Article
Multidisciplinary Sciences
Hong Li, Alvaro Duque, Pasko Rakic
Summary: New studies in rodents have provided insights into the functions of the claustrum, suggesting its involvement in attention, salience detection, slow-wave generation, and neocortical network synchronization. However, the origin and development of the claustrum, particularly in primates, remain poorly understood. This study demonstrates that the claustrum in rhesus macaque embryos expresses neocortical molecular markers and undergoes two waves of neurogenesis, establishing a core and shell cytoarchitecture. Furthermore, the claustrum is found to be an independent pallial region, indicating its potentially unique role in cognitive control.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biology
Elia Benito-Gutierrez, Giacomo Gattoni, Manuel Stemmer, Silvia D. Rohr, Laura N. Schuhmacher, Jocelyn Tang, Aleksandra Marconi, Gaspar Jekely, Detlev Arendt
Summary: The study reveals overlapping expression of conserved transcription factors that specify the telencephalon in vertebrates in the chordate amphioxus. Specific co-expression is observed in the dorsal part of the anterior brain vesicle, referred to as Pars anterodorsalis (PAD). This suggests homology between the adult amphioxus brain vesicle PAD and the vertebrate telencephalon.
Article
Multidisciplinary Sciences
Diego Cordero Cervantes, Harshavardhan Khare, Alyssa Michelle Wilson, Nathaly Dongo Mendoza, Orfane Coulon-Mahdi, Jeff William Lichtman, Chiara Zurzolo
Summary: Using a connectomic approach, we discovered complex intercellular connections in the external granular layer (EGL) of the developing cerebellum, revealing a chronological continuum of proliferative and migratory events and advancing our understanding of central nervous system development.
Article
Biochemistry & Molecular Biology
Lin Ma, Yanhua Du, Yi Hui, Nan Li, Beibei Fan, Xiaojie Zhang, Xiaocui Li, Wei Hong, Zhiping Wu, Shuwei Zhang, Shanshan Zhou, Xiangjie Xu, Zhongshu Zhou, Cizhong Jiang, Ling Liu, Xiaoqing Zhang
Summary: The dorsal and ventral regions of the human telencephalon contain different neuronal subtypes, generated from radial glial cells (RGs) through intermediate progenitor cells (IPCs_div) and early postmitotic neuroblasts (eNBs), with the transcription factor ASCL1 playing a key role in this developmental process. These findings suggest a general developmental scheme for human telencephalic progenitors, with neuronal diversity being shaped during neurogenesis and neural circuit integration.
Article
Multidisciplinary Sciences
Timothy Monko, Jaclyn Rebertus, Jeff Stolley, Stephen R. Salton, Yasushi Nakagawa
Summary: Extrinsic cues from sensory thalamic projections play an early role in the formation of cortical cytoarchitecture by enhancing the production and specification of layer 4 neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Fiona Francis, Silvia Cappello
Summary: This review highlights the genes, proteins, and subcellular mechanisms influencing cortical neuronal migration, as well as the disrupted mechanisms in a variety of migration disorders. Recent research has shown the significant role of the microtubule cytoskeleton in migrating neurons, with variable impacts revealed in different cell compartments. In addition to microtubules, disruptions of actin cytoskeleton, extracellular matrix, adhesion molecules, and signaling pathways have also been identified as causative factors in cortical neuronal migration dysfunction.
CURRENT OPINION IN NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Wentong Hong, Pifang Gong, Xinjie Pan, Yitong Liu, Guibo Qi, Congcong Qi, Song Qin
Summary: Kruppel-like Factor 7 (KLF7), a zinc finger transcription factor, plays a critical role in cellular differentiation, tumorigenesis, and regeneration. Mutations in Klf7 are associated with autism spectrum disorder characterized by neurodevelopmental delay and intellectual disability. Our study reveals that KLF7 regulates neurogenesis and neuronal migration during mouse cortical development. Depletion of KLF7 in neural progenitor cells leads to agenesis of the corpus callosum, defects in neurogenesis, and impaired neuronal migration in the neocortex. Transcriptomic profiling analysis identifies p21 and Rac3 as KLF7-regulated genes involved in neuronal differentiation and migration. These findings contribute to our understanding of the potential mechanisms underlying neurological defects associated with Klf7 mutations.
Article
Multidisciplinary Sciences
Mariela Faykoo-Martinez, Troy Collins, Diana Peragine, Manahil Malik, Fiza Javed, Matthew Kolisnyk, Justine Ziolkowski, Imaan Jeewa, Arthur H. Cheng, Christopher Lowden, Brittany Mascarenhas, Hai-Ying Mary Cheng, Melissa M. Holmes
Summary: Naked mole-rats are a long-lived rodent species that exhibit extended neuronal maturation. This study characterizes cell proliferation and neuronal maturation in naked mole-rats and establishes a timeline for future investigations on the effects of longevity and social factors on adult neurogenesis in this species. It also highlights the similarities and differences between naked mole-rats and other rodent and long-lived species.
Article
Agriculture, Multidisciplinary
Xiang-Yu Ma, Yu Zhu, Ya-Ru Xu, Muhammad Asmat Ullah Saleem, Ping-An Jian, Bao-Jin Yi, Xue-Nan Li, Jin-Long Li
Summary: Phthalates, specifically di-(2-ethylhexyl) phthalate (DEHP), have toxic effects on the ovarian granulosa cell (GC) layer, leading to reduced fertility in females. This study investigated the mechanism of DEHP toxicity, revealing that it decreases the thickness of the GC layer, damages mitochondria, and activates mitocytosis. DEHP also impacts hormone secretion and disrupts GC function.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Ellen F. Mosleth, Christian Alexander Vedeler, Kristian Hovde Liland, Anette McLeod, Gerd Haga Bringeland, Liesbeth Kroondijk, Frode Steingrimsen Berven, Artem Lysenko, Christopher J. Rawlings, Karim El-Hajj Eid, Jill Anette Opsahl, Bjorn Tore Gjertsen, Kjell-Morten Myhr, Sonia Gavasso
Summary: This study identified a common protein signature of MS/CIS patients that is not associated with elevated intrathecal inflammation, suggesting that these patients may suffer from disrupted neural development from an early stage of the disease.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Ugo Tomasello, Esther Klingler, Mathieu Niquille, Nandkishor Mule, Antonio J. Santinha, Laura de Vevey, Julien Prados, Randall J. Platt, Victor Borrell, Denis Jabaudon, Alexandre Dayer
Summary: This study reveals the regulatory role of the outer subventricular zone (oSVZ) and two microRNAs (miR-137 and miR-122) in cortical expansion, enhancing our understanding of cortical development and evolution.
Article
Multidisciplinary Sciences
Dario Magaquian, Susana Delgado Ocana, Consuelo Perez, Claudia Banchio
Summary: Neuroinflammation does not affect NSCs proliferation but induces aberrant neuronal differentiation, leading to dystrophic, non-functional neurons. PtdCho-enriched media can enhance neuronal differentiation under inflammatory stress, increasing the population of healthy normal neurons and ameliorating neuronal damage to modulate neuronal plasticity. These findings contribute to understanding NSCs behavior under inflammatory conditions and offer new avenues for improving neurogenic capacity in the brain.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Kent D. Dunlap, Magda C. Teles, Rui F. Oliveira
Summary: Research indicates that cells born in the adult zebrafish brain are sensitive to social stimuli and may play a role in regulating social behavior. This suggests that adult neurogenesis in fish may contribute to behavioral plasticity, with cells being able to respond to external cues and potentially drive changes in behavior.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Nobuhiro Kurabayashi, Kazuki Fujii, Yuta Otobe, Shingo Hiroki, Masaharu Hiratsuka, Hikari Yoshitane, Yasuhiro Kazuki, Keizo Takao
Summary: Through studying the TcMAC21 mouse model, we found that it exhibits similar brain developmental abnormalities as individuals with Down syndrome (DS), making it a valuable model for investigating the causes of intellectual disability in DS individuals.
Review
Biochemistry & Molecular Biology
Samantha A. Moore, Angelo Iulianella
Summary: This review discusses the development of the cortical hem in the vertebrate brain, as well as the key signaling pathways and molecules involved in patterning this specialized region. It also highlights the connections between the formation of the lateral ventricle choroid plexus and neurogenesis in the hippocampus during embryonic and postnatal stages.