期刊
TUMOR BIOLOGY
卷 37, 期 7, 页码 8633-8641出版社
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-015-4717-z
关键词
Gigantol; Anoikis; Epithelial to mesenchymal transition; Cancer metastasis; Lung cancer
类别
资金
- 100th Anniversary Chulalongkorn University fund for doctoral scholarship
- Ratchadapiseksomphot Endowment Fund, Chulalongkorn University [CU-56-384-HR]
Lung cancer has been the major cause of death within patients due to the high metastatic rate. One of the most essential processes of metastasis is the ability of cancer cells to resist the programmed cell death in a detached condition called anoikis. The discoveries of new natural compound that is able to sensitize anoikis in cancer cells have garnered the most interest in cancer pharmaceutical science. Gigantol, a bibenzyl compound extracted from Dendrobium draconis, has been a promising natural derived compound for cancer therapy due to several cytotoxic effects in cancer cells. This study has demonstrated for the first time that gigantol significantly decreases lung cancer cells' viability in a detached condition through anoikis and anchorage-independent assays. Western blotting analysis reveals that gigantol greatly decreases epithelial to mesenchymal transition (EMT) markers including N-cadherin, vimentin, and Slug leading to a significant suppression of protein kinase B (AKT), extracellular signal-regulated kinase (ERK), and caveolin-1 (cav-1) survival pathways during the detached condition. Therefore, gigantol could be a potential cancer therapeutic compound suggesting for further development for cancer therapy.
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