Review
Medicine, General & Internal
Toobah Farooqi, Deep Jyoti Bhuyan, Mitchell Low, Justin Sinclair, Mathew Leonardi, Mike Armour, Valentino Remorgida
Summary: This narrative review explores the role of the endocannabinoid system (ECS) and the gut microbiota in endometriosis. The review finds that both the ECS and microbiota influence endometriosis, with the former regulating inflammation and pain perception and the latter influencing immune responses and hormonal balance. Dysregulation of the ECS and the gut microbiota can impact endometriosis symptoms and progression.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Annia A. Martinez-Pena, Genevieve A. Perono, Sarah Alexis Gritis, Reeti Sharma, Shamini Selvakumar, O'Llenecia S. Walker, Harmeet Gurm, Alison C. Holloway, Sandeep Raha
Summary: In recent years, the use of cannabis during pregnancy has been on the rise in developed countries due to the trend towards legalization and lack of evidence-based knowledge. Limited research has focused on the potential long-term effects of prenatal cannabis exposure on offspring's health, with most studies emphasizing neurobehavioral effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Samridhi Lal, Anusmita Shekher, Puneet, Acharan S. Narula, Heidi Abrahamse, Subash C. Gupta
Summary: Cannabis and its constituents have shown potential anticancer effects against various types of cancers, by modulating pathways such as PKB, AMPK, CAMKK-beta, mTOR, PDHK, HIF-l alpha, and PPAR-gamma. They can inhibit cell growth, progression of cell cycle, and induce apoptosis selectively in tumor cells, while also enhancing the efficacy of cancer therapeutics.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Obstetrics & Gynecology
Noga Fuchs Weizman, Brandon A. Wyse, Peter Szaraz, Miranda Defer, Sahar Jahangiri, Clifford L. Librach
Summary: Exposure to phytocannabinoids increases endocannabinoid receptor expression, reduces DNA methylation enzyme expression, and decreases global DNA methylation in granulosa cells.
HUMAN REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Andrey F. L. Aguiar, Raquel M. P. Campos, Alinny R. Isaac, Yolanda Paes-Colli, Virginia M. Carvalho, Luzia S. Sampaio, Ricardo de Melo A. Reis
Summary: The endocannabinoid system (eCS) plays a modulatory role in synaptic activity in the Central Nervous System (CNS) and phytocannabinoids have been used for neurological disorder treatment. This study aims to evaluate the effect of CBD-enriched Cannabis extract on synaptic components in the hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Psychiatry
Shafiqa Alawadi, Ahmed Naguy
Summary: The strong interest in cannabinoids as a potential treatment for psychiatric disorders, particularly CBD, has led to numerous studies but the literature is still in its early stages. The potential therapeutic benefits should be balanced against the risks of frequent relapses and heightened violence associated with the ubiquitous use of cannabis in patients with psychiatric disorders.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Nutrition & Dietetics
Joanna Bartkowiak-Wieczorek, Edyta Madry, Michal Ksiazkiewicz, Jakub Winkler-Galicki, Milena Szalata, Marlena Szalata, Ulises Elizalde Jimenez, Karolina Wielgus, Edmund Grzeskowiak, Ryszard Slomski, Agnieszka Bienert
Summary: This study evaluated the bioavailability and stability of CBD and THC in an extract with reduced THC content derived from Cannabis sativa L. It was found that the CBD/THC ratio in the extract was 16:1, higher than typical medical preparations. The results showed higher concentrations of CBD than THC in the whole-blood and brain after oral administration, and the total bioavailability was higher for Rapae oleum compared to Cremophor.
Review
Urology & Nephrology
Mauro Maccarrone, Cinzia Rapino, Felice Francavilla, Arcangelo Barbonetti
Summary: Cannabinoids and endocannabinoids can affect various aspects of human male reproduction. Preclinical studies have shown that the endocannabinoid system is involved in negative modulation of testosterone secretion, but the effect of cannabinoids on spermatogenesis remains a matter of debate. A better understanding of the complex crosstalk between cannabinoids and endocannabinoids may enable targeting the ECS for modulation of human fertility.
NATURE REVIEWS UROLOGY
(2021)
Article
Psychiatry
Chrysanthi Blithikioti, Laia Miquel, Blanca Paniello, Laura Nuno, Antoni Gual, Belen Rubio Ballester, Adrian Fernandez, Ivan Herreros, Paul Verschure, Mercedes Balcells-Olivero
Summary: This study found that chronic cannabis users showed differences in sensorimotor adaptation, with lower adaptation rates compared to non-users. However, these differences disappeared after a period of abstinence. Furthermore, cannabis users did not show the attenuated implicit learning in the late phase of adaptation observed in the control group. This suggests a potential alteration of synaptic plasticity required for cerebellar learning in cannabis users.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Antonietta Santoro, Elena Mele, Marianna Marino, Andrea Viggiano, Stefania Lucia Nori, Rosaria Meccariello
Summary: The article discusses the interaction between the endocannabinoid system and estrogen system at both central and peripheral levels, with a focus on the central nervous system, reproduction, and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Viktoriia Cherkasova, Bo Wang, Marta Gerasymchuk, Anna Fiselier, Olga Kovalchuk, Igor Kovalchuk
Summary: This article reviews the potential use of cannabinoids in cancer treatment, including controlling side effects and tumor shrinkage, as well as the role of the endocannabinoid system in the development of cancer. Knowledge about using cannabinoids for cancer therapy is crucial for prolonging the lives of cancer patients.
Review
Gastroenterology & Hepatology
Abhilash Perisetti, Hemant Goyal
Summary: Cannabis use is increasing globally, and it is important to be aware of cannabis hyperemesis syndrome (CHS) for early recognition and treatment. CHS has unique mechanisms and clinical features that differ from cyclic vomiting syndrome (CVS). Understanding the role of the endocannabinoid system (ECS) in CHS is critical for explaining its pathophysiology.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Neurosciences
Martine Skumlien, Tom P. Freeman, Daniel Hall, Claire Mokrysz, Matthew B. Wall, Shelan Ofori, Kat Petrilli, Katie Trinci, Anna Borissova, Natalia Fernandez-Vinson, Christelle Langley, Barbara J. Sahakian, H. Valerie Curran, Will Lawn
Summary: In this study, researchers investigated the neural correlates of reward anticipation after acute exposure to cannabis in adolescents and adults. They found that cannabis use suppresses the brain's anticipatory reward response to money, and CBD does not modulate this effect. Additionally, the adolescent reward circuitry is not differentially sensitive to the acute effects of cannabis on reward anticipation.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Plant Sciences
Camila Moreno Lopes de Andrade, Thais Teixeira Valerio Caetanoa, Francisco Kimerling Campos, Vinicius Martins Gandra, Fernando Henrique Ferrari Alves, Vanessa Cristina Stein
Summary: Plants have long been utilized as primary sources of phytochemicals with various applications in nutrition, medicine, culture, and cosmetics. The emergence of scientific advancements related to the human endocannabinoid system has led to the exploration of cannabis-based medicines for innovative and targeted therapies. In the context of the cosmetic industry, optimizing large-scale production and incorporating bioactive compounds is crucial, and plant biotechnology presents a promising approach for sustainable supply. This review highlights the potential applications of Cannabis sativa in the cosmetic industry and emphasizes how plant biotechnology can enhance the production of valuable compounds.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Review
Agronomy
Maria Grazia Cappai, Sabine Aboling, Cecilia Dall'Aglio
Summary: Saliva secretion plays a crucial role in lubricating and softening the food bolus, aiding in digestion, antimicrobial activity, and maintaining proper digestion. Recent studies suggest that salivary response goes beyond just digestive functions and also influences feed selection.
Article
Pharmacology & Pharmacy
Ethan B. Russo
FRONTIERS IN PHARMACOLOGY
(2016)
Review
Behavioral Sciences
Ethan B. Russo
EPILEPSY & BEHAVIOR
(2017)
Article
Plant Sciences
Mark A. Lewis, Ethan B. Russo, Kevin M. Smith
Editorial Material
Pharmacology & Pharmacy
Ethan B. Russo
TRENDS IN PHARMACOLOGICAL SCIENCES
(2017)
Review
Medicine, General & Internal
Caroline A. MacCallum, Ethan B. Russo
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2018)
Article
Plant Sciences
Ethan B. Russo
FRONTIERS IN PLANT SCIENCE
(2019)
Article
Anesthesiology
Michelle St Pierre, Ethan B. Russo, Zach Walsh
CLINICAL JOURNAL OF PAIN
(2020)
Article
Biochemistry & Molecular Biology
Ethan B. Russo, Jeremy Plumb, Venetia L. Whiteley
Summary: This study focused on using organically grown cannabis to isolate pure trichomes via exposure to vapor from solid CO2, successfully concentrating cannabinoid content and preserving monoterpenoids. The resulting dried sifted flower by-product after dry ice processing remains a usable commodity.
Letter
Anesthesiology
Ethan B. Russo
Article
Pharmacology & Pharmacy
Ethan B. Russo, Carrie Cuttler, Ziva D. Cooper, Amanda Stueber, Venetia L. Whiteley, Michelle Sexton
Summary: This study is the first patient survey on the use of CBG-predominant cannabis, showing that most respondents believe CBG can effectively treat conditions such as anxiety, chronic pain, depression, and insomnia, with a reported superiority over conventional medications.
CANNABIS AND CANNABINOID RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ethan B. Russo, Chris Spooner, Len May, Ryan Leslie, Venetia L. Whiteley
Summary: This study investigated genetic mutations underlying Cannabinoid Hyperemesis Syndrome (CHS) and found mutations in genes affecting neurotransmitters, the endocannabinoid system, and cannabinoid metabolism in patients. Most patients improved after stopping cannabis use, but experienced symptom recurrence rapidly upon resumption.
CANNABIS AND CANNABINOID RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Natasha R. Ryz, David J. Remillard, Ethan B. Russo
CANNABIS AND CANNABINOID RESEARCH
(2017)
Review
Pharmacology & Pharmacy
Ethan B. Russo
CANNABIS AND CANNABINOID RESEARCH
(2016)
Article
Behavioral Sciences
Ethan B. Russo
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2018)
