期刊
VIROLOGY JOURNAL
卷 13, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s12985-016-0589-0
关键词
Wild rat; Chapparvovirus; Genome structure; Viral Metagenomics
类别
资金
- Natural Science Foundation of Jiangsu Province [BK20130502, BK20140537]
- National Natural Science Foundation of China [31302107]
- Professional Research Foundation for Advanced Talents of Jiangsu University [12JDG085, 13JDG087]
- Postdoctoral Foundation of Jiangsu Province [1302058C, 1302057C]
- China Postdoctoral Foundation [2014 M561597]
- China Postdoctoral Special Foundation [2015 T80503]
Chapparvovirus, a recently determined new genus in the family Parvoviridae, can infect many species of animals including bats, chickens, and pigs. Here, using viral metagenomics method, we identified a novel Chapparvovirus from feces of wild rats and designated it as rat parvovirus 2 (RPV2). The nearly complete genome of RPV2 is 4222-nt long and includes two ORFs encoding a 654-aa nonstructural protein 1 (NS1) and a 472-aa capsid protein (VP), respectively. Phylogenetic analysis over the amino acid sequence of the NS1 showed that RPV2 clustered with Eidolon helvum parvovirus 2 (EHPV2), porcine parvovirus 7 (PPV7), and turkey parvovirus 1 (TP1), forming a separate clade. Sequence analysis indicated that the NS1 protein of RPV2 shared the highest amino acid sequence identity (51 %) with that of EHPV2. According to the genetic distance-based criteria, RPV2 identified here belongs to a novel species of Chapparvovirus.
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