Article
Medicine, Research & Experimental
Yik Lim Kok, Valentina Vongrad, Sandra E. Chaudron, Mohaned Shilaih, Christine Leemann, Kathrin Neumann, Katharina Kusejko, Francesca Di Giallonardo, Herbert Kuster, Dominique L. Braun, Roger D. Kouyos, Huldrych F. Gunthard, Karin J. Metzner
Summary: Characteristics of HIV-1 integration sites are established as early as during primary infection and are found in both resting and activated CD4(+) T cells. HIV-1 integration sites preferentially occur in specific genes and highly expressed genes, regardless of the activation state of CD4(+) T cells. The preference for cancer-related genes is more prominent at later stages of HIV-1 infection.
Article
Immunology
Javier Martinez-Sanz, Raquel Ron, Elena Moreno, Matilde Sanchez-Conde, Alfonso Muriel, Luis Fernando Lopez Cortes, Jose Ramon Blanco, Juan Antonio Pineda, Alvaro Mena, Sonia Calzado Isbert, Santiago Moreno, Sergio Serrano-Villar
Summary: This study compared the impact of a 2-drug regimen with dolutegravir plus lamivudine to a 3-drug regimen based on other integrase strand transfer inhibitors (INSTIs) on the recovery of the CD4/CD8 ratio in people with HIV. The results showed no difference in the normalization rates of the CD4/CD8 ratio at 48 weeks between the two treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Sergio Serrano-Villar, Kunling Wu, Peter W. Hunt, Judith J. Lok, Raquel Ron, Talia Sainz, Santiago Moreno, Steven G. Deeks, Ronald J. Bosch
Summary: Increased CD8 counts during treated HIV are related to immunosenescence, but the additional predictive values of CD8 counts and CD4/CD8 ratio to identify individuals with higher risk of clinical events in HIV remain controversial. Patients with CD8 counts >1500/μL have a higher risk of clinical events during years 3-7, while CD4/CD8 ratio is not predictive of greater event risk.
Article
Cell Biology
Domenico Lo Tartaro, Antonio Camiro-Zuniga, Milena Nasi, Sara De Biasi, Marco A. Najera-Avila, Maria Del Rocio Jaramillo-Jante, Lara Gibellini, Marcello Pinti, Anita Neroni, Cristina Mussini, Luis E. Soto-Ramirez, Juan J. Calva, Francisco Belaunzaran-Zamudio, Brenda Crabtree-Ramirez, Christian Hernandez-Leon, Juan L. Mosqueda-Gomez, Samuel Navarro-Alvarez, Santiago Perez-Patrigeon, Andrea Cossarizza
Summary: This study focused on the impact of HIV infection on T- and B-cell subsets during the early phase of infection, showing that ART treatment can reduce HIV DNA content in memory T cells and lead to significant changes in CD4+ and CD8+ T memory stem cells.
Article
Medicine, General & Internal
Hiroshi Takata, Juyeon C. Kakazu, Julie L. Mitchell, Eugene Kroon, Donn J. Colby, Carlo Sacdalan, Hongjun Bai, Philip K. Ehrenberg, Aviva Geretz, Supranee Buranapraditkun, Suteeraporn Pinyakorn, Jintana Intasan, Somporn Tipsuk, Duanghathai Suttichom, Peeriya Prueksakaew, Thep Chalermchai, Nitiya Chomchey, Nittaya Phanuphak, Mark de Souza, Nelson L. Michael, Merlin L. Robb, Elias K. Haddad, Trevor A. Crowell, Sandhya Vasan, Victor G. Valcour, Daniel C. Douek, Rasmi Thomas, Morgane Rolland, Nicolas Chomont, Jintanat Ananworanich, Lydie Trautmann
Summary: ART initiation in acute HIV infection preserves functional HIV-specific CD8(+) T cells, albeit at numbers too low to control viral rebound post-ART. HIV remission strategies may need to boost HIV-specific CD8(+) T cell numbers and induce stem cell-like properties to reverse the residual dysfunction persisting on ART in people treated after acute infection prior to ART release.
Article
Multidisciplinary Sciences
Vincenzo Malagnino, Carlotta Cerva, Elisabetta Teti, Laura Campogiani, Mirko Compagno, Luca Foroghi Biland, Laura Saderi, Daniele Armenia, Romina Salpini, Valentina Svicher, Giovanni Sotgiu, Marco Iannetta, Massimo Andreoni, Loredana Sarmati
Summary: The study divided patients into HBV positive and negative groups, finding that HBV coinfected patients had slower growth in CD4/CD8 ratio and higher CD8+ T cell counts, while HIV monoinfected patients had faster growth in CD4/CD8 ratio after starting combination antiretroviral therapy (cART).
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Javier Martinez-Sanz, Jorge Diaz-alvarez, Marta Rosas, Raquel Ron, Jose Antonio Iribarren, Enrique Bernal, Felix Gutierrez, Andres Ruiz Sancho, Noemi Cabello, Julian Olalla, Santiago Moreno, Sergio Serrano-Villar
Summary: The study suggests that a low CD4/CD8 ratio during HIV treatment is associated with immunosenescence. Data analysis shows that patients with a CD4/CD8 ratio less than 0.3 in the second year of ART have an increased risk of developing SNAEs in the next five years.
Article
Medicine, Research & Experimental
Pablo Tebas, Julie K. Jadlowsky, Pamela A. Shaw, Lifeng Tian, Erin Esparza, Andrea L. Brennan, Sukyung Kim, Soe Yu Naing, Max W. Richardson, Ashley N. Vogel, Colby R. Maldini, Hong Kong, Xiaojun Liu, Simon F. Lacey, Anya M. Bauer, Felicity Mampe, Lee P. Richman, Gary Lee, Dale Ando, Bruce L. Levine, David L. Porter, Yangbing Zhao, Don L. Siegel, Katharine J. Bar, Carl H. June, James L. Riley
Summary: By infusing CCR5 gene-edited CD4(+) T cells, delay of HIV viral rebound and enhancement of HIV-specific immune responses can be achieved, aiding HIV cure strategies. However, only a minority of patients showed signs of viral replication control, accompanied by significant restoration of HIV-specific CD8(+) T cell responses.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Bei Li, Leidan Zhang, Ying Liu, Jing Xiao, Cuilin Li, Lina Fan, Yujiao Duan, Jiang Xiao, Yu Hao, Junyan Han, Yaxian Kong, Hongxin Zhao
Summary: Our study developed a clinical prediction model to evaluate the possibility of CD4(+)/CD8(+) ratio restoration in HIV-positive individuals. The model showed good predictive accuracy and calibration, and can be used to determine whether HIV/AIDS patients would benefit from modern antiretroviral therapy.
Article
Immunology
Alexis Yero, Tao Shi, Jean-Pierre Routy, Cecile Tremblay, Madeleine Durand, Cecilia T. T. Costiniuk, Mohammad-Ali Jenabian
Summary: This study found that acute and chronic HIV infection are associated with an increase in total, effector memory, and terminally differentiated FoxP3(+) CD8 T-cells. Early antiretroviral therapy (ART) only normalized the frequencies of total FoxP3(+) CD8 T-cells. The study also observed increased immune activation, senescence, and PD-1 expression in FoxP3(+) CD8 T-cells during acute and chronic infection, which were not normalized by early ART.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Dan Yuan, Yan Zhang, Yiping Li, Ling Li, Hong Yang, Wei Yang, Hang Yu, Liao Feng, Shu Liang
Summary: This study analyzed the CD4(+) T cell count changes of PLWH infected with different HIV-1 subtypes in Sichuan Province after treatment, identifying factors such as virus subtype, gender, age, and education level that influence CD4(+) T cell count growth.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Virology
Elena Bruzzesi, Arianna Gabrieli, Davide Bernasconi, Giulia Marchetti, Andrea Calcagno, Diego Ripamonti, Andrea Antinori, Nicola Squillace, Antonella Cingolani, Antonio Muscatello, Alessandra Bandera, Andrea Gori, Stefano Rusconi, Silvia Nozza, INACTION Study Grp
Summary: The introduction of antiretroviral therapy (ART) during primary HIV-1 infection (PHI) can restrict the establishment of HIV reservoirs. This study aimed to assess the effect of three different ART regimens on HIV-DNA load in individuals living with HIV (PLWH) who started ART in PHI. The results showed that regardless of the treatment regimen, the HIV-DNA load in PLWH decreased during the treatment period.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Eva M. Stevenson, Sandra Terry, Dennis Copertino, Louise Leyre, Ali Danesh, Jared Weiler, Adam R. Ward, Pragya Khadka, Evan McNeil, Kevin Bernard, Itzayana G. Miller, Grant B. Ellsworth, Carrie D. Johnston, Eli J. Finkelsztein, Paul Zumbo, Doron Betel, Friederike Dundar, Maggie C. Duncan, Hope R. Lapointe, Sarah Speckmaier, Nadia Moran-Garcia, Michelle Premazzi Papa, Samuel Nicholes, Carissa J. Stover, Rebecca M. Lynch, Marina Caskey, Christian Gaebler, Tae-Wook Chun, Alberto Bosque, Timothy J. Wilkin, Guinevere Q. Lee, Zabrina L. Brumme, R. Brad Jones
Summary: In a cohort of people with HIV, COVID mRNA vaccination leads to a temporary increase in a specific profile of HIV-specific T-cell responses and a corresponding decrease in residual HIV RNA, indicating productive immune engagement with infected cells.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Chao Zhang, Jin-Wen Song, Hui-Huang Huang, Xing Fan, Lei Huang, Jian-Ning Deng, Bo Tu, Kun Wang, Jing Li, Ming-Ju Zhou, Cui-Xian Yang, Qi-Wen Zhao, Tao Yang, Li-Feng Wang, Ji-Yuan Zhang, Ruo-Nan Xu, Yan-Mei Jiao, Ming Shi, Feng Shao, Rafick-Pierre Sekaly, Fu-Sheng Wang
Summary: Chronic HIV-1 infection leads to CD4(+) T cell loss, with distinct mechanisms affecting pyroptotic and apoptotic CD4(+) T cells. Pyroptosis is closely associated with inflammation and driven by NLRP3 inflammasome activation, while apoptosis is more related to T cell activation status.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Sebastiaan O. Verboeket, Ferdinand W. Wit, Eveline Verheij, Rosan A. van Zoest, Neeltje A. Kootstra, Marc van der Valk, Jan M. Prins, Maarten F. Schim van der Loeff, Peter Reiss
Summary: In this study, it was found that compared to men who only have sex with women, men who have sex with men have higher CD8(+) counts and lower CD4(+)/CD8(+) ratios, with these differences partly explained by higher CMV seroprevalence.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Health Care Sciences & Services
Dominic Chu, David Lessard, Moustafa A. Laymouna, Kim Engler, Tibor Schuster, Yuanchao Ma, Nadine Kronfli, Jean-Pierre Routy, Tarek Hijal, Karine Lacombe, Nancy Sheehan, Hayette Rougier, Bertrand Lebouche
Summary: The study found that both people living with HIV and healthcare professionals have consensus on the risks and benefits of using a patient portal in HIV care. By engaging stakeholders, the configuration of a patient portal can be optimized and concerns during implementation can be mitigated.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Heather Gelhorn, Cindy Garris, Erin Arthurs, Frank Spinelli, Katelyn Cutts, Gin Nie Chua, Hannah Collacott, Bertrand Lebouche, Erik Lowman, Howard Rice, Sebastian Heidenreich
Summary: The study revealed that the majority of PLWH prefer long-acting injectable (LAI) antiretroviral therapy over oral treatment, while physicians are also inclined to recommend LAI for patients. Patients believe that LAI can reduce daily reminders of HIV and feelings of being stigmatized.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Giada Sebastiani, Jovana Milic, Adriana Cervo, Sahar Saeed, Thomas Krahn, Dana Kablawi, Al Shaima Al Hinai, Bertrand Lebouche, Philip Wong, Marc Deschenes, Claudia Gioe, Antonio Cascio, Giovanni Mazzola, Giovanni Guaraldi
Summary: This study aims to optimize a care pathway for identifying significant liver fibrosis in HIV patients by using five simple serum biomarkers. Applying these biomarkers as first tiers can reduce the referrals for transient elastography (TE) examinations. BMI and triglycerides are independent predictors of the discordance between low fibrosis biomarkers and high TE results.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
David Ortiz-Paredes, Olivia Varsaneux, James Worthington, Hyejin Park, Shannon E. MacDonald, Nicole E. Basta, Bertrand Lebouche, Joseph Cox, Shainoor J. Ismail, Nadine Kronfli
Summary: This study explores the reasons for COVID-19 vaccine refusal among individuals in federal prisons. The findings indicate that individual-level, interpersonal-level, and system-level factors contribute to vaccine hesitancy, including risk perception, dissatisfaction with prison healthcare services, and universal distrust.
Article
Health Care Sciences & Services
Khayreddine Bouabida, Kathy Malas, Annie Talbot, Marie-Eve Desrosiers, Frederic Lavoie, Bertrand Lebouche, Niloofar Taghizadeh, Louise Normandin, Cecile Vialaron, Olivier Fortin, David Lessard, Marie-Pascale Pomey
Summary: This study evaluates the capacity and contribution of two different digital platforms in maintaining quality, safety, and patient engagement in care from health professionals' perspectives. The majority of professionals have a positive perception of the quality and safety of care provided through these platforms, but also identify issues such as a lack of training and support.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
James Iveniuk, Liviana Calzavara, Sandra Bullock, Joshua Mendelsohn, Ann Burchell, Laura Bisaillon, Amrita Daftary, Bertrand Lebouche, Renee Masching, Tamara Thompson
Summary: This study investigated how serodiscordant couples access social resources for health. The findings showed that partners with HIV have greater access to formal resources, while both partners have similar access to resources through informal social relationships. Moreover, HIV positive partners accessed a greater variety of support through formal ties.
SSM-POPULATION HEALTH
(2022)
Article
Medicine, General & Internal
Giada Sebastiani, Nathalie Paisible, Cecilia Costiniuk, Joseph Cox, Dana Kablawi, Marina B. Klein, Nadine Kronfli, Jean-Pierre Routy, Julian Falutz, Bertrand Lebouche, Giovanni Guaraldi
Summary: NAFLD diagnosed by CAP is associated with VAT in PWH independently of anthropometric measures of obesity. CAP may be a potential diagnostic marker of visceral adiposity in the practice of HIV medicine.
Article
Health Care Sciences & Services
Anish K. Arora, Kim Engler, David Lessard, Nadine Kronfli, Adriana Rodriguez-Cruz, Edmundo Huerta, Benoit Lemire, Jean-Pierre Routy, Rene Wittmer, Joseph Cox, Alexandra de Pokomandy, Lina Del Balso, Marina Klein, Giada Sebastiani, Isabelle Vedel, Amelie Quesnel-Vallee, Bertrand Lebouche
Summary: This study explores the experiences of migrant people living with HIV in a Montreal-based multidisciplinary HIV care clinic, finding that rapid initiation of antiretroviral treatment and cost coverage may help alleviate patients' concerns, address their bio-psycho-social challenges, and ultimately contribute to positive experiences.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Anthony Marcellin, Valerie Martel-Laferriere, Anne-Genevieve Genest, Bertrand Lebouche, Suzanne Marcotte
Summary: This study examines the impact of the age at which HIV was acquired on adherence. The results show that there is no difference in adherence between patients who acquired HIV in childhood and those who acquired it in adolescence/early adulthood. However, patients who acquired HIV in childhood were less likely to achieve virological/immunological efficacy. Based on resistance, patients who acquired HIV in adolescence/early adulthood were more likely to be eligible for cabotegravir/rilpivirine treatment.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ralph-Sydney Mboumba Bouassa, Judy Needham, Dana Nohynek, Joel Singer, Terry Lee, Florian Bobeuf, Suzanne Samarani, Lina Del Balso, Natalie Paisible, Claude Vertzagias, Giada Sebastiani, Shari Margolese, Enrico Mandarino, Marina Klein, Bertrand Lebouche, Joseph Cox, Marie-Josee Brouillette, Jean-Pierre Routy, Jason Szabo, Rejean Thomas, Emmanuel Huchet, Antonio Vigano, Mohammad-Ali Jenabian, Cecilia T. Costiniuk
Summary: This study suggests that cannabinoids might be safe and well-tolerated in people living with HIV, but screening and monitoring for potential liver pathology is needed.
Article
Health Care Sciences & Services
Kedar K. Mate, Bertrand Lebouche, Marie-Josee Brouillette, Lesley K. Fellows, Nancy E. Mayo
Summary: This study aimed to develop a preference-based health-related quality of life measure for HIV patients. Through an analysis of data from the Canadian Positive Brain Health Now cohort, seven independent dimensions were identified, and a scoring system was developed that takes into account patient's health status across different dimensions.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Substance Abuse
Charlotte Laniece Delaunay, Marina B. Klein, Arnaud Godin, Joseph Cox, Nadine Kronfli, Bertrand Lebouche, Carla Doyle, Mathieu Maheu-Giroux
Summary: This study assessed the potential interventions to achieve HCV elimination among PWID in Montreal, Canada. The results showed that scaling up treatment among all PWID and PWID living with HIV can achieve the incidence and mortality targets. However, COVID-19-related disruptions could have temporary impacts on HCV transmission.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2023)
Article
Cell Biology
Ralph-Sydney Mboumba Bouassa, Eve Comeau, Yulia Alexandrova, Amelie Pagliuzza, Alexis Yero, Suzanne Samarani, Judy Needham, Joel Singer, Terry Lee, Florian Bobeuf, Claude Vertzagias, Giada Sebastiani, Shari Margolese, Enrico Mandarino, Marina B. Klein, Bertrand Lebouche, Jean-Pierre Routy, Nicolas Chomont, Cecilia T. Costiniuk, Mohammad-Ali Jenabian
Summary: Chronic HIV infection is accompanied by persistent inflammation, and this study suggests that cannabinoids may help reduce systemic inflammation in people with HIV. The study found that oral cannabinoids, either in combination with THC and CBD or CBD-only, significantly reduced inflammatory markers and affected immune cell subsets. These findings can guide future large clinical trials investigating the anti-inflammatory properties of cannabinoids.
Article
Health Care Sciences & Services
Khayreddine Bouabida, Bertrand Lebouche, Marie-Pascale Pomey
Summary: This paper aims to discuss the utilization, role, and impact of telehealth, as well as opportunities and future implications during the COVID-19 pandemic. Telehealth is considered to be an effective and affordable solution for healthcare systems, but it also faces various challenges that require further research to enhance the quality and safety of telehealth services.
Article
Health Policy & Services
Derek Fehr, Bertrand Lebouche, Luciana Ruppenthal, Melodie Brownc, Nancy Obasc, Emilie Bourbonniere, Josee Girouard, Angie Massicotte, Mohammad-Ali Jenabian, Abdul-Aziz Almomen, Charles Frenette, Alexandra de Pokomandy, Joseph Cox, Andreas Giannakis, Matthew Cheng, Nadine Kronfli, Christos Tsoukas, Navid Zahedi, Jason Szabo, Kianoush Dehghani, Marie-Josee Brouillette, Julian Falutz, Howard Turner, Alexandra Hamel, Claire Duchesneau, Jasmine Lanthier-Brun, Marina Klein, Jean-Pierre Routy, Cecilia T. Costiniuk
Summary: The study in a tertiary care clinic in Montreal found that PLWH who tested positive for COVID-19 may have worse health outcomes and were at high risk due to low socioeconomic status and high-risk employment or living conditions. Three individuals died with COVID-19, with one confirmed death due to COVID-19 and two deaths with positive COVID-19 test results but unclear immediate cause.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2022)