Imatinib prevents beta cell deathin vitrobut does not improve islet transplantation outcome

Surface Coating of Pancreatic Islets with Neural Crest Stem Cells Improves Engraftment and Function after Intraportal Transplantation

(2015) Joey Lau et al.   CELL TRANSPLANTATION

Non-receptor tyrosine kinase inhibitors enhances β-cell survival by suppressing the PKCδ signal transduction pathway in streptozotocin – induced β-cell apoptosis

(2015) Udayakumar Karunakaran et al.   CELLULAR SIGNALLING

Assembly of bioactive multilayered nanocoatings on pancreatic islet cells: incorporation of α1-antitrypsin into the coatings

(2015) Zheng-Liang Zhi et al.   CHEMICAL COMMUNICATIONS

Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells

(2015) Rikard G. Fred et al.   CLINICAL SCIENCE

STI571 protects neuronal cells from neurotoxic prion protein fragment-induced apoptosis

(2015) Yaoqian Pan et al.   NEUROPHARMACOLOGY

Cotransplantation of Polymerized Hemoglobin Reduces β-Cell Hypoxia and Improves β-Cell Function in Intramuscular Islet Grafts

(2015) Daniel Espes et al.   TRANSPLANTATION

Tyrosine Kinase Inhibitors and Diabetes: A Novel Treatment Paradigm?

(2015) Athanasios Fountas et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inhibition of c-Kit Is Not Required for Reversal of Hyperglycemia by Imatinib in NOD Mice

(2014) Janet Lau et al.   PLoS One

Pre-culturing islets with mesenchymal stromal cells using a direct contact configuration is beneficial for transplantation outcome in diabetic mice

(2013) Chloe Louise Rackham et al.   CYTOTHERAPY

Co-transplantation of islets with mesenchymal stem cells in microcapsules demonstrates graft outcome can be improved in an isolated-graft model of islet transplantation in mice

(2013) Alan Kerby et al.   CYTOTHERAPY

Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5′-phosphatase interaction with c-Abl

(2013) D. Mokhtari et al.   DIABETOLOGIA

Maintenance of Islet Morphology Is Beneficial for Transplantation Outcome in Diabetic Mice

(2013) Chloe L. Rackham et al.   PLoS One

Sustained NF-κB Activation and Inhibition in β-Cells Have Minimal Effects on Function and Islet Transplant Outcomes

(2013) Aileen J. F. King et al.   PLoS One

Immunoisolation of Islets in High Guluronic Acid Barium-Alginate Microcapsules Does Not Improve Graft Outcome at the Subcutaneous Site

(2012) Alan Kerby et al.   ARTIFICIAL ORGANS

Nano-scale encapsulation enhances allograft survival and function of islets transplanted in a mouse model of diabetes

(2012) Z.-l. Zhi et al.   DIABETOLOGIA

Improved Intraportal Islet Transplantation Outcome by Systemic IKK-beta Inhibition: NF-κB Activity in Pancreatic Islets Depends on Oxygen Availability

(2011) C. Chen et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Sequential Combination of a JNK Inhibitor and Simvastatin Protects Porcine Islets from Peritransplant Apoptosis and Inflammation

(2011) Sang-Man Jin et al.   CELL TRANSPLANTATION

Co-transplantation of mesenchymal stem cells maintains islet organisation and morphology in mice

(2011) C. L. Rackham et al.   DIABETOLOGIA

Imaging the islet graft by positron emission tomography

(2011) Olof Eriksson et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Effects of Imatinib Mesylate (Gleevec) on Human Islet NF-kappaB Activation and Chemokine Production In Vitro

(2011) Dariush Mokhtari et al.   PLoS One

Conditional and specific inhibition of NF-κB in mouse pancreatic β cells prevents cytokine-induced deleterious effects and improves islet survival posttransplant

(2011) Jonathan S. Rink et al.   SURGERY

Donor Pretreatment with DHMEQ Improves Islet Transplantation

(2010) Tohru Takahashi et al.   JOURNAL OF SURGICAL RESEARCH

Potential utility of small tyrosine kinase inhibitors in the treatment of diabetes

(2009) Dariush Mokhtari et al.   CLINICAL SCIENCE

Ductal Injection of JNK Inhibitors Before Pancreas Preservation Prevents Islet Apoptosis and Improves Islet Graft Function

(2009) Hirofumi Noguchi et al.   HUMAN GENE THERAPY

Islet alpha cell number is maintained in microencapsulated islet transplantation

(2008) Sara Bohman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Improved Vascular Engraftment and Graft Function After Inhibition of the Angiostatic Factor Thrombospondin-1 in Mouse Pancreatic Islets

(2008) J. Olerud et al.   DIABETES

Imatinib mesylate improves insulin sensitivity and glucose disposal rates in rats fed a high-fat diet

(2007) Robert Hägerkvist et al.   CLINICAL SCIENCE