Article
Acoustics
V Giorgione, K. Melchiorre, J. O'Driscoll, A. Khalil, R. Sharma, B. Thilaganathan
Summary: Objective: This study aims to evaluate the changes in maternal cardiac morphology and diastolic function in twin pregnancies with and without hypertensive disorders.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Obstetrics & Gynecology
Anastasjja Arechvo, Diana Voicu, Maria M. Gil, Argyro Syngelaki, Ranjit Akolekar, Kypros H. Nicolaides
Summary: This study examined the association between race and pre-eclampsia and gestational hypertension, and found that women of black and South Asian origin have a higher risk of developing pre-eclampsia after adjustment for confounders, compared to white women.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Review
Obstetrics & Gynecology
Edin Medjedovic, Asim Kurjak, Milan Stanojevic, Edin Begic
Summary: Hypertensive syndrome in pregnancy complicates up to 15% of pregnancies, with preeclampsia occurring in about 3-10% of pregnant women. Inadequate prenatal care is associated with higher mortality from preeclampsia due to reduced monitoring and missed opportunities for early intervention. Clinicians need to monitor and stratify patients based on the risk of preeclampsia.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Environmental Sciences
Cherie Part, Jean le Roux, Matthew Chersich, Shobna Sawry, Veronique Filippi, Nathalie Roos, Lee Fairlie, Britt Nakstad, Jeroen de Bont, Petter Ljungman, Massimo Stafoggia, Sari Kovats, Stanley Luchters, Shakoor Hajat
Summary: This study found that high temperature during early pregnancy is associated with an increased risk of pre-eclampsia/eclampsia/HELLP, while high temperatures in mid-late pregnancy tend to protect against these disorders. Low temperature may increase the risk of high blood pressure/hypertension/gestational hypertension in late pregnancy.
ENVIRONMENTAL RESEARCH
(2022)
Article
Obstetrics & Gynecology
Kelly S. Gibson, C. Andrew Combs, Samuel Bauer, Rebecca Feldman Hamm, Andrew Healy, Jamie Morgan, Lorraine Toner, Amy Whitsel
Summary: Hypertensive disorders of pregnancy are a major cause of maternal morbidity and mortality, so it is necessary to establish corresponding follow-up metrics to improve the timely follow-up rate of patients with severe hypertension.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Medicine, General & Internal
Miriam Lopian, Lior Kashani-Ligumsky, Ariel Many
Summary: The decision to postpone parenting has become more popular due to changing social dynamics and improved fertility treatments. However, pregnancies at advanced maternal ages are associated with increased risks of adverse outcomes. This article focuses on the relationship between advanced maternal age and hypertensive disorders of pregnancies (HDPs), which are more common in this population and have significant maternal morbidity and mortality. It discusses the biological mechanisms and age-related risk factors, as well as management strategies to reduce the incidence and severity of HDPs. Additionally, it acknowledges the short-term and long-term postpartum implications of HDPs in women of advanced maternal age.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Mandy Goldberg, Mary Diaz-Santana, Katie M. O'Brien, Shanshan Zhao, Clarice R. Weinberg, Dale P. Sandler
Summary: This study examined the association between gestational hypertensive disorders and breast cancer in a cohort of women with a family history of breast cancer. The results showed that a history of gestational hypertensive disorder was not associated with breast cancer risk.
Article
Clinical Neurology
Satu Kotikoski, Arttu Kurtelius, Heidi J. Nurmonen, Juho Paavola, Virve Karkkainen, Terhi J. Huuskonen, Jukka Huttunen, Timo Koivisto, Mikael von Und zu Fraunberg, Juha E. Jaaskelainen, Antti E. Lindgren
Summary: This study found a higher prevalence of pre-eclampsia in patients with saccular intracranial aneurysms (sIAs) compared to the general population, with sIA patients with pre-eclampsia more frequently having irregularly shaped aneurysms. Further research is needed to determine if a history of pre-eclampsia indicates an elevated risk for sIA formation or rupture.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Obstetrics & Gynecology
Steven L. Clark, George A. Saade, Mary C. Tolcher, Michael A. Belfort, Dwight J. Rouse, John R. Barton, Robert M. Silver, Baha M. Sibai
Summary: Our understanding and management of gestational hypertension are hindered by outdated terminology and non-evidence-based practices. This has resulted in little improvement in maternal and neonatal morbidity and mortality rates. To improve the situation, it is necessary to abandon current misleading terminology and traditional practices, and instead focus on evidence-based management approaches.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
E. G. Mulder, C. Ghossein-Doha, J. R. W. Crutsen, S. M. J. Van Kuijk, B. Thilaganathan, M. E. A. Spaanderman
Summary: Pregnancy prolongation in early-onset pre-eclampsia is associated with improved offspring outcome and survival, with only a limited effect on postpartum maternal cardiovascular function.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Alisse Hauspurg, Ellen W. Seely, Janet Rich-Edwards, Christina Hayduchok, Samantha Bryan, Andrea T. Roche, Arun Jeyabalan, Esa M. Davis, Renee Hart, Jada Shirriel, Janet Catov
Summary: This study aimed to test the feasibility of a randomised trial of home blood pressure monitoring paired with a remote lifestyle intervention in individuals with a hypertensive disorder of pregnancy in the first year postpartum. The study found that the combination of home blood pressure monitoring and lifestyle intervention was feasible in the first year postpartum, but the rate of hypertension remained high.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Acoustics
J. Gutierrez Henares, R. Gutierrez Henares, H. Perry, A. Khalil, B. Thilaganathan
Summary: Objective non-invasive assessment of maternal cardiovascular potential and kinetic energy using PKR and SMII may help distinguish pregnancies affected by specific placental disorders and those exhibiting healthy cardiovascular adaptation to pregnancy. Women with HDP and/or SGA have distinctive PKR and SMII profiles, reflecting low kinetic energy in pregnancies with SGA and high potential energy in pregnancies affected by HDP. Non-invasive assessment of potential and kinetic cardiovascular energy demonstrates high-flow and low-resistance adaptation in uncomplicated pregnancies.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Peripheral Vascular Disease
Veronica Giorgione, Gwyneth Jansen, Jamie Kitt, Chahinda Ghossein-Doha, Paul Leeson, Basky Thilaganathan
Summary: There is an increased occurrence of cardiovascular diseases in women within 1 to 2 decades after a preeclamptic pregnancy. Recent evidence suggests that the abnormal biochemical and echocardiographic findings in preeclamptic women do not resolve after giving birth. Many women remain hypertensive in the immediate postnatal period, with some showing signs of cardiac dysfunction. Close monitoring and effective blood pressure control in the immediate postnatal period may lead to persistently lower blood pressures in women years after stopping medication. This review emphasizes the importance of delivering effective medical care in the fourth trimester of pregnancy to improve long-term cardiovascular health after a preeclamptic birth.
Article
Clinical Neurology
Jason Raina, Amira El-Messidi, Ahmad Badeghiesh, Togas Tulandi, Tuong-Vi Nguyen, Eva Suarthana
Summary: This population-based retrospective study of over 9 million pregnant women in the United States found increasing rates of maternal mental disorders, with anxiety showing the greatest increase. Only anxiety was consistently associated with an increased risk of gestational hypertension, preeclampsia, and eclampsia. Targeted screening for mental disorders in pregnant women, particularly anxiety, may aid in timely prevention and surveillance of hypertensive disorders of pregnancy.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Nataliia Sergeevna Karpova, Olga Pavlovna Dmitrenko, Tatyana Sergeevna Budykina
Summary: One of the main causes of maternal and neonatal morbidity and mortality is pre-eclampsia, characterized by a high sFlt1/PlGF ratio. Pregestational diseases in mothers may increase the risk, but few studies have looked at the connection between maternal comorbidities and the sFlt1/PlGF ratio. This review summarizes the latest information on the association between maternal pregestational diseases and the ratio of sFlt1/PlGF, as well as the link between changes in pregnancy hormones/metabolites and a high sFlt1/PlGF ratio. Debate remains on the association between the ratio and maternal disorders, calling for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Obstetrics & Gynecology
Laura A. Magee, Asma Khalil, Nikos Kametas, Peter von Dadelszen
Summary: Chronic hypertension in pregnancy is common and poses risks to both mothers and fetuses. Current diagnostic criteria and treatment strategies need improvement. Home blood pressure monitoring and personalized care can improve outcomes. The current research focus is on how to personalize the care of chronic hypertension in pregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Peter Horby, Wei Shen Lim, Jonathan R. Emberson, Marion Mafham, Jennifer L. Bell, Louise Linsell, Natalie Staplin, Christopher Brightling, Andrew Ustianowski, Einas Elmahi, Benjamin Prudon, Christopher Green, Timothy Felton, David Chadwick, Kanchan Rege, Christopher Fegan, Lucy C. Chappell, Saul N. Faust, Thomas Jaki, Katie Jeffery, Alan Montgomery, Kathryn Rowan, Edmund Juszczak, J. Kenneth Baillie, Richard Haynes, Martin J. Landray
Summary: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Acoustics
K. G. Lau, M. Baloi, D. Dumitrascu-Biris, K. H. Nicolaides, N. A. Kametas
Summary: This study aimed to investigate the changes in ophthalmic artery Doppler indices and their association with blood pressure in pregnant women following acute antihypertensive treatment. The results showed that antihypertensive treatment led to a reduction in blood pressure and ophthalmic artery PSV ratio. There was a significant association between PSV ratio and MAP, SBP, and DBP in hypertensive pregnant women, which disappeared after blood pressure was reduced.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Acoustics
U. Nowacka, I Papastefanou, A. Bouariu, A. Syngelaki, R. Akolekar, K. H. Nicolaides
Summary: This study investigates the additional value of second-trimester placental growth factor (PlGF) in predicting small-for-gestational-age (SGA) neonates and examines second-trimester contingent screening strategies. The results show that the combination of maternal risk factors, estimated fetal weight (EFW), uterine artery pulsatility index (UtA-PI), and PlGF significantly improves the prediction of SGA compared to maternal risk factors alone. However, the incremental improvement decreases when PlGF is added to screening with a combination of maternal risk factors, EFW, and UtA-PI. By reserving measurements of UtA-PI and PlGF for a certain percentage of the population, similar detection rates and false-positive rates can be achieved. The study concludes that the combination of maternal risk factors, EFW, UtA-PI, and PlGF provides an effective prediction of SGA in the second trimester.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Katherine G. Y. Lau, Allan Wright, Emmanouil Kountouris, Kypros H. Nicolaides, Nikos A. Kametas
Summary: The study aimed to investigate the difference in OA PSV-ratio among women with PE, GH, and CH, and found that the OA PSV-ratio was significantly higher in PE patients compared to CH and GH patients, which may be a useful test for assessing women with hypertension.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Kypros H. Nicolaides, Ioannis Papastefanou, Argyro Syngelaki, Ghalia Ashoor, Ranjit Akolekar
Summary: This study aimed to assess the predictive performance of a competing risks model for stillbirths related to placental dysfunction, based on a combination of maternal risk factors, estimated fetal weight, and uterine artery pulsatility index. The performance of this model was compared to a stillbirth-specific model and the Royal College of Obstetricians and Gynecologists (RCOG) guideline. The results showed that the competing risks model had similar predictive performance to the stillbirth-specific model and performed better than the RCOG guideline.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Medicine, General & Internal
Peter W. Horby, Guilherme Pessoa-Amorim, Natalie Staplin, Jonathan R. Emberson, Mark Campbell, Enti Spata, Leon Peto, Nigel J. Brunskill, Simon Tiberi, Victor Chew, Thomas Brown, Hasan Tahir, Beate Ebert, David Chadwick, Tony Whitehouse, Rahuldeb Sarkar, Clive Graham, J. Kenneth Baillie, Buddha Basnyat, Maya H. Buch, Lucy C. Chappell, Jeremy Day, Saul N. Faust, Raph L. Hamers, Thomas Jaki, Edmund Juszczak, Katie Jeffery, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathryn Rowan, Guy Thwaites, Marion Mafham, Richard Haynes, Martin J. Landray
Summary: In patients hospitalized with COVID-19, aspirin was not associated with reductions in 28-day mortality or in the risk of progressing to invasive mechanical ventilation or death, but was associated with a small increase in the rate of being discharged alive within 28 days.
Article
Acoustics
G. Ashoor, A. Syngelaki, I Papastefanou, K. H. Nicolaides, R. Akolekar
Summary: The study demonstrates that a model combining maternal risk factors, UtA-PI, and EFW at 19-24 weeks' gestation can effectively predict antepartum stillbirths due to impaired placentation, especially those occurring preterm.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Genetics & Heredity
David Basurto, Francesca Maria Russo, Ioannis Papastefanou, Emma Bredaki, Karel Allegaert, Africa Pertierra, Anne Debeer, Luc De Catte, Liesbeth Lewi, Roland Devlieger, Paolo De Coppi, Eduard Gratacos, Olga Gomez, Jan Deprest
Summary: This study aimed to determine the prevalence of pulmonary hypertension (PAH) in left-sided congenital diaphragmatic hernia (CDH) and explore the predictors and contribution of PAH to mortality prediction. The results showed that PAH was associated with observed/expected-lung/head-ratio and fetoscopic endoluminal tracheal occlusion on postnatal day 1, and its occurrence further increased the risk of death. Antenatal prediction of PAH was limited, highlighting the need for more accurate predictors.
PRENATAL DIAGNOSIS
(2022)
Article
Acoustics
I Papastefanou, V Thanopoulou, S. Dimopoulou, A. Syngelaki, R. Akolekar, K. H. Nicolaides
Summary: This study developed a competing-risks model for predicting SGA neonates by incorporating sonographically estimated fetal weight (EFW) and biomarkers of impaired placentation at 36 weeks' gestation. The performance of the new model was compared with that of the traditional EFW < 10th percentile cut-off. The new model showed better predictive performance, especially when there was a longer time interval between assessment and delivery.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Ioannis Papastefanou, David Wright, Argyro Syngelaki, Ranjit Akolekar, Kypros H. Nicolaides
Summary: This study aimed to stratify pregnancy care for high-risk pregnancies at risk of delivering small for gestational age neonates based on the application of a competing-risks model that combines maternal factors with sonographic estimated fetal weight and uterine artery pulsatility index at midgestation.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Editorial Material
Acoustics
I. Papastefanou, K. H. Nicolaides, L. J. Salomon
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
G. Albaiges, I. Papastefanou, I. Rodriguez, P. Prats, M. Echevarria, M. A. Rodriguez, A. Rodriguez Melcon
Summary: This study examines the external validity of the new Fetal Medicine Foundation (FMF) competing-risks model for predicting small-for-gestational-age (SGA) neonates in midgestation. The study finds that the model performs well in a large independent Spanish population.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
I. Papastefanou, E. Gyokova, B. Gungil, A. Syngelaki, K. H. Nicolaides
Summary: This study aims to investigate the association between birth weight and gestational age at delivery with adverse neonatal outcomes and describe the distribution of adverse neonatal outcomes within different risk strata derived from a population stratification scheme based on the midgestation risk assessment for small-for-gestational-age neonates. The results showed that birth weight has a continuous association with adverse neonatal outcomes, influenced by gestational age. Pregnancies at high risk of small-for-gestational-age, estimated at midgestation, are also at increased risk for adverse neonatal outcomes.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Ioannis Papastefanou, Ghalia Ashoor, Argyro Syngelaki, Ranjit Akolekar, Kypros H. Nicolaides
Summary: This study aimed to investigate the association between antepartum stillbirth and the distribution of neonatal/fetal weight for different gestational ages. The study found a continuous association between fetal weight and the weight of antepartum stillbirth, which was influenced by gestational age. The highest risk of stillbirth occurred in fetuses with weights below the 1st percentile between 24 and 28 weeks' gestation.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)