期刊
VACCINE
卷 34, 期 27, 页码 3199-3206出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2016.02.057
关键词
FMD virus; Antigenic variation; Capsid sequence; Epitopes; Polyclonal antibodies; Antigenic determinants
资金
- DEFRA grant [SE2937]
- BBSRC [BB/F009186/1, BB/H009175/1, BB/J020745/1]
- BBSRC [BBS/E/I/00001703, BB/J020745/1, BB/L004828/1, BB/H009175/1, BB/N012682/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/L004828/1, BBS/E/I/00001703, BB/N012682/1, BB/J020745/1, BB/H009175/1, BB/F009186/1] Funding Source: researchfish
A new immunologically distinct strain (A-Iran-05) of foot-and-mouth disease virus serotype A emerged in the Middle East in 2003 that replaced the previously circulating strains (A-Iran-96 and A-Iran-99) in the region. This resulted in introduction of a new vaccine of this strain (A/TUR/2006) in 2006. Though this vaccine strain has been predominantly used to control FMD in the region, recent viruses isolated in 2012 and 2013 have shown antigenic drift and a poor match with it. In this study, we report the antigenic matching results and capsid sequence data of currently circulating viruses belonging to the SIS-10 and SIS-12 sub-lineages of A-Iran-05 (isolated in 2012 and 2013), highlighting the inadequacy of the currently used serotype A vaccines. Implications of these results in the context of FMD control in the Middle East are discussed. (C) 2016 The Authors. Published by Elsevier Ltd.
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