, Juan M. Lozano, Judd Walson, Judith Rankin, Karel Allegaert, Karell G. Pelle, Karen Edmond, Katayoun Rabiei, Kathleen M. Rasmussen, Khalid Yunis, Laura Ferguson, Leith Greenslade, Lilian Kiapi, Lisa Noguchi, Louis Bont, Louise T. Day, Lynne Mofenson, Maher Aboumayaleh, Majda Aquzouz, Mamdouh Wahba, Mari Nagai, Marian Knight, Marina Melkumova, Mariyam Jenyfa, Mark I. Neuman, Martin Meremikwu, Mary Kinney, Michael Gravett, Michael T. Hawkes, Michel Pacque, Michele Walsh, Michelle K. McGuire, Nagiba AAbdulghani AlShawafi, Najwa Khuri-Bulos, Naveen Thacker, Nigel Rollins, Niranjan Kissoon, Olena Starets, Olivier Picone, Olufemi T. Oladapo, Omer Erdeve, P. Brian Smith, Philippe Van de Perre, Praveen Kumar, Punam Mangtani, Qalab Abbas, Rabeya Khatoon, Rajiv Bahl, Rakesh Lodha, Rebecca Grais, Rebecca Richards-Kortum, Reeta Rasaily, Richmond Aryeetey, Robert Pattinson, Roberta Petrucci, Rodolfo Rossi, Ryan M. Pace, Sachiyo Yoshida, Salimah R. Walani, Sanjeeva S. P. Godakandage, Sarah Bauler, Sarah S. Comstock, Saurav Basu, Senait Kebede, Senjuti Saha, Shinjini Bhatnagar, Shoo Kim Lee, Shuchita Gupta, Simon Nyovuura Antara, Soo Downe, Stephen Freedman, Stephen J. Lye, Suellen Miller, Suha Sulimani, Sylvia H. Ley, Tara D. Mangal, Tina Lavin, Ting Shi, Todd A. Florin, Ulrik Kraemer Sundekilde, Valentina Baltag, Veronica Valdes, William Cherniak, Yasir Bin Nisar, Zainularab Zohra Shamszai, Zohreh Sadat Navabi
Summary: This research identified major research gaps in maternal, newborn, child, and adolescent health through expert scoring, emphasizing the direct and indirect effects of the COVID-19 pandemic.
JOURNAL OF GLOBAL HEALTH
(2021)
Article
Medicine, General & Internal
Huynh Trung Trieu, Lam Phung Khanh, Damien Keng Yen Ming, Chanh Ho Quang, Tu Qui Phan, Vinh Chau Nguyen Van, Ertan Deniz, Jane Mulligan, Bridget Ann Wills, Steven Moulton, Sophie Yacoub
Summary: The compensatory reserve index (CRI) is a useful non-invasive method for monitoring intravascular volume status in patients with severe dengue. CRI can predict the risk of recurrent shock within a short period of time and has moderate sensitivity and specificity.
Article
Public, Environmental & Occupational Health
Kerstin D. Rosenberger, Lam Phung Khanh, Frank Tobian, Ngoun Chanpheaktra, Varun Kumar, Lucy Chai See Lum, Jameela Sathar, Ernesto Pleite's Sandoval, Gabriela M. Maron, Ida Safitri Laksono, Yodi Mahendradhata, Malabika Sarker, Ridwanur Rahman, Andrea Caprara, Bruno Souza Benevides, Ernesto T. A. Marques, Tereza Magalhaes, Patricia Brasil, Guilherme Amaral Calvet, Adriana Tami, Sarah E. Bethencourt, Tam Dong Thi Hoai, Kieu Nguyen Tan Thanh, Ngoc Tran Van, Nam Nguyen Tran, Viet Do Chau, Sophie Yacoub, Kinh Nguyen Van, Maria G. Guzman, Pedro A. Martinez, Quyen Nguyen Than Ha, Cameron P. Simmons, Bridget A. Wills, Ronald B. Geskus, Thomas Jaenisch
Summary: This study aimed to improve the early diagnosis of dengue, especially in resource-limited settings where distinguishing dengue from other febrile illnesses is crucial. The study found that platelet count and white blood cell count were strongly associated with dengue, and the importance of serial measurements over time was highlighted.
LANCET GLOBAL HEALTH
(2023)
Article
Immunology
Dong Thi Hoai Tam, Hannah Clapham, Elisabeth Giger, Nguyen Tan Thanh Kieu, Nguyen Tran Nam, Dinh Thi Tri Hong, Banh Thi Nuoi, Nguyen Thi Hong Cam, Nguyen Than Ha Quyen, Hugo C. Turner, Thomas Jaenisch, Cameron P. Simmons, Phung Khanh Lam, Bridget Wills
Summary: We assessed the condition of mainly pediatric patients in Vietnam with dengue and other febrile illnesses 3 months after acute illness. Among dengue patients, 47% reported more than one post-acute symptom. Most symptoms resolved within 3 months, but alopecia and vision problems often persisted. Our findings provide additional evidence on the burden of post-acute dengue and confirm its impact on children.
EMERGING INFECTIOUS DISEASES
(2023)