Article
Multidisciplinary Sciences
Jianguo Luo, Shaojun Chen, Jingsen Chen, Yige Zhou, Fei He, Enli Wang
Summary: This study identified differential DNA methylation profile in breast cancer with and without axillary lymph node metastasis (ALNM) using reduced representation bisulfite sequencing (RRBS). The results showed that lymph node positive breast cancer had hypermethylation in promoter regions of genes RASGRF2, AKR1B1, CRMP1, and hypomethylation in promoter region of gene RHOF. These findings provide important insights into the molecular mechanisms underlying ALNM in breast cancer.
Article
Oncology
Jian-Guo Zhou, Anna-Jasmina Donaubauer, Benjamin Frey, Ina Becker, Sandra Rutzner, Markus Eckstein, Roger Sun, Hu Ma, Philipp Schubert, Claudia Schweizer, Rainer Fietkau, Eric Deutsch, Udo Gaipl, Markus Hecht
Summary: The study identified a predictive LIPS for the survival of cancer patients treated with PD-1/PD-L1 ICI, based on immune cell subsets in peripheral blood. It was found that LIPS showed high accuracy in predicting overall survival and progression-free survival, unaffected by clinicopathological features. NKT cells and neutrophils of the LIPS can serve as dynamic predictive biomarkers for survival outcomes after the first administration of ICI.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Subramaniyan Ramanathan, Michele Bertolotto, Simon Freeman, Jane Belfield, Lorenzo E. Derchi, Dean Y. Huang, Francesco Lotti, Karolina Markiet, Olivera Nikolic, Parvati Ramchandani, Jonathan Richenberg, Laurence Rocher, Paul S. Sidhu, Katarzyna Skrobisz, Athina Tsili, Pieter De Visschere, Irene Campo, Oliwia Kozak, Vikram Dogra
Summary: Greyscale and Colour Doppler ultrasound are main imaging modalities for scrotal trauma, with Contrast-enhanced ultrasound and elastography as advanced techniques for equivocal cases. ESUR-SPIWG provides guidance for the utilization of multiparametric ultrasound in scrotal trauma evaluation.
EUROPEAN RADIOLOGY
(2021)
Article
Respiratory System
Ana Maria Vicedo-Cabrera, Erik Melen, Francesco Forastiere, Ulrike Gehring, Klea Katsouyanni, Arzu Yorgancioglu, Charlotte Suppli Ulrik, Kjeld Hansen, Pippa Powell, Brian Ward, Barbara Hoffmann, Zorana Jovanovic Andersen
Summary: Climate change poses a major threat to lung patients, leading to more frequent and extreme weather events, prolonged aeroallergen seasons, and deteriorating air quality. Therefore, immediate action is needed from the healthcare community and policymakers to prepare for a complex future.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Oncology
Richard S. P. Huang, Karthikeyan Murugesan, Meagan Montesion, Dean C. Pavlick, Douglas A. Mata, Matthew C. Hiemenz, Brennan Decker, Garrett Frampton, Lee A. Albacker, Jeffrey S. Ross
Summary: The study analyzed a large cohort of solid tumor cases to investigate CD274 copy-number changes and their correlation with PD-L1 protein expression. The prevalence of CD274 copy-number changes varied across different tumor types and was found to be significantly associated with PD-L1 positivity in certain tumor types, indicating its potential as a biomarker for immune checkpoint inhibitor therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Medical Laboratory Technology
Ejaj Ahmad, Asgar Ali, Nimisha, Abhay Kumar Sharma, Apurva, Arun Kumar, Ghulam Mehdi Dar, Real Sumayya Abdul Sattar, Renu Verma, Bhawna Mahajan, Sundeep Singh Saluja
Summary: Cancer is a common health issue worldwide, causing significant socioeconomic burden. Despite awareness campaigns, cancer cases continue to rise due to an aging population and a lack of early detection methods. As a result, researchers have focused on non-traditional approaches such as novel imaging techniques and liquid biopsy, as well as identifying biomarkers for diagnostic, prognostic, and therapeutic purposes.
CLINICA CHIMICA ACTA
(2022)
Article
Oncology
Stanley Ly, Vivek Anand, Fouad El-Dana, Khoa Nguyen, Yiming Cai, Shirong Cai, Helen Piwnica-Worms, Debasish Tripathy, Aysegul A. Sahin, Michael Andreeff, Venkata Lokesh Battula
Summary: GD2 is expressed in around 60% of primary TNBC tumors at variable levels and is associated with worse overall survival of patients with TNBC. Treatment with dinutuximab significantly decreased adhesion and migration of TNBC cells, inhibited mTOR signaling, and reduced tumor growth in both cell-line xenografts and PDX models. Our data provide proof-of-concept for the critical role of GD2 in BCSCs and demonstrate the potential of dinutuximab as a novel therapeutic approach for TNBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Lars Guelen, Thierry O. Fischmann, Jerelyn Wong, Smita Mauze, Marco Guadagnoli, Nikolina Babala, Jozef Wagenaars, Veronica Juan, David Rosen, Winnie Prosise, Maurice Habraken, Imke Lodewijks, Danling Gu, Judith Stammen-Vogelzangs, Ying Yu, Jeanne Baker, David Lutje Hulsik, Lilian Driessen-Engels, Dan Malashock, Joost Kreijtz, Astrid Bertens, Evert de Vries, Astrid Bovens, Arne Bramer, Yiwei Zhang, Richard Wnek, Sean Troth, Elliot Chartash, Konstantin Dobrenkov, Svetlana Sadekova, Andrea van Elsas, Jason K. Cheung, Laurence Fayadat-Dilman, Jannie Borst, Amy M. Beebe, Hans Van Eenennaam
Summary: MK-5890, a novel CD27 agonistic antibody, has the potential to complement PD-1 checkpoint inhibition in cancer immunotherapy and is currently undergoing clinical evaluation.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Jean-Luc Wautier, Marie-Paule Wautier
Summary: Cancer is a leading cause of death worldwide. Lung, prostate, and colorectal cancer are common in men, while breast and colorectal cancer have a high incidence in women. Improvements in detection methods, including imaging techniques, are important, but inflammatory and tumoral markers, as well as calculated scores, may also contribute to prognosis assessment. Current markers such as ESR, CRP, and CEACAM have been used for decades, but their diagnostic and prognostic value is still unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yu Xu, Wenjing Zhang, Tingting Xia, Yuliang Liu, Zhoukui Bi, Liang Guo, Weijia Xie, Ying Xiang, Zhi Xu, Zubin Yu, Yafei Li, Li Bai
Summary: This study confirmed the diagnostic value of 7 tumor-associated autoantibodies (AABs) for lung cancer and explored the potential improvement in diagnostic value by combining them with 7 traditional tumor-associated antigens (TAs).
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Anouk E. Hentschel, Irene J. Beijert, Judith Bosschieter, Paul C. Kauer, Andre N. Vis, Birgit Lissenberg-Witte, R. Jeroen A. van Moorselaar, Renske D. M. Steenbergen, Jakko A. Nieuwenhuijzen
Summary: This study validated the feasibility of using DNA methylation analysis in urine for non-invasive detection of bladder cancer, and confirmed the diagnostic potential of the GHSR/MAL marker panel.
CLINICAL EPIGENETICS
(2022)
Article
Gastroenterology & Hepatology
George J. Webster, Tareq El Menabawey, Marianna Arvanitakis, Cesare Hassan, Jeanin E. van Hooft, Helmut Messmann, Mario Dinis-Ribeiro
Summary: The primary goal of LEEs is to improve endoscopic patient care through best practice, with no additional benefits for patients treated during LEEs compared to routine settings. There is currently limited evidence on the safety of LEEs, but there is no indication of increased risk for patients. Establishing a clear endoscopic curriculum is important for attendees' learning and to prioritize patient safety throughout the process.
Article
Gastroenterology & Hepatology
Simon M. Everett, Konstantinos Triantafyllou, Cesare Hassan, Klaus Mergener, Tony C. Tham, Nuno Almeida, Giulio Antonelli, Andrew Axon, Raf Bisschops, Michael Bretthauer, Vianna Costil, Farid Foroutan, James Gauci, Istvan Hritz, Helmut Messmann, Maria Pellise, Philip Roelandt, Andrada Seicean, Georgios Tziatzios, Andrei Voiosu, Ian M. Gralnek
Summary: All endoscopic procedures carry risks, so endoscopists should involve patients in the decision-making process and respect their right to self-determination. The European Society of Gastrointestinal Endoscopy has established a series of statements as a minimum standard of practice for informed consent, but there is a lack of guidance in many countries, leading to variations in care and potential legal risks.
Article
Medicine, General & Internal
Kamala Vanarsa, Jessica Castillo, Long Wang, Kyung Hyun Lee, Claudia Pedroza, Yair Lotan, Chandra Mohan
Summary: This study identified potential biomarkers for bladder cancer diagnosis and disease progression using aptamer screening and systems biology analysis. Urine d-dimer showed high sensitivity (97%) for bladder cancer diagnosis, while urine IL-8 and IgA were associated with disease progression. These biomarkers could be used for initial triage and patient follow-up, reducing the need for invasive cystoscopy-based diagnostic methods.
Article
Genetics & Heredity
Victoria Hedley, Matt Bolz-Johnson, Ines Hernando, Rosalind Kenward, Rima Nabbout, Clara Romero, Franz Schaefer, Sheela Upadhyaya
Summary: Despite two decades of efforts in Europe to promote research and development in rare diseases, only a small percentage of these diseases have dedicated treatments. This leaves a significant unmet need, especially considering the large number of rare diseases and the increasing patient population. Europe's pace of research and innovation lags behind other regions, and a major shift in research planning and delivery is necessary to bring meaningful treatments to those in need. The European Reference Networks hold great potential to address these challenges, but only with adequate support and collaboration between stakeholders.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Obstetrics & Gynecology
Madeline F. Flanagan, Charlotte A. Vollgraff Heidweiller-Schreurs, Wentao Li, Wessel Ganzevoort, Marjon A. de Boer, Alicia Vazquez-Sarandeses, Ozhan M. Turan, Patrick M. Bossuyt, Ben W. J. Mol, Daniel L. Rolnik
Summary: The study aimed to investigate the prognostic value of different Doppler ultrasound measurements for adverse perinatal outcomes. The results showed that umbilical artery pulsatility index added prognostic value for adverse perinatal outcomes, while other Doppler ultrasound measurements did not further improve prognostic performance.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Respiratory System
Inge A. H. van den Berk, Maadrika M. N. P. Kanglie, Tjitske S. R. van Engelen, Josje Altenburg, Jouke T. Annema, Ludo F. M. Beenen, Bart Boerrigter, Marije K. Bomers, Paul Bresser, Elvin Eryigit, Maarten Groenink, Suzanne M. R. Hochheimer, Frits Holleman, Jos A. J. Kooter, Ramon B. van Loon, Mitran Keijzers, Ivo van der Lee, Paul Luijendijk, Lilian J. Meijboom, Saskia Middeldorp, Laura J. Schijf, Robin Soetekouw, Ralf W. Sprengers, Alexander D. Montauban van Swijndregt, Wouter de Monye, Milan L. Ridderikhof, Michiel M. Winter, Shandra Bipat, Marcel G. W. Dijkgraaf, Patrick M. M. Bossuyt, Jan M. Prins, Jaap Stoker
Summary: Replacing chest X-ray with ultra-low-dose chest CT (ULDCT) in the diagnostic work-up of patients suspected of non-traumatic pulmonary disease at the emergency department has similar effects on short-term functional health, hospital admissions, and length of stay. However, more incidental findings were found in the ULDCT group.
Article
Gastroenterology & Hepatology
Arthur S. Aelvoet, Victorine H. Roos, Barbara A. J. Bastiaansen, Roel Hompes, Willem A. Bemelman, Cora M. Aalfs, Patrick M. M. Bossuyt, Evelien Dekker
Summary: This study compared the development of ileal adenomas in patients with familial adenomatous polyposis (FAP) who underwent ileal pouch-anal anastomosis (IPAA) or end ileostomy. The results showed that patients with IPAA had a higher incidence of ileal adenomas compared to those with end ileostomy.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Robert A. Frank, Haben Dawit, Patrick M. M. Bossuyt, Mariska Leeflang, Trevor A. Flood, Rodney H. Breau, Matthew D. F. McInnes, Nicola Schieda
Summary: This article provides a systematic review of the available evidence on the diagnostic accuracy of biparametric (bp)-MRI and multiparametric (mp)-MRI for solid renal masses in differentiating malignant from benign, aggressive from indolent, and clear cell renal cell carcinoma (ccRCC) from other histology. The review reveals deficits in the available evidence, with limited studies and high risk of bias, as well as heterogeneity in definitions, imaging techniques, diagnostic criteria, and outcome measures for solid masses.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Letter
Medical Laboratory Technology
Eleftherios. P. P. Diamandis
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Ivan Pasic, Annie H. Ren, Ram Vasudevan Nampoothiri, Ioannis Prassas, Jeffrey H. Lipton, Jonas Mattsson, Eleftherios P. Diamandis, Fotios V. Michelis
Summary: Using a novel multiplex antibody-based proximity extension assay, researchers identified serum proteins, including SLAMF7, IL-1ra, BTN3A2, and DAB2, that may potentially serve as biomarkers for acute graft-vs.-host disease.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Annie H. Ren, Panagiota S. Filippou, Antoninus Soosaipillai, Lampros Dimitrakopoulos, Dimitrios Korbakis, Felix Leung, Vathany Kulasingam, Marcus Q. Bernardini, Eleftherios P. Diamandis
Summary: This study explored the potential of using MUC13 as an ovarian cancer biomarker to complement CA125. The results showed that MUC13 could be used to detect non-serous ovarian carcinoma and early-stage disease, in addition to CA125.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Hannu Koistinen, Ruusu-Maaria Kovanen, Morley D. Hollenberg, Antoine Dufour, Evette S. Radisky, Ulf-Hakan Stenman, Jyotsna Batra, Judith Clements, John D. Hooper, Eleftherios Diamandis, Oliver Schilling, Antti Rannikko, Tuomas Mirtti
Summary: Since the proposition of the pro-invasive activity of proteolytic enzymes over 70 years ago, several roles for proteases in cancer progression have been established. About half of the 473 active human proteases are expressed in the prostate and many of the most well-characterized members of this enzyme family are regulated by androgens, hormones essential for development of prostate cancer. Most notably, several kallikrein-related peptidases, including KLK3 (prostate-specific antigen, PSA), the most well-known prostate cancer marker, and type II transmembrane serine proteases, such as TMPRSS2 and matriptase, have been extensively studied and found to promote prostate cancer progression. Recent findings also suggest a critical role for proteases in the development of advanced and aggressive castration-resistant prostate cancer (CRPC). Perhaps the most intriguing evidence for this role comes from studies showing that the protease-activated transmembrane proteins, Notch and CDCP1, are associated with the development of CRPC.
Letter
Medical Laboratory Technology
Eleftherios P. Diamandis
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Oncology
Timo-Pekka K. Lehto, Ruusu-Maaria Kovanen, Susanna Lintula, Adrian Malen, Carolin Sturenberg, Andrew Erickson, Olli-Pekka Pulkka, Ulf-Hakan Stenman, Eleftherios P. Diamandis, Antti Rannikko, Tuomas Mirtti, Hannu Koistinen
Summary: This study aimed to investigate the mRNA levels and prognostic impact of all 15 human kallikrein-related peptidases (KLKs) and their targets, proteinase-activated receptors (PARs), in surgically treated prostate cancer (PCa). The results showed that the expression of KLK2, KLK3, KLK4, and KLK15 was closely associated with tumor aggressiveness and prognosis, suggesting their potential as prognostic biomarkers for PCa.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Health Care Sciences & Services
Jenny Lee, Nick van Es, Toshihiko Takada, Frederikus A. Klok, Geert-Jan Geersing, Jeffrey Blume, Patrick M. Bossuyt, I. P. D. study team IPD study team
Summary: This study applied covariate-specific receiver operating characteristic (ROC) curve analysis to individual patient data on D-dimer testing for excluding pulmonary embolism. The results showed significant differences in D-dimer concentration and performance among age groups, while the distribution of results was similar for sex. Estimating conditional ROC curves can improve the ability to select thresholds with greater applicability.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Letter
Medical Laboratory Technology
Eleftherios P. Diamandis
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Health Care Sciences & Services
Janneke van t Hooft, Charlotte E. van Dijk, Cathrine Axfors, Zarko Alfirevic, Martijn A. Oudijk, Ben W. . J. Mol, Patrick M. Bossuyt, John P. A. Ioannidis
Summary: By evaluating randomized controlled trials on preterm birth prevention, it was found that only 10% of the trials met more than half of the usefulness criteria, but there was improvement over time. Future research planning should focus on using informative outcomes, patient-centeredness, pragmatism, and transparency.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Meeting Abstract
Rheumatology
Renske G. Kamperman, Hannah A. W. Walter, Joost Raaphorst, Camiel Verhamme, Johannes H. T. M. Koelman, Wouter V. Potters, Robert Hemke, Frank F. Smithuis, Eleonora Aronica, Ester M. M. van Leeuwen, Paul A. Baars, Marianne de Visser, Ivo N. van Schaik, Patrick M. M. Bossuyt, Anneke J. van der Kooi
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Health Care Sciences & Services
Matthew J. Thompson, Monica Zigman Suchsland, Victoria Hardy, Danielle C. Lavallee, Sally Lord, Emily Beth Devine, Jeffrey G. Jarvik, Steven Findlay, Thomas A. Trikalinos, Fiona M. Walter, Roger Chou, Beverly B. Green, Karen J. Wernli, Annette L. Fitzpatrick, Patrick M. Bossuyt
Summary: Imaging tests are commonly used in healthcare, but concerns about their overuse have overshadowed their benefits in clinical decision-making. This study demonstrates the importance of considering patient-centered outcomes (PCOs) when evaluating the value of imaging tests. The PROD framework categorizes PCOs into four main domains and highlights the interplay between them and the factors that can modify them.
BMJ QUALITY & SAFETY
(2023)
