Review
Immunology
Susanna Esposito, Giulia Chiopris, Giulia Messina, Tiziana D'Alvano, Serafina Perrone, Nicola Principi
Summary: CMV is a common cause of congenital infection and non-genetic sensorineural hearing loss in children, with up to 2% of neonates affected, particularly in developing countries. Research on a vaccine to prevent CMV infection faces challenges due to the complex relationship between the host's immune system and the virus, highlighting the need for further studies.
Article
Immunology
Kara S. Cox, Lu Zhang, Daniel C. Freed, Aimin Tang, Shifang Zhang, Yu Zhou, I-Ming Wang, Richard E. Rupp, Stuart P. Adler, Luwy K. Musey, Dai Wang, Kalpit A. Vora, Tong-Ming Fu
Summary: The study analyzed vaccine-induced T cells for memory phenotype, antigen specificity, cytokine profiles, and cytolytic potential using multicolor flow cytometry. The results showed that vaccination elicited polyfunctional CD4 and CD8 T cells with predominantly effector phenotype responding to 2 dominant antigens, pp65 and IE1. Analysis of T-cell receptor repertoires demonstrated polyclonal expansion of antigen-specific T cells after vaccination.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Yuqing Lv, Ying Chang
Summary: A case of cytomegalovirus (CMV) proctitis following COVID-19 vaccination is reported, suggesting that the COVID-19 vaccine may cause immune disorders including both immune hyperactivity and immune deficiency.
Article
Immunology
Robert Paris, Dan Apter, Suresh Boppana, Maria D'Aloia, Nathalie De Schrevel, Jean-Marc Delroisse, Luca Grassano, Adrienne Guignard, Anil A. Panackal, Francois Roman, Jing Yu, Elsa M. Yunes, Ilse Dieussaert
Summary: Further research on the impact of congenital cytomegalovirus (CMV) infection on infants is crucial. Studies have shown that the rates of primary infection among adolescent girls in Finland, Mexico, and the United States are 5%, while reinfection rates range from 2% to 8%. Standardized markers for measuring reinfection and reactivation are needed.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Virology
Janine Zeng, Dabbu Kumar Jaijyan, Shaomin Yang, Shakai Pei, Qiyi Tang, Hua Zhu
Summary: Viral vectors, especially cytomegalovirus (CMV), have shown great potential in gene therapy due to their large packaging capacity, ability to achieve superinfection, broad host range, and capacity to induce virus-specific T cell responses. CMV vectors have been successful in various diseases and may serve as a promising vaccine vector.
Article
Biotechnology & Applied Microbiology
K. Yeon Choi, Nadia S. El-Hamdi, Alistair McGregor
Summary: The research suggests that multiple strains of human cytomegalovirus can cause congenital cytomegalovirus. Studies on small animal models have shown that gB vaccines perform well in terms of protection, but there are differences in compatibility with different viral strains. Pentamer complex antibodies have a significant impact on neutralization of non-fibroblast cell infection.
JOURNAL OF GENERAL VIROLOGY
(2021)
Article
Virology
Mark R. Schleiss, Claudia Fernandez-Alarcon, Nelmary Hernandez-Alvarado, Jian Ben Wang, Adam P. Geballe, Michael A. McVoy
Summary: The importance of immunity to the homologous PC encoded by guinea pig cytomegalovirus (GPCMV) in preventing congenital CMV was determined by generating PC-intact and PC-deficient live-attenuated vaccines. These vaccines were compared for immunogenicity and efficacy against vertical transmission in a vertical transmission model, showing promising results in reducing vertical transmission.
Article
Immunology
Jayani Pathirana, Gaurav Kwatra, Innocent Maposa, Michelle J. Groome, Shabir A. Madhi
Summary: The study found that at seven months of age, infants with congenital CMV infection, postnatal CMV infection, and CMV-uninfected infants had similar immune responses to the DTaP-Hib-HBV vaccine, with close to 100% of infants having antigen-specific IgG concentrations above the level of protection for four out of five antigens.
Review
Immunology
Sara Scarpini, Francesca Morigi, Ludovica Betti, Arianna Dondi, Carlotta Biagi, Marcello Lanari
Summary: hCMV is a common cause of congenital infection, leading to potential permanent impairment and severe disease in immunocompromised individuals. Research on hCMV vaccines is ongoing, but challenges in development include the virus's ability to evade immune response and identifying target populations for vaccination.
Article
Immunology
Alicja Sadowska-Klasa, Wendy M. Leisenring, Ajit P. Limaye, Michael Boeckh
Summary: A systematic review of randomized and observational studies from 2013-2023 indicated that antiviral preemptive therapy initiated at cytomegalovirus viral load thresholds between 2 and 3 log10 IU/mL had comparable cytomegalovirus disease rates. Thus, viral thresholds within this range appeared to effectively safeguard patients who did not receive prophylaxis.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Richard R. Rustandi, John W. Loughney, Liang Shang, Shiyi Wang, Cindy J. Pauley, Sianny Christanti, Adam Kristopeit, Timothy D. Culp
Summary: This paper presents an innovative approach using capillary western blot technology for rapid and accurate quantification of key viral surface proteins of HCMV. The method is versatile in analyzing multiple sample types and can aid in vaccine process development and virus characterization.
Article
Immunology
Vu Thuy Khanh Le-Trilling, Andreja Jagnjic, Ilija Brizic, Mareike Eilbrecht, Kerstin Wohlgemuth, Carmen Rozmanic, Alan Herdman, Katja Hoffmann, Astrid M. M. Westendorf, Hartmut Hengel, Stipan Jonjic, Mirko Trilling
Summary: Human cytomegalovirus (HCMV) can cause congenital infections with birth defects and developmental disorders. A vaccine is currently not available. In this study, CMV mutants lacking STAT2 antagonists were examined as potential live attenuated vaccine viruses in mice. Vaccination with these attenuated viruses induced strong immune responses, including neutralizing antibodies and antibodies stimulating cellular Fc gamma receptors. Vaccinated mice were fully protected against challenge infections and maternal antibodies were found to be indispensable for vaccine-induced protection against cytomegaloviruses.
Review
Biology
Marko Sustic, Maja Cokaric Brdovcak, Astrid Krmpotic, Stipan Jonjic
Summary: The 20th century saw a significant increase in the number of vaccines used to combat diseases caused by viral and bacterial pathogens. However, major public health threats such as HIV, tuberculosis, malaria, and cancer continue to pose a significant burden. CD8 T cells have emerged as promising candidates for vaccine targeting, playing a key role in protection against pathogens and tumors.
Review
Virology
Lena Royston, Stephane Isnard, John Lin, Jean-Pierre Routy
Summary: While vaccines against SARS-CoV-2 are rapidly developing, an effective HIV vaccine is still lacking. PLWH exhibit increased morbidity and mortality despite ART, partly due to HIV-related immune activation and viral coinfections, such as CMV. CMV-induced immune dysregulation can lead to reduced response to vaccines in PLWH, highlighting the need for new therapeutic advances targeting CMV.
Article
Psychiatry
Tereza Calkova, Simon Cervenka, Robert H. Yolken, Ole A. Andreassen, Dimitrios Andreou
Summary: CMV infection is associated with lower IQ in adolescent patients with schizophrenia spectrum disorders.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Infectious Diseases
Michelle J. Groome, Lee Fairlie, Julie Morrison, Alan Fix, Anthonet Koen, Maysseb Masenya, Lisa Jose, Shabir A. Madhi, Nicola Page, Monica McNeal, Len Dally, Iksung Cho, Maureen Power, Jorge Flores, Stanley Cryz
LANCET INFECTIOUS DISEASES
(2020)
Article
Immunology
Lilin Lai, Nadine Rouphael, Yongxian Xu, Amy C. Sherman, Srilatha Edupuganti, Evan J. Anderson, Pamela Lankford-Turner, Dongli Wang, Wendy Keitel, Monica M. McNeal, Kaitlyn Cross, Heather Hill, Abbie R. Bellamy, Mark J. Mulligan
Article
Pediatrics
Brian Rha, Aaron T. Curns, Joana Y. Lively, Angela P. Campbell, Janet A. Englund, Julie A. Boom, Parvin H. Azimi, Geoffrey A. Weinberg, Mary A. Staat, Rangaraj Selvarangan, Natasha B. Halasa, Monica M. McNeal, Eileen J. Klein, Christopher J. Harrison, John V. Williams, Peter G. Szilagyi, Monica N. Singer, Leila C. Sahni, Daniella Figueroa-Downing, Darius McDaniel, Mila M. Prill, Brett L. Whitaker, Laura S. Stewart, Jennifer E. Schuster, Barbara A. Pahud, Gina Weddle, Vasanthi Avadhanula, Flor M. Munoz, Pedro A. Piedra, Daniel C. Payne, Gayle Langley, Susan I. Gerber
Article
Biotechnology & Applied Microbiology
Felicia Scaggs Huang, David I. Bernstein, Karen S. Slobod, Allen Portner, Toru Takimoto, Charles J. Russell, Michael Meagher, Bart G. Jones, Robert E. Sealy, Christopher Coleclough, Kristen Branum, Michelle Dickey, Kristen Buschle, Monica McNeal, Mat Makowski, Aya Nakamura, Julia L. Hurwitz
Summary: The study demonstrated that SeVRSV vaccine was well-tolerated in healthy adults with only mild to moderate reactions and no severe adverse events. Transient vaccine genome detection was observed due to preexisting immunity towards hPIV-1 and RSV in adults. Minimal antibody responses to SeV and negligible responses to RSV F were observed.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Infectious Diseases
Brian Rha, Joana Y. Lively, Janet A. Englund, Mary A. Staat, Geoffrey A. Weinberg, Rangaraj Selvarangan, Natasha B. Halasa, John Williams, Julie A. Boom, Leila C. Sahni, Marian G. Michaels, Laura S. Stewart, Christopher J. Harrison, Peter G. Szilagyi, Monica M. McNeal, Eileen J. Klein, Bonnie Strelitz, Kirsten Lacombe, Elizabeth Schlaudecker, Mary E. Moffatt, Jennifer E. Schuster, Barbara A. Pahud, Gina Weddle, Robert W. Hickey, Vasanthi Avadhanula, Mary E. Wikswo, Aron J. Hall, Aaron T. Curns, Susan Gerber, Gayle Langley
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2020)
Article
Pediatrics
Angela P. Campbell, Constance Ogokeh, Joana Y. Lively, Mary A. Staat, Rangaraj Selvarangan, Natasha B. Halasa, Janet A. Englund, Julie A. Boom, Geoffrey A. Weinberg, John V. Williams, Monica McNeal, Christopher J. Harrison, Laura S. Stewart, Eileen J. Klein, Leila C. Sahni, Peter G. Szilagyi, Marian G. Michaels, Robert W. Hickey, Mary E. Moffat, Barbara A. Pahud, Jennifer E. Schuster, Gina M. Weddle, Brian Rha, Alicia M. Fry, Manish Patel
Article
Microbiology
Robert W. Frenck, Michelle Dickey, Akamol E. Suvarnapunya, Lakshmi Chandrasekaran, Robert W. Kaminski, Kristen A. Clarkson, Monica McNeal, Amanda Lynen, Susan Parker, Amy Hoeper, Sachin Mani, Alan Fix, Nicole Maier, Malabi M. Venkatesan, Chad K. Porter
Article
Biochemistry & Molecular Biology
Raffael Nachbagauer, Jodi Feser, Abdollah Naficy, David Bernstein, Jeffrey Guptill, Emmanuel B. Walter, Franceso Berlanda-Scorza, Daniel Stadlbauer, Patrick C. Wilson, Teresa Aydillo, Mohammad Amin Behzadi, Disha Bhavsar, Carly Bliss, Christina Capuano, Juan Manuel Carreno, Veronika Chromikova, Carine Claeys, Lynda Coughlan, Alec W. Freyn, Christopher Gast, Andres Javier, Kaijun Jiang, Chiara Mariottini, Meagan McMahon, Monica McNeal, Alicia Solorzano, Shirin Strohmeier, Weina Sun, Marie Van der Wielen, Bruce L. Innis, Adolfo Garcia-Sastre, Peter Palese, Florian Krammer
Summary: New influenza virus vaccines based on chimeric hemagglutinin have been found to induce a broad, strong, durable and functional immune response targeting the conserved stalk of the hemagglutinin protein. This suggests that these chimeric hemagglutinins have the potential to be developed as universal vaccines that protect broadly against influenza viruses.
Article
Medicine, General & Internal
Sheila Isanaka, Celine Langendorf, Monica Malone McNeal, Nicole Meyer, Brian Plikaytis, Souna Garba, Nathan Sayinzoga-Makombe, Issaka Soumana, Ousmane Guindo, Rockyiath Makarimi, Marie Francoise Scherrer, Eric Adehossi, Iza Ciglenecki, Rebecca F. Grais
Summary: The study assessed the extended and strain-specific vaccine efficacy of Rotasiil in children up to 24 months of age, showing significant protection against severe rotavirus gastroenteritis in infants during the first year of life and against evolving strains over 2 years. Rotavirus vaccines like Rotasiil offer hope for reducing the burden of rotavirus disease in resource-limited settings.
Article
Medicine, General & Internal
Sheila Isanaka, Souna Garba, Brian Plikaytis, Monica Malone McNeal, Ousmane Guindo, Celine Langendorf, Eric Adehossi, Iza Ciglenecki, Rebecca F. Grais
Summary: This study examined the effect of prenatal nutritional supplementation on infant immune response to a live oral rotavirus vaccine, finding no significant impact of the type of supplementation on immunity. Variations in immune response were observed based on previous exposure to rotavirus, suggesting alternative delivery modalities may improve vaccine performance in high transmission settings.
Article
Multidisciplinary Sciences
Malabi M. Venkatesan, Cassandra Ballou, Shoshana Barnoy, Monica McNeal, Jill El-Khorazaty, Robert Frenck, Shahida Baqar
Summary: ELISA is used to evaluate mucosal immune responses by measuring antigen-specific Antibodies in Lymphocyte Supernatant instead of Antibody Secreting Cells. Two novel live oral vaccine candidates for S. sonnei, WRSs2 and WRSs3, were found to be safe, well-tolerated, and immunogenic in a dose-dependent manner. The magnitude of antigen-specific IgA- and IgG-ALS responses were measured and compared to previously described responses, showing a strong correlation and vaccine-specificity.
Article
Immunology
Azure Tariro Makadzange, Patricia Gundidza, Charles Lau, Norest Beta, Nellie Myburgh, Nyasha Elose, Wilmot James, Lawrence Stanberry, Chiratidzo Ndhlovu
Summary: This study evaluated the adverse events following vaccination with whole inactivated COVID-19 vaccines in an African population and found that the vaccines were well tolerated with mostly mild symptoms, and no hospitalizations were required. Participants who perceived the vaccines as safe or had a personal experience with COVID-19 were less likely to report adverse events.
Review
Medicine, General & Internal
Madeleine C. C. Thomson, Lawrence R. R. Stanberry
Summary: Climate change is causing warming temperatures and changes in precipitation, which are affecting the occurrence of vectorborne diseases. It is crucial to implement effective and equitable strategies for vector control and disease management.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Immunology
Azure Tariro Makadzange, Patricia Gundidza, Charles Lau, Janan Dietrich, Nellie Myburgh, Nyasha Elose, Wilmot James, Lawrence Stanberry, Chiratidzo Ndhlovu
Summary: The low uptake of COVID-19 vaccines in many African countries is mainly due to vaccine hesitancy driven by confidence, convenience, and complacency. Findings from a survey conducted in Zimbabwe show that women, older adults, and people living with HIV have specific concerns and perceptions about vaccine safety and effectiveness. Internet users are less likely to trust vaccines, while family members play a key role in influencing vaccination decisions.
Article
Health Care Sciences & Services
Ardythe L. Morrow, Mary A. Staat, Emily A. DeFranco, Monica M. McNeal, Allison R. Cline, Shannon C. Conrey, Elizabeth P. Schlaudecker, Alexandra M. Piasecki, Rachel M. Burke, Liang Niu, Aron J. Hall, Michael D. Bowen, Susan I. Gerber, Gayle E. Langley, Natalie J. Thornburg, Angela P. Campbell, Jan Vinje, Umesh D. Parashar, Daniel C. Payne
Summary: The PREVAIL Cohort study aims to document the natural history of enteric and respiratory infections and immunity in children aged 0-2 years in the United States. Out of 245 mother-child pairs enrolled, 194 were compliant with the study requirements.
JMIR RESEARCH PROTOCOLS
(2021)
