Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases

A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity

(2016) Hui Jing et al.   CANCER CELL

Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease

(2016) Rona Yaeger et al.   GASTROENTEROLOGY

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease−Associated Colorectal Cancers

(2016) Ana I. Robles et al.   GASTROENTEROLOGY

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells

(2016) Lars Tögel et al.   MOLECULAR CANCER THERAPEUTICS

Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment

(2016) Jordan E Axelrad et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation

(2016) Francesco Paolo Fiorentino et al.   Oncotarget

The long non-coding RNA PARROT is an upstream regulator of c-Myc and affects proliferation and translation

(2016) Dubravka Vučićević et al.   Oncotarget

A reciprocal regulatory circuit between CD44 and FGFR2 via c-myc controls gastric cancer cell growth

(2016) Jihyun Park et al.   Oncotarget

miR-320b suppresses cell proliferation by targeting c-Myc in human colorectal cancer cells

(2015) Hantao Wang et al.   BMC CANCER

A dynamic exchange of TCF3 and TCF4 transcription factors controlsMYCexpression in colorectal cancer cells

(2015) Meera Shah et al.   CELL CYCLE

A Role for MYC in Lithium-Stimulated Repair of the Colonic Epithelium After DSS-Induced Damage in Mice

(2015) Wesley M. Raup-Konsavage et al.   DIGESTIVE DISEASES AND SCIENCES

Long noncoding RNAs as a novel component of the Myc transcriptional network

(2015) Melanie Winkle et al.   FASEB JOURNAL

The Histone Acetyltransferase GCN5 Expression Is Elevated and Regulated by c-Myc and E2F1 Transcription Factors in Human Colon Cancer

(2015) Yan-Wei Yin et al.   GENE EXPRESSION

RNA Interference Using c-Myc-Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models

(2015) N. K. Tangudu et al.   MOLECULAR CANCER THERAPEUTICS

Erratum: Corrigendum: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

(2015) Valentina Cianfanelli et al.   NATURE CELL BIOLOGY

Integrin α1β1 expression is controlled by c-MYC in colorectal cancer cells

(2015) S Boudjadi et al.   ONCOGENE

Aspirin and salicylic acid decrease c-Myc expression in cancer cells: a potential role in chemoprevention

(2015) Guoqiang Ai et al.   TUMOR BIOLOGY

Expression of Wnt and Notch signaling pathways in inflammatory bowel disease treated with mesenchymal stem cell transplantation: evaluation in a rat model

(2015) Yanfen Xing et al.   Stem Cell Research & Therapy

Triphala Extract Suppresses Proliferation and Induces Apoptosis in Human Colon Cancer Stem Cells via Suppressing c-Myc/Cyclin D1 and Elevation of Bax/Bcl-2 Ratio

(2015) Ramakrishna Vadde et al.   Biomed Research International

Integrin α6A splice variant regulates proliferation and the Wnt/β-catenin pathway in human colorectal cancer cells

(2014) Jean-François Groulx et al.   CARCINOGENESIS

Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo

(2014) T J Phesse et al.   CELL DEATH AND DIFFERENTIATION

Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus

(2014) Jian-Feng Xiang et al.   CELL RESEARCH

Attacking c-Myc: Targeted and Combined Therapies for Cancer

(2014) Huilin Huang et al.   CURRENT PHARMACEUTICAL DESIGN

Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics

(2014) Bing-Jia Chen et al.   International Journal of Biological Sciences

A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity

(2014) P K Bajpe et al.   ONCOGENE

Targeting RNA polymerase I to treat MYC-driven cancer

(2014) G Poortinga et al.   ONCOGENE

Ambra1 Is an Essential Regulator of Autophagy and Apoptosis in SW620 Cells: Pro-Survival Role of Ambra1

(2014) Wen Gu et al.   PLoS One

FGFR2 Is Amplified in the NCI-H716 Colorectal Cancer Cell Line and Is Required for Growth and Survival

(2014) Anjili Mathur et al.   PLoS One

Lysine Acetyltransferase GCN5 Potentiates the Growth of Non-small Cell Lung Cancer via Promotion of E2F1, Cyclin D1, and Cyclin E1 Expression

(2013) Long Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Carbon Monoxide Attenuates Dextran Sulfate Sodium-Induced Colitis via Inhibition of GSK-3βSignaling

(2013) Md. Jamal Uddin et al.   Oxidative Medicine and Cellular Longevity

Mesenchymal Stem Cell Therapy Stimulates Endogenous Host Progenitor Cells to Improve Colonic Epithelial Regeneration

(2013) Alexandra Sémont et al.   PLoS One

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma

(2013) S. A. Jensen et al.   Science Translational Medicine

Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

(2013) Alexandre Puissant et al.   Cancer Discovery

Roles of toll-like receptors in Cancer: A double-edged sword for defense and offense

(2012) Shaherin Basith et al.   ARCHIVES OF PHARMACAL RESEARCH

The chemopreventive agent ursodeoxycholic acid inhibits proliferation of colon carcinoma cells by suppressing c-Myc expression

(2012) Roser Peiró-Jordán et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells

(2012) Yasuhiro Nemoto et al.   GUT

Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma

(2012) Feng Yang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The Myc 3' Wnt-Responsive Element Regulates Homeostasis and Regeneration in the Mouse Intestinal Tract

(2012) W. M. Konsavage et al.   MOLECULAR AND CELLULAR BIOLOGY

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

(2012) H. S. Bandukwala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Genetics of Colorectal Cancer

(2011) Eric R. Fearon   Annual Review of Pathology-Mechanisms of Disease

Expressions of p53, c-MYC, BCL-2 and apoptotic index in human osteosarcoma and their correlations with prognosis of patients

(2011) Xing Wu et al.   Cancer Epidemiology

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Endogenous Myc maintains the tumor microenvironment

(2011) N. M. Sodir et al.   GENES & DEVELOPMENT

The MK5/PRAK Kinase and Myc Form a Negative Feedback Loop that Is Disrupted during Colorectal Tumorigenesis

(2011) Theresia R. Kress et al.   MOLECULAR CELL

Targeting MYC dependence in cancer by inhibiting BET bromodomains

(2011) J. A. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy

(2010) Lars-Gunnar Larsson et al.   EXPERIMENTAL CELL RESEARCH

Regulation of the p53 pathway by ubiquitin and related proteins

(2010) Andreas Hock et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The role of microRNAs in colorectal cancer

(2010) Mao Liu et al.   Journal of Genetics and Genomics

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication

(2010) I. G. Cannell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin α6Bβ4 inhibits colon cancer cell proliferation and c-Myc activity

(2009) Anders Bondo Dydensborg et al.   BMC CANCER

Myc's other life: stem cells and beyond

(2009) Elisa Laurenti et al.   CURRENT OPINION IN CELL BIOLOGY

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity

(2009) Takashi Yabana et al.   JOURNAL OF PATHOLOGY

Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

(2009) P. Hydbring et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteins that underlie neoplastic progression of ulcerative colitis

(2009) Teresa A. Brentnall et al.   Proteomics Clinical Applications

Distinct Thresholds Govern Myc's Biological Output In Vivo

(2008) Daniel J. Murphy et al.   CANCER CELL

Epigenetic Silencing of MicroRNA-34b/c and B-Cell Translocation Gene 4 Is Associated with CpG Island Methylation in Colorectal Cancer

(2008) M. Toyota et al.   CANCER RESEARCH

Topical Implantation of Mesenchymal Stem Cells Has Beneficial Effects on Healing of Experimental Colitis in Rats

(2008) Y. Hayashi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE

Apoptotic signaling by c-MYC

(2008) B Hoffman et al.   ONCOGENE