期刊
TRANSPLANT INTERNATIONAL
卷 29, 期 4, 页码 418-424出版社
WILEY-BLACKWELL
DOI: 10.1111/tri.12694
关键词
children; cryptogenic cirrhosis; liver transplantation; nonalcoholic steatohepatitis; young adults
资金
- ACG Junior Faculty Development Award
Nonalcoholic steatohepatitis (NASH) is the hepatic manifestation of obesity and insulin resistance. The aim of this study was to determine the frequency of NASH as an indication for liver transplantation (LT) in children and young adults and to characterize patient and graft survival. The study included all children and young adult patients (up to the age of 40years) who underwent LT in the United States for NASH cirrhosis from the 1987 to 2012 United Network for Organ Sharing (UNOS) database. Kaplan-Meier analysis was used to assess patient and graft survival. A total of 330 patients were included, 68% were Caucasian, and the mean BMI was 33.6 +/- 6.3. Age at time of LT ranged between 4 and 40years (mean 33.9 +/- 6.6years). Fourteen subjects were <18years of age at time of LT and 20 were between the ages of 18 and 25years. Median follow-up after 1st LT was 45.8months [10.7, 97.3]. During this time, 30% of subjects (n=100) died and 11.5% (n=38) were retransplanted including 13 for NASH recurrence. In conclusion, NASH can progress to end-stage liver disease requiring LT in childhood and early adulthood. A significant number of young patients transplanted for NASH cirrhosis required retransplantation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据