期刊
TOXICOLOGY
卷 372, 期 -, 页码 12-21出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.tox.2016.10.010
关键词
Acephate; Pregnancy; Lactation; Glucose metabolism; Lipid metabolism; Offspring
资金
- Brazilian Federal Foundation, Conselho National de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Parana Science Foundation (Fundacao Araucaria)
Acephate has been used extensively as an insecticide in agriculture. Its downstream sequelae are associated with hyperglycemia, lipid metabolism dysfunction, DNA damage, and cancer, which are rapidly growing epidemics and which lead to increased morbidity and mortality rates and soaring healthcare costs. Developing interventions will require a comprehensive understanding of which excess insecticides during perinatal life can cause insulin resistance and type 2 diabetes. A Wistar rat animal model suggests that acephate exposure during pregnancy and lactation causes alterations in maternal glucose metabolism and programs the offspring to be susceptible to type 2 diabetes at adulthood. Therapeutic approaches based on preventive actions to food contaminated with insecticides during pregnancy and lactation could prevent new cases of type 2 diabetes. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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