Review
Oncology
Yijun Wang, Tongyue Zhang, Mengyu Sun, Xiaoyu Ji, Meng Xie, Wenjie Huang, Limin Xia
Summary: Myeloid-derived suppressor cells (MDSCs) hinder T cell infiltration into tumor sites, restricting the effectiveness of immune checkpoint inhibitors for certain patients, while targeting MDSCs has shown potent inhibitory effects in multiple tumors, including hepatocellular carcinoma. Clinically, the frequency of MDSCs is closely linked to the prognosis and predictive biomarkers of HCC patients, as well as the effectiveness of immune checkpoint inhibitors and tyrosine kinase inhibitors.
Article
Immunology
Xueyan Li, Xiaoqi Luo, Siru Chen, Jiayi Chen, Xue Deng, Jiahui Zhong, Hui Wu, Xuhui Huang, Changjun Wang
Summary: Hepatocellular carcinoma is characterized by high infiltration of myeloid-derived suppressor cells (MDSCs), which are key drivers of maintaining the immunosuppressive tumor microenvironment. All-trans retinoic acid (ATRA) can differentiate MDSCs into mature myeloid cells, but its effect on liver cancer growth inhibition is unknown.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Richard Hopkins, Wenwei Xiang, Damien Marlier, Veonice Bijin Au, Qianting Ching, Lynn Xue Wu, Rujun Guan, Bernett Lee, Whay-Kuang Chia, Who-Whong Wang, Joseph Wee, Joanna Ng, Rachael Cheong, Shuting Han, Axel Chu, Chit Lai Chee, Timothy Shuen, Michael Podinger, Alexander Lezhava, Han Chong Toh, John E. Connolly
Summary: Late-stage EBV-positive NPC poses a challenge in treatment, but a combination of chemotherapy and EBVST immunotherapy has shown promising response rates. Analysis of EBV DNA plasma concentrations and peripheral monocyte levels can help predict overall survival in patients.
Review
Cell Biology
Yanan Li, Hongdan He, Ribu Jihu, Junfu Zhou, Rui Zeng, Hengxiu Yan
Summary: MDSCs are a heterogeneous group of cells generated in various pathologic conditions, known to be key components of the tumor microenvironment promoting tumor growth, and partially restoring antitumor immunity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Shinan Li, Fujie Li, Xinying Liu, Xiaoxu Zhu, Wanlin Gao, Xiaokun Shen
Summary: In this study, Pam3CSK4 injection was found to attenuate tumor growth, decrease MDSCs, and restore T cell function; Pam3CSK4 promoted MDSC polarization by targeting Runx1, while a Runx1 inhibitor reversed this effect; TLR2 and Runx1 play critical roles in regulating the differentiation and function of MDSCs, potentially through the ferroptosis pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Alexander Piening, Anand Swaminath, John Dombrowski, Ryan M. Teague, Noor Al-Hammadi, Jeevin Shahi
Summary: The study found that advanced hepatocellular carcinoma patients who received ST+SBRT had better overall survival compared to those who received ST alone. This suggests that combination therapy plays a positive role in improving survival in patients with advanced HCC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Bo-Qian Liu, Zhi-Ye Bao, Jia-Yi Zhu, Hao Liu
Summary: This study identified a positive correlation between FGL2 expression and MDSC surface markers in hepatocellular carcinoma. Both in vitro and in vivo experiments demonstrated that FGL2 promoted the undifferentiated state of bone marrow cells and the accumulation of MDSCs, ultimately facilitating tumor growth in hepatocellular carcinoma.
Review
Immunology
Yang Zhao, Junfeng Du, Xiaofei Shen
Summary: Myeloid-derived suppressor cells (MDSCs) are a major negative regulator in tumor microenvironment (TME) by inhibiting immune response and promoting immunosuppression. This review focuses on the features of MDSCs in TME and potential targets for tumor immunotherapy. Therapies aiming to reprogram TME, prevent MDSC immunosuppression, promote MDSC differentiation, and impact MDSC recruitment and abundance in tumor site are discussed. Combinatorial strategies to improve clinical efficacy and outcomes of cancer patients through better understanding of MDSCs generation and suppression in TME are also summarized.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Samantha L. Tucker, Demba Sarr, Balazs Rada
Summary: Cystic Fibrosis is a genetic disease that causes chronic lung inflammation and infections, leading to high mortality rates. Immune system disruption in CF results in impaired immune responses, chronic infections with pathogens, and alterations in T cell and neutrophil functions. The role of P. aeruginosa and gMDSCs in T cell suppression and immune evasion in CF remains a subject of ongoing research.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Xueyan Li, Xue Deng, Xiaoqi Luo, Jiahui Zhong, Hui Wu, Siru Chen, Jiayi Chen, Xuhui Huang, Changjun Wang
Summary: Alcohol consumption can inhibit the growth of liver cancer by regulating the immunosuppressive microenvironment, specifically through the downregulation of myeloid-derived suppressor cells (MDSCs) and the increase of CD4+ and CD8+ T cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Review
Oncology
Carlos Jimenez-Cortegana, Claudia Galassi, Vanessa Klapp, Dmitry Gabrilovich, Lorenzo Galluzzi
Summary: MDSCs, a group of cells with immunosuppressive functions, have been found to be associated with tumor progression and treatment resistance. They also affect the efficacy of radiotherapy, making them potential targets for immunotherapeutic tumor control.
CANCER IMMUNOLOGY RESEARCH
(2022)
Review
Immunology
Hui Zhang, Qi-Wei Li, Yuan-Yuan Li, Xue Tang, Ling Gu, Han-Min Liu
Summary: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance and pressure, and the relationship between myeloid-derived suppressor cells (MDSCs) and PH has been studied. MDSCs are a group of cells that can suppress T-cell responses and potentially exacerbate the development of diseases. Understanding the relationship between MDSCs and PH can help identify potential therapeutic targets for the treatment of PH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Jie Chen, Yong-Jian Chen, Nan Jiang, Jian-Liang Xu, Zi-Ming Liang, Ming-Jun Bai, Yan-Fang Xing, Zhuo Liu, Xiang-Yuan Wu, Xing Li
Summary: This study confirmed NAR as an independent predictor for OS among patients with HCC receiving TACE, and highlighted the association of NAR with LOX-1(+) PMN-MDSC level. The integrated NAR-CLIP score showed superior predictive capacity compared to individual CLIP score in predicting survival at different time points.
Review
Oncology
Cheng Cui, Penglin Lan, Li Fu
Summary: Gastrointestinal cancer is the most common type of cancer worldwide, with increasing incidence and mortality rates. Myeloid-derived suppressor cells (MDSCs) play a key role in regulating the immune response to tumors and may serve as prognostic markers and therapeutic targets in cancer patients.
CANCER COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Iosif Papafragkos, Efrosyni Markaki, Christina Kalpadakis, Panayotis Verginis
Summary: Myeloid-derived suppressor cells (MDSCs) are potent regulators of the immune system, playing a role in cancer but their specific contribution to lymphomas remains unclear. This review focuses on MDSCs in lymphomas, discussing literature and lessons learned from animal models, and highlights future research directions and challenges in understanding the immune system complexities in malignancies.
JOURNAL OF CLINICAL MEDICINE
(2021)