Article
Immunology
Dechao Feng, Xu Shi, Facai Zhang, Qiao Xiong, Qiang Wei, Lu Yang
Summary: The study constructed and validated an energy metabolism-related gene prognostic index (EMRGPI) for predicting biochemical recurrence (BCR) in patients undergoing radical prostatectomy. EMRGPI was associated with BCR risk and immune cells. SDC1 and ADH1B were key genes in the risk formula.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Laura Nalleli Garrido Castillo, Arnaud Mejean, Philippe Vielh, Julien Anract, Alessandra Decina, Bertrand Nalpas, Naoual Benali-Furet, Isabelle Desitter, Patrizia Paterlini-Brechot
Summary: The preoperative detection of Circulating Tumor Cells (CTC) may serve as an interesting candidate predictive marker for cancer recurrence in patients with non-metastatic prostate cancer, according to this study.
Article
Multidisciplinary Sciences
Xuezhou Zhang, Baoan Hong, Zhipeng Sun, Jiahui Zhao, Mingchuan Li, Dechao Wei, Yongxing Wang, Ning Zhang
Summary: This study demonstrated the association between CRGs and BCR as well as immunotherapy efficacy in PCa. It also suggested the potential role of CRGs in influencing BCR events through CTCs.
Article
Oncology
Shi-Heng Wang, Shu-Pin Huang, Yi-Jiun Pan, Po-Chang Hsiao, Chia-Yang Li, Lih-Chyang Chen, Chia-Cheng Yu, Chao-Yuan Huang, Victor C. Lin, Te-Ling Lu, Bo-Ying Bao
Summary: The genetic predisposition to breast cancer is associated with a low risk of prostate cancer recurrence, indicating a potential link between breast cancer susceptibility variants and prostate cancer outcomes. Further studies are needed to investigate the role of breast cancer-related genetic factors and estrogen signaling in the progression of prostate cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Chia -Yen Lin, Chun -Li Wang, Shian-Shiang Wang, Cheng-Kuang Yang, Jian-Ri Li, Chuan-Shu Chen, Sheng-Chun Hung, Kun-Yuan Chiu, Chen-Li Cheng, Yen-Chuan Ou, Shun-Fa Yang
Summary: The study investigated the associations between WWOX polymorphisms, clinicopathologic features of prostate cancer, and risk of postoperative biochemical recurrence. The findings suggest that WWOX SNPs are significantly associated with aggressive pathologic features of PCa and an elevated risk of post-RP biochemical recurrence.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Cell Biology
Xiaoru Sun, Lu Wang, Hongkai Li, Chuandi Jin, Yuanyuan Yu, Lei Hou, Xinhui Liu, Yifan Yu, Ran Yan, Fuzhong Xue
Summary: The study aimed to identify potential prognostic genes in the prostate adenocarcinoma microenvironment and found 14 genes related to prognosis, which were associated with immune responses. These findings may contribute to improved prognosis in prostate adenocarcinoma.
Article
Oncology
Adalgisa Guerra, Filipe Caseiro Alves, Kris Maes, Rui Maio, Geert Villeirs, Helena Mourino
Summary: This study assesses the impact of covariates derived from a predictive model for detecting extracapsular extension on biochemical recurrence-free survival (BCRFS) after robotic-assisted radical prostatectomy (RARP). The study includes retrospective data analysis, focusing on variables such as prostate-specific antigen (PSA) levels, patient age, prostate volume, MRI semantic features, and Grade Group (GG). The study highlights the importance of incorporating predictive MRI features pre-surgery in influencing early outcomes and clinical decision making.
Article
Oncology
Jinan Guo, Chenhui Zhao, Xinzhou Zhang, Zhong Wan, Tingting Chen, Jiashun Miao, Jinping Cai, Wenchuan Xie, Hao Chen, Mengli Huang, Xiaochen Zhao, Wei Wei, Qi Shen
Summary: By combining a molecular signature with clinicopathological features, we successfully developed a predictive model for early biochemical recurrence (BCR) after radical prostatectomy (RP), which consists of an 8-gene signature. This gene signature outperformed three commercial panels in predicting early BCR and was proven to be an independent predictor of BCR-free survival. Furthermore, a prognostic nomogram incorporating the gene signature and clinicopathologic features was constructed, showing excellent predictive ability for BCR-free survival in localized prostate cancer patients after RP. The study also revealed that the high-risk group was more susceptible to immune suppression and impaired DNA damage response.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Jinan Guo, Chenhui Zhao, Xinzhou Zhang, Zhong Wan, Tingting Chen, Jiashun Miao, Jinping Cai, Wenchuan Xie, Hao Chen, Mengli Huang, Xiaochen Zhao, Wei Wei, Qi Shen
Summary: This study developed a model containing 8-gene signature that can predict the risk of early biochemical recurrence in prostate cancer patients after radical prostatectomy. The model outperformed three commercial panels and may assist in clinical management of PCa.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Paola Mapelli, Samuele Ghezzo, Cristiano Pini, Ana Maria Samanes Gajate, Alessandro Spataro, Carolina Bezzi, Claudio Landoni, Paola Scifo, Alberto Briganti, Arturo Chiti, Maria Picchio
Summary: Localized prostate cancer can be treated with radical intent via surgery, but biochemical recurrence is common in post-surgical follow-up. PSMA PET is an accurate diagnostic tool to detect disease recurrence. Predictors of PSMA PET positivity include higher pathological status after radical prostatectomy and high levels of PSA at the time of scan.
Article
Biotechnology & Applied Microbiology
Jia-Yin Chen, Xu-Yun Huang, Fei Lin, Qi You, Yu-Ting Xue, Bin Lin, Qing-Shui Zheng, Yong Wei, Xue-Yi Xue, Xiao-Dong Li, Dong-Ning Chen, Ning Xu
Summary: This study identified tumor-associated macrophages (TAMs) related molecular subtypes and developed a prognostic model for prostate cancer (PCa) based on TAMs. Three TAMs related molecular subtypes were identified, which were associated with prognosis, clinicopathological characteristics, PD-L1 expression levels, and tumor microenvironment. The developed prognostic model showed excellent predictive performance for biochemical recurrence-free survival in PCa.
Article
Oncology
Daojun Lv, Xiangkun Wu, Xi Chen, Shuxin Yang, Wenzhe Chen, Ming Wang, Yongda Liu, Di Gu, Guohua Zeng
Summary: A novel immune-related gene-based prognostic signature (IRGPS) was identified to predict biochemical recurrence in prostate cancer patients. High-risk patients showed higher levels of regulatory T cells and M2 macrophages, while low-risk patients had higher levels of resting memory CD4 T cells and resting mast cells. A strong correlation was found between IRGPS and specific clinicopathological features.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Zheng Chen, Jue Wang, Yangbai Lu, Caiyong Lai, Lijun Qu, Yumin Zhuo
Summary: This study found that Ezrin expression is significantly upregulated in PCa tissues and cells, and promotes the migration and invasion abilities of PCa cells. Clinical data revealed that Ezrin expression in CTCs is associated with the metastatic degree of PCa. Therefore, Ezrin expression in CTCs may have potential roles in the prognosis and management of PCa.
Article
Biology
Zhi-Bin Ke, Qi You, Jia-Yin Chen, Jiang-Bo Sun, Yu-Ting Xue, Rui-Bin Zhuang, Qing-Shui Zheng, Ye-Hui Chen, Yong Wei, Xiong-Lin Sun, Xue-Yi Xue, Ning Xu
Summary: This study established and verified a novel radiation resistance related index for predicting biochemical recurrence and tumor immune environment in prostate cancer patients. The study identified radiation resistance related genes and molecular clusters, and successfully conducted internal and external validations. The index performed excellently in predicting biochemical recurrence and tumor immune environment.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Chenglin Han, Yuxuan Deng, Bin Yang, Peng Hu, Bintao Hu, Tao Wang, Jihong Liu, Qidong Xia, Xiaming Liu
Summary: In this study, a senescence-associated prognosis model was developed for patients with prostate cancer (PCa) based on the analysis of RNA sequencing data and clinical information. The model, consisting of eight senescence-related genes (SRGs), showed good predictive power and was validated in independent datasets. The model was associated with age and TNM staging, and it also had implications for immunotherapy sensitivity and drug susceptibility.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Laura Wiemer, Markus Hollenbach, Robin Heckmann, Beatrice Kittner, Henning Plage, Max Reimann, Patrick Asbach, Frank Friedersdorff, Thorsten Schlomm, Sebastian Hofbauer, Hannes Cash
Summary: The study evaluated micro-ultrasound of the prostate with real-time targeting of suspicious regions in patients suspected to have prostate cancer and found potential benefits in detecting cancer and clinically significant cancer. Micro-ultrasound appears to be a valuable addition and alternative to traditional ultrasound methods.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Oncology
Katharina Moller, Martina Kluth, Malik Ahmed, Lia Burkhardt, Christina Moller-Koop, Franziska Buscheck, Soren Weidemann, Maria-Christina Tsourlakis, Sarah Minner, Hans Heinzer, Hartwig Huland, Markus Graefen, Guido Sauter, Thorsten Schlomm, David Dum, Ronald Simon
Summary: Deletion of chromosome 5q is common in prostate cancer, with separate deletions at 5q13 and 5q21 leading to aggressive disease. Cancers with co-deletion of 5q13 and 5q21 have worse prognosis compared to those with isolated deletions at either locus. 5q21 deletions are associated with ERG negativity, while 5q13 deletions are not related to ERG status.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Jonathan D. Tward, Thorsten Schlomm, Stephen Bardot, Daniel J. Canter, Troy Scroggins, Stephen J. Freedland, Lauren Lenz, Darl D. Flake, Todd Cohen, Michael K. Brawer, Steven Stone, Jay Bishoff
Summary: The study evaluated a score combining a genomic expression classifier and clinical information to predict progression to metastatic disease in men with prostate cancer. It found that some patients could safely forgo multimodal therapy, and validated the effectiveness of the combined clinical cell-cycle risk score in assessing disease progression risk in patients.
CLINICAL GENITOURINARY CANCER
(2021)
Editorial Material
Urology & Nephrology
Arkadiusz Miernik, Thorsten Schlomm, Christian Bolenz
Article
Urology & Nephrology
T. Schlomm, T. Roediger, J. Graalmann
Summary: Medicine is becoming increasingly precise, particularly in oncology. The shift from a one-drug-fits-all model to an individualized biomarker-driven approach facilitates the transition from efficacy to effectiveness. Ensuring end-to-end precision from diagnostics to real-world evidence is crucial in achieving high-quality, affordable precision medicine for all in the future.
Article
Urology & Nephrology
M. Schoenthaler, T. Schlomm
Summary: The aim of projects like the Medical Informatics Funding Scheme is to facilitate the exchange of patient data between institutions by integrating data from various sources into a data warehouse. This will open access to high-performance and precision medicine for more patients, establish a translational link between basic research and patient care, and facilitate a detailed analysis of healthcare and treatment quality using digitally integrated patient data.
Article
Anatomy & Morphology
Doris Hoeflmayer, Christoph Fraune, Claudia Hube-Magg, Ronald Simon, Cornelia Schroeder, Franziska Buescheck, Katharina Moeller, David Dum, Soeren Weidemann, Corinna Wittmer, Thorsten Schlomm, Hartwig Huland, Hans Heinzer, Markus Graefen, Alexander Haese, Guido Sauter, Eike Burandt, Till S. Clauditz, Stefan Steurer, Sarah Minner, Waldemar Wilczak, Adam Polonski
Summary: TRIM24 upregulation in prostate cancer is associated with poor prognosis and provides additional prognostic information, independent of clinicopathologic parameters. This suggests promising potential for TRIM24 in the routine diagnostic work-up of patients with low Gleason grade tumors.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2021)
Article
Urology & Nephrology
Imke Thederan, Thenappan Chandrasekar, Pierre Tennstedt, Sophie Knipper, Laura Kuehl, Derya Tilki, Matthias Augustin, Hans Heinzer, Birgit-Christiane Zyriax
Summary: The study did not find an association between plasma vitamin D and selenium levels before radical prostatectomy and biochemical recurrence-free survival among prostate cancer patients.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Urology & Nephrology
Randi M. Pose, Sophie Knipper, Christoph Wurnschimmel, Pierre Tennstedt, Uwe Michl, Tobias Maurer, Markus Graefen, Thomas Steuber
Summary: The technique of peritoneal fenestration significantly reduces the risk of symptomatic lymphocele formation after open retropubic radical prostatectomy with pelvic lymph node dissection, leading to a decreased need for further intervention.
Meeting Abstract
Oncology
Tobias Maurer, Mehrdad Mehdi Irai, Isabel Rauscher, Ricarda Simon, Matthias Eiber, Fijs W. B. van Leeuwen, Pim van Leeuwen, Lars Budaeus, Thomas Steuber, Markus Graefen, Pierre Tennstedt, Matthias Heck, Thomas Horn, Sophie Knipper
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Imke Thederan, Aliaksandra Pott, Alexander Krueger, Thenappan Chandrasekar, Pierre Tennstedt, Sophie Knipper, Derya Tilki, Hans Heinzer, Karl-Heinz Schulz, Nataliya Makarova, Birgit-Christiane Zyriax
Summary: The present pilot study aimed to evaluate the feasibility and acceptability of a multimodal lifestyle intervention program in PCa patients after radical prostatectomy. The program showed high acceptance and resulted in improvements in lifestyle, psychological well-being, and quality of life. Further large-scale trials are needed to evaluate the effectiveness of the program in routine practice.
Article
Oncology
Francesco Gentile, Evelina La Civita, Bartolomeo Della Ventura, Matteo Ferro, Dario Bruzzese, Felice Crocetto, Pierre Tennstedt, Thomas Steuber, Raffaele Velotta, Daniela Terracciano
Summary: The widespread use of PSA for prostate cancer diagnosis has led to high rates of overdiagnosis and overtreatment. A combination of the Prostate Health Index (PHI) and Proclarix tests can improve risk stratification of PCa patients at initial diagnosis. An artificial neural network model combining kallikrein markers in PHI and cancer-related markers in Proclarix showed increased accuracy in identifying aggressive PCa at initial diagnosis.
Meeting Abstract
Oncology
Sophie Knipper, Mehrdad Mehdi Irai, Ricarda Simon, Daniel Koehler, Isabel Rauscher, Matthias Eiber, Fijs Wb van Leeuwen, Pim van Leeuwen, Hilda de Barros, Henk G. van der Poel, Lars Budaeus, Thomas Steuber, Markus Graefen, Pierre Tennstedt, Matthias Heck, Thomas Horn, Tobias Maurer
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Urology & Nephrology
Julia Tolle, Sophie Knipper, Randi Pose, Pierre Tennstedt, Derya Tilki, Markus Graefen, Hendrik Isbarn
Summary: A history of transurethral surgery of the prostate is considered a risk factor for adverse functional outcomes after radical prostatectomy. The time interval between transurethral desobstruction and prostatectomy significantly influences postoperative urinary incontinence rates.
UROLOGIA INTERNATIONALIS
(2021)
Article
Oncology
Andreas Marx, Lena Koopmann, Doris Haflmayer, Franziska Buescheck, Claudia Hube-Magg, Stefan Steurer, Till Eichenauer, Till S. Clauditz, Waldemar Wilczak, Ronald Simon, Guido Sauter, Jakob R. Izbicki, Hartwig Huland, Hans Heinzer, Markus Graefen, Alexander Haese, Thorsten Schlomm, Christian Bernreuther, Patrick Lebok, Sarah Bonk
Summary: ANO7 protein expression is strongly associated with prostate epithelial cells and its reduced expression is closely linked to adverse tumor features, serving as a strong and independent predictor of poor prognosis in prostate cancer.
CANCER BIOLOGY & MEDICINE
(2021)