Article
Biology
Sahil H. Shah, Lucio M. Schiapparelli, Yuanhui Ma, Satoshi Yokota, Melissa Atkins, Xin Xia, Evan G. Cameron, Thanh Huang, Sarah Saturday, Catalina B. Sun, Cara Knasel, Seth Blackshaw, John R. Yates, Hollis T. Cline, Jeffrey L. Goldberg
Summary: Many neurons in the adult central nervous system degenerate and die after injury, and early changes in axon protein transport have not been quantified in disease models. This study identified transport failure of the motor protein Kif5a as a cause of RGC neurodegeneration and characterized its effects on axon transport in mice. Knockout of Kif5a in RGCs resulted in progressive RGC degeneration even in the absence of injury.
Article
Oncology
Qiaoming Zhi, Daiwei Wan, Rui Ren, Zhihua Xu, Xiaobo Guo, Ye Han, Fei Liu, Ye Xu, Lei Qin, Yilin Wang
Summary: The study revealed that circ102049 plays a significant role in colorectal cancer liver metastasis by promoting CRC progression via the miR-761/miR-192-3p-FRAS1-dependent mechanism. Additionally, circ102049 may indirectly affect the levels of mature miR-761 and miR-192-3p in the cytoplasm through the distribution of DGCR8 protein.
MOLECULAR ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Zijian Chen, Zenghong Huang, Yanxin Luo, Qi Zou, Liangliang Bai, Guannan Tang, Xiaolin Wang, Guangwen Cao, Meijin Huang, Jun Xiang, Huichuan Yu
Summary: This study found that the NTRK3 gene promoter was more frequently methylated in CRC, leading to suppressed gene expression. It was confirmed that NTRK3 promoter methylation was associated with survival outcome in CRC and a nomogram predicting survival outcome was developed. Moreover, NTRK3 promoter methylation also predicted survival outcomes in other tumors.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Wanchang Li, Jian Wen, Yueyi Song, Huiyan Yuan, Bin Sun, Ren Wang, Sheng Xu
Summary: SaRCC1 negatively regulates salt stress responses in Arabidopsis by affecting stress-related gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Zhihua Chen, Quanfa Li, Yilin Lin, Suyong Lin, Ji Gao, Shaoqin Chen
Summary: This study reveals the crucial role of m5C modification in immune cell infiltration in colorectal cancer (CRC) and its association with clinical outcomes and biological processes. Patients with low m5Cscore showed better immunotherapy response. In conclusion, m5C modification plays an important role in immune cell infiltration and treatment strategies for CRC.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Junjun Wang, Xiaofei Tian, Chuanlin Feng, Chao Song, Biao Yu, Ying Wang, Xinmiao Ji, Xin Zhang
Summary: KimH3 is a kinase that can phosphorylate H3Ser10 in both interphase and mitosis, and it is upregulated in various human cancers. Its high expression is associated with reduced median survival time in cancer patients. CDK1 phosphorylates KimH3 in mitosis, while EGF activates it in interphase, and both processes regulate the phosphorylation of H3Ser10.
Article
Biochemistry & Molecular Biology
Shiqiang Cheng, Bolun Cheng, Li Liu, Xuena Yang, Peilin Meng, Yao Yao, Chuyu Pan, Jingxi Zhang, Chun'e Li, Huijie Zhang, Yujing Chen, Zhen Zhang, Yan Wen, Yumeng Jia, Feng Zhang
Summary: This study utilized the UK Biobank dataset to conduct an exome-wide association study on major depression disorder (MDD), identifying multiple rare genetic variants associated with MDD. These findings contribute to a broader understanding of the genetic basis of MDD.
MOLECULAR PSYCHIATRY
(2022)
Article
Cell Biology
Yoshiyuki Akiyama, Kyuto Sonehara, Daichi Maeda, Hiroto Katoh, Tatsuhiko Naito, Kenichi Yamamoto, Takayuki Morisaki, Shumpei Ishikawa, Tetsuo Ushiku, Haruki Kume, Yukio Homma, Yukinori Okada, Biobank Japan Project
Summary: We conducted a genome-wide association study and found that the genetic variant rs1794275 in the MHC region is associated with HIC risk. The association was confirmed in a replication set. Fine mapping revealed the contribution of a completely linked haplotype of three HLA-DQj31 amino acid positions and HLA-DPj31 amino acid position 178 to the disease risk. The functional importance of these amino acid positions in antigen presentation was suggested by their location at the peptide binding groove.
CELL REPORTS MEDICINE
(2023)
Article
Plant Sciences
Xia An, Shuqi Zhao, Xiahong Luo, Changli Chen, Tingting Liu, Wenlue Li, Lina Zou, Chendong Sun
Summary: Wheat is a widely cultivated crop and an important staple food. In this study, 76 RCC1 genes of bread wheat were identified and analyzed for their evolutionary and functional features. The expression patterns of three RCC1 genes were induced by salt, cold, and drought stresses. The study also revealed potential regulators of RCC1 genes in wheat. This research enhances our understanding of the wheat RCC1 gene family and provides valuable information for future studies and utilization of these genes.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Gastroenterology & Hepatology
Jacob Mathias Bech, Thilde Terkelsen, Annette Snejbjerg Bartels, Fabian Coscia, Sophia Doll, Siqi Zhao, Zhaojun Zhang, Nils Brunner, Jan Lindebjerg, Gunvor Iben Madsen, Xiangdong Fang, Matthias Mann, Jose Manuel Afonso Moreira
Summary: By analyzing the proteomic data of resected adenoma samples, researchers found that the proteome can predict the future occurrence of advanced lesions and progression to colorectal cancer several years in advance.
Review
Biochemistry & Molecular Biology
Kun Guo, Cheng Zhao, Bin Lang, Huiqin Wang, Hang Zheng, Feng Zhang
Summary: RCC2 is involved in regulating cell cycle and plays a crucial role in oncogenesis of various cancers, affecting tumor cell behaviors and therapeutic resistance.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Xiaohui Sun, Xiao-Ou Shu, Qing Lan, Monika Laszkowska, Qiuyin Cai, Nathaniel Rothman, Wanqing Wen, Wei Zheng, Xiang Shu
Summary: This study identified potential protein biomarkers for colorectal cancer risk using proteomics technologies in a two-stage case-control study. A total of 27 circulating proteins were found to be nominally associated with CRC risk, and 6 of them were validated in a separate validation phase. This is the first study to evaluate over 1000 circulating proteins in prediagnostic blood samples for their associations with CRC risk in East Asians.
Article
Cell Biology
Saiprasad Gowrikumar, Mark Primeaux, Kristina Pravoverov, Chao Wu, Bryan C. Szeglin, Charles-Etienne Gabriel Sauve, Ishwor Thapa, Dhundy Bastola, Xi Steven Chen, J. Joshua Smith, Amar B. Singh, Punita Dhawan
Summary: Identifying a molecular signature based on claudin-1 and claudin-7 can help predict patient survival and response to treatment in colorectal cancer. This signature is associated with poor prognosis and characteristics of treatment-resistant CRC.
Article
Plant Sciences
Shi-Kai Cao, Rui Liu, Aqib Sayyed, Feng Sun, Ruolin Song, Xiaomin Wang, Zhihui Xiu, Xiaojie Li, Bao-Cai Tan
Summary: DEK47 is an essential protein in maize for mitochondrial intron splicing and seed development, with its loss causing developmental arrest in embryos and endosperm. Mutations in DEK47 affect the splicing of nad2 introns, resulting in reduced activity of mitochondrial complex I.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Multidisciplinary Sciences
Yun Xu, Kai Liu, Cong Li, Minghan Li, Fangqi Liu, Xiaoyan Zhou, Menghong Sun, Megha Ranganathan, Liying Zhang, Sheng Wang, Xin Hu, Ye Xu
Summary: This study retrospectively investigated genetic high-risk factors in a large cohort of colorectal cancer patients and found that approximately 19.3% of patients had pathogenic germline mutations. Mismatch repair gene mutations were the most common high-risk factor, and homologous recombination gene mutations also had a significant impact, particularly in early-onset and extra-colonic cancer risk groups. Patients with different germline mutations exhibited heterogeneous clinical phenotypes and long-term prognoses.
Article
Biotechnology & Applied Microbiology
Jonas M. Stromme, Bjarne Johannessen, Susanne G. Kidd, Mari Bogaard, Kristina T. Carm, Xiaokang Zhang, Anita Sveen, Anthony Mathelier, Ragnhild A. Lothe, Ulrika Axcrona, Karol Axcrona, Rolf I. Skotheim
Summary: The study revealed extensive heterogeneity at the gene expression level in multifocal prostate cancer. Different malignant foci within the same patient showed similar levels of heterogeneity as tumors from different patients. Expression patterns linked to ETS status and extraprostatic extension were identified, and a set of 62 genes with low intrapatient heterogeneity and high interpatient heterogeneity were found, which could serve as prognostic biomarkers regardless of the sampled malignant focus.
CANCER GENE THERAPY
(2022)
Article
Medicine, Research & Experimental
Jacqueline Fontugne, Peter Y. Cai, Hussein Alnajar, Bhavneet Bhinder, Kyung Park, Huihui Ye, Shaham Beg, Verena Sailer, Javed Siddiqui, Mirjam Blattner-Johnson, Jaclyn A. Croyle, Zohal Noorzad, Carla Calagua, Theresa Y. MacDonald, Ulrika Axcrona, Mari Bogaard, Karol Axcrona, Douglas S. Scherr, Martin G. Sanda, Bjarne Johannessen, Arul M. Chinnaiyan, Olivier Elemento, Rolf Skotheim, Mark A. Rubin, Christopher E. Barbieri, Juan Miguel Mosquera
Summary: Prostate cancer is a multifocal disease with distinct molecular subtypes. This study reveals the presence of inter- and intrafocal molecular heterogeneity in primary prostate cancer, with approximately 60% of multifocal specimens showing discordant molecular alterations between foci. Collision tumors, characterized by discrepant molecular status within a single focus, are identified in about 10% of the specimens. These findings highlight the complexity of molecular heterogeneity in prostate cancer and have important implications for future genomic studies.
Article
Biochemistry & Molecular Biology
Camilla Wolowczyk, Ulrike Neckmann, Miriam Ragle Aure, Martina Hall, Bjarne Johannessen, Sen Zhao, Rolf Skotheim, Sonja B. Andersen, Rosalie Zwiggelaar, Tonje S. Steigedal, Ole Christian Lingjaerde, Kristine Kleivi Sahlberg, Eivind Almaas, Geir Bjorkoy
Summary: In breast cancer patients, the NRF2 gene is continuously activated in metastatic cells and tumors, with corresponding upregulation of related genes. Depletion of NRF2 increases reactive oxygen species levels and severely reduces tumor formation and lung metastasis. A set of NRF2-regulated genes is elevated in breast cancer biopsies and can significantly improve prognosis prediction.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Susanne G. Kidd, Mari Bogaard, Kristina T. Carm, Anne Cathrine Bakken, Aase M. V. Maltau, Marthe Lovf, Ragnhild A. Lothe, Karol Axcrona, Ulrika Axcrona, Rolf I. Skotheim
Summary: This study aimed to determine the prognostic value of candidate biomarkers transcriptional regulator ERG and related ETS family genes in prostate cancer, while considering tumor heterogeneity. The results showed that ERG protein has independent prognostic value in predicting biochemical and clinical recurrence of prostate cancer, and appears to have the greatest prognostic value for patients with Grade Groups 4-5.
MOLECULAR ONCOLOGY
(2022)
Article
Oncology
Chiara Grasso, Maja Popovic, Elena Isaevska, Fulvio Lazzarato, Valentina Fiano, Daniela Zugna, John Pluta, Benita Weathers, Kurt D'Andrea, Kristian Almstrup, Lynn Anson-Cartwright, D. Timothy Bishop, Stephen J. Chanock, Chu Chen, Victoria K. Cortessis, Marlene D. Dalgaard, Siamak Daneshmand, Alberto Ferlin, Carlo Foresta, Megan N. Frone, Marija Gamulin, Jourik A. Gietema, Mark H. Greene, Tom Grotmol, Robert J. Hamilton, Trine B. Haugen, Russ Hauser, Robert Karlsson, Lambertus A. Kiemeney, Davor Lessel, Patrizia Lista, Ragnhild A. Lothe, Chey Loveday, Coby Meijer, Kevin T. Nead, Jeremie Nsengimana, Rolf I. Skotheim, Clare Turnbull, David J. Vaughn, Fredrik Wiklund, Tongzhang Zheng, Andrea Zitella, Stephen M. Schwartz, Katherine A. McGlynn, Peter A. Kanetsky, Katherine L. Nathanson, Lorenzo Richiardi
Summary: This study found that genetic variants within the MTHFR gene are associated with the risk of testicular germ cell tumors (TGCT), potentially affecting the establishment of DNA methylation patterns. This finding suggests that the pathogenesis of TGCT may be related to the status of the folate cycle, and this relation could be partly due to hereditary factors.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Kristina T. Carm, Bjarne Johannessen, Mari Bogaard, Anne Cathrine Bakken, Aase Maltau, Andreas M. Hoff, Ulrika Axcrona, Karol Axcrona, Ragnhild A. Lothe, Rolf Skotheim
Summary: Our study highlights the spatio-temporal heterogeneity of multifocal prostate cancer and emphasizes the importance of testing a recent sample in genomics-based precision medicine for metastatic prostate cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biology
Kristina Stenlokk, Marie Saitou, Live Rud-Johansen, Torfinn Nome, Michel Moser, Mariann arnyasi, Matthew Kent, Nicola Jane Barson, Sigbjorn Lien
Summary: Supergenes are non-recombining units that play a crucial role in maintaining adaptive genetic variation. However, the process of supergene formation and the importance of underlying functional variants are still largely unknown.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Juncal Garcia-Garcia, Anne Kristin McLaren Berge, Katrine Stange Overa, Kenneth Bowitz Larsen, Zambarlal Bhujabal, Andreas Brech, Yakubu Princely Abudu, Trond Lamark, Terje Johansen, Eva Sjottem
Summary: TRIM27 is a multifunctional protein involved in various cellular functions. It has been found to facilitate mitochondrial clustering via SQSTM1/p62 and promote mitophagy by stabilizing phosphorylated TBK1 on mitochondria.
Review
Cell Biology
Nikoline Lander Rasmussen, Athanasios Kournoutis, Trond Lamark, Terje Johansen
Summary: NBR1 is an important autophagy receptor, serving as the main receptor in plants and co-existing with p62 in most animals. It participates in the selective autophagy of protein aggregates, and its mechanism and substrates are under investigation. Its roles in human diseases have also attracted attention.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Ecology
Marion Sinclair-Waters, Torfinn Nome, Jing Wang, Sigbjorn Lien, Matthew P. Kent, Harald Saegrov, Bjorn Floro-Larsen, Geir H. Bolstad, Craig R. Primmer, Nicola J. Barson
Summary: This study investigates the mutational composition of sea age at maturation in Atlantic salmon and finds that the genetic architecture may involve multiple loci with simple alleles and a locus with potentially more complex alleles. It provides a useful multi-SNP framework for characterizing genetic variation underlying phenotypes in wild populations using sequencing data.
Editorial Material
Cell Biology
Nikoline Lander Rasmussen, Jianwen Zhou, Hallvard Olsvik, Stephanie Kaeser-Pebernard, Trond Lamark, Joern Dengjel, Terje Johansen
Summary: TNIP1 is degraded through autophagy after infection to allow expression of inflammatory genes and proteins, and its levels rise again later to counteract sustained inflammatory signaling. The phosphorylation of a TNIP1 LIR motif by TBK1 regulates its selective autophagy.
Editorial Material
Cell Biology
Athanasios Kournoutis, Terje Johansen
Summary: The Atg8 family of autophagy proteins is found to have roles in both the cytoplasm and the cell nucleus. In a recent study, Jimenez-Moreno et al. (2023. J. Cell Biol.) discovered that nuclear LC3B interacts with the LIM homeodomain transcription factor LMX1B, serving as a cofactor for LMX1B-mediated transcription of autophagy genes. This interaction provides stress protection and ensures the survival of midbrain dopaminergic neurons.
JOURNAL OF CELL BIOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Hallvard Lauritz Olsvik, Terje Johansen
Article
Multidisciplinary Sciences
Viola Nahse, Camilla Raiborg, Kia Wee Tan, Sissel Mork, Maria Lyngaas Torgersen, Eva Maria Wenzel, Mireia Nager, Veijo T. T. Salo, Terje Johansen, Elina Ikonen, Kay Oliver Schink, Harald Stenmark
Summary: DFCP1 is an ATPase located on omegasomes and plays a crucial role in selective autophagy by promoting the constriction of large omegasomes. It is essential for maintaining cellular homeostasis by removing damaged organelles and protein aggregates.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Pathology
M. Bogaard, J. M. Stromme, S. G. Kidd, B. Johannessen, A. C. Bakken, R. A. Lothe, K. Axcrona, R. I. Skotheim, U. Axcrona