Article
Anatomy & Morphology
K. Yasodha, L. Lizha Mary, Pathak Surajit, R. Satish
Summary: The exchange of biological material between cells is essential for homeostasis, but can also play a role in cancer progression. This study aims to understand the effect of cancer cell-derived exosomes on primary colon cancer cells and their expression of cancer stem cell markers. The findings suggest that treatment with metastatic exosomes increases the proliferation, migration, and invasion of primary colon cancer cells, potentially contributing to metastasis.
Review
Biochemistry & Molecular Biology
Serena Barachini, Letizia Biso, Shivakumar Kolachalam, Lacopo Petrini, Roberto Maggio, Marco Scarselli, Biancamaria Longoni
Summary: Pancreatic islet transplantation is a treatment for Type 1 diabetic patients, and mesenchymal stem cells (MSCs) have shown potential in controlling graft rejection. MSCs can interact with immune system cells through direct contact or their secretome. This review discusses the role of MSCs in controlling the immune system and promoting repair in pancreatic islet transplantation, as well as challenges such as oxidative stress and impaired vasculogenesis. Preconditioning MSCs with hypoxia exposure or using stem cells with angiogenic potential in organoids may help improve transplant outcomes.
Review
Oncology
Yuanming Jing, Wenqing Liang, Lin Zhang, Junjun Tang, Zongliang Huang
Summary: Cancer stem cells modify their microenvironment by recruiting and activating specific cell types such as mesenchymal stem cells (MSCs). The interaction between cancer cells and MSCs induces a cancer stem cell phenotype.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Yutaka Naito, Yusuke Yoshioka, Takahiro Ochiya
Summary: Intercellular communication plays a crucial role in cancer initiation and progression, with cancer-associated fibroblasts (CAFs) being a key component in this process. Recent research on extracellular vesicles (EVs) as regulators of intercellular communication has shown significant advancements. EVs facilitate the transfer of functional molecules to recipient cells, influencing the communication between cancer cells and CAFs and promoting cancer progression.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Linxiang Lan, Axel Behrens
Summary: The hierarchy of heterogeneous tumor cell populations, with a small population of cancer stem cells (CSCs) at the top, is explained by the CSC model. These CSCs have the ability to self-renew and generate other cancer cell populations, similar to the function of normal adult stem cells. However, controversies exist regarding the existence and identification of CSCs, which may be attributed to technical differences in experimentation, CSC niche-dependency and plasticity, and CSC heterogeneity itself.
Article
Oncology
Rohit Sarkar, Zhihong Xu, Chamini J. Perera, Minoti Apte
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer characterized by a collagenous stromal reaction/desmoplasia surrounding tumor cells. Pancreatic stellate cells (PSCs) produce this stroma and promote PDAC progression. Recently, extracellular vesicles (EVs), particularly small extracellular vesicles (exosomes), have gained attention for their roles in cancer progression and diagnosis. This review provides an overview of PDAC, PSCs, their interactions with cancer cells, and the known role of PSC-derived EVs in PDAC progression.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ping Yang, Hong Qin, Yiyu Li, Anhua Xiao, Enze Zheng, Han Zeng, Chunxiao Su, Xiaoqing Luo, Qiannan Lu, Meng Liao, Lei Zhao, Li Wei, Zac Varghese, John F. Moorhead, Yaxi Chen, Xiong Z. Ruan
Summary: Our study reveals that the scavenger receptor CD36 is upregulated in metastasis-associated macrophages (MAMs) and deletion of CD36 in MAMs attenuates liver metastasis in mice. MAMs contain more lipid droplets and have the unique capability to engulf tumor cell-derived long-chain fatty acids carried by extracellular vesicles. These lipid-enriched vesicles are preferentially partitioned into macrophages via CD36, fueling their tumor-promoting activities and creating a highly immunosuppressive tumor microenvironment (TME) in liver metastasis.
NATURE COMMUNICATIONS
(2022)
Article
Genetics & Heredity
Bingyi Wang, Yan Xu, Yuhua Wei, Lixin Lv, Nanbin Liu, Rui Lin, Xiuyan Wang, Baomin Shi
Summary: This study demonstrates that hsa-miR-143-3p may enhance apoptosis and inhibit cell proliferation and invasion in pancreatic cancer. Results also suggest a potential targeted combinatorial effect between lncRNA RP11-363N22.3 and hsa-miR-143-3p, providing insights into the regulatory mechanisms involved in pancreatic cancer progression.
FRONTIERS IN GENETICS
(2021)
Review
Pathology
Yongfang Wang, Hanyun Liang, Jie Zheng
Summary: Research found that exosomal miRNAs play a crucial role in the interaction between tumor cells and CAFs, which may help develop more sensitive and effective cancer treatments.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Cell & Tissue Engineering
Wei-Min Chung, Ryan D. Molony, Yi-Fen Lee
Summary: This study revealed that EVs derived from NSCCs contain cargo proteins enriched in proteostasis-related functions, significantly impacting the development of CSCs to be more intrinsically chemoresistant and aggressive. This novel communication mechanism between NSCC-EVs and CSCs may promote disease progression and the acquisition of chemoresistance.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
S. M. Adnan Ali, Yumna Adnan, Saleema Mehboob Ali, Zubair Ahmad, Tabish Chawla, Hasnain Ahmed Farooqui
Summary: This report is the first of its kind internationally to assess pancreatic cancer stem cell markers and potential therapeutic targets in a single study. The study revealed significant associations between the expression of these markers and potential therapeutic targets, paving the way for precision medicine in pancreatic cancer patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Yuan Wan, Yi-Qiu Xia, Si-Yang Zheng
Summary: We speculate that ruptured circulating tumor cells in capillaries can release a large quantity of small extracellular vesicle-like vesicles called mechanically extruded sEV (sEV(me)), which are capable of encapsulating chromosomal DNA fragments. These sEV(me) share similar physicochemical properties with small extracellular vesicles spontaneously secreted by living cells (sEV(ss)), making it difficult to effectively differentiate between them based on size or membrane protein markers. Additionally, sEV(me) derived from CTC carry oncogenic payloads and can deliver cargo to recipient cells through the bloodstream, potentially promoting cancer metastasis. If validated, this speculation could enhance our understanding of extracellular vesicle biogenesis and cancer pathology, as well as provide a theoretical foundation for liquid biopsy utilizing DNA fragments from harvested sEV.
BRITISH JOURNAL OF CANCER
(2022)
Article
Chemistry, Analytical
Ping Li, Jie Wang, Mengqiu Gao, Jue Wang, Yi Ma, Yueqing Gu
Summary: Extracellular vesicles (EVs) have emerged as a promising tumor biomarker, offering benefits for cancer diagnosis, but the practicality of EV assays remains challenging due to various factors. A membrane-based biosensor has been developed for precise and sensitive EV identification, integrating EV capture and detection based on EV membrane features, showing great potential for clinical prostate cancer diagnosis.
ANALYTICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Zhilong Ma, Jie Hua, Jiang Liu, Bo Zhang, Wei Wang, Xianjun Yu, Jin Xu
Summary: Pancreatic cancer is a highly aggressive malignant tumor with poor prognosis and high mortality rates. Despite advancements in diagnosis and treatment, the current therapeutic strategies for pancreatic cancer have limited efficacy, necessitating urgent exploration of alternative options. Mesenchymal stromal cells (MSCs) have gained attention as a potential therapy for pancreatic cancer due to their tumor-homing properties, but the specific antitumor effect of MSCs remains controversial. Therefore, this study aims to focus on the potential of the MSC-based approach for anti-cancer treatment and summarize the current challenges in the clinical application of MSCs for pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Xulin Zhou, Fengyun Zhong, Yongmin Yan, Sihui Wu, Huizhi Wang, Junqiang Liu, Feifan Li, Dawei Cui, Min Xu
Summary: This article investigates the mechanism of lymphatic metastasis in pancreatic cancer and the impact of pancreatic cancer microbiomes. It is found that exosomes derived from pancreatic cancer cells promote lymphangiogenesis by regulating ABHD11-AS1 expression. The research results preliminarily reveal a new mechanism by which pancreatic cancer cells regulate peripheral lymphangiogenesis.
Article
Oncology
Zhe Wang, Anja von Au, Martina Schnoelzer, Thilo Hackert, Margot Zoeller
Article
Oncology
Kun Zhao, Zhe Wang, Thilo Hackert, Claudia Pitzer, Margot Zoeller
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2018)
Review
Oncology
Zhe Wang, Margot Zoeller
CANCER AND METASTASIS REVIEWS
(2019)
Article
Oncology
Hanxue Sun, Sanyukta Rana, Zhe Wang, Kun Zhao, Martina Schnoelzer, Jan Provaznik, Thilo Hackert, Qingjie Lv, Margot Zoeller
JOURNAL OF ONCOLOGY
(2019)
Review
Oncology
Wei Mu, Zhe Wang, Margot Zoeller
FRONTIERS IN ONCOLOGY
(2019)
Article
Oncology
Zhe Wang, Hanxue Sun, Jan Provaznik, Thilo Hackert, Margot Zoeller
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Review
Cell Biology
Zhe Wang, Kun Zhao, Thilo Hackert, Margot Zoeller
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2018)
Article
Oncology
Ulrike Erb, Kun Zhao, Zhe Wang, Li Xiao, Margot Zoeller