Review
Dermatology
Kevin Woo, Caroline Dowsett, Ben Costa, Stephen Ebohon, Emma J. Woodmansey, Matthew Malone
Summary: The study summarizes the clinical effectiveness of cadexomer iodine in the treatment of chronic wounds, promoting wound bed preparation and healing process by removing barriers to healing.
INTERNATIONAL WOUND JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Hind Mubaraki, Navin Anand Ingle, Mohammad Abdul Baseer, Osamah M. AlMugeiren, Sarah Mubaraki, Marco Cicciu, Giuseppe Minervini
Summary: The use of silver diamine fluoride (SDF) has been shown to significantly reduce the growth of bacterial biofilms, indicating its potential as an effective treatment for dental caries. Further research is advised to explore the potential of SDF as a standard therapy choice for dental caries and to further investigate its relationship with bacterial biofilms.
Article
Dermatology
Paulo J. Alves, Ruben T. Barreto, Brigitte M. Barrois, Luc G. Gryson, Sylvie Meaume, Stan J. Monstrey
Summary: Biofilms play a major role in delaying chronic wounds from healing and pose a significant treatment challenge due to their resistance towards antimicrobial agents. However, there is a window of opportunity post-debridement when biofilms are more susceptible to topical antiseptics. Among commonly used antiseptics, PVP-I stands out for its broad spectrum of antimicrobial activity, potent antibiofilm efficacy, lack of acquired resistance, low cytotoxicity, good tolerability, and wound healing promotion.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Medicine, Research & Experimental
Aaron P. Decker, Yajuan Su, Biswajit Mishra, Atul Verma, Tamara Lushnikova, Jingwei Xie, Guangshun Wang
Summary: This study investigates the effects of peptide stability on antimicrobial and antibiofilm activity and finds that peptide antimicrobial activity is critical for in vivo efficacy. Using a nanofiber/microneedle delivery device can protect peptides from degradation and provide a new approach for direct use of natural peptides or their cocktails for antimicrobial treatment.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Balaji Ayyanar Chinnappan, Marimuthu Krishnaswamy, Trishna Bal, Aditya Dev Rajora
Summary: Tridax Procumbens Extracts (TPE) blended with Carboxymethylcellulose (CMC) were used to develop a film with antibacterial activity and cell proliferation capability. The film also showed effective wound healing properties in an in-vivo study using adult mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Medicine, General & Internal
Shubham Gupta, Sangita Shinde, Raju K. Shinde
Summary: This study compares the application of povidone iodine and cadexomer iodine in wound management, evaluating their effectiveness in reducing biofilms, decreasing wound size, and promoting wound healing.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Dermatology
Christopher Girgis, Mehmet A. Suludere, Andrew Crisologo, Lawrence A. Lavery
Summary: This article reviews laboratory studies, animal wound studies, and clinical studies on the efficacy and safety of iodine-based wound products in wound healing. It concludes that both iodine-based wound products are safe and do not impede wound healing, have no higher infection risks, and do not require more amputations compared to other modalities.
WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE
(2023)
Article
Microbiology
Ewa Klara Stuermer, Isabell Plattfaut, Michael Dietrich, Florian Brill, Andreas Kampe, Vanessa Wiencke, Anna Ulatowski, Maria Geffken, Julian-Dario Rembe, Ella Alexandrovna Naumova, Sebastian Eike Debus, Ralf Smeets
Summary: The study focused on the efficacy of antimicrobial dressings for wounds with biofilms, with cadexomer-iodine (C-IOD) showing the best bacterial reduction while octendine di-hydrochloride (OCT) and ionic silver (AG) dressings did not meet expectations. Chemical interaction with biofilm extrapolymeric substance (EPS) and dressing configuration are suggested to be responsible for the diverse results, indicating a need to rethink non-debridement anti-biofilm therapy.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elmira Mohamed, Yi Wang, Philip J. Crispin, Ailene Fitzgerald, Jane E. Dahlstrom, Suzanne Fowler, David R. Nisbet, Takuya Tsuzuki, Lucy A. Coupland
Summary: Optimization of the morphological properties of nonoxidized cellulose nanofibers (CNFs) enhances hemostasis. CNFs as hemostatic materials demonstrate excellent hemostatic properties in in vitro and in vivo experiments, while also being biocompatible and biodegradable. Therefore, CNFs hold significant potential for use in surgical and first-aid environments.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Naveed Ahmad
Summary: Chronic wound management is a major challenge in healthcare due to its slow healing process and high financial burden. Traditional wound dressings are not effective for highly exudating chronic wounds, necessitating the development of newer dressings. This review provides an overview of modern wound dressings and their in vitro and in vivo characterization methods, highlighting their advantages, challenges, and future outlook.
Article
Immunology
Aliona S. Rosca, Joana Castro, Lucia G. V. Sousa, Angela Franca, Carlos Cavaleiro, Ligia Salgueiro, Nuno Cerca
Summary: This study characterized the first polymicrobial biofilm consisting of six BV-associated species and found that Thymbra capitata essential oil exhibited a high antibacterial effect against the polymicrobial biofilm. The findings provide important insights for the development of antimicrobial agents against BV.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Ecology
Michael J. Bottery, Jessica L. Matthews, A. Jamie Wood, Helle Krogh Johansen, Jon W. Pitchford, Ville-Petri Friman
Summary: The study found that multidrug-resistant Stenotrophomonas maltophilia can provide high levels of antibiotic protection to Pseudomonas aeruginosa, but is ineffective against another antibiotic. The level of exposure protection against different carbapenems is determined by differences in antibiotic efficacy and inactivation rate.
Article
Agriculture, Dairy & Animal Science
Diwakar Singh, Sanjeev Anand
Summary: This study evaluates the effectiveness of a typical clean-in-place (CIP) protocol against in vitro biofilms on whey reverse osmosis (RO) membranes developed under static condition. The results reveal that the protocol has limited effectiveness in completely removing the biofilms.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Shaydier Argel, Melissa Castano, Daiver Estiven Jimenez, Sebastian Rodriguez, Maria Jose Vallejo, Cristina Isabel Castro, Marlon Andres Osorio
Summary: In this study, bioactive wound dressings were successfully developed by loading the antibacterial povidone-iodine and anti-inflammatory acetylsalicylic acid into bacterial nanocellulose (BNC). The structure and mechanical properties of the dressings were characterized by scanning electron microscopy and mechanical tests. The release assays and histology confirmed the diffusion of the bioactive compounds in porcine skin. Antimicrobial experiments and protein denaturation tests further confirmed the antibacterial and anti-inflammatory properties of the dressings.
Article
Public, Environmental & Occupational Health
Phat Tran, Jonathan Kopel, Keaton Luth, Huy Dong, Ameesh Dev, Dilip Mehta, Kelly Mitchell, Keith W. Moeller, Cameron D. Moeller, Ted Reid
Summary: This study aimed to determine if the combination of 5% betadine solution and silver colloidal gel is more effective than either substance alone in inhibiting the growth of gram-negative and gram-positive bacteria. The results showed that silver gel had complete inhibition on all the bacteria species examined except for the Klebsiella pneumoniae clinical isolate strain, while 5% betadine solution did not completely kill any of the tested bacteria. However, when 5% betadine solution and silver gel were used together, they were able to completely eliminate K. pneumoniae. The study concluded that the combination of 5% betadine solution and silver gel was superior at eliminating all tested bacteria.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Microbiology
Eric D. Roche, Paul J. Renick, Shannon P. Tetens, Dennis L. Carson
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2012)
Article
Chemistry, Analytical
Donghui Bao, Thanh-Thai Truong, Paul J. Renick, Mark E. Pulse, William J. Weiss
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2008)
Article
Cell Biology
Eric D. Roche, Paul J. Renick, Shannon P. Tetens, Sarah J. Ramsay, Egeenee Q. Daniels, Dennis L. Carson
WOUND REPAIR AND REGENERATION
(2012)
Article
Dermatology
Shuxin Li, Paul Renick, Jon Senkowsky, Ashwin Nair, Liping Tang
Summary: Infections significantly impact the healing process of chronic wounds, leading to a burden on healthcare resources. Advances in identifying infection biomarkers and imaging modalities have improved diagnosis methods. While traditional diagnostic approaches are time-consuming and reliant on clinician's experience, there is a need for noninvasive, specific, rapid, and accurate wound infection diagnostics.
ADVANCES IN WOUND CARE
(2021)
Article
Chemistry, Medicinal
Paul J. Renick, Aditi Mulgaonkar, Cynthia M. Co, Cheng-Yang Wu, Ning Zhou, Arturo Velazquez, Jenelle Pennington, Amber Sherwood, He Dong, Laila Castellino, Orhan K. Oz, Liping Tang, Xiankai Sun
Summary: Through comparative studies with its L-isomer counterpart, we demonstrate that PET imaging with D-[5-C-11]-Gln can detect infections induced by both Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA) with significantly higher infection-to-background contrast.
ACS INFECTIOUS DISEASES
(2021)
Article
Materials Science, Biomaterials
Weike Chen, Shuxin Li, Paul Renick, Su Yang, Nikhil Pandy, Cara Boutte, Kytai T. Nguyen, Liping Tang, He Dong
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Article
Chemistry, Medicinal
In Ho Kim, Keith D. Combrink, Zhenkun Ma, Katrina Chapo, Dalai Yan, Paul Renick, Timothy W. Morris, Mark Pulse, Jerry W. Simecka, Charles Z. Ding
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2007)
Article
Microbiology
DR Macinga, PJ Renick, KM Makin, DH Ellis, AA Kreiner, M Li, KJ Rupnik, EM Kincaid, CD Wallace, B Ledoussal, TW Morris
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2003)
Article
Chemistry, Medicinal
LJ Wilson, TW Morris, QM Wu, PJ Renick, CN Parker, MC Davis, HD McKeever, PM Hershberger, AG Switzer, G Shrum, S Sunder, DR Jones, SS Soper, RLM Dobson, T Burt, KL Morand, M Stella
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2001)
Meeting Abstract
Cell Biology
Paul Renick, Eric Roche
WOUND REPAIR AND REGENERATION
(2009)
Meeting Abstract
Cell Biology
Paul Renick, Eric Roche, Dale Telgenhoff, Egeenee Daniels, Lawton Seal, Duncan Aust
WOUND REPAIR AND REGENERATION
(2009)