Article
Surgery
F. Jasmijn Smits, Maaike E. Verweij, Lois A. Daamen, C. Henri van Werkhoven, Lucas Goense, Marc G. Besselink, Bert A. Bonsing, Olivier R. Busch, Ronald M. van Dam, Casper H. J. van Eijck, Sebastiaan Festen, Bas Groot Koerkamp, Erwin van der Harst, Ignace H. de Hingh, Geert Kazemier, Joost M. Klaase, Marion van der Kolk, Mike Liem, Misha D. P. Luyer, Mark Meerdink, J. Sven D. Mieog, Vincent B. Nieuwenhuijs, Daphne Roos, Jennifer M. Schreinemakers, Martijn W. Stommel, Fennie Wit, Babs M. Zonderhuis, Vincent E. de Meijer, Hjalmar C. van Santvoort, I. Quintus Molenaar
Summary: This study aimed to quantify the impact of individual complications on mortality, organ failure, hospital stay, and readmission after pancreatoduodenectomy. The results showed that postoperative pancreatic fistula and postpancreatectomy hemorrhage had the greatest independent impact on mortality and organ failure, while delayed gastric emptying had the greatest independent impact on prolonged hospital stay. Interventions focusing on these complications may have the greatest impact on patient outcomes.
Article
Surgery
Lihan Qian, Binwei Hu, Jiancheng Wang, Xiongxiong Lu, Xiaxing Deng, Weimin Chai, Zhiwei Xu, Weishen Wang, Baiyong Shen
Summary: This study investigated the impact of remnant pancreas and other perioperative factors on postoperative pancreatic fistula (POPF) occurring after robot-assisted distal pancreatectomy (RDP) for nonmalignant pancreatic neoplasms. The results showed that a transection plan involving the tail of the pancreas and spleen preservation independently increased the incidence of POPF. The length of the remnant pancreas was also found to be a risk factor for POPF.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Stefano Partelli, Valentina Andreasi, Marco Schiavo Lena, Paola M. Rancoita, Michele Mazza, Serena Mele, Giovanni Guarneri, Nicolo Pecorelli, Stefano Crippa, Domenico Tamburrino, Claudio Doglioni, Massimo Falconi
Summary: After pancreaticoduodenectomy, the risk of postoperative pancreatic fistula and acute pancreatitis is associated with the acinar content at the pancreatic resection margin, with an increased risk when the acinar content is over 60%.
Article
Multidisciplinary Sciences
Sun Hye Shin, Sumin Shin, Yunjoo Im, Genehee Lee, Byeong-Ho Jeong, Kyungjong Lee, Sang-Won Um, Hojoong Kim, O. Jung Kwon, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Jhingook Kim, Jae Ill Zo, Young Mog Shim, Juhee Cho, Danbee Kang, Hye Yun Park
Summary: Bronchodilator therapy during the perioperative period was effective in preserving lung function in COPD patients undergoing surgery for non-small cell lung cancer, with no significant difference in postoperative complications between patients treated with and without bronchodilators.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Ingmar F. Rompen, Daniela C. Merz, Karam T. Alhalabi, Rosa Klotz, Eva Kalkum, Thomas M. Pausch, Hendrik Strothmann, Pascal Probst
Summary: This study aimed to provide an evidence-based overview on the best perioperative drug treatment in pancreatic surgery. The analysis showed that somatostatin analogues and glucocorticoids can reduce the incidence of postoperative pancreatic fistula, while there is limited evidence for other drug treatments.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Manuel Buitrago-Ruiz, Ismael Martinez-Nicolas, Victor Soria-Aledo
Summary: This study validates the use of prolonged length of stay as a substitute for traditional coding of complications in colorectal cancer surgery to calculate failure-to-rescue rates. The results show that ICD-10 codes poorly identified complications, and prolonged length of stay could be a valid replacement when measuring failure-to-rescue in colorectal surgical patients.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Alessandra Pulvirenti, Ammar A. Javed, Theodoros Michelakos, Yurie Sekigami, Jian Zheng, Hannah L. Kalvin, Caitlin A. Mcintyre, Martina Nebbia, Joanne F. Chou, Mithat Gonen, Nitya Raj, Diane L. Reidy-Lagunes, Amer H. Zureikat, Cristina R. Ferrone, Jin He, Alice C. Wei
Summary: This study aimed to describe the recurrence pattern, treatments received, and oncological outcomes of pancreatic neuroendocrine tumors (PanNETs) after curative surgery. The study found that recurrence following surgery is infrequent but reduces survival, with most recurrences being distant and managed with multiple therapies. Prospective studies are needed to establish surveillance strategies and treatment sequences to control the disease and prolong survival.
Article
Oncology
Emma Hasselgren, Daniel Hertzberg, Tina Camderman, Hakan Bjorne, Sahar Salehi
Summary: The study found that in surgery for advanced epithelial ovarian cancer, perioperative fluid balance exceeding 3000 mL increases the risk of major postoperative complications.
GYNECOLOGIC ONCOLOGY
(2021)
Review
Pediatrics
Kelli N. Patterson, Andrew T. Trout, Archana Shenoy, Maisam Abu-El-Haija, Jaimie D. Nathan
Summary: Pancreatic tumors in children are rare and often difficult to diagnose due to their non-specific clinical presentation and overlapping imaging characteristics. These tumors can be categorized as epithelial or non-epithelial, with epithelial tumors further classified as tumors of the exocrine or endocrine pancreas. The most prevalent solid pancreatic tumor in children is the solid pseudopapillary neoplasm, while pancreatoblastoma is the most common malignant tumor.
FRONTIERS IN PEDIATRICS
(2022)
Article
Gastroenterology & Hepatology
Rony Takchi, Heidy Cos, Gregory A. Williams, Cheryl Woolsey, Chet W. Hammill, Ryan C. Fields, Steven M. Strasberg, William G. Hawkins, Dominic E. Sanford
Summary: The study found that while the implementation of ERP led to a decrease in superficial surgical site infections, there was an increase in urinary retention. ERP can reduce PLOS but may not significantly impact the total postoperative time spent in the hospital within 90 days (i.e. CLOS).
Review
Cell Biology
Joan Casamitjana, Elisa Espinet, Meritxell Rovira
Summary: Ex vivo organoid cultures have gained attention as a model for studying regenerative medicine and diseases in the pancreas. Pancreatic organoids can be generated for diabetes research and studying pancreatic ductal adenocarcinoma, serving as a translational bridge between in vitro and in vivo models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Xuan Dai, Wenjun Ding, Yongshan He, Shiyong Huang, Yun Liu, Tingyu Wu
Summary: The emergence of the Omicron variant has led to increased infectiousness but decreased virulence compared to ancestral COVID-19 variants. Previous studies have recommended delaying non-emergency surgeries for up to 4-8 weeks after COVID-19 infection. However, postponing surgery has been linked to tumor progression and worse survival outcomes for colorectal cancer patients. In this study, we examined the risk and optimal timing for surgery in colorectal cancer patients with perioperative COVID-19 infection.
Article
Gastroenterology & Hepatology
Kai Wang, Kaiwei Li, Yunxuan Deng, Xinyu Wang, Chao Yang, Chengnan Chu, Weiqin Li, Jieshou Li, Weiwei Ding
Summary: This study investigated the risk factors and outcomes of postoperative hemorrhage (POH) after pancreatic injury. The results showed that intra-abdominal abscess, intestinal fistula, shock on admission, absence of abdominal suction drainage, and higher body mass index were associated with POH. Additionally, POH was associated with a poor prognosis.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Medicine, General & Internal
Biao Zhou, Haoyang Ji, Yumeng Liu, Zhe Chen, Nianrong Zhang, Xinyu Cao, Hua Meng
Summary: The study compared perioperative outcomes of laparoscopic bariatric surgery between patients with ERAS and conventional care, showing that ERAS group had shorter length of hospital stay, higher day 1 discharge rate, lower complications, and readmissions within 30 days postoperatively.
Article
Surgery
Jose M. Ramia, Esteban Cugat, Roberto De la Plaza, Miguel A. Gomez-Bravo, Elena Martin, Luis Munoz-Bellvis, Francisco J. Padillo, Luis Sabater, Mario Serradilla-Martin
Summary: Very few surveys have been conducted on oncosurgical decisions for pancreatic cancer patients and the differences in therapeutic approaches between low/medium and high-volume centers. This study aimed to investigate the management strategies and potential differences in surgical decisions among Spanish centers affiliated to the Spanish Group of Pancreatic Surgery (GECP). Consensus was reached on a limited number of questions regarding pre-, intra-, and post-operative management, with higher agreement observed in high-volume centers for certain intra-operative procedures. A further prospective study is necessary to evaluate the reasons why high-volume centers achieve better outcomes.
UPDATES IN SURGERY
(2023)
Article
Surgery
Gianpaolo Balzano, Alessandro Zerbi, Francesca Aleotti, Giovanni Capretti, Raffella Melzi, Nicolo Pecorelli, Alessia Mercalli, Rita Nano, Paola Magistretti, Francesca Gavazzi, Francesco De Cobelli, Dario Poretti, Marina Scavini, Chiara Molinari, Stefano Partelli, Stefano Crippa, Paola Maffi, Massimo Falconi, Lorenzo Piemonti
Summary: This study compared pancreaticoduodenectomy (PD) and total pancreatectomy (TP) with islet autotransplantation (IAT) in high-risk patients for postoperative pancreatic fistula (POPF). The results showed that although PD had a higher incidence of complications, TP-IAT had a shorter postoperative stay and patients had good metabolic control and sustained C-peptide production.
Article
Surgery
Dilmurodjon Eshmuminov, Debora J. Studer, Victor Lopez Lopez, Marcel A. Schneider, Jan Lerut, Mary Lo, Linda Sher, Thomas J. Musholt, Oana Lozan, Nabila Bouzakri, Carlo Sposito, Rosalba Miceli, Shoma Barat, David Morris, Helga Oehler, Teresa Schreckenbach, Peri Husen, Charles B. Rosen, Gregory J. Gores, Toshihiko Masui, Tan-To Cheung, Corina Kim-Fuchs, Aurel Perren, Philipp Dutkowski, Henrik Petrowsky, Espen Thiis-Evensen, Pal-Dag Line, Michal Grat, Stefano Partelli, Massimo Falconi, Lulu Tanno, Ricardo Robles-Campos, Vincenzo Mazzaferro, Pierre-Alain Clavien, Kuno Lehmann
Summary: This multicenter study compares the outcomes of liver resection (LR) and liver transplantation (LT) in patients with neuroendocrine liver metastasis (NELM). The results suggest that LT provides a survival benefit over LR, but adherence to selection criteria is important.
Article
Oncology
Stefano Partelli, Valentina Andreasi, Marisa Peralta Ferreira, Diego Palumbo, Francesca Muffatti, Anna Battistella, Francesca Fermi, Paola Mapelli, Domenico Tamburrino, Nicolo Pecorelli, Stefano Crippa, Massimo Falconi
Summary: This study compared the clinicopathologic features and survival between patients with nodal relapse and those with distant relapse after surgery for NF-PanNETs. It also identified predictors of nodal relapse after surgery for NF-PanNETs.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Alessandro Cucchetti, Benjamin Djulbegovic, Stefano Crippa, Iztok Hozo, Monica Sbrancia, Athanasios Tsalatsanis, Cecilia Binda, Carlo Fabbri, Roberto Salvia, Massimo Falconi, Giorgio Ercolani
Summary: A regret-based decision model was applied to evaluate attitudes toward neoadjuvant therapy versus upfront surgery for potentially resectable pancreatic adenocarcinoma. Results showed that regret of omission and commission influenced clinicians' therapeutic decisions, and surgeons or specialists working in surgical centers were less likely to recommend neoadjuvant therapy.
Review
Oncology
Jeffrey W. Chen, Charlotte M. Heidsma, Anton F. Engelsman, Ertunc Kabaktepe, Susan van Dieren, Massimo Falconi, Marc G. Besselink, Els J. M. Nieveen van Dijkum
Summary: The risk prediction for tumor recurrence after surgery for non-functional pancreatic neuroendocrine tumors is a major unmet clinical need. Multiple prediction models have been developed, but none are currently incorporated into international guidelines. This systematic review found 13 original models, of which 3 were validated outside the patient group in which they were developed. The lack of external validation hinders the progress toward clinical use.
Article
Oncology
Gianpaolo Balzano, Giovanni Guarneri, Nicolo Pecorelli, Stefano Partelli, Stefano Crippa, Augusto Vico, Massimo Falconi, Giovanni Baglio
Summary: This study highlights the significant disparities in access to pancreatic surgery in Italy. The distribution of adequate facilities for pancreatic surgery is uneven across the country, with patients from the south and central regions having higher rates of mobility to the north for surgery. The study also found that mortality rates were higher for non-migrating patients in the south and central regions, indicating the need for improved facilities and equal access to care.
Article
Surgery
Nicolo Pecorelli, Giovanni Guarneri, Alessia Vallorani, Chiara Limongi, Alice W. Licinio, Francesca Di Salvo, Domenico Tamburrino, Stefano Partelli, Stefano Crippa, Massimo Falconi
Summary: Objective of this study was to evaluate the reliability, construct validity, and responsiveness of the PROMIS-29 profile questionnaire as a measure of recovery after pancreatic surgery. The questionnaire demonstrated good reliability and construct validity, successfully discriminated between different recovery trajectories, and showed responsiveness up to 90 days after surgery.
Article
Gastroenterology & Hepatology
Alessandro Cucchetti, Philip Johnson, Gabriele Capurso, Stefano Crippa, Carlo Alberto Pacilio, Carlo Fabbri, Massimo Falconi, Giorgio Ercolani
Summary: The aim of this study was to explore the correlation between incidence and mortality of pancreatic cancer and healthcare indicators in 36 European countries. The results showed that both incidence and mortality were increasing, and they were strongly positively correlated. Higher health expenditure, availability of beds and medical technology, as well as the number of practicing doctors were related to higher incidence. On the other hand, lower mortality was associated with indicators such as outpatient curative care expenditure, the number of pet scanners, and radiation therapy equipment. The study highlights the impact of healthcare environment on pancreatic cancer incidence and mortality.
Article
Health Care Sciences & Services
Maarten Korrel, Leia R. Jones, Jony van Hilst, Gianpaolo Balzano, Bergthor Bjornsson, Ugo Boggi, Svein Olav Bratlie, Olivier R. Busch, Giovanni Butturini, Giovanni Capretti, Riccardo Casadei, Bjorn Edwin, Anouk M. L. H. Emmen, Alessandro Esposito, Massimo Falconi, Bas Groot Koerkamp, Tobias Keck, Ruben H. J. de Kleine, Dyre B. Kleive, Arto Kokkola, Daan J. Lips, Sanne Lof, Misha D. P. Luyer, Alberto Manzoni, Ravi Marudanayagam, Matteo de Pastena, Nicolo Pecorelli, John N. Primrose, Claudio Ricci, Roberto Salvia, Per Sandstrom, Frederique L. I. M. Vissers, Ulrich F. Wellner, Alessandro Zerbi, Marcel G. W. Dijkgraaf, Marc G. Besselink, Mohammad Abu Hilal
Summary: This is a non-inferiority trial comparing open distal pancreatectomy (ODP) with minimally invasive distal pancreatectomy (MIDP) in patients with resectable pancreatic cancer. The results show that MIDP is not inferior to ODP in terms of radical resection rates, and the postoperative outcomes and survival rates are comparable as well.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Meeting Abstract
Urology & Nephrology
Chiara Re, Federico Belladelli, Francesco Cei, Lucia Salerno, Sara Cusano, Floriana Iannace, Giovanni Battista Pipitone, Paola Carrera, Annalisa Russo Raucci, Maria Grazia Patricelli, Andrea Falini, Francesco De Cobelli, Pietro Mortini, Francesco Bandello, Rosangela Lattanzio, Massimo Falconi, Stefano Partelli, Andrea Necchi, Laura Marandino, Irene Franco, Isaline Rowe, Francesco Montorsi, Umberto Capitanio, Alessandro Larcher, Andrea Salonia
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Federico Belladelli, Chiara Re, Francesco Cei, Lucia Salerno, Sara Cusano, Floriana Iannace, Paola Carrera, Maria Grazia Patricelli, Andrea Falini, Francesco De Cobelli, Pietro Mortini, Francesco Bandello, Rosangela Lattanzio, Massimo Falconi, Stefano Partelli, Andrea Necchi, Daniele Raggi, Laura Marandino, Roberta Luciano, Isaline Rowe, Irene Franco, Francesco Montorsi, Umberto Capitanio, Alessandro Larcher, Andrea Salonia
JOURNAL OF UROLOGY
(2023)
Article
Surgery
Nicolo Pecorelli, Diego Palumbo, Giovanni Guarneri, Chiara Gritti, Francesco Prato, Marco Schiavo Lena, Alessia Vallorani, Stefano Partelli, Stefano Crippa, Claudio Doglioni, Francesco De Cobelli, Massimo Falconi
BRITISH JOURNAL OF SURGERY
(2023)
