Review
Gastroenterology & Hepatology
Ngozi Enwerem, Moo Y. Cho, Joshua Demb, Ashley Earles, Karen M. Heskett, Lin Liu, Siddharth Singh, Samir Gupta
Summary: The incidence and mortality of early-onset colorectal cancer (CRC) are increasing, with a prevalence of young-onset adenomas increasing with age. Studies found a 6% risk of metachronous advanced neoplasia after baseline young-onset adenoma diagnosis.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Oncology
Charlotte Ryder-Burbidge, Ruth L. Diaz, Ronald D. Barr, Sumit Gupta, Paul C. Nathan, Sarah J. McKillop, Miranda M. Fidler-Benaoudia
Summary: The study found that adolescent and young adult cancer survivors are at increased risk of second cancers, chronic conditions, and deaths. Factors such as radiation exposure and younger age contribute to this increased risk.
Article
Oncology
Xunwen Ye, Yonglin Chen, Jialin Gu
Summary: This meta-analysis examined 30 potential risk factors for young-onset advanced colorectal neoplasia, and found that male sex, metabolic syndrome, hypertension, diabetes, inflammatory bowel disease, obesity, sedentary behavior, smoking, high alcohol consumption, high intake of sugar and red meat, as well as family history of colorectal cancer, were all significant risk factors. These findings provide important guidance for the development of targeted primary prevention strategies.
Article
Nutrition & Dietetics
Carolina Di Somma, Elisabetta Scarano, Luigi Barrea, Domenico Solari, Enrico Riccio, Rossana Arianna, Luigi Maria Cavallo, Fiammetta Romano, Elea Di Benedetto, Alice Rodriguez, Giulia de Alteriis, Annamaria Colao
Summary: The study aimed to investigate the potential association between Craniopharyngioma (CP), chronotypes, and metabolic risk profile. Results showed that patients with evening chronotype had higher blood pressure values and worse metabolic parameters than those with morning chronotype. The study suggests that alterations of chronotype might represent an additional risk factor for CP patients and a possible target for integrated management.
Article
Gastroenterology & Hepatology
Wei-Yuan Chang, Hsuan-Ho Lin, Li-Chun Chang, Wen-Feng Hsu, Ming-Shiang Wu, Han-Mo Chiu
Summary: Maintaining an active exercise habit after polypectomy is associated with a lower risk of developing metachronous advanced colorectal neoplasms, particularly for individuals with advanced neoplasms identified during screening colonoscopy.
DIGESTIVE ENDOSCOPY
(2022)
Article
Medicine, General & Internal
Wei-Chun Cheng, Po-Jun Chen, Jui-Wen Kang, Wei-Ying Chen, Bor-Shyang Sheu
Summary: The study identified risk factors associated with advanced colorectal neoplasia (AN) in subjects with negative Fecal Immunochemical Test (FIT), including age, gender, smoking history, and metabolic syndrome. For FIT-negative cases, colonoscopy screening should be considered for male patients over 50 years old with a history of smoking and metabolic syndrome to detect AN.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Gastroenterology & Hepatology
Joseph A. Rothwell, Neil Murphy, Jelena Besevic, Nathalie Kliemann, Mazda Jenab, Pietro Ferrari, David Achaintre, Audrey Gicquiau, Beatrice Vozar, Augustin Scalbert, Inge Huybrechts, Heinz Freisling, Cornelia Prehn, Jerzy Adamski, Amanda J. Cross, Valeria Maria Pala, Marie-Christine Boutron-Ruault, Christina C. Dahm, Kim Overvad, Inger Torhild Gram, Torkjel M. Sandanger, Guri Skeie, Paula Jakszyn, Kostas K. Tsilidis, Krasimira Aleksandrova, Matthias B. Schulze, David J. Hughes, Bethany van Guelpen, Stina Boden, Maria-Jose Sanchez, Julie A. Schmidt, Verena Katzke, Tilman Kuhn, Sandra Colorado-Yohar, Rosario Tumino, Bas Bueno-de-Mesquita, Paolo Vineis, Giovanna Masala, Salvatore Panico, Anne Kirstine Eriksen, Anne Tjonneland, Dagfinn Aune, Elisabete Weiderpass, Gianluca Severi, Veronique Chajes, Marc J. Gunter
Summary: This study found that adherence to WCRF/AICR guidelines is associated with colorectal cancer risk, and specific changes in metabolites are more strongly associated with risk than the overall WCRF/AICR score.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sinwon Lee, Yoon Suh Do, Hyo Jeong Lee, Gwang-Un Kim, Hye Won Park, Hye-Sook Chang, Jaewon Choe, Jeong-Sik Byeon, Ji Young Lee
Summary: This study found that weight gain is associated with an increased risk of metachronous advanced colorectal neoplasm (ACRN) recurrence. Regardless of age and gender, weight gain was correlated with ACRN recurrence.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Health Care Sciences & Services
Laura Amaya Pascasio, Marina Blanco Ruiz, Rodrigo Milan Pinilla, Juan Manuel Garcia Torrecillas, Antonio Arjona Padillo, Cristina Del Toro Perez, Patricia Martinez-Sanchez
Summary: Recent research in Spain has shown an increased incidence of ischemic stroke (IS) in young adults, with a higher percentage of vascular risk factors. This study analyzed data from a nationwide inpatient sample and estimated the in-hospital incidence of IS and its comorbidities by sex and age group. The findings revealed a higher incidence of IS in men under the age of 50, and young adults with IS had a higher prevalence of vascular risk factors compared to the general population. These results provide important insights for primary and secondary prevention strategies.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Obstetrics & Gynecology
Xiaomei Wang, Yuan Lin, Zhaozhen Liu, Xinxin Huang, Rongxin Chen, Huihui Huang
Summary: The study investigated the causes and influencing factors of fetal loss in women of advanced maternal age. Fetal factors were the most common cause of fetal loss, followed by maternal factors, umbilical cord factors, and placental factors. Low education level, unemployment, abnormal pregnancy/labor history, and pregnancy complications were identified as risk factors for fetal loss in advanced maternal age.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Geriatrics & Gerontology
Seong-A. Jeong, Jeong Hwan Yook, Moon-Won Yoo, Beom Su Kim, In-Seob Lee, Sehee Kim, Chung Sik Gong, Chang Seok Ko
Summary: This study analyzed the predictors of postoperative complications and risk factors related to long-term survival in elderly patients with gastric cancer. The results indicated that being overweight, the extent of gastrectomy, tumor stage, and overall complications were significant risk factors affecting long-term survival in these patients.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Sandra Baile-Maxia, Carolina Mangas-Sanjuan, Uri Ladabaum, Cesare Hassan, Matthew D. Rutter, Michael Bretthauer, Licia Medina-Prado, Noelia Sala-Miquel, Oscar Murcia Pomares, Pedro Zapater, Rodrigo Jover
Summary: This study aimed to assess the association between HRA characteristics and the outcomes of CRC or AAs surveillance. The study found that adenomas larger than 20mm, high-grade dysplasia (HGD), and adenomas with villous component were associated with higher risk of metachronous CRC. However, multiplicity of adenomas did not seem to be significantly associated with higher CRC risk in the near term.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Biology
Zhongjie Fu, Anders K. Nilsson, Ann Hellstrom, Lois E. H. Smith
Summary: Retinopathy of prematurity (ROP) is caused by the suppression of physiological retinal vascular development, leading to compensatory but pathological neovascularization. Promoting normal vessel growth can prevent ROP. Early perinatal metabolic dysregulation is a risk factor for ROP and other long-term sequelae. Controlling postnatal hyperglycemia, dyslipidemia, and hyperoxia can promote normal retinal development.
Article
Public, Environmental & Occupational Health
Hoyoung Wang, Su Youn Nam, Junwoo Jo
Summary: This study investigated the association between hepatic and metabolic factors and renal cancer risk. The results showed that high serum HDL-C levels reduced renal cancer risk, while hepatitis B virus antigen and chronic HBV infection increased its risk. In addition, BMI and alcohol consumption were also associated with renal cancer risk.
PREVENTIVE MEDICINE
(2023)
Article
Oncology
Daniel Rydbeck, Dan Asplund, David Bock, Eva Haglind, Jennifer Park, Jacob Rosenberg, Sofie Walming, Eva Angenete
Summary: Younger age at diagnosis of colorectal cancer is associated with a diagnostic delay, while symptomatology at diagnosis remains similar regardless of age. Younger patients are more likely to report specific symptoms such as blood in stool and diarrhea.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Gastroenterology & Hepatology
Hyunbeom Chae, Hyo-Joon Yang, Soo-Kyung Park, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
Summary: The study found that metabolically healthy obese individuals and metabolically abnormal obese individuals have an increased risk of colorectal adenoma occurrence, while there was no increased risk in metabolically abnormal nonobese individuals.
Article
Medicine, General & Internal
Nam Hee Kim, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
Summary: The presence of nonalcoholic fatty liver disease has been associated with a higher risk of developing metachronous colorectal neoplasia after polypectomy, particularly in women. This suggests a possible role of NAFLD in the pathogenesis of colorectal neoplasia.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Yoon Suk Jung, Nam Hee Kim, Youngwoo Kim, Dong Il Park
Summary: This study compared the risk of metachronous colorectal neoplasia (CRN) according to adenoma location and found that proximal adenoma was associated with an increased risk of metachronous CRN, but not with an increased risk of metachronous advanced CRN (ACRN).
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Health Care Sciences & Services
Yoonsuk Jung, Eui Im, Jinhee Lee, Hyeah Lee, Changmo Moon
Summary: This study compared the performance of FITs for CRC detection between users and non-users of antiplatelet agents and warfarin using a large-scale population-based database. It found that users of antiplatelet agents had lower positive predictive values for CRC detection compared to non-users, while there were no significant differences for warfarin users.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Surgery
Yoon Suk Jung, Eui Im, Chan Hyuk Park
Summary: The use of antithrombotic agents significantly lowered the PPV of FIT for detecting advanced colorectal neoplasia, potentially increasing false positives.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Medicine, General & Internal
Yoon Suk Jung, Jinhee Lee, Chang Mo Moon
Summary: The study found that positive fecal immunochemistry test (FIT) results are associated with an increased risk of mortality from CRC and various other chronic diseases, suggesting that FIT could be a predictor of mortality independent of its association with CRC.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Health Care Sciences & Services
Chan Hyuk Park, Jung Ho Park, Yoon Suk Jung
Summary: Immunosuppressive therapy (IST) negatively affects the performance of interferon gamma release assays (IGRAs) in patients with inflammatory bowel disease (IBD), supporting the need for IGRA screening before initiating IST. Using both an IGRA and tuberculin skin test (TST) in IBD patients on IST may improve the diagnosis rate of latent tuberculosis infection (LTBI).
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Yoon Suk Jung, Sunyong Kim, Hyun-Young Kim, Seung Jae Noh, Jung Ho Park, Chan Hyuk Park
Summary: A retrospective study in Korea found that a 14-day treatment regimen with tegoprazan-based triple therapy had a higher eradication rate for Helicobacter pylori infection compared to a 7-day regimen, with acceptable adverse events. These results suggest that a 14-day treatment regimen may be more suitable in regions with high clarithromycin resistance.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Health Care Sciences & Services
Yoon Suk Jung, Yongho Jee, Eui Im, Min-ho Kim, Chang Mo Moon
Summary: The study showed a significant association between bowel preparation and undergoing colonoscopy with the risk of atrial fibrillation (AF), especially in elderly patients with hypertension.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Yoon Suk Jung, Huiyeon Song, Mai Thi Xuan Tran, Boyoung Park, Chang Mo Moon
Summary: Large-scale studies on the association between family history and colorectal cancer (CRC) risk in Asians are lacking. We conducted a study in the Korean population and found that individuals with a family history of CRC, especially in younger age groups, had a higher risk of developing CRC compared to those without a family history.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Yoon Suk Jung, Sunyong Kim, Hyun-Young Kim, Seung Jae Noh, Jung Ho Park, Chong Sohn, Chan Hyuk Park
Summary: This study compared the eradication rates of tegoprazan-based and rabeprazole-based triple therapy for Helicobacter pylori infection. The results showed no significant difference in the eradication rates between the two groups, as well as similar rates of adverse events.
Article
Health Care Sciences & Services
Chan Hyuk Park, Myung Jin Song, Byung Wook Jung, Jung Ho Park, Yoon Suk Jung
Summary: In the treatment of Helicobacter pylori infection, a 10-day tegoprazan-based concomitant therapy showed higher eradication rate and lower adverse event rate compared to a 14-day tegoprazan-based triple therapy. The adherence rates were similar between the two therapies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Yoon Suk Jung, Mai Thi Xuan Tran, Boyoung Park, Chang Mo Moon
Summary: This study evaluated the associations between gastric cancer family history and colorectal cancer risk, as well as between colorectal cancer family history and gastric adenoma risk. The results showed that gastric cancer family history was associated with an increased risk of gastric cancer, while colorectal cancer family history was not associated with the risk of gastric cancer or gastric adenoma. However, individuals with family histories of both gastric cancer and colorectal cancer had a higher risk of gastric adenoma. The study suggests that family histories of gastric cancer and colorectal cancer may affect each other's neoplastic lesion risk.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Yoon Suk Jung, Mai Thi Xuan Tran, Huiyeon Song, Boyoung Park, Chang Mo Moon
Summary: This study found that early treatment of H. pylori infection is associated with a reduced risk of gastric cancer. The gap in gastric cancer risk between patients with and without a family history of gastric cancer widens as the age at H. pylori eradication increases. The findings suggest that early treatment of H. pylori infection can maximize gastric cancer prevention.
Review
Gastroenterology & Hepatology
Yoon Suk Jung
Summary: Recently, updated guidelines for post-polypectomy surveillance have been published by multiple societies, and this review summarizes and compares the recommendations of these guidelines. There are differences in the recommended surveillance intervals, particularly for different types of adenomas. Surveillance recommendations for patients with serrated polyps are limited, and more research is needed in this area.
INTESTINAL RESEARCH
(2023)
