Article
Engineering, Biomedical
Dongxu Ye, Junnan Xue, Sishen Yuan, Fan Zhang, Shuang Song, Jiaole Wang, Max Q-H Meng
Summary: In this study, a magnetically-actuated biopsy capsule (MABC) robot was designed to achieve locomotion and biopsy functions for GI tract diagnosis. The robot can be remotely controlled to achieve accurate sampling in multiple directions without internal power sources, paving the way towards precision sampling techniques for GI diseases in clinical procedures.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Medicine, General & Internal
Manh Cuong Hoang, Kim Tien Nguyen, Jayoung Kim, Jong-Oh Park, Chang-Sei Kim
Summary: This study introduces an active locomotion capsule endoscope system with 5D position sensing and real-time automated polyp detection for small-bowel and colon applications. The system, integrated with a deep learning model, YOLOv3, demonstrated an average precision of 85% in identifying colorectal polyps. In vitro experiments in a phantom duodenum validated the feasibility of the proposed method, providing a high-potential solution for automatic diagnostics of the bowel and colon that can be applied in clinical settings in the future.
Article
Engineering, Electrical & Electronic
Min Wang, Shuang Song, Jun Liu, Max Q. -H. Meng
Summary: This study proposed a method for simultaneous localization using magnetic density of sampling points to offset background noise field, achieving multipoint simultaneous positioning. The robustness of the proposed method in different environments was verified through simulation and experimental analysis.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2021)
Article
Chemistry, Analytical
Muhammad Rehan, Andrew G. Yeo, Muhammad Uzair Yousuf, Ebubekir Avci
Summary: This paper presents the design and development of an anchoring mechanism and actuation system to hold a capsule endoscope in place within the small intestine. The experiments show that the proposed design can anchor the capsule at the target site and resist peristaltic forces, allowing for a better examination of the intestine.
Review
Medicine, General & Internal
Seung Han Kim, Hoon Jai Chun
Summary: Capsule endoscopy is an innovative technology with great potential for development and convenience, but it also has fundamental limitations such as passive movement and space restriction. Current research is focusing on overcoming these limitations to facilitate the wider application of capsule endoscopy.
Review
Medicine, General & Internal
Ji Hyung Nam, Kwang Hoon Lee, Yun Jeong Lim
Summary: Capsule endoscopy (CE) is a non-invasive diagnostic tool that allows direct visualization of the gastrointestinal tract. Initially developed for small-bowel investigation, its clinical application is expanding and there are ongoing technological advances. The future development of a mouth to anus (M2A) capsule that can investigate the entire GI tract with a single capsule is discussed in this review.
Article
Engineering, Electrical & Electronic
Shuang Song, Shuo Wang, Sishen Yuan, Jiaole Wang, Wei Liu, Max Q. -H. Meng
Summary: The study introduces a novel method for tracking wireless capsules in a mobile setup based on differential signals from adjacent magnetic sensors. It eliminates interference of the geomagnetic field without requiring additional compensation sensors. The relationship between position error and distance of adjacent sensors has been explored to enhance tracking accuracy.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2021)
Article
Medicine, General & Internal
Jurgen Herp, Ulrik Deding, Maria M. Buijs, Rasmus Kroijer, Gunnar Baatrup, Esmaeil S. Nadimi
Summary: A model based on tracking feature points in videos retrieved from colon capsule endoscopy investigations was proposed to locate significant findings for follow-up therapeutic colonoscopy; the model successfully tracked the displacement and orientation of the capsule, with an average path difference as low as 4 ± 0.7 cm and an accuracy of 86% in frame classification.
Article
Computer Science, Information Systems
Si-Liang Liu, Jayoung Kim, Ayoung Hong, Jong-Oh Park, Chang-Sei Kim
Summary: This study presents a six-dimensional localization method and theoretical analysis for a robotic capsule endoscope (RCE). It resolves the challenge of implementing simultaneous localization of 3D position and 3D orientation for an RCE using optimization with an induced magnetostatic field and RCE kinematics. The proposed method is validated through simulations and experiments.
Article
Chemistry, Analytical
Samuel Zeising, Kivanc Ararat, Angelika Thalmayer, Daisuke Anzai, Georg Fischer, Jens Kirchner
Summary: Capsule endoscopy is a reliable diagnostic tool for the gastrointestinal tract, and the static magnetic differential method shows promising results for localizing capsule endoscopes. The most significant factors affecting the differential approach are sensor misalignment and nearby ferromagnetic materials. The proposed method outperforms current geomagnetic compensation methods, with mean position and orientation errors of approximately 2 mm and 1 degree, respectively.
Review
Pharmacology & Pharmacy
Xinyang Li, Chen Liang, Yexuan Guo, Jing Su, Xi Chen, Robert B. Macgregor Jr, Rui Xue Zhang, Hong Yan
Summary: Posterior capsule opacification (PCO) is the most common cause of vision loss after cataract surgery. Current clinical management strategies, such as implantation of specially designed intraocular lenses (IOL) or laser ablation, have limitations and associated complications. This review focuses on recent advances in drug delivery approaches, including drug-eluting IOLs, injectable hydrogels, nanoparticles, and implants, for PCO prophylaxis. Rational design of drug delivery systems considering the intraocular environment and long-term ocular safety shows potential for safe and effective anti-PCO therapies.
Article
Chemistry, Analytical
Sangjun Moon
Summary: This article presents a planar electroplated nickel micro-biopsy tool suitable for use with a capsule-type endoscope. Through in vitro experiments, these fabricated biopsy tools have demonstrated sufficient strength and sharpness for clinical applications, such as cancer tissue biopsy.
Article
Chemistry, Multidisciplinary
Ying Zheng, Guizhou Zheng, Yuan Yuan Li, Xia Gong, Zhipeng Chen, Linyu Zhu, Yunsheng Xu, Xi Xie, Shuo Wu, Lelun Jiang
Summary: An implantable magnetically-actuated capsule (IMAC) and its portable magnetic actuator (MA) have been developed for on-demand and robust drug delivery. The IMAC utilizes magnetic balls to trigger drug release under a strong magnetic field, ensuring precise and reproducible drug delivery. The IMAC can navigate to lesion sites and release drugs in a controlled manner using magnetic fields.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Medicine, General & Internal
Trevor Tabone, Anastasios Koulaouzidis, Pierre Ellul
Summary: Colon capsule endoscopy is increasingly recognized as a safe diagnostic tool, especially in the context of reduced endoscopy services. It allows for standardization of reporting and reproducibility through various scores, and can be used to monitor inflammatory bowel disease activity and for colorectal cancer screening.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Robotics
Furkan Peker, Mert Alperen Beser, Ecem Isildar, Yavuz Terzioglu, Ahmet Can Erten, Tufan Kumbasar, Onur Ferhanoglu
Summary: This study presents the design and deployment of a capsule endoscope using external electromagnets for locomotion, along with its digital twin implementation based on interval type-2 fuzzy logic systems (IT2-FLSs). The proposed locomotion approach is validated through experiments and demonstrated to be effective in simulating the movement of a capsule endoscope in a non-linear and uncertain environment.