期刊
TUMOR BIOLOGY
卷 37, 期 8, 页码 10785-10791出版社
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-016-4871-y
关键词
CacyBP/SIP; beta-Catenin; Tumorigenesis; Multidrug resistance
类别
资金
- National Nature Science Foundation of China [81272203, 2012K-13-01-08, 30872964]
- Irma and Paul Milstein Program for Senior Health Awards
Calcyclin-binding protein/Siah-1-interacting protein (CacyBP/SIP) was initially described as a binding partner of S100A6 in the Ehrlich ascites tumor cells and later as a Siah-1-interacting protein. This 30 kDa protein includes three domains and is involved in cell proliferation, differentiation, cytoskeletal rearrangement, and transcriptional regulation via binding to various proteins. Studies have also shown that the CacyBP/SIP is a critical protein in tumorigenesis. But, its promotion or suppression of cancer progression may depend on the cell type. In this review, the biological characteristics and target proteins of CacyBP/SIP have been described. Moreover, the exact role of CacyBP/SIP in various cancers is discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据