Article
Biochemistry & Molecular Biology
Tao Qin, Danni Feng, Bangyue Zhou, Lirong Bai, Yinyan Yin
Summary: Melatonin, a natural compound with powerful antioxidant and anti-inflammatory properties, was found to suppress oxidative stress in dendritic cells (DCs) in an acute lung injury (ALI) model. The inhibition of oxidative stress was achieved through the regulation of antioxidant enzymes and the Nrf2/HO-1 axis. These findings suggest that melatonin could be a promising strategy for ALI treatment.
Article
Medicine, Research & Experimental
Yin Zhang, Peifang Cong, Changci Tong, Hongxu Jin, Yunen Liu, Mingxiao Hou
Summary: The study demonstrated that melatonin pretreatment alleviated blast-induced behavioral abnormalities in mice and maintained HPG axis hormone homeostasis in rats. Melatonin upregulated Nrf2/HO-1 expression, inhibited NF-kappa B expression, and reversed blast-induced oxidative stress, inflammation, and apoptosis. This suggests that melatonin could be a potential treatment for blast-induced HPG axis hormonal and behavioral abnormalities.
Article
Biochemistry & Molecular Biology
Shan Hu, Beilei Liu, Manqi Yang, Shuai Mao, Hao Ju, Zheyu Liu, Min Huang, Gang Wu
Summary: A study found that carnosic acid (CA) can inhibit the oxidative damage, apoptosis, and pyroptosis induced by doxorubicin (DOX) in the heart, thereby protecting the heart. This study suggests that CA could be a potential therapeutic strategy in the prevention of DOX-associated cardiomyopathy.
Article
Food Science & Technology
Mona F. Mahmoud, Noura Ali, Ismail Mahdi, Omar Mouhtady, Islam Mostafa, Assem M. El-Shazly, Mohamed A. O. Abdelfattah, Rehab A. Hasan, Mansour Sobeh
Summary: Coriander essential oil, rich in linalool, gamma-terpinene and alpha-pinene, has been found to ameliorate dexamethasone-induced liver injury through Nrf2/HO-1 and antiapoptotic signaling pathways.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Immunology
Xiaoxue Bai, Yingjie Zhu, Jing Jie, Dan Li, Lei Song, Jingjing Luo
Summary: This study found that Maackiain, a natural compound from Sophora flavescens, protects against sepsis by reducing organ injury, inflammation, and oxidative stress. Maackiain activates the AMPK/Nrf2/HO-1 pathway, leading to its anti-inflammatory and antioxidant effects. Inhibition of this pathway abolishes the protective effects of Maackiain.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Sally E. Abu-Risha, Samia S. Sokar, Heba R. Elbohoty, Alaa E. Elsisi
Summary: This experiment aimed to explore the hepatoprotective effects of carvacrol and cilostazol alone and in combination against alcoholic liver fibrosis, and the underlying mechanisms. The results showed that carvacrol, cilostazol, and their combination significantly improved ethanol-induced hepatic fibrosis, and these effects were associated with upregulation of SIRT1, Nrf2, and HO-1 genes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Somayyeh Ghareghomi, Faezeh Moosavi-Movahedi, Luciano Saso, Mehran Habibi-Rezaei, Ali Khatibi, Jun Hong, Ali A. Moosavi-Movahedi
Summary: Oxidative stresses play a pivotal role in various pathophysiological conditions. The Keap1/Nrf2 pathway is a dual-edged sword with beneficial effects on both normal and cancer cells by regulating endogenous antioxidant enzymes. Targeting the Nrf2/HO-1 axis is considered a novel strategy for cancer treatment, especially in lung cancer.
Article
Medicine, Research & Experimental
Aya E. Mohamed, Ayman M. Mahmoud, Wafaa R. Mohamed, Tarek Mohamed
Summary: This study aimed to investigate the therapeutic potential and underlying mechanism of low-level laser therapy (LLLT) for liver fibrosis in rats. The results showed that LLLT attenuated CCl4-induced liver fibrosis by suppressing extracellular matrix (ECM) production and deposition, reducing oxidative injury and inflammation, and upregulating PPAR gamma and Nrf2/HO-1 signaling.
Review
Biochemistry & Molecular Biology
Khalid Saad Alharbi, Waleed Hassan Almalki, Mohammed Albratty, Abdulkarim M. Meraya, Asim Najmi, Govind Vyas, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta
Summary: Liver cancer is a leading cause of cancer death, and the overexpression of Nrf2 and HO-1 due to oxidative stress has been associated with tumor growth and poor prognosis. Nutraceuticals found in fruits and vegetables may be an effective strategy for treating liver cancer.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Immunology
Ruozhi Dang, Mingyang Wang, Xinhui Li, Haiyang Wang, Lanxiang Liu, Qingyuan Wu, Jianting Zhao, Ping Ji, Lianmei Zhong, Julio Licinio, Peng Xie
Summary: Inflammation and oxidative stress have been implicated in the development of depression. This study investigated the antidepressant effects and mechanisms of action of Edaravone (EDA), a free radical scavenger. The results demonstrated that EDA alleviated depressive and anxiety-like behaviors in a chronic social defeat stress (CSDS) depression model. Furthermore, EDA reduced neuronal loss, oxidative stress damage, and activation of inflammatory cytokines in the hippocampus and medial prefrontal cortex. The antidepressant effects of EDA were mediated through the Sirt1/Nrf2/HO-1/Gpx4 signaling pathway and Gpx4-mediated ferroptosis.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Apeksha Joshi, Kapil K. Upadhyay, Aliasgar Vohra, Kavita Shirsath, Ranjitsinh Devkar
Summary: Melatonin treatment improved oscillatory patterns of clock genes and antioxidant genes in conditions of high-fat high fructose diet and/or jet lag-mediated NAFLD, leading to improvements in lipid metabolism, liver function, and histomorphology of fatty liver. The reprogramming of hepatic core clock and Nrf2-HO-1 genes by melatonin contributed to the overall improvement in HFHF/JL-induced NAFLD.
Article
Biochemistry & Molecular Biology
Meng Wang, Lei Zhang, Hao Yue, Weizhen Cai, Haowen Yin, Yingying Tian, Ping Dong, Jingfeng Wang
Summary: This study investigated the hepatoprotective effects of peptides from Antarctic krill (AKP) on carbon tetrachloride (CCl4)-induced acute liver injury (ALI) in mice and found that AKP pretreatment significantly attenuated CCl4-induced liver injury. This protective effect was associated with the activation of the Nrf2/HO-1 pathway and the improvement of redox balance.
Article
Engineering, Chemical
Wesam Al-Amarat, Mohammad H. Abukhalil, Osama Y. Althunibat, Manal A. Alfwuaires, Mashael M. Alnamshan, Amany Alqosaibi, Ahmad F. Ahmeda, Emadeldin M. Kamel, Hany H. Arab, Ayman M. Mahmoud
Summary: Galangin ameliorates hyperglycemia, glucose intolerance, oxidative stress, inflammation, and apoptosis, and enhances antioxidants and Nrf2/HO-1 signaling in diabetic rats.
Article
Pharmacology & Pharmacy
Xiaohang Zheng, Jianxin Qiu, Han Zhang, Ning Gao, Ting Jiang, Yuhang Gong, Weikang Zhang, Ze Li, Xingbing Feng, Zhenghua Hong
Summary: PD184352 is a small molecule inhibitor with potential anti-inflammatory and antioxidant activity. This study found that PD184352 has a protective effect against destabilized medial meniscus (DMM)-induced osteoarthritis (OA), showing higher Nrf2 expression and milder cartilage damage in the PD184352-treated group. In vitro experiments also showed that PD184352 suppressed IL-113-induced production of NO, iNOS, and PGE2, and attenuated pyroptosis. PD184352 treatment promoted antioxidant protein expression and reduced ROS accumulation by activating the Nrf2/HO-1 axis. The anti-inflammatory and antioxidant effects of PD184352 were partially dependent on Nrf2 activation. This study reveals the potential of PD184352 as an antioxidant and provides a new strategy for OA treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Enrico Gugliandolo, Rosalba Siracusa, Marika Cordaro, Tiziana Genovese, Alessio Filippo Peritore, Rosalia Crupi, Livia Interdonato, Davide Di Paola, Salvatore Cuzzocrea, Roberta Fusco, Daniela Impellizzeri, Rosanna Di Paola
Summary: Exposure to endocrine disruptors (EDs) may worsen the progression of Parkinson's disease, leading to neuroinflammation and oxidative stress. Additionally, ED exposure can cause changes in behavior and cognition, with a more significant impact observed with exposure to herbicides.
Article
Biochemistry & Molecular Biology
Minka Hristova, Maria Tzaneva, Ganka Bekyarova, Dariya Chivchibashi, Nadezhda Stefanova, Yoana Kiselova-Kaneva
Article
Pharmacology & Pharmacy
G. Bekyarova, S. Tancheva, M. Hristova
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
(2009)
Article
Pharmacology & Pharmacy
G. Bekyarova, S. Tancheva, M. Hristova
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
(2010)
Article
Medicine, General & Internal
Ganka Bekyarova, Yordanka Bratchkova, Stoyanka Tancheva, Minka Hristova
CENTRAL EUROPEAN JOURNAL OF MEDICINE
(2012)
Review
Medicine, General & Internal
Ganka Bekyarova, Maria Tzaneva, Minka Hristova, Krasimir Hristov
CENTRAL EUROPEAN JOURNAL OF MEDICINE
(2014)