Article
Veterinary Sciences
Sehyeong Ham, Jeongmin Suh, Taehwan Oh, Chonghan Kim, Byoung-Joo Seo, Chanhee Chae
Summary: This study evaluated the efficacy of a novel bivalent vaccine containing porcine circovirus type 2d (PCV2d) and Mycoplasma hyopneumoniae. The results showed that pigs vaccinated with this bivalent vaccine exhibited improved growth performance and elicited immune responses against PCV2d and M. hyopneumoniae. The vaccination also reduced the viral and mycoplasmal loads in pigs' blood and larynx, as well as decreased lung and lymphoid lesion severity.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Yongjun Ahn, Siyeon Yang, Taehwan Oh, Kee Hwan Park, Hyejean Cho, Jeongmin Suh, Chanhee Chae
Summary: The study demonstrated that the new single-dose bivalent vaccine effectively protected pigs against dual PCV2b and M. hyopneumoniae challenge by significantly increasing neutralizing antibodies and cell-mediated immunity, reducing viremia and nasal shedding, and decreasing the severity of lung and lymphoid lesions associated with the infections.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Immunology
Zhisong Gao, Lingxiao Chen, Tao Song, Xuan Pan, Xiaojing Li, Guangzong Lu, Yajie Tang, Xiang Wu, Baohua Zhao, Ran Zhang
Summary: Porcine reproductive and respiratory syndrome virus (PRRSV) and Mycoplasma hyopneumoniae (Mhp) are common pathogens in porcine respiratory disease complex (PRDC). In this study, a recombinant epitope protein rEP-PM was developed by screening B cell and T cell epitopes of PRRSV-GP5, PRRSV-M, Mhp-P46, and Mhp-P65 proteins. Immunization with rEP-PM induced high levels of antibodies and a Th1-dominant cellular immune response in mice.
Article
Microbiology
Siyeon Yang, Taehwan Oh, Kee Hwan Park, Hyejean Cho, Jeongmin Suh, Chanhee Chae
Summary: The experimental study evaluated the efficacy of a new trivalent vaccine containing PCV2a/b and Mycoplasma hyopneumoniae. Results showed that vaccinated pigs had a significant amount of protective immunity and reduced viral load compared to unvaccinated pigs. The trivalent vaccination provided good protection against single and dual challenges of PCV2d and M. hyopneumoniae.
VETERINARY MICROBIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Jacquelyn Horsington, Maarten Witvliet, Antonius A. C. Jacobs, Ruud P. A. M. Segers
Summary: This study found that simultaneously vaccinating against the four major pathogens in swine using intradermal application had equivalent efficacy to single vaccinations. The combined vaccination method offers benefits such as reduced time and labor costs, as well as improved animal welfare.
Article
Immunology
Tiphany Chrun, Emmanuel A. Maze, Eleni Vatzia, Veronica Martini, Basudev Paudyal, Matthew D. Edmans, Adam McNee, Tanuja Manjegowda, Francisco J. Salguero, Nanchaya Wanasen, Surapong Koonpaew, Simon P. Graham, Elma Tchilian
Summary: The study indicated that co-infection of PRRSV-2 and swine influenza H3N2 virus weakened the protective effect of PRRS modified live virus vaccine while enhancing antibody responses. In contrast, co-infection in non-immunized animals helped reduce viral load and potentiate T cell responses. The upregulation of inhibitory cytokines gene expression in vaccinated pigs' lungs may have influenced responses to H3N2 and PRRSV-2.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Jeonggyo Lim, Myongha Jin, Injoong Yoon, Han Sang Yoo
Summary: This study evaluated the efficacy of two new bivalent vaccines of PCV2 and MHP in SPF pigs and found that both vaccines effectively protected pigs against PCV2d infection.
JOURNAL OF VETERINARY SCIENCE
(2022)
Article
Immunology
Sim-In Lee, Chang-Gi Jeong, Sameer ul Salam Mattoo, Salik Nazki, Ram Prasad Aganja, Seung-Chai Kim, Amina Khatun, Yeonsu Oh, Sang-Hyun Noh, Sang-Myeong Lee, Won-Il Kim
Summary: This study demonstrated that intradermally administered inactivated vaccines against PCV2 and Mhp can efficiently induce protective immune responses in pigs, leading to higher weight gain, lower pathogen load, higher antibody responses, and increased levels of CTLs, Th1, and Th17 cells. Effective antigen delivery to antigen-presenting cells in the dermis may contribute to these immune responses.
Article
Veterinary Sciences
Joo Young Lee, Kee Hwan Park, Taehwan Oh, Siyeon Yang, Jeongmin Suh, Hee Jin Ham, Chanhee Chae
Summary: The study aimed to reproduce severe pneumonic lesions by dual inoculation of pigs with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae at 6 weeks of age, followed by inoculation with porcine circovirus type 2. Results demonstrated that this triple pathogen inoculation can lead to severe interstitial pneumonia with peribronchial or peribronchiolar lymphoid hyperplasia and fibrosis.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Immunology
Jose Carlos Mancera Gracia, Megan Smutzer, Lucas Taylor, Monica Balasch, Meggan Bandrick
Summary: The vaccine effectively reduced PCV2 viremia and shedding, with some impact on pathological changes post-challenge, especially in terms of immunohistochemistry and histiocytic replacement following PCV2b challenge.
Article
Veterinary Sciences
Jeongmin Suh, Sehyeong Ham, Taehwan Oh, Chanhee Chae
Summary: The study demonstrates that a trivalent vaccine provides cross-protection against dual PCV-2e and M. hyopneumoniae challenges and significantly improves the growth performance of pigs.
CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE
(2023)
Article
Veterinary Sciences
Elana Raaphorst, Abdolvahab Farzan, Robert M. Friendship, Brandon N. Lillie
Summary: Older pigs were more likely to test positive for PRRSV but negative for M. hyopneumoniae. Pigs were more likely to test positive for IAV at weaning and the grower/finisher stages, and those positive for IAV were more likely to test positive for both PRRSV and M. hyopneumoniae.
BMC VETERINARY RESEARCH
(2021)
Article
Immunology
Patricia Pleguezuelos, Marina Sibila, Raul Cuadrado-Matias, Rosa Lopez-Jimenez, Diego Perez, Eva Huerta, Monica Perez, Florencia Correa-Fiz, Jose Carlos Mancera-Gracia, Lucas P. Taylor, Stasia Borowski, Gillian Saunders, Joaquim Segales, Sergio Lopez-Soria, Monica Balasch
Summary: Four preclinical and clinical studies were conducted to evaluate the efficacy of a new trivalent vaccine against Porcine circovirus 2 (PCV-2) infection. The results showed that the vaccinated pigs had a significant reduction in PCV-2 viraemia and faecal excretion, as well as lower histopathological lymphoid lesions and PCV-2 immunohistochemistry scores compared to non-vaccinated pigs.
Article
Immunology
Hyungmin Um, Siyeon Yang, Taehwan Oh, Keehwan Park, Hyejean Cho, Jeongmin Suh, Kyung-Duk Min, Chanhee Chae
Summary: This study compared two combined vaccines for porcine circovirus type 2 (PCV2) and Mycoplasma hyopneumoniae in herds with subclinical PCV2d infection and enzootic pneumonia, finding that the trivalent vaccine containing PCV2a, 2b, and M. hyopneumoniae showed better growth performance and reduction of pathogens compared to the bivalent vaccine. No statistical differences were observed between one- and two-dose trivalent-vaccinated groups.
Article
Plant Sciences
Jordan T. T. VanderBurgt, Ondre Harper, Christopher P. P. Garnham, Susanne E. E. Kohalmi, Rima Menassa
Summary: This research aimed to display antigenic portions of the M and GP5 proteins on the surface of tobacco mosaic virus-like particles. The modified tobacco mosaic virus coat protein (TMVc) was expressed in Nicotiana benthamiana plants and resulted in self-assembly and surface display of the M-GP5 epitope.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Duy Tien Do, Toan Tat Nguyen, Nguyen Tien Hoang Nguyen, Mai Ha Phuong Nguyen, Hien Thanh Le, Nam Thi Thu Nguyen, Ninh Thi Phuoc Nguyen, Chanhee Chae, Choew Kong Mah
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2020)
Article
Microbiology
Taehwan Oh, Chanhee Chae
VETERINARY MICROBIOLOGY
(2020)
Article
Virology
Changhoon Park, Jong Hyuk Baek, Sun Hee Cho, Jiwoon Jeong, Chanhee Chae, Su-Hwa You, Sang-Ho Cha
Article
Infectious Diseases
Kee Hwan Park, Chanhee Chae
Summary: The study aimed to determine the prevalence of porcine circovirus type 2e (PCV2e) compared to other PCV2 genotypes in lymph nodes of slaughter pigs. Results showed PCV2d as the dominant genotype, with PCV2e being the least prevalent. Multiple infections were rare, with PCV2a+PCV2d being the most common combination.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Veterinary Sciences
Siyeon Yang, Yongjun Ahn, Taehwan Oh, Hyejean Cho, Kee Hwan Park, Chanhee Chae
Summary: Vaccination with the bivalent vaccine significantly improved growth performance, reduced clinical scores, decreased PCV2d and M. hyopneumoniae loads, elicited higher levels of protective immunity, and lowered the scores of M. hyopneumoniae-induced pneumonia and PCV2-associated lymphoid lesions compared to unvaccinated animals under field conditions.
VETERINARY MEDICINE AND SCIENCE
(2021)
Review
Immunology
Chanhee Chae
Summary: PRRSV is a challenging viral pathogen in the global pork industry, with MLV vaccines being the principal strategy for control. The efficacy of the vaccines is often unpredictable and depends heavily on the field virus.
Article
Immunology
Hyungmin Um, Siyeon Yang, Taehwan Oh, Keehwan Park, Hyejean Cho, Jeongmin Suh, Kyung-Duk Min, Chanhee Chae
Summary: This study compared two combined vaccines for porcine circovirus type 2 (PCV2) and Mycoplasma hyopneumoniae in herds with subclinical PCV2d infection and enzootic pneumonia, finding that the trivalent vaccine containing PCV2a, 2b, and M. hyopneumoniae showed better growth performance and reduction of pathogens compared to the bivalent vaccine. No statistical differences were observed between one- and two-dose trivalent-vaccinated groups.
Article
Veterinary Sciences
Taehwan Oh, Duy Tien Do, Hung Van Vo, Hyeok-il Kwon, Seung-Chul Lee, Min Ho Kim, Dung Thi Thu Nguyen, Quang Tin Vinh Le, Tan Minh Tran, Toan Tat Nguyen, Joo Young Lee, Chanhee Chae
Summary: The use of renal-derived swine macrophages as a novel primary cell candidate offers a solution to ethical constraints and consistency problems in ASFV propagation. These primary cells are proven to be permissive to both cell adapted ASFV and wild-type ASFV, making them useful for virus isolation and propagation. Additionally, compared to commercial cell lines, renal-derived macrophages demonstrate consistent molecular characteristics and are more suitable for isolating field viruses.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Yongjun Ahn, Siyeon Yang, Taehwan Oh, Kee Hwan Park, Hyejean Cho, Jeongmin Suh, Chanhee Chae
Summary: The study demonstrated that the new single-dose bivalent vaccine effectively protected pigs against dual PCV2b and M. hyopneumoniae challenge by significantly increasing neutralizing antibodies and cell-mediated immunity, reducing viremia and nasal shedding, and decreasing the severity of lung and lymphoid lesions associated with the infections.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Microbiology
Siyeon Yang, Taehwan Oh, Kee Hwan Park, Hyejean Cho, Jeongmin Suh, Chanhee Chae
Summary: The experimental study evaluated the efficacy of a new trivalent vaccine containing PCV2a/b and Mycoplasma hyopneumoniae. Results showed that vaccinated pigs had a significant amount of protective immunity and reduced viral load compared to unvaccinated pigs. The trivalent vaccination provided good protection against single and dual challenges of PCV2d and M. hyopneumoniae.
VETERINARY MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Duy Tien Do, Khanh Doan Vinh Tran, Anh Tuyet Quach, David Lee, Frank C. J. Chang, Carol P. Y. Wu, Toan Nguyen Tat, Chanhee Chae
Summary: The study demonstrated that the CIRCOQ porcine circovirus type 2 (PCV2) subunit vaccine is effective in protecting piglets with high maternally derived antibodies against disease caused by natural infection with PCV2d. Vaccinated pigs showed lower signs of respiratory disorder and dermatitis, lower mortality rates, and higher body weight and productivity compared to unvaccinated pigs.
CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE
(2021)
Article
Veterinary Sciences
SooHwan Kim, Taehwan Oh, Siyeon Yang, Hyejean Cho, Chanhee Chae
Summary: This study evaluated the efficacy of a new Mycoplasma hyopneumoniae bacterin in Korean pigs under experimental conditions. The vaccinated pigs showed a strong cell-mediated immunity and reduced nasal shedding and lung lesions compared to the unvaccinated pigs. Overall, the evaluated vaccine was effective in controlling M. hyopneumoniae infection.
CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE
(2021)
Article
Veterinary Sciences
Joo Young Lee, Kee Hwan Park, Taehwan Oh, Siyeon Yang, Jeongmin Suh, Hee Jin Ham, Chanhee Chae
Summary: The study aimed to reproduce severe pneumonic lesions by dual inoculation of pigs with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae at 6 weeks of age, followed by inoculation with porcine circovirus type 2. Results demonstrated that this triple pathogen inoculation can lead to severe interstitial pneumonia with peribronchial or peribronchiolar lymphoid hyperplasia and fibrosis.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Veterinary Sciences
Siyeon Yang, Ikjae Kang, Hyejean Cho, Taehwan Oh, Kee Hwan Park, Kyung-Duk Min, Chanhee Chae
CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE
(2020)
Article
Veterinary Sciences
Siyeon Yang, Ikjae Kang, Jiwoon Jeong, Taehwan Oh, Kee Hwan Park, Su-Jin Park, Hee Jin Ham, Guang-Ri Jin, Bog-Hieu Lee, Chanhee Chae
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2020)
Article
Veterinary Sciences
L. Alibrandi, R. Tognetti, O. Domenech, M. Croce, M. Giuntoli, G. Grosso, T. Vezzosi
Summary: This study assessed the feasibility and diagnostic reliability of a new smartphone-based ECG device in dogs, and found no significant differences compared to a traditional ECG device. The results suggest that the smartphone-based device is clinically reliable for assessing heart rate and rhythm in dogs.
VETERINARY JOURNAL
(2024)