期刊
WOUND REPAIR AND REGENERATION
卷 24, 期 3, 页码 602-606出版社
WILEY-BLACKWELL
DOI: 10.1111/wrr.12422
关键词
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资金
- NIGMS [NIGM78421]
- National Cancer Institute [CA170140]
- Hammond Fund
- Division of Trauma Reinvestment Fund
- American Surgical Association Foundation Research Fellowship
- Department of Defense [W81XWH-10-1-0527]
In light of the central role of inflammation in normal wound repair and regeneration, we hypothesize that the preponderance of human-specific genes expressed in human inflammatory cells is commensurate with the genetic versatility of inflammatory response and the emergence of injuries associated with uniquely hominid behaviors, like a bipedal posture and the use of tools, weapons and fire. The hypothesis underscores the need to study human-specific signaling pathways in experimental models of injury and infers that a selection of human-specific genes, driven in part by the response to injury, may have facilitated the emergence of multifunctional genes expressed in other tissues.
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