Review
Biochemistry & Molecular Biology
Javier Florido, Cesar Rodriguez-Santana, Laura Martinez-Ruiz, Alba Lopez-Rodriguez, Dario Acuna-Castroviejo, Iryna Rusanova, Germaine Escames
Summary: ROS are highly reactive molecules that regulate important signaling pathways. Tumor cells have altered redox balance compared to normal cells, making them susceptible to anti-tumoral therapy targeting ROS levels and antioxidant system capacity. Melatonin has potential as an innovative cancer treatment, but its mechanism of action remains unclear, limiting its clinical applications.
Article
Biochemistry & Molecular Biology
Hyo-Gu Kang, Sanghoon Lee, Pil-Soo Jeong, Min Ju Kim, Soo-Hyun Park, Ye Eun Joo, Sung Hyun Park, Bong-Seok Song, Sun-Uk Kim, Min Kyu Kim, Bo-Woong Sim
Summary: The study found that supplementation of 0.1 μM lycopene enhanced embryonic development in pigs by regulating oxidative stress and mitochondria-dependent apoptosis.
Article
Plant Sciences
Adeola Folasade Ehigie, Peng Wei, Taotao Wei, Xiyun Yan, Olufunso O. Olorunsogo, Fiyinfoluwa Demilade Ojeniyi, Leonard Ona Ehigie
Summary: The study aimed to investigate the mechanism of cell death in breast and lung cancer cell lines treated with fractions derived from bitter melon extract. The results showed that the fractions reduced mitochondrial membrane potential and intracellular ATP levels, while increasing reactive oxygen species levels. However, they did not activate caspase-3 or release cytochrome c in the cancer cells, suggesting a different mechanism of cell death induction.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Reproductive Biology
Wen-Jie Yu, Cheng-Zhen Chen, Yan-Xia Peng, Ze Li, Yan Gao, Shuang Liang, Bao Yuan, Nam-Hyung Kim, Hao Jiang, Jia-Bao Zhang
Summary: SAL significantly improves porcine preimplantation embryo development by increasing blastocyst formation rate, proliferation ability, and mitochondrial activity while reducing ROS accumulation and apoptosis levels. This improvement is achieved through the reduction of ROS accumulation.
Article
Cell Biology
Yanhong Wang, Xinyu Mang, Xuran Li, Zhengyu Cai, Fei Tan
Summary: This study investigated the effect and mechanism of cold atmospheric plasma (CAP) on the proliferation and apoptosis of lung cancer and colon cancer cells. The results showed that CAP treatment inhibited tumor cell proliferation and induced apoptosis through the activation of the mitochondrial pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Zhi-Hong Wen, Hsiao-Mei Kuo, Po-Chang Shih, Ling-Chen Hsu, Jimmy Ming-Jung Chuang, Nan-Fu Chen, Hsi-Wen Sun, Hsin-Tzu Liu, Chun-Sung Sung, Wu-Fu Chen
Summary: This study evaluated the effects of isoaaptamine and aaptamine on cell viability in glioblastoma multiforme (GBM) cell lines. The results showed that isoaaptamine was more potent than aaptamine in these cell lines, with GBM 8401 being the most sensitive. The study also found that isoaaptamine could induce apoptosis, increase oxidative stress, disrupt mitochondrial function, and trigger autophagy in GBM cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Hulya Gizem Oezkan, Andriy Mokhir
Summary: Hybrid drugs containing ferrocene and phenol residues exhibit potent anticancer activity, but their mode of action, specificity, and metabolism need further investigation. In this study, we synthesized prodrugs of aminoferrocene-phenol hybrids and confirmed their activation in cancer cells while remaining inactive in normal cells. The anticancer activity of the prodrug relies on the generation of reactive oxygen species in cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
James H. Schofield, Zachary T. Schafer
Summary: The relationship between mitophagy and ROS production is complex and not fully understood. This review discusses mtROS generation and their detrimental effects on cellular viability, along with the cellular defense mechanisms against oxidative stress. Furthermore, the prominent mechanisms governing mitophagy induction that bear on oxidative stress are explored.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Chemistry, Multidisciplinary
Hao Heng, Gang Song, Xuetong Cai, Jian Sun, Ke Du, Xiaoran Zhang, Xia Wang, Fude Feng, Shu Wang
Summary: In this study, a strategy for environment-responsive in situ synthesis of molecular fluorescent dyes was developed. The efficient synthesis of cyanine dyes was achieved using a photoextension strategy, and the potential application in cancer cells was explored. The results showed preferential cyanine expression in cancer cells, making it a promising approach for cancer imaging and therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Medicinal
Andy Ying, Laiqiang Ying
Summary: A new hydrocyanine probe has been developed to image reactive oxygen species (ROS) in live cell mitochondria. This probe is cell-permeable, selectively targets mitochondria, and responds to superoxide and hydroxyl radical, allowing for detection of ROS production caused by oxidative stress in live cell mitochondria.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Cell Biology
Yuta Kanamori, Alessia Finotti, Laura Di Magno, Gianluca Canettieri, Tomoaki Tahara, Fabio Timeus, Antonio Greco, Paola Tirassa, Jessica Gasparello, Pasquale Fino, Carlo Maria Di Liegro, Patrizia Proia, Gabriella Schiera, Italia Di Liegro, Roberto Gambari, Enzo Agostinelli
Summary: Neuroblastoma is a common malignant solid tumor in children, with N-Myc amplification being a poor prognostic marker in NB patients. Treatment with BSAO/SPM leads to increased mRNA levels of proapoptotic genes in NB cell lines, inducing apoptosis activity.
Article
Medicine, Research & Experimental
Renkai Li, Chengwen Zheng, Polly Ho-Ting Shiu, Panthakarn Rangsinth, Wen Wang, Yiu-Wa Kwan, Emily Sze-Wan Wong, Yanbo Zhang, Jingjing Li, George Pak-Heng Leung
Summary: Despite various therapeutic approaches, developing novel and more effective methods for colorectal cancer treatment is crucial due to its high fatality rate. The recent study explored the anticancer effects of GAR E, a bioactive xanthone found in mangosteen, and identified the involvement of the ROS/JNK signaling pathway in its mechanism of action. The experiments demonstrated that GAR E inhibited colony formation and wound healing in cancer cells, triggered ROS production, induced mitochondrial dysfunction and apoptosis, and caused cell cycle arrest. In vivo experiments also confirmed the antitumor effect of GAR E in a xenograft mouse model. These findings suggest that GAR E could be a potential chemotherapeutic agent for colorectal cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Jie Du, Fan Jiang, Shen-Sheng Xu, Zi-Feng Huang, Li-Li Chen, Li Li
Summary: Tephrosin exhibits potent anticancer activity against pancreatic cancer cells by suppressing cell viability and promoting apoptosis through increased ROS production and DNA damage. Additionally, it demonstrates strong antitumor activity with low toxicity in a mouse model.
Article
Engineering, Environmental
Guoliang Chen, Mingxing Wang, Panpan Zhu, Guixue Wang, Tingzhang Hu
Summary: Pyraoxystrobin (SYP-3343), a newly-invented strobilurin fungicide, exhibits high toxicity to aquatic organisms, particularly in zebrafish embryos, through affecting cell cycle, mitochondrial membrane potential, and reactive oxygen species generation. This toxicity is dose- and time-dependent, inducing apoptosis in zebrafish embryos.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Immunology
Miranda D. Chavez, Hubert M. Tse
Summary: Mitochondrial dysfunction and oxidative stress are associated with T cell-mediated autoimmune diseases, and targeting metabolic pathways can inhibit autoreactive T cell activation. Increasing the requirements of Tregs for ROS and oxidative phosphorylation can promote self-tolerance and inhibit the activity of autoreactive T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Minxia Zhang, Xinan Li, Xinna Cai, Yajin Qu, Dongfang Hu, Lin Lv, Sidang Liu, Xiaomin Zhao, Leyi Wang, Yihong Xiao
INFECTION GENETICS AND EVOLUTION
(2016)
Article
Reproductive Biology
Hongling Zhang, Yong Huang, Lili Wang, Tingting Yu, Zengguo Wang, Lingling Chang, Xiaomin Zhao, Xiaomao Luo, Liang Zhang, Dewen Tong
Article
Immunology
Delong Li, Yong Huang, Qian Du, Zhenyu Wang, Lingling Chang, Xiaomin Zhao, Dewen Tong
Article
Biochemical Research Methods
Xiaomin Zhao, Xiaoyuan Bai, Lijuan Guan, Juejun Li, Xiangjun Song, Xuelian Ma, Jianxiong Guo, Zhichao Zhang, Qian Du, Yong Huang, Dewen Tong
MOLECULAR & CELLULAR PROTEOMICS
(2018)
Article
Reproductive Biology
Liang Zhang, Yong Huang, Zhenyu Wang, Xiaomao Luo, Hongling Zhang, Qian Du, Lingling Chang, Xiaomin Zhao, Dewen Tong
Article
Immunology
Delong Li, Qian Du, Bin Wu, Juejun Li, Lingling Chang, Xiaomin Zhao, Yong Huang, Dewen Tong
Article
Immunology
Delong Li, Dan Xu, Zhenyu Wang, Qian Du, Lingling Chang, Xiaomin Zhao, Yong Huang, Dewen Tong
Article
Immunology
Beibei Cui, Wenli Liu, Xiaoya Wang, Yu Chen, Qian Du, Xiaomin Zhao, Hai Zhang, Shan-Lu Liu, Dewen Tong, Yong Huang
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Immunology
Qian Du, Xingchen Wu, Tongtong Wang, Xuefeng Yang, Zhenyu Wang, Yingying Niu, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong, Yong Huang
JOURNAL OF IMMUNOLOGY
(2018)
Article
Virology
Tongtong Wang, Qian Du, Xingchen Wu, Yingying Niu, Lijuan Guan, Zhenyu Wang, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong, Yong Huang
JOURNAL OF VIROLOGY
(2018)
Article
Immunology
Xiaomao Luo, Xiujuan Zhang, Xingchen Wu, Xuefeng Yang, Cong Han, Zhengyu Wang, Qian Du, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong, Yong Huang
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Biochemical Research Methods
Xiaomin Zhao, Xiangjun Song, Xiaoyuan Bai, Zhanhang Tan, Xuelian Ma, Jianxiong Guo, Zhichao Zhang, Qian Du, Yong Huang, Dewen Tong
MOLECULAR & CELLULAR PROTEOMICS
(2019)
Article
Toxicology
Lingling Chang, Zheng Lu, Delong Li, Liang Zhang, Zhenyu Wang, Qian Du, Yong Huang, Xiaomin Zhao, Dewen Tong
TOXICOLOGY LETTERS
(2018)
Article
Biotechnology & Applied Microbiology
Xuelian Ma, Xiaomin Zhao, Zhichao Zhang, Jianxiong Guo, Lijuan Guan, Juejun Li, Mi Mi, Yong Huang, Dewen Tong
Correction
Virology
Tongtong Wang, Qian Du, Xingchen Wu, Yingying Niu, Lijuan Guan, Zhenyu Wang, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong, Yong Huang
JOURNAL OF VIROLOGY
(2018)