Article
Plant Sciences
Richalynn Leong, Javier Jingheng Tan, Sally Shuxian Koh, Ting-Ying Wu, Kimitsune Ishizaki, Daisuke Urano
Summary: This study investigated the cellular mechanisms of calcium deficiency in plants using the bryophyte Marchantia polymorpha as a model. The results revealed metabolic compounds and genetic pathways involved in the occurrence and expansion of foliar tipburn. Furthermore, comparable changes in gene expression were observed in other plant species, suggesting the conservation of these pathways.
Article
Multidisciplinary Sciences
Chen Shen, Anmada Nayak, Leif R. Neitzel, Amber A. Adams, Maya Silver-Isenstadt, Leah M. Sawyer, Hassina Benchabane, Huilan Wang, Nawat Bunnag, Bin Li, Daniel T. Wynn, Fan Yang, Marta Garcia-Contreras, Charles H. Williams, Sivanesan Dakshanamurthy, Charles C. Hong, Nagi G. Ayad, Anthony J. Capobianco, Yashi Ahmed, Ethan Lee, David J. Robbins
Summary: This study reveals how the Wnt ligand can enhance CRBN-dependent protein degradation and highlights the importance of CRBN in physiological Wnt signaling.
NATURE COMMUNICATIONS
(2021)
Article
Plant Sciences
Go Takahashi, Shigeyuki Betsuyaku, Natsuki Okuzumi, Tomohiro Kiyosue, Yuki Hirakawa
Summary: Research has shown that peptide hormones MpCLE1 and MpCLE2 in Marchantia polymorpha play crucial roles in cell division and sexual reproduction by interacting with specific receptors at the apical meristem. Compared to other plants, Marchantia polymorpha possesses a minimal set of CLE family peptides, exhibiting higher conservation in evolutionary terms.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Cell Biology
Nyshadham S. N. Chaitanya, Prasad Tammineni, Ganji Purnachandra Nagaraju, Aramati B. M. Reddy
Summary: The cytosolic adaptor protein ECSIT is involved in the toll-like receptor pathway and regulates various biological processes. It interacts with multiple signaling intermediates and its molecular functions in pathophysiology remain unclear.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Cell Biology
Liang Xu, Peixue Li, Xue Hao, Yi Lu, Mingxian Liu, Wenqian Song, Lin Shan, Jiao Yu, Hongyu Ding, Shishuang Chen, Ailing Yang, Yi Arial Zeng, Lei Zhang, Hai Jiang
Summary: The study identifies SHANK2 as a frequently amplified regulator of the Hippo pathway in human cancer, promoting cancer progression. Overexpression of SHANK2 in multiple human cell lines disrupts Hippo signaling, while depletion of SHANK2 restores Hippo signaling and halts cellular proliferation.
Article
Microbiology
Charles Roussin-Leveillee, Gaele Lajeunesse, Meliane St-Amand, Varusha Pillay Veerapen, Guilherme Silva-Martins, Kinya Nomura, Sandrine Brassard, Ayooluwa Bolaji, Sheng Yang He, Peter Moffett
Summary: High atmospheric humidity levels facilitate bacterial pathogens in plants by inducing an aqueous living space, as shown by the effectors HopM1 and AvrE1. This study reveals that these effectors work together to reprogram the transcriptome of Arabidopsis thaliana, leading to the accumulation of abscisic acid (ABA) and subsequent stomatal closure, reduced leaf transpiration, and water-soaking lesions. Moreover, these effectors preferentially increase ABA accumulation in guard cells, with the ABA transporter ABCG40 playing a crucial role in the induction of water-soaking lesions. These findings provide molecular insights into the manipulation of stomatal responses during infection.
CELL HOST & MICROBE
(2022)
Article
Geriatrics & Gerontology
Jerome Teuliere, Charles Bernard, Eduardo Corel, Francois-Joseph Lapointe, Johannes Martens, Philippe Lopez, Eric Bapteste
Summary: The genetic roots of ageing and longevity variations are not well understood. Comparative analyses have identified evolutionarily conserved pathways associated with longevity or ageing. This study focused on Opisthokonta species to analyze protein interactions related to ageing or longevity, providing comprehensive understanding of the evolution of ageing and longevity pathways. The study identified key antagonistic regulators of ageing/longevity and predicted novel evolutionarily conserved longevity/ageing-related proteins in humans, which could serve as potential targets for anti-ageing treatments.
Article
Biochemistry & Molecular Biology
Bodhisattwa Banerjee, Iryna Khrystoforova, Baruh Polis, Inbar Ben Zvi, David Karasik
Summary: Living organisms develop evolutionary strategies to cope with stressful events, such as the urea cycle for dealing with ammonia excess and the polyamine stress response. Researches have found that oxidative stress can trigger the expression of specific genes in fish and have specific effects on aging animals.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Donghong Cai, Jing-Dong J. Han
Summary: NF kappa B controls aging, inflammation, and senescence by regulating an increasing family of lncRNAs. These aging-associated lncRNAs are enriched for functional elements and play a role in aging process by modulating the NF kappa B pathway.
Article
Multidisciplinary Sciences
Peter J. Osseward, Neal D. Amin, Jeffrey D. Moore, Benjamin A. Temple, Bianca K. Barriga, Lukas C. Bachmann, Fernando Beltran, Miriam Gullo, Robert C. Clark, Shawn P. Driscoll, Samuel L. Pfaff, Marito Hayashi
Summary: The study revealed that the expansion of neuronal types in the spinal cord follows a stepwise manner similar to animal speciation, and defined transcriptomic relationships and genetic tiers to explain the diverse features of neurons. Furthermore, it was discovered that neuronal projection features are related to neuronal birth date and are consistent across different cardinal classes.
Article
Microbiology
Xiaoqin Zhou, Jiangyong Li, Nianwu Tang, Hongyun Xie, Xiaoning Fan, Hui Chen, Ming Tang, Xianan Xie
Summary: AM fungi form a mutualistic symbiosis with terrestrial plants, utilizing multiple nutrient sensing and signaling pathways that may regulate gene expression and influence important developmental processes such as spore germination, appressorium formation, arbuscule longevity, and sporulation.
Article
Genetics & Heredity
Melissa R. Bentley-Ford, Melissa LaBonty, Holly R. Thomas, Courtney J. Haycraft, Mikyla Scott, Cameron LaFayette, Mandy J. Croyle, Reagan S. Andersen, John M. Parant, Bradley K. Yoder
Summary: This study identified a genetic interaction between ciliary genes Nphp4 and Bbs5, which may contribute to the variability in ciliopathy phenotypes.
Article
Multidisciplinary Sciences
Aoshi Kobayashi, Mayuko Hamada, Masa-Aki Yoshida, Yasuhisa Kobayashi, Naoaki Tsutsui, Toshio Sekiguchi, Yuta Matsukawa, Sho Maejima, Joseph J. Gingell, Shoko Sekiguchi, Ayumu Hamamoto, Debbie L. Hay, John F. Morris, Tatsuya Sakamoto, Hirotaka Sakamoto
Summary: VP/OT-related peptides play essential roles in antidiuresis, sociosexual behavior, and reproduction in mammals. This study identifies orthologous genes to VP/OT in planarians and characterizes the neuropeptide derived from this gene, naming it the platytocin system. The experiments suggest that platytocin functions as an antidiuretic hormone and also plays a role in reproduction and chemosensory behavior. The findings provide insights into the physiological adaptations of bilaterians to amphibious lives.
Review
Oncology
Vaishali Aggarwal, Hardeep Singh Tuli, Mehmet Varol, Muobarak Tuorkey, Katrin Sak, Nidarshana Chaturvedi Parashar, Tushar Singh Barwal, Uttam Sharma, Ashif Iqubal, Gaurav Parashar, Aklank Jain
Summary: The Notch signaling pathway plays a crucial role in cell differentiation, development, and tumor progression. While it has been identified as a potential target for cancer treatment, it also has tumor-suppressive functions. This review discusses the dual role of the Notch pathway in cancer progression and the potential for targeted therapy.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Xue Dong, Cassandra Malecki, Elizabeth Robertson, Brett Hambly, Richmond Jeremy
Summary: Thoracic aortic disease affects all ages, with a majority of cases having a genetic cause. Surgical intervention is currently the main treatment option. The mechanism of thoracic aneurysm is less understood compared to abdominal aortic aneurysm. This paper examines key cell signaling systems and explores potential novel therapeutic approaches for thoracic aortic aneurysm.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Muhammed Burak Demircan, Peter C. Mgbecheta, Anne Kresinsky, Tina M. Schnoeder, Katrin Schroeder, Florian H. Heidel, Frank D. Boehmer
Summary: AML cells have high levels of ROS, which promote cell proliferation and oxidative stress. Setanaxib, a compound that inhibits NOX4 and modulates ROS, showed inhibitory activity on AML cells and enhanced the cytotoxic effect of anthracyclines.
Letter
Hematology
Christian Spaeth, Mandy Schoenau, Sophie Gaubert, Thomas Neumann, Christian A. Schmidt, Florian H. Heidel, William H. Krueger
ANNALS OF HEMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Kyung Mok Kim, Anna Mura-Meszaros, Marie Tollot, Murali Shyam Krishnan, Marco Grundl, Laura Neubert, Marco Groth, Alejo Rodriguez-Fraticelli, Arthur Flohr Svendsen, Stefano Campaner, Nico Andreas, Thomas Kamradt, Steve Hoffmann, Fernando D. Camargo, Florian H. Heidel, Leonid Bystrykh, Gerald de Haan, Bjorn von Eyss
Summary: As individuals age, the immune system's function declines due to defects in hematopoietic stem cells (HSCs). Researchers have discovered that the Hippo pathway coactivator TAZ plays a crucial role in protecting aging HSCs from functional decline by buffering the loss of PU.1 activity, and have identified Clca3a1 as a marker for young-like HSCs even in old mice.
NATURE COMMUNICATIONS
(2022)
Article
Hematology
Steffen Koschmieder, Susanne Isfort, Dominik Wolf, Florian H. Heidel, Andreas Hochhaus, Philippe Schafhausen, Martin Griesshammer, Denise Wolleschak, Uwe Platzbecker, Konstanze Doehner, Philipp J. Jost, Stefani Parmentier, Markus Schaich, Nikolas von Bubnoff, Frank Stegelmann, Angela Maurer, Martina Crysandt, Deniz Gezer, Maike Kortmann, Jeremy Franklin, Julia Frank, Martin Hellmich, Tim H. Bruemmendorf
Summary: This study found that treatment with ruxolitinib is effective, well-tolerated, and efficient for previously untreated patients with polycythemia vera, with significant reduction in symptoms and improvement in hematological parameters.
ANNALS OF HEMATOLOGY
(2023)
Article
Hematology
Maximilian Schoenung, Mark Hartmann, Stephen Kraemer, Sina Staeble, Mariam Hakobyan, Emely Kleinert, Theo Aurich, Defne Cobanoglu, Florian H. Heidel, Stefan Froehling, Michael D. Milsom, Matthias Schlesner, Pavlo Lutsik, Daniel B. Lipka
Summary: The study reveals significant changes in DNA methylation during the differentiation of hematopoietic cells, which is associated with the differentiation of immune cells. By using the Infinium Mouse Methylation BeadChip technology, researchers successfully obtained a detailed DNA methylation map of mouse hematopoiesis. They found that dynamically regulated DNA methylation is closely associated with cell type-specificity and the expression of hematopoietic genes, and identified a large number of novel putative cis-regulatory elements. This study provides an important platform for studying the epigenetic regulation of normal and malignant hematopoiesis.
EXPERIMENTAL HEMATOLOGY
(2023)
Article
Oncology
Jasmin Straube, Theresa Eifert, Therese Vu, Yashaswini Janardhanan, Rohit Haldar, Bjoern von Eyss, Leanne Cooper, Claudia Bruedigam, Victoria Y. Ling, Emily Cooper, Ann-Marie Patch, Lars Bullinger, Tina M. Schnoeder, Megan Bywater, Florian H. Heidel, Steven W. Lane
Summary: Murine models are useful for studying AML subtypes and compound mutations. The Cre recombinase expression in a transgenic murine model can lead to aggressive leukemia phenotype, polyclonal expansion of FLT3(ITD/ITD) progenitor cells, differentiation block and activation of Myc-dependent gene expression programs. Our report highlights the potential risks and unexpected effects of Cre expression in investigating oncogenic mutations in murine cancer models.
Review
Oncology
Andreas Schmidt, Christiane Bernhardt, Dieter Buerkle, Stefan Fries, Carla V. Hannig, Kathleen Jentsch-Ullrich, Andreas Josting, Stephan Kreher, Marcel Reiser, Hans Tilman Steinmetz, Hans Tesch, Stephanie Terner, Alexander Schulte, Carl C. Crodel, Francesca Palandri, Florian H. Heidel
Summary: This study evaluated the real-life approach to clinical characteristics, diagnostic assessment, risk stratification, and treatment decisions for MPN patients classified as ET or MF after the implementation of the WHO 2016 classification. It was found that some patients diagnosed with ET did not undergo bone marrow testing, and some patients diagnosed with MF did not receive early prognostic risk assessment. Improved histopathologic diagnostics and dynamic risk stratification are recommended for precise risk assessment and therapeutic stratification.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Annamaria Brioli, Laura Gengenbach, Katia Mancuso, Mascha Binder, Thomas Ernst, Florian H. Heidel, Thomas Stauch, Elena Zamagni, Inken Hilgendorf, Andreas Hochhaus, Monika Engelhardt, Marie von Lilienfeld-Toal
Summary: This study investigates the role of pomalidomide combinations in daratumumab-refractory multiple myeloma (MM) patients. The results show that pomalidomide-based combinations can be effective and safe for daratumumab-refractory patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Letter
Oncology
Frank Stegelmann, Lino L. Teichmann, Florian H. Heidel, Carl C. Crodel, Thomas Ernst, Sebastian Kreil, Andreas Reiter, Sara Otten, Stefanie Schauer, Ruth-Miriam Korber, Kim Kricheldorf, Susanne Isfort, Hartmut Doehner, Tim H. H. Bruemmendorf, Martin Griesshammer, Konstanze Doehner, Steffen Koschmieder
Article
Oncology
Florian H. Heidel, Carl C. Crodel, Hans H. Kreipe
Summary: This review focuses on primary myelofibrosis (PMF) and provides an overview of diagnostic criteria, clinical presentation, and therapeutic options. Diagnostic criteria include histopathologic characteristics, molecular evidence, and exclusion of other myeloid neoplasms. Treatment strategies are based on risk of progression and symptom burden, including allogeneic stem cell transplantation and JAK inhibitors.
