Article
Pharmacology & Pharmacy
Na-Yeon Kim, Chae-Min Lim, Hyo-Min Park, Jinju Kim, Thu-Huyen Pham, Young Yang, Hee Pom Lee, Jin Tae Hong, Do-Young Yoon
Summary: In this study, the researchers demonstrated the adipogenic effects of MMPP in vitro through regulating PPAR gamma transcriptional activity. MMPP directly binds to PPAR gamma and enhances the expression of adipogenic markers. Additionally, MMPP improves insulin sensitivity and glucose uptake. Therefore, MMPP may be a potential drug for type 2 diabetes and metabolic disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Dan-dan Li, Ying Wang, Eun La Kim, Jongki Hong, Jee H. Jung
Summary: A new triterpene compound called asperflagin was isolated from the jellyfish-derived fungus Aspergillus flavus through activity-guided fractionation. It showed selective and moderate effects on PPAR-gamma activation. Unlike other full agonistic antidiabetic drugs, it potentially functions as a partial agonist of PPAR-gamma, retaining antidiabetic effects without causing weight gain. Further studies revealed that asperflagin exhibited higher glucose uptake in liver cells but significantly lower adipogenesis and lipid accumulation in adipocytes compared to rosiglitazone, suggesting its potential as an advanced antidiabetic lead.
Article
Biochemistry & Molecular Biology
Jain Jeong, Soyoung Jang, Song Park, Wookbong Kwon, Si-Yong Kim, Soyoen Jang, Jiwon Ko, Si Jun Park, Su-geun Lim, Duhak Yoon, Junkoo Yi, Sanggyu Lee, Myoung Ok Kim, Seong-Kyoon Choi, Zae Young Ryoo
Summary: The study highlighted the important role of JAZF1 in adipocyte differentiation and related metabolism through experiments in vitro and in vivo. Heterozygous JAZF1 knockout mice exhibited abnormalities in adipose tissue mass and glucose metabolism, providing new insights for treating obesity and metabolic disorders.
CELL AND BIOSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Amir Hossein Faghfouri, Yaser Khajebishak, Laleh Payahoo, Elnaz Faghfuri, Mohammadreza Alivand
Summary: Autophagy pathways are involved in the pathogenesis of some obesity related health problems. PPAR-gamma as the main modulator of adipogenesis process can be effective in regulating obesity related phenotypes. The effects of PPAR-gamma and its agonists on autophagy modulation in obesity have been investigated in a limited number of studies.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sasikumar Jalajakumari Soumya, Chandran Sheela Abhinand, Arya Saseendran Nair, Priji Sathyan Sonu, Govindapillai Mohanadasan Nair, Appukuttan Nair Gangaprasad, Achuthsankar S. Nair, Ananthakrishnan Jayakumaran Nair
Summary: Chrysin inhibits adipogenesis by modulating the key adipogenic transcription factor PPAR-γ, which may provide potential therapeutic interventions for controlling adiposity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Endocrinology & Metabolism
Dongliang Fang, Xinyi Shi, Xiaowei Jia, Chun Yang, Lulu Wang, Baopu Du, Tao Lu, Lin Shan, Yan Gao
Summary: The research reveals that FSTL1 promotes adipogenesis through the integrin/FAK/ERK signaling pathway, with glycosylated modification at the N142 site playing a key role. Lack of FSTL1 inhibits preadipocyte differentiation and obesity development.
MOLECULAR METABOLISM
(2022)
Article
Cell Biology
Xin Lv, Jun Qiu, Tao Hao, Haoran Zhang, Haiping Jiang, Yang Tan
Summary: The study demonstrated that TSA inhibited adipogenesis in 3T3-L1 preadipocytes by activating the AMPK pathway, leading to decreased lipid accumulation. Furthermore, TSA was also able to reverse the weight gain and adipose tissue increase induced by a high-fat diet in obese mouse models.
Article
Cell Biology
Hang Wu, Taner Pula, Daniel Tews, Ez-Zoubir Amri, Klaus-Michael Debatin, Martin Wabitsch, Pamela Fischer-Posovszky, Julian Roos
Summary: miR-27a-3p plays a crucial role in human adipogenesis by repressing PPARγ, while LPL is not involved in the regulation of human adipogenesis.
Article
Biochemistry & Molecular Biology
Maria N. Evseeva, Daniyar T. Dyikanov, Maxim N. Karagyaur, Tatyana A. Prikazchikova, Anna F. Sheptulina, Maria S. Balashova, Timofei S. Zatsepin, Yury P. Rubtsov, Konstantin Y. Kulebyakin
Summary: Obesity is closely related to type 2 diabetes and other metabolic diseases, with dysregulation of adipocyte homeostasis playing a key role. The Hhex gene may regulate adipogenesis by affecting the level of the PPAR-gamma protein.
Article
Chemistry, Medicinal
Ken-Ichi Nakashima, Marina Okamura, Imari Matsumoto, Nanae Kameda, Tomoe Tsuboi, Eiji Yamaguchi, Akichika Itoh, Makoto Inoue
Summary: This study synthesized two retinoid X receptor (RXR) agonists, 4 ' OHE and 6OHE, and found that 4 ' OHE enhanced adipogenesis similar to rosiglitazone, while 6OHE and 6OHA suppressed adipogenesis.
JOURNAL OF NATURAL MEDICINES
(2023)
Review
Nutrition & Dietetics
Danielle L. Avila, Nubia A. M. Nunes, Paulo H. R. F. Almeida, Juliana A. S. Gomes, Carla O. B. Rosa, Jacqueline Alvarez-Leite
Summary: Capsaicin shows promise as an anti-obesity agent, potentially acting through TRPV1 activation and involvement of PPAR pathways. Studies have demonstrated various beneficial effects in obesity models, but further research is needed to elucidate the mechanisms of action.
ADVANCES IN NUTRITION
(2021)
Article
Endocrinology & Metabolism
Wan Xu, Jingjing Zhang, Jing Xiao
Summary: The selective PDE4 inhibitor Roflumilast was found to suppress adipogenesis and promote lipolysis, showing therapeutic potential in obesity-related diseases in cell culture and mouse models.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huilan Zeng, Alina V. Dumitrescu, David Wadkins, Benjamin W. Elwood, Oliver W. Gramlich, Markus H. Kuehn
Summary: Neuroinflammation is a significant factor in the pathophysiology of neurodegenerative diseases, including glaucoma. Pioglitazone, an agonist of PPAR gamma, shows potential in protecting retinal ganglion cells and reversing vision loss in glaucomatous retina.
Article
Engineering, Chemical
Seung-Min Lee, So-Hyeon Bok, Min-Hee Kim, Ki Sun Lee, Dae-Hun Park
Summary: In 2016, 13% of the global adult population was obese. By 2030, this number is projected to reach 34%. Obesity is a non-communicable disease that can lead to various health problems. Study results showed that P. erosus effectively controls obesity by regulating leptin-C/EBPa-PPARgamma and FAS levels, and preventing lipid droplet accumulation.
Article
Medicine, Research & Experimental
Saveta G. Mladenova, Martina S. Savova, Andrey S. Marchev, Claudio Ferrante, Giustino Orlando, Martin Wabitsch, Milen I. Georgiev
Summary: This study investigated the anti-adipogenic capacity of Ononis spinosa L. root and its secondary metabolites in human adipocytes. The results showed that the root, ononin, and maackiain all reduced lipid accumulation during adipocyte differentiation. They also affected the expression of proteins involved in adipogenic regulation. Although the root did not inhibit adipogenic differentiation, it could be used as a source of natural leads with anti-adipogenic potential. The multi-directional mechanism of action of maackiain needs further validation in in vivo obesity models.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Meeting Abstract
Surgery
Monica D. Chow, Andrew M. Wassef, Bo Kong, Jianliang Shen, Laura E. Armstrong, Justin D. Schumacher, Daniel Rizzolo, Ragui W. Sadek, Grace L. Guo, Yi-Horng Lee
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2017)
Article
Gastroenterology & Hepatology
Min Zhang, Bo Kong, Mingxing Huang, Ruixuan Wan, Laura E. Armstrong, Justin D. Schumacher, Daniel Rizzolo, Monica D. Chow, Yi-Horng Lee, Grace L. Guo
DIGESTIVE AND LIVER DISEASE
(2018)
Article
Biochemistry & Molecular Biology
Laura E. Armstrong, Maureen V. Driscoll, Ajay C. Donepudi, Jialin Xu, Angela Baker, Lauren M. Aleksunes, Jason R. Richardson, Angela L. Slitt
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2013)
Article
Chemistry, Multidisciplinary
Supriya R. Kulkarni, Laura E. Armstrong, Angela L. Slitt
PHARMACEUTICAL RESEARCH
(2013)
Article
Gastroenterology & Hepatology
Bo Kong, Min Zhang, Mingxing Huang, Dan Rizzolo, Laura E. Armstrong, Justin D. Schumacher, Monica D. Chow, Yi-Horng Lee, Grace L. Guo
DIGESTIVE AND LIVER DISEASE
(2019)
Article
Gastroenterology & Hepatology
Justin D. Schumacher, Bo Kong, Jason Wu, Daniel Rizzolo, Laura E. Armstrong, Monica D. Chow, Michael Goedken, Yi-Horng Lee, Grace L. Guo
Article
Biochemistry & Molecular Biology
Laura E. Armstrong, Stephen Akinbo, Angela L. Slitt
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2020)
Article
Medicine, Research & Experimental
Mingxing Huang, Bo Kong, Min Zhang, Daniel Rizzolo, Laura E. Armstrong, Justin D. Schumacher, Monica D. Chow, Yi-Horng Lee, Laurie B. Joseph, Mary Stofan, Lanjing Zhang, Grace L. Guo
LABORATORY INVESTIGATION
(2020)
Article
Toxicology
Rulaiha Taylor, Laura Armstrong, Anisha Bhattacharya, Zakiyah Henry, Anita Brinker, Brian Buckley, Bo Kong, Grace Guo
Summary: This study aimed to clarify the effects of Myclobutanil exposure on FXR activation and NAFLD development. The results showed that Myclobutanil inhibits FXR activity and modulates FXR activity differentially in mice fed low-fat diet or high-fat-high-sugar diet.
TOXICOLOGICAL SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Laura E. Armstrong, Grace L. Guo
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2019)