Letter
Gastroenterology & Hepatology
Peng Chen, Fuchao Chen
Summary: This article is related to Ikegami et al's papers.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Hailan Zhao, Haoming Xu, Shuzhen Chen, Jie He, Youlian Zhou, Yuqiang Nie
Summary: A systematic review and meta-analysis found a negative association between abundance of F. prausnitzii and IBD activity, but a cut-off level of F. prausnitzi for diagnosing and treating IBD has not been determined.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Li-ting Jin, Ming-Zhi Xu
Summary: In obese patients, the connection between the gut microbiota and the onset of non-alcoholic fatty liver (NAFLD) is yet unknown. A study comparing the gut microbiota of obese individuals with and without NAFLD found a lower quantity of Faecalibacterium prausnitzii in the NAFLD group. Bacteroides, Clostridium leptum, and Clostridium butyricum were more prevalent in the NAFLD group, while Bacteroides, Clostridium butyricum, and F. prausnitzii were more prevalent in the simple obesity group. Lymphocytes and F. prausnitzii may play a role in determining the development of NAFLD in obese patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Kairuo Wang, Yixuan Guo, Yuanyuan Liu, Xiao Cui, Xiang Gu, Lixiang Li, Yanqing Li, Ming Li
Summary: This study found that the deficiency of F. prausnitzii in the gut is associated with elevated F. prausnitzii-reactive IgA in ulcerative colitis (UC) patients. Forced immunization of rabbits with F. prausnitzii led to intestinal inflammation. PFOR was identified as an IgA-binding antigen of F. prausnitzii and its immunoreactivity was validated in peripheral blood mononuclear cells (PBMCs), which showed elevated expression of inflammatory cytokines. Phylogenetic analysis revealed that PFOR is a common but conserved protein among gut bacteria.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Camille Kropp, Katy Le Corf, Karima Relizani, Kevin Tambosco, Ccori Martinez, Florian Chain, Georges Rawadi, Philippe Langella, Sandrine P. Claus, Rebeca Martin
Summary: Christensenella minuta displays strong anti-inflammatory activity by inhibiting the NF-kappa B signaling pathway, protects intestinal epithelial integrity, and shows potential for treating IBDs.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Shu-lan Qu, Long Chen, Xue-shan Wen, Jian-ping Zuo, Xiao-yu Wang, Zhi-jie Lu, Yi-fu Yang
Summary: The study shows that cinnamaldehyde (CA) can ameliorate ulcerative colitis by suppressing Th17 cells via the S1P2 pathway and regulating lncRNA H19 and MIAT.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Plant Sciences
Zhaocheng Li, Minling Lin, Yadi Li, Jing Shao, Ruiting Huang, Yongyi Qiu, Yi Liu, Lei Chen
Summary: Sophora flavescens Aiton total flavonoids extracts (SFE), especially the flavonoid ingredient Kurarinone, have significant immunoregulatory effects against ulcerative colitis (UC) by inhibiting the activation of the JAK2/STAT3 signaling pathway and regulating the differentiation of Th17/Treg cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Stefania De Santis, Aurelia Scarano, Marina Liso, Francesco Maria Calabrese, Giulio Verna, Elisabetta Cavalcanti, Annamaria Sila, Antonio Lippolis, Maria De Angelis, Angelo Santino, Marcello Chieppa
Summary: The health status of mother microbiota has a significant impact on the neonatal gut microbiota. Using a murine model of UC predisposition, this study evaluated the effects of maternal diet during pregnancy and lactation on offspring microbiota, indicating that a diet enriched with bioactive polyphenols from tomato can reduce dysbiosis in genetically predisposed offspring.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Cell Biology
Brendan A. Daisley, David Koenig, Kathleen Engelbrecht, Liz Doney, Kiel Hards, Kait F. Al, Gregor Reid, Jeremy P. Burton
Summary: This article highlights that the traditional viewpoint of single-celled microbial metabolism is insufficient to depict energy flow in host-adapted microbial communities at a system level. Emerging paradigms suggest that interconnected and interdependent electron transport chains develop in microbial communities, relying on cooperative production and sharing of bioenergetic machinery in the extracellular space.
Article
Immunology
Xue-Yuan Leng, Jia Yang, Heng Fan, Qian-Yun Chen, Bing-Jie Cheng, Hong-Xia He, Fei Gao, Feng Zhu, Ting Yu, Yu-Jin Liu
Summary: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unclear etiology and pathogenesis. This study provides evidence that histone modification plays an important regulatory role in UC, identifying it as a potential therapeutic target.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Mika Sato, Yoshio Suzuki
Summary: This study investigated changes in the intestinal microbiota of ultramarathon runners and found a significant decrease in the abundance of butyrate-producing bacteria, which affects butyrate levels in the intestine and host immune function.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Li-Ming Fan, Yu-Qin Zhang, Ya-Ping Chen, Lin-Lin Chen, Wei-Heng Xu, Li-Hong Nan, Wei Xu, Bin Lu, Yan Wang, Ke-Dan Chu, Jun-Ping Zhang
Summary: The study demonstrates that cryptotanshinone (CTS) can alleviate acute and chronic ulcerative colitis (UC) by suppressing STAT3 activation and Th17 cell differentiation, suggesting it as a promising candidate drug for UC treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Yongzhi Hua, Ruiqi Liu, Min Lu, Xueneng Guan, Suyang Zhuang, Yaozhou Tian, Zhenhai Zhang, Li Cui
Summary: Juglone has been found to have therapeutic effects on ulcerative colitis in mice, modulating gut microbiota and restoring Th17/Treg balance. The results show that juglone can alleviate UC symptoms, reduce inflammatory protein levels, and impact gut microbiota and Th17/Treg ratio.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zihan Zhou, Shengnan Yu, Luwen Cui, Kaidi Shao, Hao Pang, Zhipeng Wang, Ningning He, Shangyong Li
Summary: This study demonstrates the preventive and therapeutic effect of food-grade isomaltulose on colitis. Isomaltulose helps prevent colon shortening, reduce intestinal epithelial destruction, inhibit inflammation, and restore the balance between immune cells. It also partially restores the disturbed gut microbiota in ulcerative colitis. These findings suggest that isomaltulose may be a promising therapeutic agent for the prevention and adjunctive treatment of colitis.
Article
Plant Sciences
Meihua Liu, Zhonghua Wang, Xuan Liu, Hang Xiao, Yangcheng Liu, Jiaqi Wang, Changlan Chen, Xin Wang, Wei Liu, Zheng Xiang, Dongmei Yue
Summary: This study investigated the therapeutic effect and metabolic analysis of a traditional Chinese medicine prescription, Yiyi Fuzi Baijiang formula (YFB), on ulcerative colitis (UC) in rats induced by 2,4,6-trinitro-benzene sulfonic acid (TNBS). The results showed that YFB formula has an anti-inflammatory effect on UC by regulating the balance of Th17/Treg cells in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sumeng Gao, Min Chen, Wei Wei, Xiaoqi Zhang, Mingming Zhang, Yuling Yao, Ying Lv, Tingsheng Ling, Lei Wang, Xiaoping Zou
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Oncology
Lei Xu, Yang Li, Lixing Zhou, Robert Gregory Dorfman, Li Liu, Rui Cai, Chenfei Jiang, Dehua Tang, Yuming Wang, Xiaoping Zou, Lei Wang, Mingming Zhang
Article
Oncology
Lei Xu, Lei Wang, Lixing Zhou, Robert Gregory Dorfman, Yida Pan, Dehua Tang, Yuming Wang, Yuyao Yin, Chengfei Jiang, Xiaoping Zou, Jianlin Wu, Mingming Zhang
Article
Multidisciplinary Sciences
Mingming Zhang, Lixing Zhou, Yuejie Xu, Min Yang, Yilai Xu, Garrison Paul Komaniecki, Tatsiana Kosciuk, Xiao Chen, Xuan Lu, Xiaoping Zou, Maurine E. Linder, Hening Lin
Article
Immunology
Yuejie Xu, Rui Cai, Zhenguo Zhao, Lixing Zhou, Qian Zhou, Shahzeb Hassan, Shan Huang, Mingming Zhang, Guifang Xu, Xiaoping Zou
Summary: The study found that Th17 levels are strongly correlated with IBD, and SIRT2 plays a role in metabolic reprogramming. The results show that TM reduces UC progression by inhibiting Th17 differentiation and promoting LDHA acetylation. SIRT2 may be a potential target for IBD treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Chang Zheng, Yuming Wang, Yuejie Xu, Lixing Zhou, Shahzeb Hassan, Guifang Xu, Xiaoping Zou, Mingming Zhang
Summary: The study found that BBR increased the expression of zonula occludens proteins-1 (ZO-1) and occludin in the colonic epithelium of DSS-induced mice, while reducing the ratio of T-helper 17/T regulatory cells. BBR was also observed to eliminate DSS-induced disturbances in intestinal flora, particularly increasing Bacteroides fragilis (B. fragilis) both in vivo and in vitro. B. fragilis was found to decrease interleukin-6 induced by dendritic cells through a heat-resistant component rather than nucleic acids or proteins.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ping Jiang, Chang Zheng, Ying Xiang, Sara Malik, Dan Su, Guifang Xu, Mingming Zhang
Summary: The pathogenesis of inflammatory bowel disease (IBD) is still unclear and immune dysfunction might play a key role. CD4+ T helper (Th) cells are especially important in this process, with Th17 cells being a major component of CD4+ T cells. Th17 cells produce IL-17 and protect mucous membranes and epithelial tissues against infection. However, when immune regulation is dysfunctional, Th17 cells proliferate abnormally and produce large amounts of proinflammatory cytokines, leading to abnormal immune responses and the development of autoimmune diseases. Recent studies have shown the importance of Th17 cells in the pathogenesis of IBD and their potential as a target for therapy.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Multidisciplinary Sciences
Miao Wang, Yugang Zhang, Garrison P. Komaniecki, Xuan Lu, Ji Cao, Mingming Zhang, Tao Yu, Dan Hou, Nicole A. Spiegelman, Ming Yang, Ian R. Price, Hening Lin
Summary: This study reveals the role of protein deacetylase SIRT2 in Golgi stress induced by bacterial infection. Shigella secrete effector protein IcsB, which transfers fatty acyl groups to modify host proteins to evade immune surveillance. Upregulated SIRT2 counteracts this function by removing the fatty acyl groups and enhancing the killing of Shigella.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Lei Ye, Yi Jiang, Mingming Zhang
Summary: Metabolites of glycolytic metabolism play roles as signaling molecules and regulators of gene expression in immune cells. Recent studies have revealed the non-metabolic signaling functions of intermediates of the mitochondrial pathway and glycolysis. Lactate, as the end product of glycolysis, plays important roles in immune cell biology and associated pathologies.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Article
Gastroenterology & Hepatology
Yi Jiang, Yuejie Xu, Chang Zheng, Lei Ye, Ping Jiang, Sara Malik, Guifang Xu, Qian Zhou, Mingming Zhang
Summary: This study reveals that the gut bacterium A. muciniphila is involved in the post-translational modification of proteins in colorectal cancer (CRC). A specific enzyme, Amuc_2172, is capable of acetylating histone H3 and promoting the expression and secretion of HSP70 in cancer cells, leading to enhanced immune activity of CTLs. Furthermore, bioengineered nanoparticles provide a potential drug delivery strategy for the treatment of CRC.
Article
Immunology
Mingming Zhang, Lixing Zhou, Yuming Wang, Robert Gregory Dorfman, Dehua Tang, Lei Xu, Yida Pan, Qian Zhou, Yang Li, Yuyao Yin, Shimin Zhao, Jianlin Wu, Chenggong Yu
INTERNATIONAL IMMUNOLOGY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Mingming Zhang
Meeting Abstract
Gastroenterology & Hepatology
Mingming Zhang
Meeting Abstract
Gastroenterology & Hepatology
Mingming Zhang
Meeting Abstract
Gastroenterology & Hepatology
Mingming Zhang