Article
Hematology
Christina U. Lorentz, Erik Tucker, Norah G. Verbout, Joseph J. Shatzel, Sven R. Olson, Brandon D. Markway, Michael Wallisch, Martina Ralle, Monica T. Hinds, Owen J. T. McCarty, David Gailani, Jeffrey Weitz, Andras Gruber
Summary: In patients with ESRD undergoing heparin-free hemodialysis, the use of the unique antibody AB023 can effectively reduce clotting within the dialyzer, maintaining good blood flow and potentially improving patient outcomes.
Article
Multidisciplinary Sciences
Peng Wang, Zhitao Huang, Yili Peng, Hongwei Li, Tong Lin, Yingyu Zhao, Zheng Hu, Zhanmei Zhou, Weijie Zhou, Youhua Liu, Fan Fan Hou
Summary: This study identifies a circular RNA called circBNC2, which inhibits G2/M arrest of epithelial cells to prevent fibrosis in damaged kidney and liver, providing a potential target for intervention in fibrosis.
NATURE COMMUNICATIONS
(2022)
Article
Hematology
Michal Tomasz Zabczyk, Maksymilian Hanarz, Krzysztof P. Malinowski, Elzbieta Pociask, Saulius Butenas, Grzegorz Gajos, Anetta Undas
Summary: This study investigates the prognostic value of active coagulation factors in atrial fibrillation (AF) patients. The results show that the presence of FXIa in circulating blood is associated with an increased risk of ischemic stroke and cardiovascular death in AF patients during long-term follow-up.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Multidisciplinary Sciences
Livia Whiting, Nathan Bianchi, Mohamed Faouzi, Antoine Schneider
Summary: This study aimed to evaluate the dynamics and factors associated with decreased membrane performance in continuous kidney replacement therapy (CKRT). Mixed-effects logistic regression model analyses showed that time significantly affected these values and identified independent predictors of decreased membrane performance. Additionally, COVID-19 infection was not associated with an increased risk of decreased membrane performance.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Adrian Vega-Perez, Laura H. Villarrubia, Cristina Godio, Alejandra Gutierrez-Gonzalez, Lidia Feo-Lucas, Margarita Ferriz, Natalia Martinez-Puente, Julieta Alcain, Alfonso Mora, Guadalupe Sabio, Maria Lopez-Bravo, Carlos Ardavin
Summary: In this study, it was found that large peritoneal macrophages form cellular aggregates in the peritoneum to combat Escherichia coli infection, which helps to efficiently control the infection and prevent overt inflammation in the peritoneum.
Article
Medicine, General & Internal
Alesa Orsag, Mojca Bozic-Mijovski, Samo Hudoklin, Sasa Simcic, Jakob Gubensek
Summary: The study compared two different doses of citrate in regional citrate anticoagulation and found no significant difference in biocompatibility parameters, indicating that the standard dose of citrate may be sufficient for chronic hemodialysis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Violaine L. Harris, Jaina A. Wollowitz, Jacelyn Greenwald, Alyssa Carlson, Saud Sadiq
Summary: Mesenchymal stem cell-neural progenitors (MSC-NP) derived from MS and non-MS donors exhibited significant differential gene expression compared to MSCs, with upregulated and downregulated genes related to cell signaling, cell communication, neuronal differentiation, chemotaxis, migration, and complement activation. The downregulation of cell cycle genes in MSC-NPs suggests reduced proliferation, while the enrichment of signaling and chemotactic genes supports their therapeutic potential in MS.
Article
Medicine, Research & Experimental
Venkata Garlapati, Michael Molitor, Thomas Michna, Gregory S. Harms, Stefanie Finger, Rebecca Jung, Jeremy Lagrange, Panagiotis Efentakis, Johannes Wild, Maike Knorr, Susanne Karbach, Sabine Wild, Ksenija Vujacic-Mirski, Thomas Muenzel, Andreas Daiber, Moritz Brandt, Tommaso Gori, Hendrik Milting, Stefan Tenzer, Wolfram Ruf, Philip Wenzel
Summary: Despite advances in MI interventions, adverse cardiac remodeling and fibrosis leading to IHF remain a major cause of death. A profibrotic coagulation signaling pathway involving MAPK could be targeted for improved cardiac function post-MI. Targeted interventions with trametinib in this pathway show promising results in a murine model.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Hematology
Erica M. Sparkenbaugh, Michael W. Henderson, Megan Miller-Awe, Christina Abrams, Anton Ilich, Fatima Trebak, Nirupama Ramadas, Shantel Vital, Dillon Bohinc, Kara L. Bane, Chunsheng Chen, Margi Patel, Michael Wallisch, Thomas Renne, Andras Gruber, Brian Cooley, David Gailani, Malgorzata Kasztan, Gregory M. Vercellotti, John D. Belcher, Felicity E. Gavins, Evi X. Stavrou, Nigel S. Key, Rafal Pawlinski
Summary: A hypercoagulable state, chronic inflammation, and increased risk of venous thrombosis and stroke are observed in patients with sickle cell disease (SCD). Activation of coagulation factor XII (FXII) and the contact pathway is increased in SCD, leading to enhanced thrombin generation and systemic inflammation. Inhibition of FXII effectively reduces experimental thromboinflammation and vascular complications in a mouse model of SCD, suggesting that it may provide a safe approach for interfering with inflammation, thrombotic complications, and vaso-occlusion in patients with SCD.
Article
Chemistry, Multidisciplinary
Jin Wang, Juan Song, Xian Zhang, Shu-Min Wang, Bin Kang, Xiang-Ling Li, Hong-Yuan Chen, Jing-Juan Xu
Summary: Real-time observation of receptor tyrosine kinases family (RTKs) at single-molecule level based on plasmon rulers enables precise regulation and dynamic monitoring of dimerization process. These nanoprobes show substantial application in regulating RTKs protein dimerization/phosphorylation and activating downstream signaling pathways.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Urology & Nephrology
Raisa Thielemans, Floris Vanommeslaeghe, Ivan Josipovic, Filip De Somer, Katrien Devreese, Matthieu Boone, Wim Van Biesen, Sunny Eloot
Summary: During extended (nocturnal) hemodialysis, the dose of LMWH can be given as a single injection or divided over different time points. This study investigated whether a single injection of LMWH is sufficient to maintain dialyzer fiber patency, and whether anti-Xa accurately predicts fiber blocking. The results showed that there is no need to administer enoxaparin over two injections for ENHD up to 8 hours, and the usefulness of anti-Xa to predict fiber patency can be questioned.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Immunology
Hong-Dien Phan, Modeline N. Longjohn, Delania J. B. Gormley, Reilly H. Smith, May Dang-Lawson, Linda Matsuuchi, Michael R. Gold, Sherri L. Christian
Summary: Extracellular vesicles (EVs) can transfer functional cargo to recipient cells, impacting the physiology of the recipient cells. Stimulation of CD24 or IgM on donor cells leads to transfer of lipids, CD24, and IgM to recipient cells through EVs, providing recipient cells with a second BCR or sensitivity to anti-CD24-induced apoptosis. This transfer of extracellular signals through EVs can change neighboring cells' sensitivity to stimuli, potentially influencing B cell development or activation.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Chih-Yu Wu, Ting-Ying Wu, Zhen-Yu Guan, Peng-Yuan Wang, Yen-Ching Yang, Chao-Wei Huang, Tzu-Hung Lin, Hsien-Yeh Chen
Summary: Current methods for modular assembly of biomaterials have limitations, but the vapor-phase deposition technique presented in this study allows for the fabrication of 3D polymeric materials with biomolecule functionalization, tunable mass transport, and mechanical properties control. The modular scaffolds fabricated demonstrated high cell viability, enhanced cell proliferation, osteogenesis, and neurogenesis, as well as the potential for mass production. Additionally, the scaffolds enabled independent activities of osteogenesis and angiogenesis in separate compartments within the same construct.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Adeola Grace Atobatele, Elisa Tonoli, Jayakumar Vadakekolathu, Maria Pia Savoca, Melissa Barr, Yukti Kataria, Marta Rossanese, Izhar Burhan, Stephanie McArdle, Daniela Caccamo, Elisabetta A. M. Verderio
Summary: In this study, the silencing of transglutaminase-2 (TG2) expression by CRISPR-Cas9 was found to be associated with upregulation of androgen receptor (AR) transcription in prostate cancer (PCa) cell lines. Knockout of TG2 reversed the migratory potential and anchorage independency of PC3 and DU145 cells and revealed a reduced level of mucin-1 (MUC1) RNA transcript through unbiased multi-omics profiling, which was restored by selective add-back of the truncated TG2 isoform (TGM2_v2). It was also discovered that TG2 affects transcriptional regulation of MUC1 via repressing AR expression.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Xiaoyan Tang, Dezheng Chen, Ling Zhang, Ping Fu, Yanxia Chen, Zhou Xiao, Xiangcheng Xiao, Weisheng Peng, Li Cheng, Yanmin Zhang, Hongbo Li, Kehui Li, Bizhen Gou, Xin Wu, Qian Yu, Lijun Jian, Zaizhi Zhu, Yu Wen, Cheng Liu, Hen Xue, Hongyu Zhang, Xin He, Bin Yan, Liping Zhong, Bin Huang, Mingying Mao
Summary: The two-stage regional citrate anticoagulation combined with sequential anticoagulation and standard calcium-containing dialysate can effectively reduce clotting events during hemodialysis, prolong dialysis time, with no significant difference in urea clearance compared to saline flushing.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)