Article
Multidisciplinary Sciences
Yan Wang, Lily Guo, Xihui Yin, Ethan C. McCarthy, Mandy I. Cheng, Aline T. Hoang, Ho-Chung Chen, Anushi Y. Patel, Denise Allard Trout, Erin Xu, Natalie Yakobian, Willy Hugo, James F. Howard, Katherine M. Sheu, Alexander Hoffmann, Melissa G. Lechner, Maureen A. Su
Summary: Immune cells play divergent roles in injury and autoimmunity. Understanding the phenotypes of these cells can reveal new therapeutic targets for inflammatory neuropathies. A TNF-alpha signaling axis is associated with autoimmune demyelination, and blocking this axis can ameliorate clinical symptoms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Lijun Xie, Huiying Wang, Dan Wu, Feng Zhang, Wei Chen, Yuqing Ye, Fang Hu
Summary: This study reveals the novel role of adipose chemokine CXCL13 in the regulation of BAT activity and thermogenesis by recruiting M2 macrophages and inhibiting pro-inflammatory factor TNF-alpha level.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xing-Xing Zhen, Long Yang, Yan Gu, Qian Yang, Wen-Wen Gu, Ya-Ping He, Yan-Ling Wang, Jian Wang
Summary: Decidual macrophages (dM phi) play critical roles in maintaining pregnancy at the maternal-fetal interface, and aberrantly increased expression of MNSF beta in dM phi from patients with recurrent pregnancy loss (RPL) may promote TNF alpha production via its interaction with RC3H1, potentially disrupting the immune balance and leading to pregnancy loss.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rajkishor Nishad, Dhanunjay Mukhi, Srinivas Kethavath, Sumathi Raviraj, Atreya S. V. Paturi, Manga Motrapu, Sreenivasulu Kurukuti, Anil Kumar Pasupulati
Summary: This study finds that podocytes in diabetic kidney disease (DKD) may contribute to renal inflammation by secreting TNF-alpha and promoting macrophage migration. Inhibiting the action of GH or TNF-alpha in podocytes could be a novel therapeutic approach for treating DKD.
Article
Multidisciplinary Sciences
Farshad Babaeijandaghi, Adrianna Paiero, Reece Long, Lin Wei Tung, Shannon Percival Smith, Ryan Cheng, Joshua Smandych, Nasim Kajabadi, Chih-Kai Chang, Amirhossein Ghassemi, William D. M. Kennedy, Hesham Soliman, Peter W. Schutz, Fabio M. Rossi
Summary: In this study, it is found that natural killer (NK) cells are the main source of IFN gamma in regenerating muscle. The production of IFN gamma is also limited to a small population of T cells. However, NK cells do not play a major role in muscle regeneration. The absence of IFN gamma per se has no effect on muscle regeneration, but its role is partially unmasked when TNF alpha is also neutralized.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Camille Chauvin, Daniel Alvarez-Simon, Katarina Radulovic, Olivier Boulard, William Laine, Myriam Delacre, Nadine Waldschmitt, Elodie Segura, Jerome Kluza, Mathias Chamaillard, Lionel F. F. Poulin
Summary: The recruitment of pathogenic macrophages in Crohn's Disease (CD) patients with NOD2 risk alleles is believed to be caused by the recruitment of monocytes from the intestine. However, this study suggests that NOD2 may instead inhibit the differentiation of monocytes into macrophages from the bloodstream.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Food Science & Technology
Pawel Skrzydlewski, Magdalena Twaruzek, Jan Grajewski
Summary: Mycotoxins, secondary metabolites of molds, are important to assess for their cytotoxicity, but the evaluation in cell lines lacks the interaction typical for complex organisms.
Article
Oncology
Xue Yang, Changchun Shao, Lixia Duan, Xiaojuan Hou, Yihua Huang, Lu Gao, Chen Zong, Wenting Liu, Jinghua Jiang, Fei Ye, Junxia Shi, Qiudong Zhao, Dong Wu, Lixin Wei
Summary: The study found that Oncostatin M (OSM) plays an important role in hepatocarcinogenesis by regulating liver inflammation, potentially serving as a target for the prevention and treatment of HCC, as well as an indicator for HCC prognosis.
Article
Chemistry, Multidisciplinary
Feng-xiang Zhang, Min Li, Yu-lin-lan Yuan, Shuang-Shuang Cui, Zuo-cheng Qiu, Rui-man Li
Summary: The study employed a combination of chemical profiling, network pharmacology, and in vitro experimental validation to analyze the trace constituents of Rhizoma coptidis (RC) and characterize their functional mechanism, showcasing its potential pharmacological mechanism against inflammation.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hassan S. Alamri, Maaged A. Akiel, Talal S. Alghassab, Mohammad A. Alfhili, Bahauddeen M. Alrfaei, Maha Aljumaa, Tlili Barhoumi
Summary: Research has shown that Erythritol can induce a proinflammatory phenotype in THP-1 macrophages and increase the population of necroptotic macrophages.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Alessia Furgiuele, Franca Marino, Emanuela Rasini, Massimiliano Legnaro, Alessandra Luini, Maria Giulia Albizzati, Alessia di Flora, Barbara Pacchetti, Marco Cosentino
Summary: This study investigated the effects of CBD on human peripheral blood mononuclear cells (PBMCs) and CD4+ T cells, and found that CBD can affect cytokine production, cell proliferation, and the functional properties of regulatory T cells. However, the effects of CBD on cell proliferation and protein production were inconsistent, suggesting a complex activity that warrants further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Michael Mauermeir, Martha Oelke, Inaya Hayek, Jan Schulze-Luehrmann, Katja Dettmer, Peter J. Oefner, Christian Berens, Christian Menge, Anja Luehrmann
Summary: Coxiella burnetii is a zoonotic pathogen that infects various species. The infection response differs between human and bovine macrophages, but the underlying mechanisms are unknown.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yue Wen, Xiuqing Wang, Wei Meng, Wenli Guo, Chenyang Duan, Jingjing Cao, Lifei Kang, Ningfei Guo, Qiang Lin, Ping Lv, Rong Zhang, Lingxiao Xing, Xianghong Zhang, Haitao Shen
Summary: High expression of PD-L1 in CD11b(+)CD206(+) macrophages is positively correlated with tumor progression and the population of PD-1(+)CD8(+) T cells in human adenocarcinoma patients. In a mouse model, PD-L1 is mainly upregulated in monocyte-derived macrophages (MoMs) and anti-PD-L1 treatment can reduce T cells exhaustion and inhibit tumorigenesis. Tumor-promoting inflammation depends on TNF-alpha to upregulate PD-L1 in recruited MoMs.
Article
Environmental Sciences
Xiaoqi Hu, Jingran Su, Mo Chen, Yikun Tu, Chunyan Wu, Xue Cao, Xinyi Yuan, Fang Zhang, Wenjun Ding
Summary: The study revealed that macrophage-secreted exosomal TNF-alpha can trigger epithelial cell SPs expression, providing a new insight and potential target in the mechanism of epithelial cell dysfunction in PM2.5-induced acute lung injury (ALI).
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Daan J. Kloosterman, Leila Akkari
Summary: Macrophages play versatile and heterogeneous roles in innate immunity, maintaining immune responses and tissue repair. However, when co-opted by malignant outgrowth, macrophages can contribute to tumor evolution within the tumor microenvironment. This review explores the sources of influence that shape tumor-associated macrophage (TAM) phenotypic states in solid neoplasms and discusses how TAMs steer tumor evolution in response to these signals. The authors propose new therapeutic approaches to exploit the complex roles of TAMs in cancer.
Article
Engineering, Environmental
Janaina Nones, Anita Solhaug, Gunnar Sundstol Eriksen, Domingos Lusitaneo Pier Macuvele, Anicleto Poli, Cintia Soares, Andrea Goncalves Trentin, Humberto Gracher Riella, Jader Nones
JOURNAL OF HAZARDOUS MATERIALS
(2017)
Article
Toxicology
Anette Kocbach Bolling, Anita Solhaug, Else Morisbak, Jorn A. Holme, Jan Tore Samuelsen
TOXICOLOGY LETTERS
(2017)
Article
Toxicology
Lada Ivanova, Christiane Kruse Faeste, Anita Solhaug
TOXICOLOGY LETTERS
(2018)
Article
Toxicology
Vegard Saeter Grytting, Bergitte Pearl Olderbo, Jorn A. Holme, Jan Tore Samuelsen, Anita Solhaug, Rune Becher, Anette Kocbach Bolling
TOXICOLOGY IN VITRO
(2019)
Article
Environmental Sciences
M. H. B. Mueller, A. Polder, O. B. Brynildsrud, R. Gronnestad, M. Karimi, E. Lie, W. B. Manyilizu, R. H. Mdegela, F. Mokiti, M. Murtadha, H. E. Nonga, J. U. Skaare, A. Solhaug, J. L. Lyche
ENVIRONMENTAL RESEARCH
(2019)
Article
Environmental Sciences
Elisabeth Oya, Anita Solhaug, Anette K. Bolling, Reidun Ovstebo, Tonje B. Steensen, Anani K. J. Afanou, Jorn A. Holme
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2019)
Article
Mycology
Carlos A. F. Oliveira, Lada Ivanova, Anita Solhaug, Christiane K. Faeste
MYCOTOXIN RESEARCH
(2020)
Article
Pharmacology & Pharmacy
A. Solhaug, M. L. Torgersen, J. A. Holme, J. Wiik-Nilsen, B. Thiede, G. S. Eriksen
Article
Pharmacology & Pharmacy
Aziza H. Said, Anita Solhaug, Morten Sandvik, Flower E. Msuya, Margareth S. Kyewalyanga, Aviti J. Mmochi, Jan L. Lyche, Selma Hurem
Article
Food Science & Technology
J. Nones, A. Solhaug, H. G. Riella, G. S. Eriksen, J. Nos
Summary: Bentonite clays have high adsorption capacity for contaminants, making them useful in reducing toxicity of mycotoxins; organophilic treatments can increase their adsorption capacity for ZEN; both natural bentonite and bentonite treated with BAC302 protect cells against ZEN-induced cytotoxicity, showing potential for further in vivo testing in ZEN-contaminated animal feeds.
WORLD MYCOTOXIN JOURNAL
(2021)
Article
Cell Biology
Hilde Sindre, Mona C. Gjessing, Johanna Hol Fosse, Lene C. Hermansen, Inger Bockerman, Marit M. Amundsen, Maria K. Dahle, Anita Solhaug
Summary: The establishment of the first Lumpfish Gill cell line (LG-1) provides valuable insights into the biology of lumpfish, with the cells originating from an epithelial or endothelial cell type. LG-1 can serve as an important in vitro research tool for studying gill cell function and host-pathogen interactions in lumpfish.
Article
Virology
Johanna Hol Fosse, Maria Aamelfot, Tonje Sonstevold, Simon Chioma Weli, Niccolo Vendramin, Petra Elisabeth Petersen, Anita Solhaug, Marit Masoy Amundsen, Inger Austrheim Heffernan, Argelia Cuenca, Debes Hammershaimb Christiansen, Knut Falk
Summary: Research shows that infectious salmon anaemia virus (ISAV) can bind to erythrocytes in Atlantic salmon and play a role in the infection process. However, erythrocytes do not significantly contribute to the replication of ISAV, which primarily occurs in endothelial cells.
Article
Food Science & Technology
Christiane Kruse Faeste, Anita Solhaug, Marion Gaborit, Florian Pierre, Dominique Massotte
Summary: Chronic exposure to the mycotoxin deoxynivalenol (DON) can have neurotoxic effects on brain cells, including impacts on glial cells, cell cycle, inflammatory cytokine release, and neuronal morphology.
Article
Biotechnology & Applied Microbiology
Anita Solhaug, Mona Gjessing, Morten Sandvik, Gunnar Sundstol Eriksen
Summary: This study compared the handling and tolerance of reactive oxygen species (ROS) in two gill epithelial cell lines, RTgill-W1 from Rainbow trout and ASG-10 from Atlantic salmon. The results showed that the differences in mitochondrial status, glutathione (GSH), and catalase activities may contribute to the different tolerance towards ROS in these two cell lines. This highlights the importance of considering these differences in the selection of experimental models and interpretation of results.
Article
Biochemistry & Molecular Biology
Lada Ivanova, Christiane Kruse Faeste, Anita Solhaug
Summary: This study characterized the metabolic capacity of the ASG-10 gill epithelial cell line from Atlantic salmon. The cell line was found to have inducible CYP1A expression and established activities of important cytochrome P450 (CYP) and uridine 5'-diphospho-glucuronosyltransferase (UGT) enzymes. Metabolism of benzocaine in ASG-10 confirmed esterase and acetyl transferase activities. The ASG-10 cell line was deemed suitable for investigating biotransformation in gills.
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)