期刊
CLINICAL INFECTIOUS DISEASES
卷 60, 期 10, 页码 1528-1531出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/civ062
关键词
interleukin-18; inflammasome; rhinovirus infection; asthma
资金
- European Research Council (ERC) [233015]
- Chair from Asthma UK [CH11SJ]
- Medical Research Council Centre [G1000758]
- National Institute of Health Research Biomedical Research Centre [P26095]
- Predicta FP7 Collaborative Project [260895]
- National Institute for Health Research Biomedical Research Centre at Imperial College London
- Novartis Institute for Biomedical Research
- Asthma UK [CH11SJ, MRC-Asthma UK Centre] Funding Source: researchfish
- Medical Research Council [G1000758, G1000758B] Funding Source: researchfish
Rhinoviruses cause the common cold and exacerbations of asthma. Animal models of infection have identified a protective role for interleukin-18 (IL-18). Following experimental rhinovirus infection, we observed increased respiratory symptoms in healthy and asthmatic subjects with low nasal and bronchial IL-18 levels.
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