Article
Pathology
Kaori Ueda, Takayuki Murase, Daisuke Kawakita, Toshitaka Nagao, Kimihide Kusafuka, Masato Nakaguro, Makoto Urano, Hidetaka Yamamoto, Ken-ichi Taguchi, Satoshi Kano, Yuichiro Tada, Kiyoaki Tsukahara, Kenji Okami, Tetsuro Onitsuka, Yasushi Fujimoto, Kazuo Sakurai, Nobuhiro Hanai, Toru Nagao, Ryo Kawata, Naohito Hato, Ken-ichi Nibu, Hiroshi Inagaki
Summary: Approximately 60% of adenoid cystic carcinoma (AdCC) cases are positive for MYB::NFIB or MYBL1::NFIB, and MYB/MYBL1 oncoprotein is overexpressed in most cases. This study examined 160 AdCC cases for rearrangements in MYB/MYBL1 loci and peri-MYB/MYBL1 areas. The results suggest that peri-MYB/MYBL1 rearrangements may be a frequent event in AdCC and may have similar consequences to MYB/MYBL1 rearrangements.
Article
Dentistry, Oral Surgery & Medicine
Eri Shibata, Kei-ichi Morita, Kou Kayamori, Shoichiro Tange, Hiroki Shibata, Yosuke Harazono, Yasuyuki Michi, Tohru Ikeda, Hiroyuki Harada, Issei Imoto, Tetsuya Yoda
Summary: This study identified six novel gene fusions in AdCC, in addition to the known MYB/MYBL1-NFIB fusions. Detecting these new fusion genes and investigating the molecular mechanisms could contribute to the development of novel molecular targeted therapies for this disease.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Article
Oncology
Renata Ferrarotto, Yoshitsugu Mitani, Daniel J. McGrail, Kaiyi Li, Tatiana Karpinets, Diana Bell, Steven J. Frank, Xingzhi Song, Michael E. Kupferman, Bin Liu, J. Jack Lee, Bonnie S. Glisson, Jianhua Zhang, Jon C. Aster, Shiaw-Yih Lin, P. Andrew Futreal, John Heymach, Adel K. El-Naggar
Summary: Salivary gland adenoid cystic carcinoma (ACC) exhibits heterogeneous clinical behavior and can be classified into two molecular subtypes: ACC-I and ACC-II. ACC-I is characterized by poor prognosis, upregulation of MYC and NOTCH mutations, while ACC-II shows less aggressive clinical course with upregulation of TP63 and receptor tyrosine kinases.
CLINICAL CANCER RESEARCH
(2021)
Article
Genetics & Heredity
Maicon Fernando Zanon, Cristovam Scapulatempo-Neto, Ricardo Ribeiro Gama, Marcia Maria Chiquitelli Marques, Rui Manuel Reis, Adriane Feijo Evangelista
Summary: This study examined the miRNA expression profile in salivary gland ACC patients and identified differential miRNA associated with pathological features and clinical progression. The findings revealed miRNA expression patterns associated with aggressiveness in adenoid cystic carcinoma, providing important new insights into the aggressive behavior of this tumor type.
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Marie-Delphine Lanic, Francois Le Loarer, Vinciane Rainville, Vincent Sater, Mathieu Viennot, Ludivine Beaussire, Pierre-Julien Viailly, Emilie Angot, Isabelle Hostein, Fabrice Jardin, Philippe Ruminy, Marick Lae
Summary: A new molecular diagnostic assay has been developed for the detection of gene fusions in sarcomas. This assay is rapid, reliable, highly sensitive, and multiplexed, facilitating precise diagnosis and identification of tumors with potential targetable fusions.
Article
Otorhinolaryngology
Haitao Liu, Linlin Chen, Chenliang Wang, Haibo Zhou
Summary: This study investigated the relationship between MMP-7 expression and the clinical and pathological characteristics of SACC. The findings revealed that high MMP-7 expression in SACC samples was associated with tumor differentiation, invasiveness, and clinical stage, and positively correlated with VEGF-A expression.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Israel Pena, Gary L. Clayman, Elizabeth G. Grubbs, Jeffrey M. Bergeron, Steven G. Waguespack, Maria E. Cabanillas, Ramona Dadu, Mimi I. Hu, Bryan M. Fellman, Yisheng Li, Neil D. Gross, Stephen Y. Lai, Erich M. Sturgis, Mark E. Zafereo
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2018)
Article
Oncology
Moran Amit, Mongkol Boonsripitayanon, Ryan P. Goepfert, Samantha Tam, Naifa L. Busaidy, Maria E. Cabanillas, Ramona Dadu, Jeena Varghese, Steven G. Waguespack, Neil D. Gross, Paul Graham, Michelle D. Williams, Erich M. Sturgis, Mark E. Zafereo
ANNALS OF SURGICAL ONCOLOGY
(2018)
Article
Otorhinolaryngology
Samantha Tam, Moran Amit, Mark Zafereo, Diana Bell, Randal S. Weber
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Otorhinolaryngology
Moran Amit, Samantha Tam, Hideaki Takahashi, Karen Y. Choi, Mark Zafereo, Diana Bell, Randal S. Weber
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Review
Medicine, Research & Experimental
Rick Schneider, Gregory W. Randolph, Gianlorenzo Dionigi, Che-Wei Wu, Marcin Barczynski, Feng-Yu Chiang, Zaid Al-Quaryshi, Peter Angelos, Katrin Brauckhoff, Claudio R. Cernea, John Chaplin, Jonathan Cheetham, Louise Davies, Peter E. Goretzki, Dana Hartl, Dipti Kamani, Emad Kandil, Natalia Kyriazidis, Whitney Liddy, Lisa Orloff, Joseph Scharpf, Jonathan Serpell, Jennifer J. Shin, Catherine F. Sinclair, Michael C. Singer, Samuel K. Snyder, Neil S. Tolley, Sam Van Slycke, Erivelto Volpi, Ian Witterick, Richard J. Wong, Gayle Woodson, Mark Zafereo, Henning Dralle
Review
Medicine, Research & Experimental
Che-Wei Wu, Gianlorenzo Dionigi, Marcin Barczynski, Feng-Yu Chiang, Henning Dralle, Rick Schneider, Zaid Al-Quaryshi, Peter Angelos, Katrin Brauckhoff, Jennifer A. Brooks, Claudio R. Cernea, John Chaplin, Amy Y. Chen, Louise Davies, Gill R. Diercks, Quan Yang Duh, Christopher Fundakowski, Peter E. Goretzki, Nathan W. Hales, Dana Hartl, Dipti Kamani, Emad Kandil, Natalia Kyriazidis, Whitney Liddy, Akira Miyauchi, Lisa Orloff, Jeff C. Rastatter, Joseph Scharpf, Jonathan Serpell, Jennifer J. Shin, Catherine F. Sinclair, Brendan C. Stack, Neil S. Tolley, Sam Van Slycke, Samuel K. Snyder, Mark L. Urken, Erivelto Volpi, Ian Witterick, Richard J. Wong, Gayle Woodson, Mark Zafereo, Gregory W. Randolph
Article
Oncology
Yoshitsugu Mitani, Sue-Hwa Lin, Kristen B. Pytynia, Renata Ferrarotto, Adel K. El-Naggar
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Candace A. Frerich, Hailey N. Sedam, Huining Kang, Yoshitsugu Mitani, Adel K. El-Naggar, Scott A. Ness
Article
Oncology
David Y. Lee, Kathryn J. Brayer, Yoshitsugu Mitani, Eric A. Burns, Pulivarthi H. Rao, Diana Bell, Michelle D. Williams, Renata Ferrarotto, Kristen B. Pytynia, Adel K. El-Naggar, Scott A. Ness
Article
Oncology
Tatiana Karpinets, Yoshitsugu Mitani, Bin Liu, Jianhua Zhang, Kristen B. Pytynia, Linton D. Sellen, Danice T. Karagiannis, Renata Ferrarotto, Andrew P. Futreal, Adel K. El-Naggar
Summary: This study analyzed the genetic alterations of common salivary gland carcinomas (SGCs) and identified novel and recurrent alterations within and among different subtypes. These alterations could potentially serve as biomarkers in tumor-specific clinical trials, and are associated with early phenotypic commitment and the biologic progression of SGCs.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Amriti R. Lulla, Said Akli, Cansu Karakas, Min Jin Ha, Natalie W. Fowlkes, Yoshitsugu Mitani, Tuyen Bui, Jing Wang, Xiayu Rao, Kelly K. Hunt, Laurent Meijer, Adel K. El-Naggar, Khandan Keyomarsi
Summary: This study established a novel transgenic mouse model efficiently recapitulating the major histological subtype of human SGC. LMW-E was found to preferentially bind to CDK5 in the absence of CDK2. Clinical evidence showed that co-expression of LMW-E/CDK5 was significantly associated with decreased recurrence free survival in human SGC.
Article
Oncology
Marta Persson, Mattias K. Andersson, Yoshitsugu Mitani, Margaret S. Brandwein-Weber, Henry F. Frierson, Christopher Moskaluk, Isabel Fonseca, Renata Ferrarotto, Werner Boecker, Thomas Loening, Adel K. El-Naggar, Goran Stenman
Summary: This study reveals the high frequency and clinical significance of MYB/MYBL1 alterations in adenoid cystic carcinoma (ACC), as well as identifies genes with tumor suppressive functions on chromosome 6 that contribute to poor prognosis in ACC.
Review
Oncology
Beatriz G. Cavalheiro, Jatin P. Shah, Gregory W. Randolph, Jesus E. Medina, Ralph P. Tufano, Mark Zafereo, Dana M. Hartl, Iain J. J. Nixon, Orlando Guntinas-Lichius, Vincent Vander Poorten, Fernando Lopez, Avi Hefetz Khafif, Randall P. Owen, Ashok Shaha, Juan P. Rodrigo, Alessandra Rinaldo, Antti A. Maekitie, Carl E. Silver, Alvaro Sanabria, Luiz P. Kowalski, Alfio Ferlito
Summary: Surgery is often the preferred treatment for locoregional recurrences of well-differentiated thyroid carcinomas, but other therapies can be considered on an individual basis. These patients have prolonged survival, but may require long periods of active disease and subsequent treatments. This review discusses various treatment options for well-differentiated thyroid cancer, including surgery, active surveillance, radioactive iodine therapy, and more.
Review
Medicine, General & Internal
Agata Czarnywojtek, Ewa Florek, Krzysztof Pietronczyk, Nadia Sawicka-Gutaj, Marek Ruchala, Ohad Ronen, Iain J. Nixon, Ashok R. Shaha, Juan Pablo Rodrigo, Ralph Patrick Tufano, Mark Zafereo, Gregory William Randolph, Alfio Ferlito
Summary: Vitamin D deficiency has received significant attention in medical research due to its role in regulating calcium-phosphorus metabolism and its potential impact on the immune system. Studies have shown that Vitamin D deficiency can affect autoimmune diseases, coeliac disease, infections, and cancer. Recent research has also highlighted its significant role in autoimmune thyroid diseases such as Hashimoto thyroiditis, Graves' disease, and postpartum thyroiditis. This review summarizes the current state of knowledge on the role of Vitamin D in autoimmune thyroid diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Renata Ferrarotto, Yoshitsugu Mitani, Daniel J. McGrail, Kaiyi Li, Tatiana Karpinets, Diana Bell, Steven J. Frank, Xingzhi Song, Michael E. Kupferman, Bin Liu, J. Jack Lee, Bonnie S. Glisson, Jianhua Zhang, Jon C. Aster, Shiaw-Yih Lin, P. Andrew Futreal, John Heymach, Adel K. El-Naggar
Summary: Salivary gland adenoid cystic carcinoma (ACC) exhibits heterogeneous clinical behavior and can be classified into two molecular subtypes: ACC-I and ACC-II. ACC-I is characterized by poor prognosis, upregulation of MYC and NOTCH mutations, while ACC-II shows less aggressive clinical course with upregulation of TP63 and receptor tyrosine kinases.
CLINICAL CANCER RESEARCH
(2021)