期刊
TRAFFIC
卷 17, 期 12, 页码 1322-1328出版社
WILEY
DOI: 10.1111/tra.12446
关键词
antimicrobial peptide; chloroplast; endosymbiosis; organelles; mitochondria; targeting peptide
类别
资金
- CNRS
- UPMC
- Grant DYNAMO [ANR-11-LABX-0011-01]
Primary endosymbiosis, which gave rise to mitochondria or chloroplasts, required successful targeting of a number of proteins from the host cytosol to the endosymbiotic organelles. A survey of studies published in separate fields of biological research over the past 40years argues for an antimicrobial origin of targeting peptides. It is proposed that mitochondria and chloroplast derive from microbes that developed a resistance strategy to antimicrobial peptides that consisted in their rapid internalization and proteolytic disposal by microbial peptidases.
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