Article
Endocrinology & Metabolism
N. Li, J. P. van den Bergh, A. Boonen, C. E. Wyers, S. P. G. Bours, M. Hiligsmann
Summary: This study assessed the lifetime cost-effectiveness of a fracture liaison service (FLS) compared to no-FLS in the Netherlands and found that FLS was cost-effective for patients aged 50 years and older with a recent fracture. The implementation of FLS could lead to lifetime health-economic benefits.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Nannan Li, Lei Si, Annelies Boonen, Joop P. van den Bergh, Mickael Hiligsmann
Summary: This study, based on a model, suggests that fracture liaison services (FLS) in China could potentially lead to lifelong cost savings in patients who have experienced a fracture. However, Chinese-specific real-world data is needed to confirm these findings.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
C. -B. Chang, R. -S. Yang, L. -Y. Chang, J. -K. Peng, K. -S. Tsai, W. -J. Huang, T. -H. Yang, D. -C. Chan
Summary: The study aimed to evaluate the effectiveness of osteoporosis liaison service (OLS) in improving osteoporosis care, and found that the program led to increased medication adherence, calcium/vitamin D/protein intake, and reduced fall rates among participants after 1 year.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Andrea Senay, Julio C. Fernandes, Josee Delisle, Suzanne N. Morin, Alice Dragomir, Sara Nazha, Sylvie Perreault
Summary: This study found that implementing a high-intensity Fracture Liaison Service with systematic follow-up may be cost-effective, especially when patients attend follow-up visits. The high followers and intermediate followers showed better cost-effectiveness during follow-up, with the overall FLS demonstrating favorable cost-effectiveness as well.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Smita Nayak, Andrea Singer, Susan L. Greenspan
Summary: The study evaluated the cost-effectiveness of secondary fracture prevention intervention for Medicare beneficiaries, showing that the intervention was more effective and less expensive than usual care. It resulted in cost savings and increased quality-adjusted life-years, making it a recommended strategy for improving outcomes and reducing healthcare costs.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Endocrinology & Metabolism
E. Soreskog, I. Lindberg, J. A. Kanis, K. E. Akesson, D. Willems, M. Lorentzon, O. Strom, P. Berling, F. Borgstrom
Summary: The study indicates that sequential romosozumab-to-alendronate treatment may be a cost-effective option for postmenopausal women at high risk of fracture.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Rafael Pinedo-Villanueva, Edward Burn, Christopher Maronga, Cyrus Cooper, M. Kassim Javaid
Summary: Osteoporotic-related fractures lead to patient disability and burden on health care systems. Fracture liaison services (FLSs) provide effective secondary fracture prevention, but are not widely available. This study developed an economic model to estimate the benefits and budget impact of FLSs and support their international implementation.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Andre Manoel Inacio, Larissa Lauzy Macedo Marques, Victoria Zeghbi Cochenski Borba, Carolina Aguiar Moreira
Summary: Evaluating the results of the Fracture Liaison Service (FLS) operation and analyzing the clinical characteristics of patients in its first two years of operation can effectively reduce the risk of new fractures in high-risk patients.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Lisanne Vranken, Irma J. A. de Bruin, Annemariek H. M. Driessen, Piet P. M. Geusens, John A. Eisman, Jacqueline R. Center, Robert Y. van der Velde, Heinrich M. J. Janzing, Sjoerd Kaarsemaker, Joop P. van den Bergh, Caroline E. Wyers
Summary: Fracture liaison services (FLS) are effective in preventing secondary fractures. This study evaluated whether FLS care is associated with reduced subsequent fracture and mortality risk over a 3-year follow-up period. The results showed that FLS care was associated with a lower mortality risk and lower subsequent major/hip fracture risk in the first year for patients with a major/hip index fracture, but not for patients with a non-major/non-hip fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Luis Fernando Valladales-Restrepo, Edgar Eduardo Castro-Osorio, Jessica Ramirez-Osorio, Luisa Fernanda Echeverry-Martinez, Veronica Sanchez-Rios, Andres Gaviria-Mendoza, Manuel Enrique Machado-Duque, Jorge Enrique Machado-Alba
Summary: Fracture Liaison Services programs reduce mortality and the risk of refracture while increasing treatment and adherence rates. This study aimed to determine the characteristics of patients over 50 years old who suffered fractures and the effectiveness of a Fracture Liaison Services program in a healthcare institution in Colombia.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Endocrinology & Metabolism
Maria Jose Montoya-Garcia, Cristina Carbonell-Abella, Jose Manuel Cancio-Trujillo, Maria Jesus Moro-Alvarez, Jesus Mora-Fernandez, Rafael Izquierdo-Avino, Xavier Nogues, Manuel Mesa-Ramos, Rosa Maria San Segundo-Mozo, Elena Calero-Munoz, Manuel Naves-Diaz, F. Jesus Olmo-Montes, Enric Duaso
Summary: REFRA-FLS is a new registry in Spain aimed at identifying individuals over 50 years old with a fragility fracture. The study found that hip fracture is the most prevalent type of fracture, with a treatment rate of 87.7% and adherence rate of 65.3%. The results provide a comprehensive picture of fragility fractures identified by FLS units in Spain.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
Sebastian Ruehling, Julian Schwarting, Matthias F. Froelich, Maximilian T. Loeffler, Jannis Bodden, Moritz R. Hernandez R. Petzsche, Thomas Baum, Maria Wostrack, A. Kaywan Aftahy, Vanadin Seifert-Klauss, Nico Sollmann, Claus Zimmer, Jan S. Kirschke, Fabian Tollens
Summary: Opportunistic quantitative computed tomography (oQCT) derived from non-dedicated routine CT has demonstrated high accuracy in diagnosing osteoporosis and predicting vertebral fractures (VFs). In terms of cost-effectiveness, oQCT screening is more cost-effective than DXA screening and can prevent more VFs.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Sarah J. Billups, Danielle R. Fixen, Lisa M. Schilling, Arwa El-Sheikh, Alexandra M. Marcus, Micol S. Rothman
Summary: The study describes the evolution of a centralized FLS and analyzes the impact of adding clinical pharmacist consultation. The results demonstrate that FLS significantly improves patient follow-up, DXA, and medication initiation.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Review
Rheumatology
Julien Paccou, Cecile Philippoteaux, Bernard Cortet, Patrice Fardellone
Summary: In response to the decline in prescriptions for anti-osteoporosis medication after fragility fractures, fracture liaison services (FLSs) have been established to address this treatment gap. While FLS programs have shown benefits in managing osteoporosis-related fractures, some studies have highlighted their varying effectiveness in reducing subsequent fractures and mortality. Long-term medication persistence and monitoring, as well as timely interventions, are critical issues in FLS programs. Introducing additional services such as vertebral fracture identification and utilizing digital technologies could support improved patient care, but the quality of research evaluating these approaches is limited.
Article
Endocrinology & Metabolism
Anthony Delbar, Arnaud Pflimlin, Isabelle Delabriere, Camille Ternynck, Christophe Chantelot, Francois Puisieux, Bernard Cortet, Julien Paccou
Summary: The study at Lille University Hospital assessed persistence with osteoporosis treatment in patients from the Fracture Liaison Service over a period of 1 year. The results showed a high persistence rate at 12 months but dropped at 24 months. Independent predictors of non-persistence included follow-up performed by a general practitioner and treatment with zoledronic acid.
