Editorial Material
Immunology
Pin Li, Napoleone Ferrara
Summary: This study reveals the crosstalk between VEGF receptors in different organs and emphasizes the importance of VEGF receptor expression and interplay in vascular heterogeneity.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Cuilin Zhu, Qing Liu, Xin Li, Ran Wei, Tongtong Ge, Xiufen Zheng, Bingjin Li, Kexiang Liu, Ranji Cui
Summary: This review systematically summarizes the role of H2S in vascular diseases, including hypertension, atherosclerosis, inflammation and angiogenesis. It also outlines a novel therapeutic perspective involving the crosstalk between H2S and smooth muscle cell function.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Yingkun He, Yanyan He, Weixing Bai, Dehua Guo, Taoyuan Lu, Lin Duan, Zhen Li, Lingfei Kong, Juha A. Hernesniemi, Tianxiao Li
Summary: This study analyzed the vascular stability of brain arteriovenous malformation (bAVM) in patients after partial embolization. The results showed that the biomarkers for bAVM vascular stability were most abnormal between 1 and 28 days after partial embolization.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
Rida Al-Rifai, Marie Vandestienne, Jean-Remi Lavillegrand, Tristan Mirault, Julie Cornebise, Johanne Poisson, Ludivine Laurans, Bruno Esposito, Chloe James, Olivier Mansier, Pierre Hirsch, Fabrizia Favale, Rayan Braik, Camille Knosp, Jose Vilar, Giuseppe Rizzo, Alma Zernecke, Antoine-Emmanuel Saliba, Alain Tedgui, Maxime Lacroix, Lionel Arrive, Ziad Mallat, Soraya Taleb, Marc Diedisheim, Clement Cochain, Pierre-Emmanuel Rautou, Hafid Ait-Oufella
Summary: JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm.
NATURE COMMUNICATIONS
(2022)
Article
Surgery
Helen Mackie, Hiroo Suami, Belinda M. Thompson, Quan Ngo, Asha Heydon-White, Robbie Blackwell, Louise A. Koelmeyer
Summary: This study used indocyanine green (ICG) lymphography to investigate retrograde lymph flow in patients with lymphedema. The findings contradicted the conventional understanding of lymphedema pathology, as retrograde lymph flow was rare and not necessarily related to disease progression. Instead, it may be associated with toxic or asymptomatic lymphangitis. These findings have implications for conservative management and lymphovenous anastomosis surgery.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2022)
Article
Health Care Sciences & Services
Giuseppe Visconti, Alessandro Bianchi, Marzia Salgarello, Alba Di Leone, Akitatsu Hayashi, Riccardo Masetti, Gianluca Franceschini
Summary: This study presented the experience of lymphatic transfer in 30 patients with extremity lymphedema and 15 patients with post-traumatic lower extremity soft tissue defects. Results indicated that LFT may be a valid treatment option, reducing lymphedema index and improving stability in patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Sanjeeva Metikala, Michael Warkala, Satish Casie Chetty, Brendan Chestnut, Diandra Rufin Florat, Elizabeth Plender, Olivia Nester, Andrew L. Koenig, Sophie Astrof, Saulius Sumanas
Summary: During embryogenesis, new vascular progenitors emerge from a distinct site and incorporate into established vasculature. Similar progenitors have been observed in zebrafish and mouse embryos. This mechanism plays an important role in vascular recovery and formation.
DEVELOPMENTAL CELL
(2022)
Article
Oncology
Ryan W. Huey, Brandon G. Smaglo, Jeannelyn S. Estrella, Aurelio Matamoros, Michael J. Overman, Gauri R. Varadhachary, Kanwal P. S. Raghav
Summary: Cancer of unknown primary (CUP) rarely presents as bone-predominant (BCUP) or lymph node-only (LNCUP) disease. BCUP patients often have issues with fractures and pain, receiving radiation as a common treatment. The median overall survival of BCUP was 14.5 months, similar to a larger CUP comparison cohort, while LNCUP patients had a longer overall survival at 32.6 months, especially in those without disseminated disease. Poor-risk Culine group and high neutrophil-to-lymphocyte ratio were associated with worse survival. Tips regarding diagnosis and management of these rare malignant subsets are provided.
Article
Biochemistry & Molecular Biology
Vignesh Ramakrishnan, Rebecca Schoenmehl, Annalena Artinger, Lina Winter, Hendrik Boeck, Stephan Schreml, Florian Guertler, Jimmy Daza, Volker H. Schmitt, Andreas Mamilos, Pablo Arbelaez, Andreas Teufel, Tanja Niedermair, Ondrej Topolcan, Marie Karlikova, Samuel Sossalla, Christoph B. Wiedenroth, Markus Rupp, Christoph Brochhausen
Summary: In this paper, a pipeline of vision algorithms is proposed to visualize and analyze 3D blood vessels from tissue samples. The technique involves blood vessel segmentation using a U-net neural network, image registration for alignment, and branching analysis using a skeletonization algorithm. This method is useful for researchers, pathologists, and doctors in understanding vascular morphogenesis and potential diagnostic applications under different pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Lu Han, Dandan Li, Yanwen Hang, Xiaojuan Zong, Jiashun Lv, Xiaolu Bai, Yi Lu, Peng Zhang, Meiling Zhou, Zhaodi Wu, Wei Hu
Summary: The study revealed the significant role of hsa_circ_0004543 in atherosclerosis, showing its impact on the proliferation, migration, invasion, apoptotic rate, and PI3K/AKT/NOS3 pathway in HUVECs induced by oxLDL. This circRNA may serve as a potential target for treating endothelial cell damage in atherosclerosis.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Jaya Mary Thomas, Dhakshmi Sasankan, Mathew Abraham, Sumi Surendran, Chandrasekharan C. Kartha, Arumugam Rajavelu
Summary: Arteriovenous malformation (AVM) is a complex condition involving a tangle of arteries and veins, which can lead to catastrophic hemorrhage in vulnerable sites such as the brain. While aberrant hemodynamic forces at the artery-vein junction are known to contribute to AVM development, the specific pathways remain unclear.
CLINICAL EPIGENETICS
(2022)
Review
Genetics & Heredity
Ryan O. Snodgrass, Timothy J. A. Chico, Helen M. Arthur
Summary: Hereditary haemorrhagic telangiectasia (HHT) is a genetic disorder characterized by arteriovenous malformations (AVMs) formed when arteries and veins directly connect due to reduced endoglin (ENG) or ACVRL1 activity. Targeting VEGF signaling has shown beneficial outcomes in treating HHT, but further research is needed to identify critical targets within this complex pathway.
Review
Chemistry, Medicinal
Di Chen, Martijn A. van der Ent, Nathaniel L. Lartey, Philip D. King
Summary: Ephrin receptors are a family of receptor tyrosine kinases that regulate various cellular responses. In the cardiovascular system, Ephrin receptor B4 (EPHB4) plays a critical role in blood and lymphatic vascular development and function. Instead of acting as a growth factor receptor, EPHB4 inhibits the Ras-MAPK pathway in endothelial cells through its interaction with RASA1. Loss of EPHB4-RASA1 signaling leads to vascular abnormalities and mutations in these genes cause vascular anomalies in humans. Drug therapy targeting EPHB4 and RASA1 may offer potential treatment options for these vascular anomalies.
Review
Pediatrics
Giovanna Stefania Colafati, Eleonora Piccirilli, Antonio Marrazzo, Alessia Carboni, Andrea Diociaiuti, May El Hachem, Francesco Esposito, Mario Zama, Massimo Rollo, Carlo Gandolfo, Paolo Toma
Summary: Vascular anomalies of the pediatric orbit include vascular tumors and vascular malformations. These disorders can cause symptoms and functional damage. Imaging plays a crucial role in diagnosis and treatment, with radiologists playing an important role in multidisciplinary management.
FRONTIERS IN PEDIATRICS
(2022)
Review
Gastroenterology & Hepatology
Ken Liu, Claude Dennis, David S. Prince, Felix Marsh-Wakefield, Cositha Santhakumar, Jennifer R. Gamble, Simone I. Strasser, Geoffrey W. McCaughan
Summary: VETC is a distinct histologic vascular pattern associated with a novel mechanism of metastasis, which has significant prevalence and prognostic significance in hepatocellular carcinoma. It is a robust biomarker of aggressive disease and can guide treatment. Radiological recognition of VETC pattern is an active area of research and becoming increasingly accurate.
Letter
Cell Biology
Onno J. de Boer, Gabrielle Krebbers, Claire Mackaaij, Sandrine Florquin, Menno A. de Rie, Allard C. van der Wal, Marcel B. M. Teunissen
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2020)
Review
Pathology
Annalisa Angelini, Cira di Gioia, Helen Doran, Marny Fedrigo, Rosa Henriques de Gouveia, Siew Yen Ho, Ornella Leone, Mary N. Sheppard, Gaetano Thiene, Konstantinos Dimopoulos, Barbara Mulder, Massimo Padalino, Allard C. van der Wal
Article
Cardiac & Cardiovascular Systems
Cristina Basso, Ornella Leone, Stefania Rizzo, Monica De Gaspari, Allard C. van der Wal, Marie-Christine Aubry, Melanie C. Bois, Peter T. Lin, Joseph J. Maleszewski, James R. Stone
EUROPEAN HEART JOURNAL
(2020)
Article
Genetics & Heredity
Eva S. van Walree, Gregor Dombrowsky, Iris E. Jansen, Masa Umicevic Mirkov, Rob Zwart, Aho Ilgun, Dongchuan Guo, Sally-Ann B. Clur, Ahmed S. Amin, Jeanne E. Savage, Allard C. van der Wal, Quinten Waisfisz, Alessandra Maugeri, Anna Wilsdon, Frances A. Bu'Lock, Matthew E. Hurles, Sven Dittrich, Felix Berger, Enrique Audain Martinez, Vincent M. Christoffels, Marc-Philip Hitz, Dianna M. Milewicz, Danielle Posthuma, Hanne Meijers-Heijboer, Alex V. Postma, Inge B. Mathijssen
Summary: The study identified a loss-of-function variant in the HEY2 gene associated with cardiovascular defects, with heterozygous carriers and homozygous patients showing varying degrees of heart diseases.
GENETICS IN MEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Michael Mills, Malou van Zanten, Marco Borri, Peter S. Mortimer, Kristiana Gordon, Pia Ostergaard, Franklyn A. Howe
Summary: Magnetic resonance lymphangiography (MRL) is a noninvasive technique that can assess lymphatic drainage, providing 3D imaging of the lymphatic vasculature. Further research is needed to optimize protocol design and fully realize the potential of MRL in improving understanding and detection of lymphatic diseases.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Letter
Medicine, Legal
Katarzyna Michaud, Allard C. van der Wal, Jytte Banner, Mary N. Sheppard, Cristina Basso
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2021)
Article
Pathology
Cristina Basso, Katarzyna Michaud, Giulia d'Amati, Jytte Banner, Joaquin Lucena, Kristopher Cunningham, Ornella Leone, Aryan Vink, Allard C. van der Wal, Mary N. Sheppard
Summary: For accurate assessment of cardiac hypertrophy at autopsy, uniform terminology and methodology are required, as well as a systematic approach to measuring heart weight, size, and thickness with age, gender, and body weight and height considerations. Recommendations have been made by the Association for European Cardiovascular Pathology for this purpose. In cases where expertise in cardiovascular pathology is lacking, seeking a second opinion from a specialist pathologist is essential, particularly through systematic histologic analysis. Genetic testing postmortem should be considered in the management of sudden cardiac death.
Correction
Pathology
Cristina Basso, Katarzyna Michaud, Giulia d'Amati, Jytte Banner, Joaquin Lucena, Kristopher Cunningham, Ornella Leone, Aryan Vink, Allard C. van der Wal, Mary N. Sheppard
Article
Cardiac & Cardiovascular Systems
Karel T. N. Breeman, Romy du Long, Niek E. G. Beurskens, Allard C. van der Wal, Arthur A. M. Wilde, Fleur V. Y. Tjong, Reinoud E. Knops
Summary: The study found that tissue adhesion is common during leadless pacemaker retrieval, mainly consisting of fibrosis and thrombus which may affect the safety of retrieval. Leadless pacemakers may adhere to the heart's valves or subvalvular apparatus, suggesting risk stratification for excessive fibrotic encapsulation and adhesions should be considered in end-of-life strategy optimization.
Article
Cardiac & Cardiovascular Systems
Linghe Wu, Umit Baylan, Britt van der Leeden, Bernadette Schurink, Eva Roos, Casper G. Schalkwijk, Marianna Bugiani, Paul van der Valk, Albert C. van Rossum, Sacha S. Zeerleder, Leo M. A. Heunks, Reinier A. Boon, Onno J. de Boer, Allard C. van der Wal, Hans W. M. Niessen, Paul A. J. Krijnen
Summary: The study revealed that cardiac inflammation, cardiomyocyte injury, and microvascular thrombogenicity were significantly decreased in the second wave of COVID-19 patients compared to the first wave, possibly due to the increased use of steroids in the treatment during the second wave.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Anatomy & Morphology
Hanne C. E. Riekerk, Bram F. Coolen, Gustav J. Strijkers, Allard C. van Der Wal, Steffen E. Petersen, Mary N. Sheppard, Roelof-Jan Oostra, Vincent M. Christoffels, Bjarke Jensen
Summary: This study investigated the impact of higher spatial resolution on the detection of trabeculation in human hearts. The results showed that measurements using high resolution MRI provide greater accuracy in evaluating cardiac wall morphology, with the number of detected trabeculations and T/C ratio positively correlated with higher spatial resolution. Additionally, the study could not replicate the previous reported correlation between trabeculations of the left and right ventricle using histological validation.
JOURNAL OF ANATOMY
(2022)
Article
Oncology
Nicoline W. E. van den Berg, Makiri Kawasaki, Benedetta Fabrizi, Fransisca A. Nariswari, Arianne C. Verduijn, Jolien Neefs, Robin Wesselink, Rushd F. M. Al-Shama, Allard C. van der Wal, Onno J. de Boer, Jan Aten, Antoine H. G. Driessen, Aldo Jongejan, Joris R. de Groot
Summary: The study found that in atrial fibrillation (AF) patients, there was a decrease in epicardial cell gene expression, while an upregulation of epithelial-to-mesenchymal transition (EMT) and mesenchymal cell gene expression. Immunohistochemistry analysis showed thickening of the epicardium and an increase in (myo)fibroblast-like cells in the myocardium in AF patients. Additionally, endothelial cell proliferation, angiogenesis, and endothelial signaling were found to be upregulated in AF patients.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Legal
Romy du Long, Judith Fronczek, Hans W. M. Niessen, Allard C. van der Wal, Hans H. de Boer
Summary: Determining the significance of myocardial inflammation for the cause of death can be challenging. Our study reviewed the histological spectrum of myocardial inflammation between three groups of autopsy cases, defined by their reported cause of death. Only a diffuse increase of inflammatory cells could reliably discriminate between an incidental presence of inflammation or a potentially significant one. Determining the cause of death in case of myocardial inflammation requires a comprehensive approach.
FORENSIC SCIENCES RESEARCH
(2022)
Article
Dermatology
Benny Yau, Kristiana Gordon
Summary: Streptococcal sex syndrome is a rare disease that is often overlooked. It is characterized by recurrent cellulitis in the pubic, genital or thigh area, which is associated with sexual intercourse, pelvic surgery or radiation. Lymphatic dysfunction may be involved in the pathogenesis of this syndrome.
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2022)
Article
Infectious Diseases
Bernadette Schurink, Eva Roos, Teodora Radonic, Ellis Barbe, Catherine S. C. Bouman, Hans H. de Boer, Godelieve J. de Bree, Esther B. Bulle, Eleonora M. Aronica, Sandrine Florquin, Judith Fronczek, Leo M. A. Heunks, Menno D. de Jong, Lihui Guo, Romy du Long, Rene Lutter, Pam C. G. Molenaar, E. Andra Neefjes-Borst, Hans W. M. Niessen, Carel J. M. van Noesel, Joris J. T. H. Roelofs, Prof Eric J. Snijder, Eline C. Soer, Joanne Verheij, Alexander P. J. Vlaar, Wim Vos, Nicole N. van der Wel, Allard C. van der Wal, Paul van der Valk, Marianna Bugiani
