Article
Pharmacology & Pharmacy
Shan Zhu, Ning Yang, Chao Niu, Wan Wang, Xue Wang, Junge Bai, Yuan Qiao, Shuanglin Deng, Yi Guan, Jingtao Chen
Summary: This study found that imiquimod (IMQ) can enhance the acquisition of stem-cell-like properties and chemoresistance by upregulating MMP1 expression and downregulating miR-145 expression. MiR-145 suppresses MMP1 expression through direct binding, and IMQ downregulates miR-145 by promoting DNA methylation at its promoter.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Genetics & Heredity
Han Wu, Xibo Zhao, Jing Wang, Xinyan Jiang, Yan Cheng, Yanan He, Liyuan Sun, Guangmei Zhang
Summary: This study elucidates the role of CDR1as in cisplatin-resistant ovarian cancer and provides new insights for the clinical applications of cisplatin-resistant ovarian cancer.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Florian Posch, Felix Prinz, Amar Balihodzic, Christian Mayr, Tobias Kiesslich, Christiane Klec, Katharina Jonas, Dominik A. Barth, Jakob M. Riedl, Armin Gerger, Martin Pichler
Summary: Biliary tract cancer is a rare malignancy with poor survival rates, and cisplatin-based treatments are commonly used as first-line strategies. MiR-200c-3p may play a significant role in cisplatin resistance in biliary tract cancer, independent of its interaction with ZEB1.
Article
Cell Biology
Zi-Jiang Zhu, Yao Pang, Gang Jin, Hong-Yi Zhang, Wen-Hao Wang, Jia-Wei Liu, Guang-Xin Tuo, Peng Wu, Yi Yang, Ze-Quan Wang, Kui Wang
Summary: This study identified a novel lncRNA-EMS/miR-758-3p/WTAP axis involved in hypoxia-mediated chemoresistance to cisplatin in esophageal cancer. Hypoxia induced the expressions of lncRNA EMS and WTAP, and reduced the expression of miR-758-3p in EC cell line ECA-109. The study also found correlations between tumor expressions of these molecules and showed that higher levels of EMS/WTAP or lower levels of miR-758-3p in tumors predicted worse survivals of EC patients. Additionally, targeted knockdown of EMS and WTAP in ECA-109 cells attenuated the resistance of tumors to cisplatin treatments in a xenograft mouse model.
Review
Cell Biology
Boya Peng, Poh Ying Theng, Minh T. N. Le
Summary: miR-125b, a key miRNA in cancer pathogenesis, is deregulated in various types of cancer and plays important roles in tumourigenesis and cancer progression. Its potential as a diagnostic and prognostic biomarker, as well as a therapeutic tool against cancer, is supported by emerging evidence on its essential functions.
CELL PROLIFERATION
(2021)
Article
Cell Biology
Ying Wang, Chenming Yan, Junxia Qi, Chunyan Liu, Juan Yu, Huabin Wang
Summary: The study found that the downregulation of miR-874-3p in epithelial ovarian cancer cells is associated with cisplatin resistance, and reversing cisplatin resistance and enhancing sensitivity to cisplatin-induced apoptosis can be achieved by targeting XIAP.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Oncology
Rui M. Gil da Costa, Christine Levesque, Daniella Bianchi-Frias, Payel Chatterjee, Hung-Ming Lam, Carlos Santos, Ilsa M. Coleman, Pedro Ferreirinha, Manuel Vilanova, Nazare Pinto da Cunha, Hugo Carvalho, Alexandra Moreira-Pais, Ana Faustino-Rocha, Tiago Neto, Jose Batista da Costa, Jonathan L. Wright, Rita Ferreira, Paula A. Oliveira, Joaquim Mendes, Margarida M. S. M. Bastos, Bruno Colaco, Carlos Lopes, Peter C. Black, Christopher J. Sweeney, Peter S. Nelson
Summary: This study found that most patients with muscle-invasive bladder cancer (MIBC) are not cured by platinum chemotherapy. The up-regulation of nuclear factor kappa light-chain enhancer of activated B cells (NF-?B) is a major mechanism underlying chemoresistance, and its pharmacological inhibition may increase platinum efficacy. Both in vitro and in vivo experiments showed that the NF-?B inhibitor dimethylaminoparthenolide (DMAPT) significantly improved the efficacy of cisplatin, without aggravating immuno-hematological toxicity.
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
Haidong Cheng, Gaowa Sharen, Zhaoyang Wang, Jing Zhou
Summary: The UCA1/miR-513a-3p/CYP1B1 axis plays a crucial role in regulating cisplatin resistance in human GC cells, providing a potential target for treating chemoresistance in GC.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Yang Li, Lingling Zu, Heng Wu, Fang Zhang, Yaguang Fan, Hongli Pan, Xinxin Du, Fengjie Guo, Qinghua Zhou
Summary: MiR-192 plays a crucial role in cisplatin-resistance of lung cancer cells and may represent a therapeutic target for overcoming resistance to cisplatin-based chemotherapy in lung cancer.
Article
Medicine, Research & Experimental
Adil Ali Sayyed, Piyush Gondaliya, Mukund Mali, Abhijeet Pawar, Palak Bhat, Amit Khairnar, Neha Arya, Kiran Kalia
Summary: The study demonstrates that miR-155 inhibitor-loaded exosomes show therapeutic potential in reversing cisplatin resistance in oral cancer by upregulating FOXO3a, inducing epithelial-to-mesenchymal transition, and inhibiting stem cell-like properties. This provides a novel alternative therapeutic strategy for refractory oral cancer patients.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biochemical Research Methods
Priyanka Singh, Radheshyam Yadav, Malkhey Verma, Ravindresh Chhabra
Summary: In this study, it was found that hsa-miR-145-5p and hsa-miR-203a-5p can counter IM resistance by targeting the overall metabolic profile of IM-resistant K562 cells. The enriched pathways included glucose metabolism, fatty acid biosynthesis, lipogenesis, and nucleotide metabolism. The introduction of hsa-miR-203a-5p resulted in a remarkable change in the metabolic profile of IM-resistant cells, showing a high similarity with IM-sensitive cells.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2023)
Article
Biochemical Research Methods
Priyanka Singh, Radheshyam Yadav, Malkhey Verma, Ravindresh Chhabra
Summary: This study investigated the effect of hsa-miR-145-5p and hsa-miR-203a-5p on overcoming Imatinib resistance in chronic myeloid leukemia. The results showed that the introduction of these microRNAs resulted in a decrease in the levels of several metabolites associated with resistance. Additionally, hsa-miR-203a-5p showed a particularly remarkable efficacy in altering the metabolic profile of resistant cells.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2023)
Retraction
Chemistry, Multidisciplinary
Laura Fisher
Summary: The article has been retracted.
Article
Oncology
Ria Winkelmann, Katrin Bankov, Claudia Doering, Jaroslav Cinatl, Sebastian Grothe, Florian Rothweiler, Martin Michaelis, Christina Schmitt, Peter J. J. Wild, Melanie Demes, Jindrich Cinatl Jr, Stefan Vallo
Summary: In this study, a cell line with acquired resistance to chemotherapy was generated to investigate the mechanism of chemotherapy resistance in penile cancer and identify potential alternative treatments.
Article
Biotechnology & Applied Microbiology
Chong Wang, Zhao Tang, Ze Zhang, Tiantian Liu, Jingwei Zhang, Houbao Huang, Yawei Li
Summary: Bladder cancer is one of the most common cancers in men, and miR-7-5p acts as a tumor suppressor gene in its treatment by inhibiting migration, invasion, and autophagy, and improving chemosensitivity.
Article
Oncology
Dong Yang, Tao Chen, Ming Zhan, Sunwang Xu, Xiangfan Yin, Qin Liu, Wei Chen, Yunhe Zhang, Dejun Liu, Jinchun Yan, Qihong Huang, Jian Wang
Summary: Limited therapeutic options are available for patients with gallbladder cancer (GBC). However, research shows that mTOR inhibitors and HDAC inhibitors can serve as potential therapeutics for GBC, and phosphorylation of mTOR and S6K1 may serve as biomarkers for GBC.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Gastroenterology & Hepatology
Wei Wang, Chuan Xin Yang, Xin Zhe Yu, Shi Lei Zhang, Jie Wang, Jian Wang
Summary: Primary gallbladder neuroendocrine carcinomas (GB-NEC) are malignant neoplasms that require further study. This study aimed to summarize the clinicopathological characteristics, effective treatments, and prognostic factors for patients with GB-NEC. The study included 15 patients from Shanghai Jiao Tong University Affiliated Sixth People's Hospital and Renji Hospital, School of Medicine, Shanghai Jiao Tong University, and 47 patients from previous studies. Surgical resection, specifically R-0 resection, was associated with significantly longer overall survival for GB-NEC patients. Patients aged 60 years or older, with carcinoid syndrome, and non-R-0 resection were independently associated with reduced survival.
JOURNAL OF DIGESTIVE DISEASES
(2022)
Article
Cell Biology
Peizhang Li, Huan Xu, Liu Yang, Ming Zhan, Yuanping Shi, Caoxu Zhang, Dajun Gao, Meng Gu, Yanbo Chen, Zhong Wang
Summary: This study evaluated the expression and roles of lncRNA DLEU2 in prostate cancer and found that patients with high expression of DLEU2 had a poor prognosis. Overexpression of DLEU2 promoted the proliferation, migration, and invasion of prostate cancer. Mechanistically, DLEU2 acted as an miR-582-5p sponge to promote the expression of SGK1, and its transcription was activated by the dysregulation of E2F2 expression. Animal experiments confirmed that knockdown of DLEU2 attenuated prostate cancer tumorigenesis. These findings suggest that E2F2-activated DLEU2 may function as a competing endogenous RNA to facilitate prostate cancer progression.
CELL DEATH & DISEASE
(2022)
Article
Gastroenterology & Hepatology
Xinsen Xu, Min He, Hui Wang, Ming Zhan, Linhua Yang
Summary: The study aimed to develop a prognostic nomogram for predicting survival of gallbladder cancer patients after surgery. The nomogram showed good discrimination and calibration in both the primary and validation cohorts. It also had a higher concordance index compared to the Nevin staging system and the 8th TNM staging system. The proposed nomogram resulted in more accurate prognostic prediction for patients with gallbladder cancer after surgery.
BMC GASTROENTEROLOGY
(2022)
Correction
Biochemistry & Molecular Biology
Xince Huang, Min He, Shuai Huang, Ruirong Lin, Ming Zhan, Dong Yang, Hui Shen, Sunwang Xu, Wei Cheng, Jianxiu Yu, Zilong Qiu, Jian Wang
Article
Endocrinology & Metabolism
Huan Xu, Zhixiao Liu, Dajun Gao, Peizhang Li, Yanting Shen, Yi Sun, Lingfan Xu, Nan Song, Yue Wang, Ming Zhan, Xu Gao, Zhong Wang
Summary: This study investigates the effect of metabolic reprogramming on lineage differentiation in prostate cancer cells. The results show that metabolic reprogramming leads to antiandrogen drug resistance and tumor development, and this lineage differentiation can be reversed by the overexpression of certain genes.
MOLECULAR METABOLISM
(2022)
Article
Immunology
Guopeng Yu, Jiahao Bao, Ming Zhan, Jiangyi Wang, Xinjuan Li, Xin Gu, Shangqing Song, Qing Yang, Yushan Liu, Zhong Wang, Bin Xu
Summary: This study investigated the genetic, transcriptional alterations, and prognostic value of m5C regulatory genes in prostate cancer. The findings suggest that these genes may play a role in clinical features and the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Guopeng Yu, Bo Liang, Keneng Yin, Ming Zhan, Xin Gu, Jiangyi Wang, Shangqing Song, Yushan Liu, Qing Yang, Tianhai Ji, Bin Xu
Summary: The study identified a metabolism-related gene-based subgroup in prostate cancer, revealing the survival advantage of subgroup 2 and its associated metabolic and immunological mechanisms.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yu Lin, Haisong Tan, Guopeng Yu, Ming Zhan, Bin Xu
Summary: Although several therapeutic options have been shown to improve survival of most patients with prostate cancer, progression to castration-refractory state continues to present challenges in clinics and scientific research. Noncoding RNAs (ncRNAs) are closely related to almost all biological regulations, and their role in castration-resistant prostate cancer (CRPC) has been investigated. In clinical practice, ncRNAs, especially miRNAs and lncRNAs, may function as potential biomarkers for diagnosis and prognosis of CRPC. This review summarizes the recent findings of miRNAs and lncRNAs, discusses their potential mechanisms, and highlights their clinical application prospects in CRPC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Wei Wang, Chuanxin Yang, Jie Wang, Wei Chen, Jian Wang
Summary: A novel classification system for hepatolithiasis was proposed, which can be used to standardize treatment. The results showed that patients in the matching group had significantly better rates of residual stones, recurrence, and good quality of life compared to the nonmatching group and previous reports.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Biochemistry & Molecular Biology
Jiayida Nulali, Ming Zhan, Kaiwen Zhang, Pinghui Tu, Yu Liu, Huaidong Song
Summary: The extracellular matrix (ECM) is composed of noncellular components and has special properties for influencing cell behavior and tissue structure. Small leucine-rich proteoglycans (SLRPs) are nonfibrillar ECM components that serve as structural scaffolds and signaling molecules. Osteoglycin (OGN), a class III SLRP, is a ubiquitous ECM component that not only helps to organize the extracellular matrix but also regulates a number of important biological processes. In addition to its role in fiber assembly and fibrosis, OGN is also found in cancer tissues and is involved in cellular processes linked to tumorigenesis.
Article
Oncology
Yu Lin, Ming Zhan, Bin Xu
Summary: In this study, the expression pattern and prognostic significance of XPO7 in prostate cancer (PCa) were determined using immunohistochemistry and bioinformatics. It was found that XPO7 was overexpressed in PCa tissues and predicted a poorer prognosis. Further experiments revealed that ectopic expression of XPO7 promoted cell proliferation, migration, cell cycle progression, and EMT in PCa cells in vitro and tumor growth in vivo. Mechanistically, XPO7 was found to regulate cell cycle-related and PI3K-AKT pathways and showed a significantly positive correlation with TCF3 expression. Targeting XPO7 may have therapeutic benefits for patients with PCa.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Genetics & Heredity
Feng-Yao Wu, Rui-Meng Yang, Hai-Yang Zhang, Ming Zhan, Ping-Hui Tu, Ya Fang, Cao-Xu Zhang, Shi-Yang Song, Mei Dong, Ren-Jie Cui, Xiao-Yu Liu, Liu Yang, Chen-Yan Yan, Feng Sun, Rui-Jia Zhang, Zheng Wang, Jun Liang, Huai-Dong Song, Feng Cheng, Shuang-Xia Zhao
Summary: Through next-generation sequencing and in vitro and in vivo experiments, this study identified MAML2 and MAMLD1 gene variants that downregulated Notch signaling, leading to impaired thyroid hormone biosynthesis in patients with congenital hypothyroidism.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Oncology
Linhua Yang, Hui Wang, Miaomiao Guo, Min He, Wei Zhang, Ming Zhan, Yingbin Liu
Summary: This study found a consistent positive correlation between ELF3 overexpression and gemcitabine resistance in gallbladder cancer cells. ELF3 upregulated the expression of PKMYT1 by interacting with the DNA binding region of PKMYT1, thereby promoting the phosphorylation of CDK1 and inducing gemcitabine resistance. Therefore, the ELF3/PKMYT1/CDK1 axis may represent a promising drug target for treating gallbladder cancer patients.
Article
Urology & Nephrology
Yanbo Chen, Huan Xu, Dajun Gao, Meng Gu, Chong Liu, Ming Zhan, Zhikang Cai, Qi Chen, Zhong Wang
Summary: This study examined the efficiency and safety of two different morcellator systems in HoLEP surgery. The Piranha morcellator showed higher efficiency for prostates larger than 60 mL.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)