Article
Clinical Neurology
Pietro Falco, Steven Hovius, Nens van Alfen
Summary: This study used high-resolution ultrasound to observe the peripheral nerves in a patient with severe bilateral cleft hand syndrome. The results showed that the peripheral nerve anatomy accurately reflected the corresponding muscle and skin innervation areas, which is important for surgical treatment planning and assessing complex limb malformations.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Weili Xia, Zhongfei Bai, Rongxia Dai, Jiaqi Zhang, Jiani Lu, Wenxin Niu
Summary: The study found that early SR with mirror visual feedback and the combinational use of classic SR and topical temporary anesthetic seemed to have long- and short-term effects, respectively on improving the sensibility and reducing the disabilities of the hand. However, evidence supporting the effects of conventional classical SR on improving hand functions was not strong. Further well-designed trials are needed to evaluate the effects of different SR techniques on hand function after nerve repair over short- and long-term periods.
NEUROREHABILITATION
(2021)
Article
Biochemical Research Methods
Qianru He, Fanhui Yu, Meng Cong, Yuhua Ji, Qi Zhang, Fei Ding
Summary: Peripheral nerve repair and functional recovery depend on the rate of nerve regeneration and the quality of target reinnervation. A quantitative proteomic technique was used to analyze the protein expression pattern between injured motor and sensory nerves, revealing 176 proteins with differential expressions. Functional categorization indicated that these differentially expressed proteins are linked to various molecular functions, which might play a crucial role in peripheral nerve regeneration.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Health Care Sciences & Services
Martin Aman, Kim S. Zimmermann, Mirjam Thielen, Benjamin Thomas, Simeon Daeschler, Arne H. Boecker, Annette Stolle, Amir K. Bigdeli, Ulrich Kneser, Leila Harhaus
Summary: This study comprehensively analyzed the epidemiological and etiological factors of peripheral nerve lesions in a large cohort. The findings highlight the importance of early diagnosis and treatment for early return to work and improved long-term functional outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Yoshiki Tamaru, Akiyoshi Yanagawa, Akiyoshi Matsugi
Summary: The study found that the combination of surgery and nerve gliding exercise significantly improved hand function after carpal tunnel release surgery, with gender and preoperative sensory nerve conduction velocity identified as factors influencing grip and pinch strength improvement. However, no significant improvement was observed in pain.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Health Care Sciences & Services
Johannes C. Heinzel, Lucy F. Dadun, Cosima Prahm, Natalie Winter, Michael Bressler, Henrik Lauer, Jana Ritter, Adrien Daigeler, Jonas Kolbenschlag
Summary: Peripheral nerve injuries not only impact physical capabilities, but also have a significant effect on psychosocial aspects of life. Factors such as pain, depression, stress, employment status, and worker's compensation can be influenced by peripheral nerve lesions and serve as predictors of functional outcomes. Interdisciplinary, individualized treatment is necessary to identify patients at risk and provide emotional support during their adaptation to new life situations.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, Research & Experimental
Xijie Zhou, Jian Du, Liming Qing, Thomas Mee, Xiang Xu, Zhuoran Wang, Cynthia Xu, Xiaofeng Jia
Summary: This study suggests that a combination of ChAT and CGRP is the most reliable method for distinguishing motor and sensory nerve fibers. The mean gray value method was found to be the most accurate for quantifying the expression of nerve markers in immunofluorescence images.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Arne Boecker, Martin Aman, Ulrich Kneser, Leila Harhaus, Frank Siemers, Felix Stang
Summary: The efficacy of chitosan-based nerve conduits in regenerating sensory nerves in the hand was evaluated in this study. The results showed that this type of nerve conduit had similar functional outcomes and patient satisfaction to autologous nerve grafts in treating small nerve defects.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Shinichiro Nakada, Yuichiro Otsuka, Jun Ishii, Tetsuya Maeda, Kazutaka Kimura, Yu Matsumoto, Yuko Ito, Hideaki Shimada, Kimihiko Funahashi, Masayuki Ohtsuka, Hironori Kaneko
Summary: In this retrospective study, researchers found that the predictor of conversion to hand-assisted laparoscopic surgery (HALS) in laparoscopic liver resection (LLR) was a tumor located in segments 7 or 8. Conversion to HALS did not result in significantly different blood loss compared to direct selection of HALS, and there were similar operation time, hospital stay, and severe complication rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Vittoria Nazzi, Niccolo Innocenti, Nicolo Castelli, Irene Tramacere, Marica Eoli, Vittoria Cojazzi, Laura Gatti, Francesco Acerbi, Jacopo Falco, Ignazio G. Vetrano
Summary: Peripheral nerve sheath tumors (PNST) mainly include schwannomas and neurofibromas. Surgical resection is the primary treatment, but distinguishing between intact functional nerve and the fibers from which the PNST arose can be challenging. Intraoperative tools to visualize these tumors could improve the success rate of gross-total resection.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Lawrence R. Robinson
Summary: This article reviews the epidemiology, classification, localization, prognosis, and mechanisms of recovery of traumatic peripheral nerve injuries (PNIs). Electrodiagnostic assessments are critical in treating patients with PNIs, as they aid in localizing the injury and determining the extent of axon loss. Mechanisms of recovery may include recovery from conduction block, muscle fiber hypertrophy, distal axonal sprouting, and axon regrowth. Early surgical intervention is recommended for patients with complete or severe nerve injuries.
Review
Clinical Neurology
Widya Adidharma, Alexander N. Khouri, Jennifer C. Lee, Kathryn Vanderboll, Theodore A. Kung, Paul S. Cederna, Stephen W. P. Kemp
Summary: Sensory afferent fibers, a crucial component of motor nerves, play a significant role in proprioception and motor control. After peripheral nerve injury, these fibers can reinnervate muscle, even unrelated ones, allowing for cross-innervation. This has important clinical applications in peripheral nerve repair, sensory protection, and prosthetic sensorimotor control.
Article
Clinical Neurology
Aiko Okuma, Tomohiko Nakamura, Masahisa Katsuno, Tadashi Matsushita
Summary: This study examined the relationship between the immature development of the myelin sheath in children and the occurrence of bimodal waveforms in sensory nerve conduction studies. The findings showed that the frequency of bimodal waveforms and interpeak latency decreased with age, indicating that the bimodal waveform is present until the age of 15-16 years. This suggests that the underlying cause of the bimodal waveform is an immature myelin sheath.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Review
Medicine, General & Internal
Dan L. Longo, Rachel C. Sisodia, Marcela G. del Carmen
Summary: Lesions of the ovary and fallopian tube can be acute or chronic, and it is important to distinguish between benign and malignant causes. Referral to a gynecologic oncologist is often necessary for diagnostic assessment.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Neurosciences
Yachen Yang, Wei Yang, Ruofan Zhang, Yanqing Wang
Summary: This study discusses the peripheral mechanism of Cancer-induced bone pain (CIBP), including tissue injury in the bone, changes in the tumor microenvironment, and the role of the dorsal root ganglion. The interaction between nerve-cancer cells and cancer-immunocytes in the tumor microenvironment leads to the development of CIBP.
NEUROSCIENCE BULLETIN
(2023)