Review
Biochemistry & Molecular Biology
Gareth W. Davison, Rachelle E. Irwin, Colum P. Walsh
Summary: The prevalence of type 2 diabetes continues to rise globally. Lifestyle factors such as poor dietary intake and lack of exercise may contribute to disease onset and progression. Metabolic connections and epigenetic alterations play a crucial role in regulating DNA methylation and gene transcription in the context of type 2 diabetes.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Nutrition & Dietetics
Rodolfo Deusdara, Amanda de Moura Souza, Moyses Szklo
Summary: This study evaluated the additive and multiplicative interactions between components of Metabolic syndrome (MetS) regarding type 2 diabetes mellitus. The results showed that the joint presence of certain components had a stronger association with the prevalence of type 2 diabetes mellitus in adolescents.
Article
Medicine, General & Internal
Jisun Bang, Sang Ah Lee, Gwanpyo Koh, Soyeon Yoo
Summary: This study investigated the association between glucagon to insulin ratio and metabolic syndrome in patients with type 2 diabetes. The results showed that the fasting glucagon to insulin ratio was inversely associated with metabolic syndrome, indicating a higher risk of metabolic syndrome with lower fasting glucagon to insulin ratio.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Bertram Pitt, Gerasimos Filippatos, Rajiv Agarwal, Stefan D. Anker, George L. Bakris, Peter Rossing, Amer Joseph, Peter Kolkhof, Christina Nowack, Patrick Schloemer, Luis M. Ruilope
Summary: Finerenone therapy improved cardiovascular outcomes in patients with type 2 diabetes and stage 2 to 4 CKD with moderately elevated albuminuria or stage 1 or 2 CKD with severely elevated albuminuria, compared to placebo. The risk of the primary outcome event was significantly lower in the finerenone group, primarily driven by a reduction in hospitalization for heart failure.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Health Care Sciences & Services
A-Ra Cho, Yu-Jin Kwon, Jong-Koo Kim
Summary: This study aimed to investigate the prevalence of pre-MetSyn and its components, as well as their associations with new-onset T2D or hypertension in Korean men and women aged 40-69 years. The results showed that the prevalence of pre-MetSyn and its components varied by sex and disease, suggesting that specific phenotypes of pre-MetSyn may play a crucial role in predicting and preventing the development of T2D and hypertension.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Physiology
Tomas Grega, Gabriela Vojtechova, Monika Gregova, Miroslav Zavoral, Stepan Suchanek
Summary: A substantial body of literature shows that type 2 diabetes mellitus (T2DM) and colorectal neoplasia share common risk factors and pathophysiological mechanisms, with changes in glucose metabolism and abdominal obesity being key factors. Understanding the role of gut microbiota in metabolic diseases like T2DM and colorectal cancer is crucial for effective treatment and prevention. Uncovering common pathophysiological characteristics is essential for understanding the nature of these diseases and may lead to effective treatment and prevention.
PHYSIOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Shifteh Abedian, Ali Abbasi, Anthonius de Boer, Bruno H. Stricker, Stephan J. L. Bakker, Pim van der Harst, Sanaz Sedaghat, Maryam Darvishian, M. Arfan Ikram, Gerjan Navis, Abbas Dehghan, Ido Pen, Ronald P. Stolk, Harold Snieder, Olaf H. Klungel, Patrick Souverein, Behrooz Z. Alizadeh
Summary: Genetic determinants play a role in the development of co-morbid diseases in T2D patients, with certain SNPs identified to be associated with them. The study found that CVD was most common, followed by chronic eye disease, with potential involvement of specific SNPs like rs1870849 and rs8051326 in chronic eye disease incidence in T2D patients. Further research is needed to validate these associations.
SCIENTIFIC REPORTS
(2021)
Review
Nutrition & Dietetics
Gabriele Piuri, Monica Zocchi, Matteo Della Porta, Valentina Ficara, Michele Manoni, Gian Vincenzo Zuccotti, Luciano Pinotti, Jeanette A. Maier, Roberta Cazzola
Summary: Magnesium (Mg2+) deficiency is often underestimated in Western countries, especially in obese individuals with type 2 diabetes and metabolic syndrome. Proper intake of Mg2+ can help improve metabolic syndrome by regulating gene expression, proteomic profile, and impacting intestinal microbiota and vitamin metabolism.
Article
Multidisciplinary Sciences
Shaza B. Zaghlool, Anna Halama, Nisha Stephan, Valborg Gudmundsdottir, Vilmundur Gudnason, Lori L. Jennings, Manonanthini Thangam, Emma Ahlqvist, Rayaz A. Malik, Omar M. E. Albagha, Karsten Suhre, Abdul Badi Abou-Samra
Summary: This study translates T2D subtypes previously identified in European individuals to an Arab population and identifies specific metabolic and proteomic signatures for each subtype, providing further understanding of the pathogenesis of these subtypes.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Marietta Rottenkolber, Christina Gar, Cornelia Then, Lorena Wanger, Vanessa Sacco, Friederike Banning, Anne L. Potzel, Stefanie Kern-Matschilles, Claudia Nevinny-Stickel-Hinzpeter, Harald Grallert, Nina Hesse, Jochen Seissler, Andreas Lechner
Summary: This study re-evaluated the prevailing hypothesis that metabolic syndrome components are central to all cases of T2DM. Results showed that a significant proportion of T2DM cases did not display any components of metabolic syndrome, indicating the existence of a second, unrelated pathophysiology.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Wei Li, Yan Wang, Shengrong Ouyang, Mengdi Li, Rui Liu, Yuqi Zhang, Xiaojun Liu, Tianfang Li, Shengyun Liu
Summary: In patients with type 2 diabetes mellitus, elevated serum uric acid levels are closely associated with metabolic syndrome and its components, but not with carotid atherosclerosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Fouad Chouairi, Clancy W. Mullan, Ahmed Ahmed, Jasjit Bhinder, Avirup Guha, P. Elliott Miller, Ania M. Jastreboff, Michael Fuery, Maya Rose Chiravuri, Arnar Geirsson, Nihar R. Cesar, Christopher Maulion, Sounok Sen, Tariq Ahmad, Muhammad Anwer
Summary: This study examined the demographics and outcomes of heart transplant recipients with type 2 diabetes. The proportion of patients with type 2 diabetes undergoing heart transplantation has increased in the past ten years, but they have a lower likelihood of transplantation and a higher likelihood of post-transplant mortality.
Article
Biochemistry & Molecular Biology
Alexandra Katsimardou, Dimitrios Patoulias, Ioanna Zografou, Fotios Siskos, Konstantinos Stavropoulos, Konstantinos Imprialos, Zoi Tegou, Aristi Boulmpou, Vivian Georgopoulou, Nikoleta Hatzipapa, Christodoulos Papadopoulos, Michael Doumas
Summary: This study aimed to examine the impact of metabolic syndrome and its components on the erectile function of patients with type 2 diabetes mellitus. The results showed that metabolic syndrome was not associated with erectile dysfunction (ED) or its severity. However, high-density lipoprotein cholesterol (HDL) was found to be associated with ED and erectile function scores.
Article
Cardiac & Cardiovascular Systems
Li Zhang, Jianchao Zhang, Zhen Qin, Na Liu, Zenglei Zhang, Yongzheng Lu, Yanyan Xu, Jinying Zhang, Junnan Tang
Summary: The study identifies EV-carried miRNAs as potential diagnostic biomarkers for IHD-DM, allowing for quick identification and early treatment, thus reducing the occurrence of cardiovascular adverse events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Valentin Maisons, Jean-Michel Halimi, Gregoire Fauchier, Jean-Baptiste de Freminville, Nicolas Goin, Juliette Gueguen, Philippe Gatault, Benedicte Sautenet, Denis Angoulvant, Julien Herbert, Arnaud Bisson, Pierre-Henri Ducluzeau, Laurent Fauchier
Summary: This study aimed to examine the effect of type 2 diabetes mellitus on cardiorenal syndrome. It found that type 2 diabetes mellitus patients accounted for nearly half of the patients with cardiorenal syndrome and were younger than non-diabetic counterparts. Type 2 diabetes mellitus doubled the risk of cardiorenal syndrome and increased the risk of death, cardiovascular events, and end-stage kidney disease, but not ischemic stroke.
DIABETES & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Katarina Mitrova, Barbora Pipek, Martin Bortlik, Ludek Bouchner, Jan Brezina, Tomas Douda, Tomas Drasar, Pavel Klvana, Pavel Kohout, Vaclav Leksa, Petra Minarikova, Ales Novotny, Pavel Svoboda, Jan Skorpik, Jan Ulbrych, Marek Veinfurt, Blanka Zborilova, Milan Lukas, Dana Duricova
Summary: The safety of ustekinumab and vedolizumab treatment during pregnancy was evaluated in this study. The outcomes of pregnancy and postnatal infants were found to be favorable. Ustekinumab had a similar infant-to-maternal drug level ratio, while vedolizumab had an inverse ratio compared to anti-TNF preparations.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Multidisciplinary Sciences
Martin Wasserbauer, Stepan Hlava, Jiri Drabek, Jan Stovicek, Petra Minarikova, Lenka Nedbalova, Tomas Drasar, Zdena Zadorova, Jiri Dolina, Stefan Konecny, Vladimir Kojecky, Jana Kozeluhova, Pavlina Cernikova, Dita Pichlerova, Barbora Kucerova, Stepan Coufal, Radan Keil
Summary: This prospective observational study demonstrated the effectiveness of adalimumab biosimilars FKB327 and GP2017 in patients with IBD.
Article
Oncology
Tereza Halkova, Renata Ptackova, Anastasiya Semyakina, Stepan Suchanek, Eva Traboulsi, Ondrej Ngo, Katerina Hejcmanova, Ondrej Majek, Jan Bures, Miroslav Zavoral, Marek Minarik, Lucie Benesova
Summary: Identifying patients at high risk of early recurrence of metachronous adenomas remains a challenge. This study focused on analyzing the mutation heterogeneity in colorectal lesions to improve identification of high-risk patients. The findings showed a significant association between mutation in exon 7 of the TP53 gene in index lesions and early occurrence of metachronous adenomas.
Article
Multidisciplinary Sciences
Ondrej Majek, Jakub Gregor, Nesrin Mogulkoc, Katarzyna Lewandowska, Martina Sterclova, Veronika Muller, Marta Hajkova, Mordechai R. Kramer, Jasna Tekavec-Trkanjec, Dragana Jovanovic, Michael Studnicka, Natalia Stoeva, Klaus-Uwe Kirchgassler, Simona Littnerova, Ladislav Dusek, Martina Koziar Vasakova
Summary: This study confirms the positive effects of pirfenidone treatment in patients with confirmed IPF, and suggests that patients with probable or possible IPF can also benefit from it.
Article
Medical Laboratory Technology
J. A. Hubacek, T. Philipp, V. Adamkova, O. Majek, L. Dusek
Summary: This study found that genetic mutations associated with hereditary haemochromatosis are related to susceptibility to COVID-19. The minor allele of the rs1800562 polymorphism (Tyr282) was found to have a higher frequency in COVID-19 patients, which is associated with increased iron concentrations.
CLINICA CHIMICA ACTA
(2023)
Article
Public, Environmental & Occupational Health
Ondrej Ngo, Katerina Hejcmanova, Stepan Suchanek, Lucie Pehalova, Ladislav Dusek, Miroslav Zavoral, Jan Bures, Bohumil Seifert, Karel Hejduk, Norbert Kral, Ondrej Majek
Summary: This study evaluated the coverage by examinations associated with CRC screening and early cancer detection in the Czech Republic. The results showed that the coverage within the recommended interval was around 30%, and complete coverage reached over 37% and 50% at the 3-year interval.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Biochemical Research Methods
Lenka Michalkova, Stepan Hornik, Jan Sykora, Vladimir Setnicka, Bohus Bunganic
Summary: Nuclear magnetic resonance (NMR) metabolomics was used to identify metabolic changes in pancreatic cancer (PC) blood plasma samples. Discrimination between PC stages and control groups was achieved with high accuracy. A predictive model based on discriminant analyses identified individuals at risk of pancreatic pathology development.
JOURNAL OF PROTEOME RESEARCH
(2023)
Editorial Material
Respiratory System
Brian Ward, Martina Koziar Vasakova, Carlos Robalo Cordeiro, Arzu Yorgancioglu, Joanna Chorostowska-Wynimko, Torsten Gerriet Blum, Hans-Ulrich Kauczor, Miroslav Samarzija, Claudia Henschke, Craig Wheelock, Jonathan Grigg, Zorana Jovanovic Andersen, Vladimir Koblizek, Ondrej Majek, Mikaela Odemyr, Pippa Powell, Luis M. Seijo
Meeting Abstract
Public, Environmental & Occupational Health
O. Ngo, J. Kouril, S. Suchanek, L. Dusek, B. Seifert, M. Zavoral, O. Majek
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
R. A. Lyons, A. E. Schmidt, S. Aldridge, S. Mathis-Edenhofer, F. Estupinan-Romerot, M. Thissen, M. Gissler, L. Palmieri, O. Majek
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2022)
Meeting Abstract
Obstetrics & Gynecology
J. Masata, A. Martan, R. Chloupkova, M. Koudelkova, O. Majek
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Stepan Suchanek, Premysl Falt, Ondrej Ngo, Renata Chloupkova, Ondrej Urban, Ondrej Majek, Miroslav Zavoral
GASTROINTESTINAL ENDOSCOPY
(2022)
Correction
Public, Environmental & Occupational Health
Romana Haneef, Mariken Tijhuis, Rodolphe Thiebaut, Ondrej Majek, Ivan Pristas, Hanna Tolonen, Anne Gallay
ARCHIVES OF PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Romana Haneef, Mariken Tijhuis, Rodolphe Thiebaut, Ondrej Majek, Ivan Pristas, Hanna Tolenan, Anne Gallay
Summary: This study developed methodological guidelines for calculating population-based health indicators using linked data and machine learning techniques, providing a systematic approach for researchers. The guidelines include detailed checklists for research question, study design, data sources, outcomes, analysis, and limitations, aiming to support high-quality research methods and improve population health information. There is a need for more high-quality research methodologies utilizing linked data and machine learning techniques to enhance population health outcomes effectively.
ARCHIVES OF PUBLIC HEALTH
(2022)