Article
Pediatrics
Benas Prusinskas, Sinja Ohlsson, Simone Kathemann, Denisa Pilic, Kristina Kampmann, Rainer Buescher, Andreas Paul, Lars Pape, Peter F. Hoyer, Elke Lainka
Summary: Calculating the individual weight-adjusted TAC C/D ratio can help estimate the risk of therapy-associated complications in pediatric liver transplant patients. Lower TAC levels may be tolerable in fast metabolizers, especially in certain conditions such as EBV infection or reduced renal function.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Erika T. Rhone, Elissa Bardhi, Sai Vineela Bontha, Patrick D. Walker, Jorge A. Almenara, Catherine I. Dumur, Helen Cathro, Daniel Maluf, Valeria Mas
Summary: The study evaluated gene expression profiles in pediatric kidney transplant recipients and found oxidative phosphorylation and mitochondrial dysfunction, decreased ATP synthesis, and other toxicology pathways in CNIT patients. An integrative analysis identified a panel of 13 significant miRNAs and their 33 CNIT-specific gene targets, which may serve as future molecular markers for CNIT diagnosis and potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Andrea Karolin, Genevieve Escher, Stefan Rudloff, Daniel Sidler
Summary: The study revealed that cyclosporine A acts independently of NFAT on kidney epithelial cells. Moreover, inhibition of serine/threonine protein kinases mimics cyclosporine A's activity on kidney epithelial cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hidenori Yasuda, Yoshiyasu Fukusumi, Veniamin Ivanov, Ying Zhang, Hiroshi Kawachi
Summary: FKBP12 is highly expressed in the glomeruli, particularly in podocytes, where it interacts with actin and associated proteins. Inhibition of FKBP12 in podocytes leads to decreased process formation. Adriamycin treatment decreases FKBP12 expression in podocytes, while treatment with Tacrolimus can ameliorate this decrease. Tacrolimus treatment also enhances FKBP12 interaction with synaptopodin, suggesting a role in maintaining processes and mitigating podocyte injury.
Article
Pharmacology & Pharmacy
Wei Zhang, Ryosuke Matsukane, Nobuaki Egashira, Yuichi Tsuchiya, Rao Fu, Shota Yamamoto, Takeshi Hirota, Ichiro Ieiri
Summary: This study found that tacrolimus can cause neurotoxicity, and ibudilast can alleviate this toxicity. The results suggest that tacrolimus induces neuronal damage in the brain, specifically in the cerebral cortex and CA1 region of the hippocampus, and ibudilast can act as a protective agent against this adverse event.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Babak Monshi, Christina Ellersdorfer, Michael Edelmayer, Gabriella Dvorak, Clemens Ganger, Christian Ulm, Klemens Rappersberger, Igor Vujic
Summary: In this study, it was found that patients with refractory oral lichen planus (OLP) who received low-dose cyclosporine mouth rinse treatment showed significant improvement in pain, disease extent, and quality of life, which worsened after drug withdrawal. Patients with higher initial pain scores seemed to benefit the most.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Jihoon G. Yoon, Seung Hwan Song, Sungkyoung Choi, Jaeseong Oh, In-Jin Jang, Young Jin Kim, Sanghoon Moon, Bong-Jo Kim, Yuri Cho, Hyo Kee Kim, Sangil Min, Jongwon Ha, Ho Sik Shin, Chul Woo Yang, Hye Eun Yoon, Jaeseok Yang, Min Goo Lee, Jae Berm Park, Myoung Soo Kim
Summary: Rare variant profiling of CYP3A5 and CYP3A4, combined with haplotype structures of the CYP3A locus, provides additional value for personalized TAC dosing. Moreover, a novel association between rare variants of CYP1A1 and TAC PK variability in CYP3A5 nonexpressers was identified, warranting further investigation.
Article
Biochemistry & Molecular Biology
Asmae Belhaj, Laurence Dewachter, Astrid Monier, Gregory Vegh, Sandrine Rorive, Myriam Remmelink, Melanie Closset, Christian Melot, Jacques Creteur, Isabelle Salmon, Benoit Rondelet
Summary: Tacrolimus can prevent right ventricular dysfunction caused by brain death by inhibiting apoptosis and inflammation activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Christophe Masset, Jacques Dantal, Jean-Paul Soulillou, Alexandre Walencik, Florent Delbos, Sophie Brouard, Magali Giral
Summary: Although withdrawal of calcineurin inhibitors (CM) can help avoid their side effects, selecting suitable patients for this immunosuppression minimization strategy remains challenging. Significant progress has been made in the past decade in evaluating allograft rejection, but the specific impact of these tools in clinical practice still needs to be clarified.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Dermatology
Joanna Chojnacka-Purpurowicz, Ewa Wygonowska, Waldemar Placek, Agnieszka Owczarczyk-Saczonek
Summary: Drug-induced gingival overgrowth (DIGO) is an undesirable effect caused by phenytoin, calcium channel blockers, and cyclosporine A therapy. It leads to gingivitis, periodontitis, and even tooth loss. Treatment and good oral hygiene can help alleviate the symptoms.
DERMATOLOGIC THERAPY
(2022)
Article
Allergy
Lise Gether, Heidi Storgaard, Sanja Kezic, Ivone Jakasa, Bolette Hartmann, Kirsa Skov-Jeppesen, Jens J. Holst, Anders J. Pedersen, Julie Forman, Gerrit van Hall, Ole E. Sorensen, Lone Skov, Mads A. Ropke, Filip K. Knop, Jacob Pontoppidan Thyssen
Summary: This study investigated whether whole-body treatment with topical corticosteroids for atopic dermatitis could lead to insulin resistance and increased bone resorption. The results showed that short-term use of these corticosteroids did not affect glucose metabolism but had a negative impact on bone formation.
Article
Clinical Neurology
Zhirong Fan, Lin Lei, Shengyao Su, Shu Zhang, Nairong Xie, Ling Li, Yan Lu, Li Di, Min Wang, Min Xu, Xin-Ming Shen, Yuwei Da
Summary: The advantage of using tacrolimus alone in mild to moderate myasthenia gravis (MG) is unknown. This study compared the effectiveness and side effects of mono-tacrolimus and mono-glucocorticoid treatment. The results showed no significant differences in the time to reach minimal manifestations status or better, time to relapse, and changes in Myasthenia Gravis-specific Activities of Daily Living scores between the two treatment groups. However, the rate of adverse events was lower in the mono-tacrolimus group compared to the mono-glucocorticoid group.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Jacqueline D. Silva, Giulio Taglialatela, Daniel C. Jupiter
Summary: This study found that patients prescribed CNIs have a reduced prevalence of dementia, with tacrolimus showing better results. Inhibition of calcineurin within the brain is more effective in reducing dementia than peripheral inhibition.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Pharmacology & Pharmacy
Marith I. Francke, Louise M. Andrews, Hoang Lan Le, Jacqueline van de Wetering, Marian C. Clahsen-van Groningen, Teun van Gelder, Ron H. N. van Schaik, Bronno van der Holt, Brenda C. M. de Winter, Dennis A. Hesselink
Summary: Algorithm-based tacrolimus dosing leads to the achievement of the target tacrolimus C-0 in as many as 58% of patients on day 3 after kidney transplantation.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Urology & Nephrology
Ehsan Habeeb, Steven Gabardi, Keri Townsend, Miae Kim
Summary: This retrospective study evaluated the effect of remdesivir on calcineurin inhibitor (CNI) levels. The results showed that CNI levels were significantly elevated after starting remdesivir. Further research is needed to evaluate this interaction.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Surgery
Rashmi Shingde, Vaishnavi Calisa, Jonathan C. Craig, Jeremy R. Chapman, Angela C. Webster, Henry Pleass, Philip J. O'Connell, Richard Allen, Paul Robertson, Lawrence Yuen, Kathy Kable, Brian Nankivell, Natasha M. Rogers, Germaine Wong
TRANSPLANT INTERNATIONAL
(2020)
Article
Immunology
Tejas Deshmukh, Peter Emerson, Patricia Anderson, Eddy Kizana, Philip J. O'Connell, D. Jane Holmes-Walker, James J. H. Chong
Summary: Cardiac autonomic neuropathy (CAN) is a significant issue for individuals with type 1 (T1D) and type 2 (T2D) diabetes. This study compared heart rate variability (HRV) among different groups, finding that CAN was not reversible in T1D patients post-islet cell transplantation at a median of 4 years. Differences in HRV parameters between control groups and T1D, as well as between control groups and T2D, suggest potential impacts of hypoglycemia on HRV.
Editorial Material
Immunology
Stephen I. Alexander, Min Hu, Philip J. O'Connell
Article
Surgery
Tristan J. Bampton, D. Jane Holmes-Walker, Chris J. Drogemuller, Toni Radford, Patricia Anderson, C. Etherton, C. H. Russell, S. Khurana, David J. Torpy, J. J. Couper, R. L. T. Couper, Pamela Macintyre, E. L. Neo, Paul Benitez-Aguirre, G. Thomas, T. Loudovaris, H. E. Thomas, Lyle J. Palmer, Denghao Wu, Natasha M. Rogers, L. Williams, W. J. Hawthorne, P. J. O'Connell, Tom W. Kay, Henry Pleass, John W. Chen, P. Toby Coates
Summary: The TP-IAT program in Australia has been shown to be a successful new therapy for managing individuals with chronic pancreatitis, including hereditary forms refractory to medical treatment, to improve pain management with 50% insulin independence rates.
ANZ JOURNAL OF SURGERY
(2021)
Editorial Material
Immunology
Jennifer Li, Philip J. O'Connell
Article
Multidisciplinary Sciences
Wilson K. M. Wong, Mugdha Joglekar, Vijit Saini, Guozhi Jiang, Charlotte X. Dong, Alissa Chaitarvornkit, Grzegorz J. Maciag, Dario Gerace, Ryan J. Farr, Sarang N. Satoor, Subhshri Sahu, Tejaswini Sharangdhar, Asma S. Ahmed, Yi Vee Chew, David Liuwantara, Benjamin Heng, Chai K. Lim, Julie Hunter, Andrzej S. Januszewski, Anja E. Sorensen, Ammira S. A. Akil, Jennifer R. Gamble, Thomas Loudovaris, Thomas W. Kay, Helen E. Thomas, Philip J. O'Connell, Gilles J. Guillemin, David Martin, Ann M. Simpson, Wayne J. Hawthorne, Louise T. Dalgaard, Ronald C. W. Ma, Anandwardhan A. Hardikar
Summary: The study identified eight microRNAs associated with insulin transcription levels and demonstrated their regulatory roles in (pro-)endocrine gene expression, providing valuable insights for further investigation of microRNA-mRNA interactions in regulating insulin transcription.
Article
Immunology
Sam R. Adhikary, Peter Cuthbertson, Leigh Nicholson, Katrina M. Bird, Chloe Sligar, Min Hu, Philip J. O'Connell, Ronald Sluyter, Stephen Alexander, Debbie Watson
Summary: This study demonstrates that PTCy reduces GVHD in a preclinical humanized mouse model by depleting reactive human donor T cells and reducing human Tregs, resulting in decreased weight loss, clinical GVHD, and improved survival.
Review
Immunology
Dominic Mudiayi, Soroush Shojai, Ikechi Okpechi, Emily A. Christie, Kevin Wen, Mostafa Kamaleldin, Mohamed Elsadig Osman, Meaghan Lunney, Bhanu Prasad, Mohamed A. Osman, Feng Ye, Maryam Khan, Htay Htay, Fergus Caskey, Kailash K. Jindal, Scott Klarenback, Vivekanand Jha, Eric Rondeau, Rumeyza Turan Kazancioglu, Shahrzad Ossareh, Kitty J. Jager, Csaba P. Kovesdy, Philip J. O'Connell, Elmi Muller, Timothy Olanrewaju, John S. Gill, Marcello Tonelli, David C. Harris, Adeera Levin, David W. Johnson, Aminu K. Bello
Summary: This study explores the availability, accessibility, and quality of kidney transplantation (KT) across countries and regions. The results demonstrate significant disparities in KT incidence, prevalence, availability, accessibility, and quality worldwide, with lower rates observed in low- and lower-middle income countries. Understanding these differences will inform efforts to improve awareness and ensure the provision of high-quality KT care globally.
Review
Immunology
Min Hu, Natasha M. Rogers, Jennifer Li, Geoff Y. Zhang, Yuan Min Wang, Karli Shaw, Philip J. O'Connell, Stephen Alexander
Summary: Tregs play a crucial role in kidney transplantation by limiting immune activation and potentially reducing the need for immunosuppression. Studies have shown their importance in improving allo-specific Treg function in both animal and human models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wayne J. Hawthorne, Sussan Davies, Hee-chang Mun, Yi Vee Chew, Lindy Williams, Patricia Anderson, Natasha Rogers, Philip J. O'Connell
Summary: This study compared the isolation and transplant outcomes of donor pancreata according to the distance from the islet isolation facility. The results showed that the distance of donors did not significantly impact the isolation and transplant outcomes.
Article
Urology & Nephrology
Zhengzi Yi, Fadi Salem, Madhav C. Menon, Karen Keung, Caixia Xi, Sebastian Hultin, M. Rizwan Haroon Al Rasheed, Li Li, Fei Su, Zeguo Sun, Chengguo Wei, Weiqing Huang, Samuel Fredericks, Qisheng Lin, Khadija Banu, Germaine Wong, Natasha M. Rogers, Samira Farouk, Paolo Cravedi, Meena Shingde, R. Neal Smith, Ivy A. Rosales, Philip J. O'Connell, Robert B. Colvin, Barbara Murphy, Weijia Zhang
Summary: This study utilized deep-learning to objectively and quantitatively assess the pathological lesions in kidney transplant recipients. The findings showed that this method accurately detected and quantified the lesions, and demonstrated superior predictive ability for post-transplant graft loss. This research has significant implications for medical prediction and monitoring of transplant recipients.
KIDNEY INTERNATIONAL
(2022)
Review
Immunology
Min Hu, Wayne J. Hawthorne, Shounan Yi, Philip J. O'Connell
Summary: Porcine islet xenografts face rejection primarily mediated by CD4(+) T cells, resulting in infiltration of macrophages, B cells, and T cells (CD4(+) and CD8(+)). Compared to alloimmune response, xenograft rejection is more difficult to suppress and involves the activation of CD4(+) T cells, recruitment of macrophages, and B cell responses. Macrophages are believed to be a major effector cell, while B cells play a crucial role in priming effector T cells and producing xenospecific antibodies. Strategies to expand regulatory T cell influence and inhibit and/or reduce macrophage and B cell responses are required for effective suppression of the T cell-initiated xenograft response in islet xenotransplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Wayne J. Hawthorne, Evelyn J. Salvaris, Yi Vee Chew, Heather Burns, Joanne Hawkes, Helen Barlow, Min Hu, Andrew M. Lew, Mark B. Nottle, Philip J. O'Connell, Peter J. Cowan
Summary: Genetically modified pig donors, combined with immunosuppression, can provide long-term cure and excellent graft survival in diabetic baboon models.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Michael G. Collins, Magid A. Fahim, Elaine M. Pascoe, Carmel M. Hawley, David W. Johnson, Julie Varghese, Laura E. Hickey, Philip A. Clayton, Kathryn B. Dansie, Rachael C. McConnochie, Liza A. Vergara, Charani Kiriwandeniya, Donna Reidlinger, Peter F. Mount, Laurence Weinberg, Colin J. McArthur, P. Toby Coates, Zoltan H. Endre, David Goodman, Kirsten Howard, Martin Howell, Jagadish S. Jamboti, John Kanellis, Jerome M. Laurence, Wai H. Lim, Steven J. McTaggart, Philip J. O'Connell, Helen L. Pilmore, Germaine Wong, Steven J. Chadban, Australasian Kidney Trials Network
Summary: In patients undergoing deceased donor kidney transplantation, intravenous fluid therapy with balanced crystalloid solution reduces the incidence of delayed graft function (DGF) compared to saline.
Article
Medicine, Research & Experimental
Zhongyang Zhang, Zeguo Sun, Jia Fu, Qisheng Lin, Khadija Banu, Kinsuk Chauhan, Marina Planoutene, Chengguo Wei, Fadi Salem, Zhengzi Yi, Ruijie Liu, Paolo Cravedi, Haoxiang Cheng, Ke Hao, Philip J. O'Connell, Shuta Ishibe, Weijia Zhang, Steven G. Coca, Ian W. Gibson, Robert B. Colvin, John Cijiang He, Peter S. Heeger, Barbara Murphy, Madhav C. Menon
Summary: The presence of recipient APOL1 risk alleles is independently associated with transplant outcomes, especially in African American and Hispanic recipients, potentially impacting immune response. This finding suggests broader implications for immune-mediated injury to native kidneys.
JOURNAL OF CLINICAL INVESTIGATION
(2021)