Article
Mathematical & Computational Biology
Xiuxian Zhu, Xianxiong Ma, Chuanqing Wu
Summary: The study successfully identified a 9-DNA methylation signature for predicting recurrence free survival in kidney renal clear cell carcinoma patients. The robustness of the methylation signature was validated through ROC analysis in internal and external datasets. Additionally, a nomogram combining methylation risk score with clinic-related covariates showed good performance in improving prognostic predictive ability for KIRC patients.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Kalle E. Mattila, Teemu D. Laajala, Sara V. Tornberg, Tuomas P. Kilpelainen, Paula Vainio, Otto Ettala, Peter J. Bostrom, Harry Nisen, Laura L. Elo, Panu M. Jaakkola
Summary: The study aimed to develop a prognostic model for predicting metastasis-free survival after surgery of localized clear cell RCC, identifying key features such as tumor size, grade and microvascular invasion. The model demonstrated high accuracy, with concordance indices comparable to existing prediction models.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Jiayi Li, Dongyan Cao
Summary: We developed two prognostic nomograms for predicting recurrence and long-term survival in patients with ovarian clear cell carcinoma (OCCC) after primary treatment, and validated them in patients from the same center. This tool, which uses variables specifically related to OCCC, was more accurate than the FIGO system, making it relatively easy to use in clinic for patient counseling, postoperative management, and follow-up for individual patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiangyu Li, Woonghee Kim, Kajetan Juszczak, Muhammad Arif, Yusuke Sato, Haruki Kume, Seishi Ogawa, Hasan Turkez, Jan Boren, Jens Nielsen, Mathias Uhlen, Cheng Zhang, Adil Mardinoglu
Summary: The study stratified ccRCC into three molecular subtypes using systems biology approach, developed biomarkers for patient classification and prognosis prediction, and identified potential drug targets. Mitotane, a repositioned drug targeting SOAT1, showed potential in treating ccRCC based on in vitro experiments.
Article
Ophthalmology
Qi Wan, Pengxia Wan, Weiqin Liu, Yaqi Cheng, Simin Gu, Qian Shi, Yaru Su, Xiaoran Wang, Chang Liu, Zhichong Wang
Summary: Cytokine profiles in tear samples of pterygium patients were studied to identify biomarkers for accurate diagnosis and prognosis prediction. Certain cytokines were found to be associated with pterygium recurrence and effective diagnostic and prognostic models were developed. This finding provides a simple and accurate prediction for early pterygium recurrence after resection.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Immunology
Zhipeng Wu, Yanhao Shen, DeSen Fan, JinHui Liu, Dongming Chen, Kai Wang, Xianlin Xu
Summary: This study identified potential immune genes associated with ccRCC, constructed a 4-gene signature to predict clinical outcomes successfully, and revealed an increase in immune cell abundance in the high-risk group. These findings may contribute to immunotherapy research in ccRCC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Yao-Cheng Yang, Jun-Jie Wang, Yun Huang, Wei-Xin Cai, Qian Tao
Summary: A reliable nomogram model was developed in this study to predict the recurrence-free survival of patients with ameloblastoma of the jaw, which was successfully internally validated. The nomogram included four independent predictors, including cortical bone perforation, root(s) resorption, WHO classification, and treatment pattern, to assist surgeons in tailored therapy and follow-up.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Oncology
Haixiang Shen, Jin Liu, Shiming Chen, Xueyou Ma, Yufan Ying, Jiangfeng Li, Weiyu Wang, Xiao Wang, Liping Xie
Summary: High expression of CD68+ TAMs and M2-TAMs are risk factors for poor prognosis in ccRCC patients. TAMs' high density is associated with advanced clinicopathological features in ccRCC. TAMs could be potential biomarkers for prognosis and novel targets for immunotherapy in ccRCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zijian Zhou, Jiajin Wu, Yuanyuan Yang, Peng Gao, Lujia Wang, Zhong Wu
Summary: This study found that hepcidin expression is upregulated in clear cell renal cell carcinoma (ccRCC) and is correlated with patient age, T stage, and pathologic stage. Hepcidin promoter methylation is significantly associated with poor clinical parameters and hepcidin may serve as an independent prognostic factor. Mechanistically, hepcidin is involved in immune-related and metabolism-related pathways.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Genetics & Heredity
Zhi Liu, Jun Zhang, Deyun Shen, Xuechun Hu, Zongpan Ke, I. Nyoman Ehrich Lister, Bungaran Sihombing
Summary: This study found that cytoskeleton-associated protein 2-like protein is upregulated in clear cell renal cell carcinoma tissues and may promote disease progression through multiple signaling pathways. It can serve as a prognostic marker and a potential treatment target in clear cell renal cell carcinoma.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Yufeng Gu, Yao Fu, Xin Pan, Yulin Zhou, Changwei Ji, Tangliang Zhao, He Miao, Huichen Lv, Jianping Da, Jingping Ge, Linhui Wang, Le Qu, Silun Ge, Hongqian Guo, Wenquan Zhou
Summary: This study aims to determine the prognostic value of SII in non-metastatic ccRCC patients with VTT. The results showed that SII was an independent prognostic factor for these patients and can improve the accuracy of predictive models.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Chunxiu Yang, Jingjing Pang, Jian Xu, He Pan, Yueying Li, Huainian Zhang, Huan Liu, Shu-Yuan Xiao
Summary: Our study revealed that LRRK2 plays a crucial role in the tumorigenesis and progression of ccRCC, and may serve as a potential predictor and therapeutic target for this type of cancer. The up-regulation of LRRK2 in ccRCC was found to be correlated with DNA methylation and associated with a better prognosis in patients with ccRCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Lei Yan, Guangjie Yang, Jingjing Cui, Wenjie Miao, Yangyang Wang, Yujun Zhao, Ning Wang, Aidi Gong, Na Guo, Pei Nie, Zhenguang Wang
Summary: The study developed and validated a nomogram combining clinical factors and radiomics features to estimate overall survival in ccRCC patients, showing the incremental value of radiomics for OS estimation. The radiomics nomogram demonstrated higher discrimination capability compared to the clinical nomogram, suggesting its usefulness in assisting quantitative and personalized treatment for ccRCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Dzenis Koca, Irinka Seraudie, Remy Jardillier, Claude Cochet, Odile Filhol, Laurent Guyon
Summary: The COL7A1 gene has been identified as a potential prognostic marker for ccRCC patients, capable of stratifying them into different risk groups.
Article
Cell Biology
Zhiwen Xie, Lei Wu, Shan Hua, Yongqing Zhang, Fei Shi, Min Chen, Sheng Zhao, Zhihong Liu, Meng Liu, Juntao Jiang
Summary: This study reveals the prognostic value of immune-associated genes for clear cell renal cell carcinomas, characterizes immunological subpopulations using various algorithms, and develops a novel prognosis-associated model based on an immune-gene panel. The results were verified using the GEO dataset and aligned with clinicopathological characteristics of ccRCCs, ultimately leading to a nomogram with high prognostic efficiency for ccRCC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Changwen Zhai, Huan Wang, Shimin Li, Dehui Wang
Summary: This study evaluated the clinicopathological and molecular characteristics of five cases of Low-grade Papillary Schneiderian Carcinoma (LGPSC) in the sinonasal tract, confirming it as a new aggressive carcinoma with metastatic potential. Further research is needed to fully understand its behavior and characteristics.
Article
Pathology
Huan Wang, Changwen Zhai, Chen Zhang, Quan Liu, Huankang Zhang, Xicai Sun, Lan Lin, Hongmeng Yu, Dehui Wang
Summary: Acinic cell carcinoma (AiCC) in the nasal cavity and paranasal sinuses is rare, with similar clinical and histopathological characteristics to salivary gland AiCC. NR4A3 is a reliable biomarker for distinguishing sinonasal AiCC from other sinonasal carcinomas.
Article
Otorhinolaryngology
Huan Wang, Jiaying Zhou, Le Shi, Chen Zhang, Wanpeng Li, Li Hu, Changwen Zhai, Xicai Sun
Summary: This study compares the inflammatory pattern, epithelial cell proliferation capacity, and EGFR mutation status between unilateral sinonasal inverted papilloma (IP) and contralateral nasal polyps (NP). The results demonstrate distinct inflammatory patterns between IP and contralateral NP, suggesting the oncogenic role of neutrophils in the pathogenesis of IP. EGFR mutations may be an early event in IP development by enhancing epithelial cell proliferation.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2022)
Article
Ophthalmology
H. U. Sun, R. O. N. G. R. O. N. G. Cai, C. H. A. N. G. W. E. N. Zhai, W. A. N. J. I. N. G. Song, J. Sun, Y. I. N. G. W. E. N. Bi
Summary: This study evaluated the clinicopathologic and molecular characteristics of lacrimal apparatus mucoepidermoid carcinoma (MEC) to define its typical diagnostic features. The study included 8 cases, with 6 cases occurring in the lacrimal gland and 2 cases in the lacrimal sac and nasolacrimal duct. The histological type and immunohistochemistry results were helpful for definitive diagnosis, and the potential etiologic role of HPV type 6 infection was mentioned.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)