Article
Public, Environmental & Occupational Health
Alice J. Cohen, Lisa Boggio, Henny H. Billett, Maria Teresa DeSancho, Manila Gaddh, Peter Kouides, Ming Lim, Lalitha Nyak, Sandeep Rajan, Rachel Rosovsky, Michael Streiff, Tzu-Fei Wang, Lisa Baumann Kreuziger
Summary: The survey revealed that in North America, there is consistent use of prophylactic low-molecular weight heparin for prevention of pregnancy-associated VTE in low-risk individuals. However, there is a lack of consensus in the use and dosage of anticoagulants in higher-risk individuals, as well as variability in the duration of postpartum prophylaxis. These findings suggest that there is room for improvement in standardizing practices among providers in managing thrombophilia and pregnancy.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Surgery
Angela Liu, John Phair, Leonard Naymagon
Summary: This study found that hereditary thrombophilia (HT) has no significant impact on the risk of recurrent venous thromboembolism (VTE) for patients with first-time lower extremity deep vein thrombosis (DVT). Therefore, routine testing for HT would not be necessary for patients with DVT.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2022)
Article
Medicine, General & Internal
Zeinab El Mawla, Bilal Damen
Summary: Ovarian vein thrombosis (OVT) is a rare condition that is most commonly seen in the immediate postpartum period. Typical symptoms include pelvic pain, fever, and abdominal mass. Early recognition and prompt treatment are crucial due to the potential for fatal complications.
ANNALS OF MEDICINE AND SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Mohammed Alsheef, Yacoub Abuzied, Muteb Alosaimi, Amer Altamimi, Qusai Alwazna, Qusai Almahmood, Noura Ali AlBulushi, Jehan Almutair, Abdul Rehman Zia Zaidi, Jenny Gray, Amani Abu-Shaheen
Summary: Ovarian vein thrombosis (OVT) is a rare condition that mainly occurs in women during their postpartum period, with the right ovarian vein being more commonly affected. Other associated factors include hypertension, diabetes, and a higher body mass index (BMI) of above 25 kg/m2. The most frequent symptoms are abdominal pain and fever. The standard treatment for OVT is the administration of enoxaparin (a low molecular weight heparin) for one to three months, which has a low recurrence rate.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Surgery
Dimitrios Giannis, Georgios Geropoulos, Christos D. Kakos, Weiying Lu, Salim El Hadwe, Massimiliano Fornasiero, Andrew Robertson, Chetan Parmar
Summary: This study aimed to determine the incidence and risk factors of Portomesenteric vein thrombosis (PMVT) in patients undergoing sleeve gastrectomy (SG). The incidence of PMVT was found to be 0.50% and was mainly diagnosed with computed tomography (CT). Advanced age and low center volume were significantly associated with PMVT, while other factors such as gender, BMI, and thromboprophylaxis did not affect the incidence.
Article
Oncology
Marganit Benish, Shai Shrot, Assaf Barg, Iris Kventsel, Ronit Elhasid, Gili Kenet, Sarina Levy-Mendelovich
Summary: This article presents the experience with pediatric ocular venous thrombosis in four patients and discusses recommended management for evaluation and treatment. Thrombophilia workup is suggested for all pediatric patients with RVO or SOVT, and anticoagulation therapy is highly recommended for patients with thrombophilia risk factors or additional thrombi. More research is needed to determine the optimal management strategy.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Gastroenterology & Hepatology
Antonio Guerrero, Laura del Campo, Fabio Piscaglia, Bernhard Scheiner, Guohong Han, Francesco Violi, Carlos-Noronha Ferreira, Luis Tellez, Thomas Reiberger, Stefania Basili, Javier Zamora, Agustin Albillos
Summary: This study used an individual patient data meta-analysis to demonstrate the safety and efficacy of anticoagulation in the recanalization of portal vein thrombosis in patients with cirrhosis. Anticoagulation reduces all-cause mortality, but at the expense of increasing non-portal hypertension-related bleeding.
JOURNAL OF HEPATOLOGY
(2023)
Letter
Medicine, Research & Experimental
Georges El Hasbani, Ali T. Taher
Summary: The inflammatory response caused by SARS-CoV-2 can lead to a prothrombotic state in patients, necessitating specific anticoagulant treatment, especially for those with inherited thrombophilia. Identifying these patients, particularly in susceptible populations like the eastern Mediterranean region, is important for risk assessment in choosing the optimal anticoagulation or antiplatelet plan.
MEDICAL HYPOTHESES
(2021)
Article
Obstetrics & Gynecology
Ippei Takazawa, Daisuke Matsubara, Yoshifumi Takahashi, Shigeki Matsubara
Summary: This case report presents a patient with bilateral ovarian vein thrombosis (OVT) without underlying conditions. Prompt administration of an oral anticoagulant led to symptom improvement and disappearance of OVTs without evidence of pulmonary embolism.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Review
Medicine, General & Internal
Adrianna Marcinkowska, Slawomir Cisiecki, Marcin Rozalski
Summary: RVO is a complex disorder with multifactorial pathogenesis involving vascular, platelet, and hypercoagulable factors. Platelet function and related markers play key roles in RVO diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Obstetrics & Gynecology
Elvira Grandone, Gregory Piazza
Summary: Recurrent pregnancy loss (RPL) is defined as the loss of two or more pregnancies, often due to factors such as aneuploidy, anatomic or physiological abnormalities, and potentially inherited or acquired thrombophilias. Recent research has also suggested a role for systemic inflammation in infertility. Antithrombotic therapy and antiplatelet agents have been proposed as possible tools for preventing RPL, but the multifactorial nature of the condition leads to different diagnostic and therapeutic recommendations among clinicians of various specialties.
SEMINARS IN REPRODUCTIVE MEDICINE
(2021)
Article
Obstetrics & Gynecology
Yoshifumi Takahashi, Shigeki Matsubara, Kohei Tamura, Takahiro Koyanagi, Takahiro Yoshiba, Suzuyo Takahashi, Akiyo Taneichi, Yuji Takei, Yasushi Saga, Hiroyuki Fujiwara
Summary: This is a case report on ovarian vein thrombosis (OVT) after adnexectomy leading to pulmonary embolism (PE). The patient, a woman with early stage endometrial cancer, developed a fever and bilateral OVT was detected on CT scan 12 days after surgery. Anticoagulant and antibacterial therapy was started and the fever subsided, but PE was observed on day 19. PE resolved by day 60. This case highlights the possibility of symptomatic OVT and subsequent PE after adnexectomy and suggests the consideration of anticoagulation therapy.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2023)
Editorial Material
Urology & Nephrology
Katsuyuki Tanabe, Jota Maki, Hikari Nakatou
Summary: A 30-year-old pregnant woman developed postpartum HELLP syndrome with thrombosis in the right inferior renal capsular vein. This rare thrombotic disorder in postpartum women may be predisposed by hypercoagulability related to pregnancy complications. Recognizing the potential risk for pulmonary embolism in rare pregnancy-related thrombosis is crucial.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2021)
Article
Multidisciplinary Sciences
Nicola Mumoli, Francesco Dentali, Giulia Conte, Alessandra Colombo, Riccardo Capra, Cesare Porta, Giuseppe Rotiroti, Francesca Zuretti, Marco Cei, Flavio Tangianu, Isabella Evangelista, Jose Vitale, Antonino Mazzone, Igor Giarretta
Summary: This study investigated the incidence of upper extremity deep vein thrombosis (UEDVT) in patients with moderate to severe COVID-19 infection and found that patients requiring helmet continuous positive airway pressure (CPAP) ventilation were at higher risk of developing UEDVT, which was associated with increased mortality.
Review
Medicine, General & Internal
Sarah Cheah, Yijun Gao, Shirley Mo, Georgia Rigas, Oliver Fisher, Daniel L. Chan, Michael G. Chapman, Michael L. Talbot
Summary: Obesity in pregnant women in Australia is common, with bariatric surgery recommended to improve fertility and pregnancy outcomes. Pregnancy should be delayed after surgery, contraception methods may need to change, and close monitoring for nutritional deficiencies is important throughout pregnancy.
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Article
Obstetrics & Gynecology
Amihai Rottenstreich, Neta Gochman, Geffen Kleinstern, Gabriel Levin, Yishay Sompolinsky, Misgav Rottenstreich, Hen Y. Sela, Simcha Yagel, Shay Porat
Summary: This retrospective study found that dynamic cervical shortening is associated with an increased risk of preterm birth, especially when the minimal cervical length is measured. The rates of spontaneous preterm birth were significantly higher in those with dynamic cervix compared to the control group matched for maximal cervical length, and similar to the control group matched for minimal cervical length. The value of cervical length as a negative predictor of preterm birth is limited in the setting of dynamic cervical change.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Oncology
Geffen Kleinstern, J. Brice Weinberg, Sameer A. Parikh, Esteban Braggio, Sara J. Achenbach, Dennis P. Robinson, Aaron D. Norman, Kari G. Rabe, Nicholas J. Boddicker, Celine M. Vachon, Connie E. Lesnick, Timothy G. Call, Danielle M. Brander, Laura Z. Rassenti, Thomas J. Kipps, Janet E. Olson, James R. Cerhan, Neil E. Kay, Richard R. Furman, Curtis A. Hanson, Tait D. Shanafelt, Susan L. Slager
Summary: This study found significant associations between 41 CLL susceptibility variants and CLL-PRS with MBL risk, while little evidence of any association between MBL risk and environmental factors was observed. The CLL-PRS showed significant associations with EA-CLL risk and AA-CLL risk, indicating the need for further research in this population.
Article
Obstetrics & Gynecology
Naama Lessans, Stav Martonovits, Misgav Rottenstreich, Simcha Yagel, Geffen Kleinstern, Hen Y. Sela, Shay Porat, Gabriel Levin, Joshua Rosenbloom, Yosef Ezra, Amihai Rottenstreich
Summary: Spontaneous labor onset, epidural anesthesia, and prior cesarean delivery due to non-arrest disorders are independently associated with higher vaginal birth after cesarean rate among women delivering a macrosomic fetus, with overall favorable success rate in the presence of these factors.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Geffen Kleinstern, Roy Zigron, Shay Porat, Joshua Rosenbloom, Misgav Rottenstreich, Yishay Sompolinsky, Amihai Rottenstreich
Summary: The duration of the second stage of labor in a first term vaginal delivery is not associated with subsequent spontaneous preterm birth (sPTB). However, there is an increased risk of sPTB following a second-stage cesarean section, especially if performed after a prolonged second stage.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Oncology
Geffen Kleinstern, Melissa C. Larson, Stephen M. Ansell, Carrie A. Thompson, Grzegorz S. Nowakowski, Timothy G. Call, Dennis P. Robinson, Matthew J. Maurer, Raphael Mwangi, Andrew L. Feldman, Neil E. Kay, Anne J. Novak, Thomas M. Habermann, Susan L. Slager, James R. Cerhan
Summary: This study investigated the association between vaccinations and the risk of different lymphoma subtypes. The results showed that vaccinations against influenza and yellow fever were inversely associated with lymphoma risk. However, the association between hepatitis B vaccination and lymphoma risk was complex. These findings suggest that the vaccination-related lymphoma risk may vary depending on the time since vaccination and the type of vaccine.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Immunology
Amihai Rottenstreich, Gila Zarbiv, Esther Oiknine-Djian, Olesya Vorontsov, Roy Zigron, Geffen Kleinstern, Dana G. Wolf, Shay Porat
Summary: Maternal antibody levels and transplacental antibody transfer vary based on the gestational age at the time of SARS-CoV-2 vaccination, with lowest levels observed in those vaccinated in the first trimester. A third booster dose may enhance antibody levels and could be beneficial for those who completed the 2-dose vaccine series early in pregnancy.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Amihai Rottenstreich, Gila Zarbiv, Esther Oiknine-Djian, Olesya Vorontsov, Roy Zigron, Geffen Kleinstern, Dana G. Wolf, Shay Porat
Summary: This study aimed to evaluate the impact of maternal vaccination against SARS-CoV-2 in early versus late third trimester on transplacental transfer and neonatal levels of antibodies. The results showed that early vaccination in pregnancy enhanced transplacental antibody transfer and increased neonatal neutralizing antibody levels, indicating that early vaccination in the third trimester may enhance neonatal immune protection.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Letter
Oncology
Nicholas J. Boddicker, Sara J. Achenbach, Sameer A. Parikh, Geffen Kleinstern, Esteban Braggio, Aaron D. Norman, Kari G. Rabe, Celine M. Vachon, Connie E. Lesnick, Timothy G. Call, Janet E. Olson, James R. Cerhan, Neil E. Kay, Curtis A. Hanson, Tait D. Shanafelt, Susan L. Slager
Article
Immunology
Amihai Rottenstreich, Olesya Vorontsov, Or Alfi, Gila Zarbiv, Esther Oiknine-Djian, Roy Zigron, Geffen Kleinstern, Michal Mandelboim, Shay Porat, Dana G. Wolf
Summary: Neutralization efficiency against SARS-CoV-2 Omicron variant was evaluated in maternal and cord blood sera after antenatal BNT162b2 vaccination. The study found that neutralizing antibodies against Omicron were not present at the time of delivery after two doses of vaccination. Thus, a third booster dose was necessary to build neutralizing antibody capacity against Omicron in mothers and neonates.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Oncology
Geffen Kleinstern, Dirk R. Larson, Cristine Allmer, Aaron D. Norman, Grace Muntifering, Jason Sinnwell, Alissa Visram, Vincent Rajkumar, Angela Dispenzieri, Robert A. Kyle, Susan L. Slager, Shaji Kumar, Celine M. Vachon
Summary: High body mass index is a prognostic factor for the progression of MGUS, and this association may be stronger among females.
BLOOD CANCER JOURNAL
(2022)
Article
Hematology
Celine M. Vachon, Josiah Murray, Cristine Allmer, Dirk Larson, Aaron D. Norman, Jason P. Sinnwell, Angela Dispenzieri, Geffen Kleinstern, Alissa Visram, Robert A. Kyle, S. Vincent Rajkumar, Susan L. Slager, Shaji K. Kumar, David L. Murray
Summary: Mass-spectrometry (MS) assays can detect monoclonal gammopathy of undetermined significance (MGUS) at an earlier stage, and the prevalence of heavy chain MGUS is higher in African Americans and first-degree relatives of patients with hematologic disorders. The MALDI-TOF assay can identify more cases of MGUS compared to conventional gel-based methods, but the relative differences based on race, family history, and age are similar to prior studies.
Article
Hematology
Susan L. Slager, Sameer A. Parikh, Sara J. Achenbach, Aaron D. Norman, Kari G. Rabe, Nicholas J. Boddicker, Janet E. Olson, Geffen Kleinstern, Connie E. Lesnick, Timothy G. Call, James R. Cerhan, Celine M. Vachon, Neil E. Kay, Esteban Braggio, Curtis A. Hanson, Tait D. Shanafelt
Summary: Monoclonal B-cell lymphocytosis (MBL) is a common hematological premalignant condition that is associated with a fourfold increased risk of lymphoid malignancies in individuals with low-count MBL (LC-MBL).
Article
Immunology
Amihai Rottenstreich, Gila Zarbiv, Esther Oiknine-Djian, Olesya Vorontsov, Roy Zigron, Geffen Kleinstern, Shay Porat, Dana G. Wolf
Summary: This study investigated the durability of maternally-derived anti-SARS-CoV-2 antibodies in infants following antenatal BNT162b2 vaccination. The results showed that maternal vaccination led to efficient transplacental transfer of antibodies, with persistent anti-SARS-CoV-2 antibodies detected at 3 months of age in all infants. Furthermore, the timing of antenatal immunization had an impact on the kinetics and concentration of maternally-derived antibodies.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Oncology
Terry Boyle, Geffen Kleinstern, Paige M. Bracci, James R. Cerhan, Yolanda Benavente, Delphine Casabonne, Brian C-H Chiu, Thomas M. Habermann, Elizabeth A. Holly, Mark Liebow, Aaron Norman, Ora Paltiel, Dennis Robinson, Nathaniel Rothman, Rania Abu Seir, Susan L. Slager, Paul J. Villeneuve, Sophia S. Wang, Dennis D. Weisenburger, John J. Spinelli
Summary: This study, which pooled data from nine case-control studies, found that moderate-to-vigorous intensity physical activity can reduce the risk of non-Hodgkin lymphoma.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Correction
Oncology
Sonja I. Berndt, Joseph Vijai, Yolanda Benavente, Nicola J. Camp, Alexandra Nieters, Zhaoming Wang, Karin E. Smedby, Geffen Kleinstern, Henrik Hjalgrim, Caroline Besson, Christine F. Skibola, Lindsay M. Morton, Angela R. Brooks-Wilson, Lauren R. Teras, Charles Breeze, Joshua Arias, Hans-Olov Adami, Demetrius Albanes, Kenneth C. Anderson, Stephen M. Ansell, Bryan Bassig, Nikolaus Becker, Parveen Bhatti, Brenda M. Birmann, Paolo Boffetta, Paige M. Bracci, Paul Brennan, Elizabeth E. Brown, Laurie Burdett, Lisa A. Cannon-Albright, Ellen T. Chang, Brian C. H. Chiu, Charles C. Chung, Jacqueline Clavel, Pierluigi Cocco, Graham Colditz, Lucia Conde, David V. Conti, David G. Cox, Karen Curtin, Delphine Casabonne, Immaculata De Vivo, Arjan Diepstra, W. Ryan Diver, Ahmet Dogan, Christopher K. Edlund, Lenka Foretova, Joseph F. Fraumeni, Attilio Gabbas, Herve Ghesquieres, Graham G. Giles, Sally Glaser, Martha Glenn, Bengt Glimelius, Jian Gu, Thomas M. Habermann, Christopher A. Haiman, Corinne Haioun, Jonathan N. Hofmann, Theodore R. Holford, Elizabeth A. Holly, Amy Hutchinson, Aalin Izhar, Rebecca D. Jackson, Ruth F. Jarrett, Rudolph Kaaks, Eleanor Kane, Laurence N. Kolonel, Yinfei Kong, Peter Kraft, Anne Kricker, Annette Lake, Qing Lan, Charles Lawrence, Dalin Li, Mark Liebow, Brian K. Link, Corrado Magnani, Marc Maynadie, James McKay, Mads Melbye, Lucia Miligi, Roger L. Milne, Thierry J. Molina, Alain Monnereau, Rebecca Montalvan, Kari E. North, Anne J. Novak, Kenan Onel, Mark P. Purdue, Kristin A. Rand, Elio Riboli, Jacques Riby, Eve Roman, Gilles Salles, Douglas W. Sborov, Richard K. Severson, Tait D. Shanafelt, Martyn T. Smith, Alexandra Smith, Kevin W. Song, Lei Song, Melissa C. Southey, John J. Spinelli, Anthony Staines, Deborah Stephens, Heather J. Sutherland, Kaitlyn Tkachuk, Carrie A. Thompson, Herve Tilly, Lesley F. Tinker, Ruth C. Travis, Jenny Turner, Celine M. Vachon, Claire M. Vajdic, Anke Van den Berg, David J. Van den Berg, Roel C. H. Vermeulen, Paolo Vineis, Sophia S. Wang, Elisabete Weiderpass, George J. Weiner, Stephanie Weinstein, Nicole Wong Doo, Yuanqing Ye, Meredith Yeager, Kai Yu, Anne Zeleniuch-Jacquotte, Yawei Zhang, Tongzhang Zheng, Elad Ziv, Joshua Sampson, Nilanjan Chatterjee, Kenneth Offit, Wendy Cozen, Xifeng Wu, James R. Cerhan, Stephen J. Chanock, Susan L. Slager, Nathaniel Rothman
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
