期刊
TRENDS IN IMMUNOLOGY
卷 37, 期 3, 页码 221-232出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2016.01.007
关键词
-
类别
资金
- National Institutes of Health [P01 AI110657]
- Netherlands Organization for Scientffic Research (NWO)
- European Research Council [ERC-StG-2011-280829-SHEV]
The identification of multiple broadly neutralizing antibodies (bNAbs) against the HIV-1 envelope glycoprotein (Env) trimer has facilitated its structural characterization and guided Env immunogen design. Several recent studies constitute progress in utilizing this knowledge for the development of an HIV-1 vaccine that induces bNAbs. Native-like Env trimers can induce autologous NAb responses against resistant (Tier-2) viruses in several animal models. Here we review recent studies aimed at addressing the challenge of driving the strong but narrowly focused NAb responses to Env trimers towards ones with much greater breadth. Among strategies that merit pursuing are using multiple trimers as sequential or simultaneous immunogens, targeting the germline precursors of bNAbs, delivering sequential lineages of trimers derived from infected individuals who developed bNAbs, and presenting trimers as particulate antigens.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据