Article
Gastroenterology & Hepatology
Aldo J. Montano-Loza, Vincenzo Ronca, Maryam Ebadi, Bettina E. Hansen, Gideon Hirschfield, Saleh Elwir, Mohamad Alsaed, Piotr Milkiewicz, Maciej K. Janik, Hanns-Ulrich Marschall, Maria Antonella Burza, Cumali Efe, Ali Riza Caliskan, Murat Harputluoglu, Gokhan Kabacam, Debora Terrabuio, Fernanda de Quadros Onofrio, Nazia Selzner, Alan Bonder, Albert Pares, Laura Llovet, Murat Akyildiz, Cigdem Arikan, Michael P. Manns, Richard Taubert, Anna-Lena Weber, Thomas D. Schiano, Brandy Haydel, Piotr Czubkowski, Piotr Socha, Natalia Oldak, Nobuhisa Akamatsu, Atsushi Tanaka, Cynthia Levy, Eric F. Martin, Aparna Goel, Mai Sedki, Irena Jankowska, Toru Ikegami, Maria Rodriguez, Martina Sterneck, Christina Weiler-Normann, Christoph Schramm, Maria Francesca Donato, Ansgar Lohse, Raul J. Andrade, Vilas R. Patwardhan, Bart van Hoek, Maaike Biewenga, Andreas E. Kremer, Yoshihide Ueda, Mark Deneau, Mark Pedersen, Marlyn J. Mayo, Annarosa Floreani, Patrizia Burra, Maria Francesca Secchi, Benedetta Terziroli Beretta-Piccoli, Marco Sciveres, Giuseppe Maggiore, Syed-Mohammed Jafri, Dominique Debray, Muriel Girard, Florence Lacaille, Ellina Lytvyak, Andrew L. Mason, Michael Heneghan, Ye Htun Oo
Summary: Recurrence of autoimmune hepatitis (AIH) is common after liver transplantation, and it is associated with younger age at transplantation, the use of mycophenolate mofetil post-transplant, sex mismatch, and high pre-transplant IgG levels. Recurrent AIH is associated with impaired graft and overall survival. Better characterization, prevention, and treatment strategies are needed for the management of recurrent AIH.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Eric M. Sieloff, Brian Rutledge, Cuyler Huffman, Duncan Vos, Thomas Melgar
Summary: The study highlighted the significant healthcare and economic burden of genetic liver diseases in the USA, with a notable increase in hospitalizations and associated costs. It emphasized the importance of increased funding and research efforts to improve medical treatments and the overall quality of life for at-risk patients with genetic liver diseases.
GASTROENTEROLOGY REPORT
(2021)
Article
Oncology
Lei Liu, Si Xie, Yu-Xian Teng, Zhu-Jian Deng, Kang Chen, Hao-Tian Liu, Rong-Rui Huo, Xiu-Mei Liang, Ping-Ping Guo, Da-Long Yang, Liang Ma, Bang-De Xiang, Le-Qun Li, Jian-Hong Zhong
Summary: The study found that patients with HCC in the context of MAFLD had less severe background liver disease at the time of HCC diagnosis and better long-term survival after curative liver resection compared to counterparts with CHB/MAFLD or CHB.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Reino Heikkila, Tor Age Myklebust, Bjorn Moller
Summary: Cancer services in Norway aim to provide high quality services and equal access, but there is a regional variation in cancer survival rates. The study showed that over the last three decades, the variation in cancer survival rates at regional and intraregional levels was minor, with no evidence of impact from organizational reforms on regional variation.
CANCER EPIDEMIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Zhuolun Song, Wei Chen, Dipti Athavale, Xiaodong Ge, Romain Desert, Sukanta Das, Hui Han, Natalia Nieto
Summary: Despite being initially discovered in bone, osteopontin (OPN) is expressed in other tissues as well. In addition to its well-established physiological roles, research suggests that OPN is also involved in chronic liver disease.
Article
Medical Laboratory Technology
Pooja Basthi Mohan, Siddheesh Rajpurohit, Balaji Musunuri, Ganesh Bhat, Rajiv Lochan, Shiran Shetty
Summary: Chronic liver disease (CLD) is a major cause of mortality and morbidity, especially in developing countries. The study of exosomes in CLD is an emerging field that shows potential in diagnosing and treating liver diseases. Exosomes released by injured hepatic cells have an impact on intercellular communication and carry specific proteins and miRNAs that can be used as diagnostic biomarkers and treatment targets. Early diagnosis and therapeutic intervention of CLD are crucial for improving patient survival rates.
CLINICA CHIMICA ACTA
(2023)
Article
Gastroenterology & Hepatology
Kazuto Tajiri, Yuka Hayashi Futsukaichi, Aiko Murayama, Masami Minemura, Terumi Takahara, Ichiro Yasuda
Summary: Although patients with chronic liver disease (CLD) usually show few symptoms, their overall health-related quality of life (HRQOL) is decreased with occurrence of complications. The Chronic Liver Disease Questionnaire (CLDQ) is a useful tool for assessing HRQOL in CLD patients and predicting their prognosis, and can be used for management in clinical practice.
HEPATOLOGY RESEARCH
(2022)
Article
Immunology
Navpreet Kaur, Juliet Emamaullee, Tiffany Lian, Mary Lo, Philip Ender, Jeffrey Kahn, Linda Sher
Summary: This study evaluates the impact of BMI on liver transplant candidacy and post-transplant outcomes, indicating that patients with BMI >= 40 may have slightly lower survival rates post-LT, but careful selection could potentially equalize these numbers.
Review
Public, Environmental & Occupational Health
Guanghui Zang, Xv Sun, Yufeng Sun, Yan Zhao, Yang Dong, Kun Pang, Ping Cheng, Meng Wang, Yuli Zheng
Summary: Chronic liver diseases (CLDs) can lead to liver fibrosis and cirrhosis, causing liver dysfunction. The prevalence of CLDs in China is estimated to exceed 447 million, including chronic hepatitis, fatty liver, and cirrhosis. CLDs often result in abnormalities in the metabolism of sex hormones, glucose, and lipids, as well as mental and psychological illnesses, which are significant risk factors for erectile dysfunction (ED). The prevalence of ED in male patients with CLDs ranges from 24.6% to 85.0%. Liver transplantation may improve the erectile function of CLDs patients with ED, indicating a link between CLDs and ED.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Gastroenterology & Hepatology
Shahreedhan Shahrani, Sandeep Singh Gill, Choong Yeong Sooi, Ruben Skantha, C. Vikneshwaran Chandra Kumar, Mohd Fairul Limun, Nik Arsyad Nik Muhamad Affendi, Kee Huat Chuah, Stanley Khoo, Ruveena Bhavani Rajaram, Wah Kheong Chan, Sanjiv Mahadeva
Summary: This study found that hepatic steatosis is common in chronic liver disease, regardless of etiology. Nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis B (CHB) are the most common causes of steatosis. NAFLD has also become the leading cause of advanced fibrosis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Cell Biology
Kevin De Muynck, Bart Vanderborght, Hans Van Vlierberghe, Lindsey Devisscher
Summary: Chronic liver disease is a growing health concern, commonly associated with obesity, alcohol overconsumption, and progressive cholestasis, leading to persistent low-grade inflammation and advancing fibrosis. The pathophysiology of CLD also involves intestinal dysbiosis, bile acid dysregulation, and gut barrier disruption, where macrophages play a crucial role in disease progression and intestinal barrier breakdown.
Article
Medicine, General & Internal
Mignote Yilma, Nicole J. Kim, Amy M. Shui, Michele Tana, Charles Landis, Ariana Chen, Saroja Bangaru, Neil Mehta, Kali Zhou
Summary: Less than one-third of cirrhosis patients with high MELD-Na scores were referred for liver transplant, and sociodemographic factors were identified as barriers to referral. Standardizing transplant referral practices could increase access to life-saving transplant for underserved patients.
Review
Gastroenterology & Hepatology
Carmen Berasain, Maria Arechederra, Josepmaria Argemi, Maite G. Fernandez-Barrena, Matias A. Avila
Summary: The identity of adult hepatocytes is established during embryonic development and regulated after birth. Transcription factors and pre-mRNA splicing regulators play a crucial role in defining the transcriptome, which determines the complex functions of the liver. Persistent downregulation of key identity genes is a major factor in chronic liver disease and organ dysfunction. Therefore, understanding the disruption of core transcription factors and splicing regulators in diseased hepatocytes is clinically important.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ashwani K. Singal, Yong-Fang Kuo, Muhammad Waleed, Robert J. Wong, Vinay Sundaram, Rajiv Jalan
Summary: This study aimed to develop a risk score for LT recipients and donor selection among patients with ACLF-3. By analyzing a large dataset of LT recipients, several factors associated with 1-year patient survival were identified and a risk score model was established. This model can help doctors make better choices during liver transplantation and improve patient outcomes.
LIVER INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Eyal Yosefof, Nir Tsur, Ofir Zavdy, Noga Kurman, Dean Dudkiewicz, Moshe Yehuda, Gideon Bachar, Thomas Shpitzer, Aviram Mizrachi, Sharon Tzelnick
Summary: The impact of regional disease among different age groups with oral squamous cell carcinoma (OSCC) was investigated. The study found that regional metastases correspond with worse prognosis in patients younger than 40 compared to older patients, and this association was not significant in other age groups.
Editorial Material
Primary Health Care
Sumi M. Sexton, Caroline R. Richardson, Sarina B. Schrager, Marjorie A. Bowman, John Hickner, Christopher P. Morley, Timothy F. Mott, Nicholas Pimlott, John Saultz, Barry D. Weiss
Article
Public, Environmental & Occupational Health
Travertine Garcia, Betsy Ford, Denise Pike, Richard Bryce, Caroline Richardson, Julia A. Wolfson
Summary: A community-tailored, food agency-based cooking programme was developed and implemented at a community health centre in Detroit. The study showed that hands-on cooking classes were an effective way to engage patients and increase cooking confidence.
PUBLIC HEALTH NUTRITION
(2021)
Editorial Material
Primary Health Care
Sumi M. Sexton, Caroline R. Richardson, Sarina B. Schrager, Marjorie A. Bowman, John Hickner, Christopher P. Morley, Timothy F. Mott, Nicholas Pimlott, John W. Saultz, Barry D. Weiss
ANNALS OF FAMILY MEDICINE
(2021)
Editorial Material
Primary Health Care
Sumi M. Sexton, Caroline R. Richardson, Sarina B. Schrager, Marjorie A. Bowman, John Hickner, Christopher P. Morley, Timothy F. Mott, Nicholas Pimlott, John W. Saultz, Barry D. Weiss
JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE
(2021)
Article
Health Care Sciences & Services
John P. Ney, Stephanie A. Robinson, Caroline R. Richardson, Marilyn L. Moy
Summary: The study evaluated the cost-effectiveness of a technology-based physical activity intervention for COPD and found that both intervention methods were cost-effective. Further research should focus on more direct estimates of health utilities and downstream healthcare costs.
TELEMEDICINE AND E-HEALTH
(2021)
Article
Endocrinology & Metabolism
Amanda L. Missel, Laura R. Saslow, Dina H. Griauzde, Donna Marvicsin, Ananda Sen, Caroline R. Richardson, Xuefeng Liu
Summary: This study found a significant association between higher fasting insulin levels and higher levels of CRP, suggesting that treatment approaches targeting both insulin and glucose levels may have additive anti-inflammatory effects and improve long-term outcomes for adults with type 2 diabetes.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Gastroenterology & Hepatology
Monica A. Tincopa, Angela Lyden, Jane Wong, Elizabeth A. Jackson, Caroline Richardson, Anna S. Lok
Summary: This pilot study assessed the acceptability and feasibility of a mobile-technology based lifestyle program for NAFLD patients, and found that the program promoted physical activity and was associated with improvement in clinical parameters in some patients.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Carmel Ashur, Thomas M. Cascino, Christopher Lewis, Whitney Townsend, Ananda Sen, Dorothy Pekmezi, Caroline R. Richardson, Elizabeth A. Jackson
Summary: The study found that the use of activity trackers among cardiac rehabilitation participants led to significant increases in daily step count and aerobic capacity compared to controls. Larger trials are needed to further assess the effectiveness of activity trackers in cardiac rehabilitation programs.
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2021)
Article
Multidisciplinary Sciences
Cornelius D. Jamison, Margaret Greenwood-Ericksen, Caroline R. Richardson, Hwajung Choi, Tammy Chang
Summary: The study found that individuals who usually seek healthcare in the emergency department are more likely to have a positive urine CT result. Understanding this association has the potential to improve STI clinical and policy interventions, as the emergency department may be a critical site in combating the record high rates of STIs.
Article
Cardiac & Cardiovascular Systems
Adam J. Nelson, Neha J. Pagidipati, Vanita R. Aroda, Matthew A. Cavender, Jennifer B. Green, Renato D. Lopes, Hussein Al-Khalidi, Tanya Gaynor, Lisa A. Kaltenbach, Julienne K. Kirk, Ildiko Lingvay, Melissa L. Magwire, Emily C. O'Brien, Jonathan Pak, Rodica Pop-Busui, Caroline R. Richardson, Monica Reed, Cagri Senyucel, Laura Webb, Darren K. McGuire, Christopher B. Granger
Summary: SGLT-2 inhibitors and GLP-1 receptor agonists have significant cardiovascular and kidney benefits, but are underused in clinical practice. Cardiologists and primary care providers need to collaborate to reposition these drugs as agents primarily targeting cardiovascular and kidney disease risk reduction. Additional interventions involving clinicians, patients, payers, professional societies, and health systems are necessary to increase adoption and improve outcomes for patients with type 2 diabetes at high risk for cardiovascular and kidney disease.
Article
Endocrinology & Metabolism
Rodica Pop-Busui, James L. Januzzi, Dennis Bruemmer, Sonia Butalia, Jennifer B. Green, William B. Horton, Colette Knight, Moshe Levi, Neda Rasouli, Caroline R. Richardson
Summary: Heart failure is a common complication of diabetes, even in the absence of other cardiovascular diseases. With the increasing prevalence of diabetes globally, particularly type 2 diabetes, the burden of heart failure on the healthcare system is expected to rise. This consensus report aims to provide clear guidance to practitioners on screening and diagnosing heart failure in individuals with diabetes.
Article
Information Science & Library Science
Sarina Schrager, Sumi Sexton, Marjorie Bowman, Caroline Richardson
Summary: Editors of 10 North American Family Medicine journals published a Joint Call for Action in January 2021 to address systemic racism and encourage diversity, equity, inclusion and accessibility/antiracism (DEIA) initiatives. Since then, the journals have taken actions such as diversifying editorial teams, enhancing DEIA content, mentoring underrepresented authors in medicine, and presenting DEIA-related content at national meetings. The editors had a follow-up meeting in November 2022 to continue working towards reducing racism and increasing DEIA initiatives in Family Medicine publications.
LEARNED PUBLISHING
(2023)
Article
Public, Environmental & Occupational Health
Michele Heisler, Wendy T. Dyer, Holly Finertie, Shelley C. Stoll, Deanne Wiley, Cassie D. Turner, Tali Sedgwick, Jeffrey Kullgren, Caroline R. Richardson, Monique Hedderson, Julie A. Schmittdiel
Summary: This study examined the effects of a low-intensity peer support program on a diverse population with prediabetes. The results showed that peer support improved participation in formal diabetes prevention programs and perceived social support, but had no significant impact on weight and HbA1c control.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Education, Scientific Disciplines
Julia A. Wolfson, Jillian Tse, Adeline Ho, Janice Bowie, Nisa Maruthur, Caroline R. Richardson, Amy Trubek
Summary: This study aimed to characterize food agency among participants of the Diabetes Prevention Program and gather perspectives on their experiences. The results showed that participants had high confidence and frequency in cooking, but faced barriers related to lack of time and energy.
JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR
(2023)
Article
Health Care Sciences & Services
Daniel Litrownik, Elizabeth A. Gilliam, Peter M. Wayne, Caroline R. Richardson, Reema Kadri, Pamela M. Rist, Marilyn L. Moy, Gloria Y. Yeh
Summary: This study aims to develop a novel multimodal mind-body exercise intervention to impact long-term physical activity engagement for individuals with COPD and HF. The pilot randomized controlled feasibility trial of the Mindful Steps intervention is currently ongoing, with outcomes including feasibility measures as well as patient-centered measures. Through integration of components from a web-based physical activity intervention and mind-body exercise, the study aims to collect valuable information for designing a future clinical trial to assess the efficacy of this multimodal approach.
JMIR RESEARCH PROTOCOLS
(2021)