期刊
TRENDS IN MOLECULAR MEDICINE
卷 22, 期 5, 页码 377-390出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2016.03.008
关键词
-
资金
- Medical Research Service, Department of Veterans Affairs
- Rehabilitation Research Service, Department of Veterans Affairs
- European Union [602273]
Peripheral neuropathy results from damage to peripheral nerves and is often accompanied by pain in affected limbs. Treatment represents an unmet medical need and a thorough understanding of the mechanisms underlying axonal injury is needed. Longer nerve fibers tend to degenerate first (length-dependence), and patients carrying pathogenic mutations throughout life usually become symptomatic in mid- or late-life (time-dependence). The activity of voltage gated sodium channels can contribute to axonal injury and sodium channel gain-of-function mutations have been linked to peripheral neuropathy. Recent studies have implicated sodium channel activity, mitochondria(compromise, and reverse-mode Na+/Ca2+ exchange in time- and length-dependent axonal injury. Elucidation of molecular mechanisms underlying axonal injury in peripheral neuropathy may provide new therapeutic strategies for this painful and debilitating condition.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据