期刊
TUMOR BIOLOGY
卷 37, 期 10, 页码 12905-12913出版社
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-016-5216-6
关键词
miRNAs; Cisplatin; Drug resistance; Breast
类别
资金
- National Natural Science Foundation of China [81272470]
Cisplatin is a widely used chemotherapeutic agent in breast cancer treatments with inevitable rapidly acquired resistance or intrinsically resistance. Enormous evidence points to the bioprocesses of resistant formation consisting of diverse miRNAs direct and indirect actions on relevant encoding genes. In this report, we overview detailed information on the miRNAs effect on cisplatin-induced resistance, including alterations in cell survival, modification of DNA damage response, changes in cellular uptake or efflux of the drug, altered DNA methylation, and perturbations in the miRNA biogenesis pathway. This will provide potential miRNA-targeted strategies for the treatment of breast cancer therapy and requires further clinical application.
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