Article
Peripheral Vascular Disease
Tatsuya Maruhashi, Masato Kajikawa, Shinji Kishimoto, Takayuki Yamaji, Takahiro Harada, Yu Hashimoto, Aya Mizobuchi, Shunsuke Tanigawa, Farina Mohamad Yusoff, Yukiko Nakano, Kazuaki Chayama, Ayumu Nakashima, Chikara Goto, Yukihito Higashi
Summary: This study investigated the associations of vascular function with season and outdoor temperature. The results showed no significant correlation between vascular function and season or outdoor temperature.
HYPERTENSION RESEARCH
(2023)
Article
Cell & Tissue Engineering
Liping Su, Xiaocen Kong, Szejie Loo, Yu Gao, Bingli Liu, Xiaofei Su, Rinkoo Dalan, Jianhua Ma, Lei Ye
Summary: This study aimed to evaluate the effect of thymosin beta-4 (Tb-4) on endothelial function using diabetic human induced pluripotent stem cell derived endothelial cells (dia-hiPSC-ECs) as a model. The results showed that Tb-4 improved endothelial dysfunction by enhancing cell viability, reducing senescence and endothelin-1 production, and improving angiogenic potency in diabetes.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Liping Su, Xiaocen Kong, Sze Jie Loo, Yu Gao, Jean-Paul Kovalik, Xiaofei Su, Jianhua Ma, Lei Ye
Summary: By studying hiPSC-ECs derived from patients with type 2 diabetes mellitus, researchers found that these cells exhibited disrupted glycine homeostasis, increased senescence, impaired mitochondrial function, and reduced angiogenic potential compared to healthy hiPSC-ECs. These signature phenotypes can help establish dia-hiPSC-ECs as a model for endothelial dysfunction in diabetes and facilitate the identification and testing of new targets for treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Peripheral Vascular Disease
Xin Wen, Yidi Peng, Bohao Zheng, Shaying Yang, Jing Han, Fan Yu, Tingting Zhou, Li Geng, Zhiming Yu, Lei Feng
Summary: Silybin, extracted from Silybum marianum seeds, has been used as a dietary supplement for hepatic diseases and metabolic syndrome. This study found that silybin can activate TRPV4 channels, leading to calcium influx and improved vascular dilation and decreased blood pressure.
HYPERTENSION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yuji Takaeko, Tatsuya Maruhashi, Masato Kajikawa, Shinji Kishimoto, Takayuki Yamaji, Takahiro Harada, Yu Hashimoto, Yiming Han, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Farina Mohamad Yusoff, Kenichi Yoshimura, Ayumu Nakashima, Yukihito Higashi
Summary: Subjects with extremely low levels of triglycerides (<50 mg/dL) have the highest flow-mediated vasodilation (FMD) values and better endothelial function.
JOURNAL OF CLINICAL LIPIDOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ewa Rudnicka-Drozak, Paulina Drozak, Grzegorz Mizerski, Martyna Drozak
Summary: Endothelial progenitor cells (EPCs) play an important role in neurovascular disorders and have potential therapeutic applications. Decreased levels of EPCs are associated with worse disease outcomes. EPCs show promising safety and efficacy in the treatment of Alzheimer's disease and ischemic stroke.
Article
Cardiac & Cardiovascular Systems
Thaysa Ghiarone, Jorge A. Castorena-Gonzalez, Christopher A. Foote, Francisco I. Ramirez-Perez, Larissa Ferreira-Santos, Francisco J. Cabral-Amador, Roger de la Torre, Rama R. Ganga, Andrew A. Wheeler, Camila Manrique-Acevedo, Jaume Padilla, Luis A. Martinez-Lemus
Summary: This study investigates the involvement of ADAM17 in causing impaired insulin-induced vasodilation in type 2 diabetes (T2D). It provides evidence that ADAM17 activity is increased in the vasculature of T2D patients and supports the notion that ADAM17-mediated shedding of endothelial IRa ectodomains is a novel mechanism causing vascular insulin resistance. Targeting ADAM17 activity may be a potential therapeutic strategy to correct vascular insulin resistance in T2D.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Takayuki Yamaji, Takahiro Harada, Yu Hashimoto, Yukiko Nakano, Masato Kajikawa, Kenichi Yoshimura, Chikara Goto, Aya Mizobuchi, Shunsuke Tanigawa, Farina Mohamad Yusoff, Shinji Kishimoto, Tatsuya Maruhashi, Ayumu Nakashima, Yukihito Higashi
Summary: This study investigated the relationship between daily coffee intake and vascular function in patients with hypertension. The findings suggest that moderate coffee consumption may have beneficial effects on endothelial function and vascular smooth muscle function in these patients.
Article
Cardiac & Cardiovascular Systems
Adrian H. Chester, Ann McCormack, Edmund J. Miller, Mohamed N. Ahmed, Magdi H. Yacoub
Summary: This study demonstrates that ChAT-expressing T cells can induce vasodilation in the coronary circulation, relying on a direct interaction between T cells and coronary vascular endothelium. This suggests a potential immunomodulatory role for T cells in the coronary circulation, with implications for coronary blood flow and myocardial ischemic events.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Christopher J. Garland, Kim A. Dora
Summary: Research on endothelium-derived hyperpolarizing factor (EDHF) has revealed the complexity of signaling in small arteries, including the origin of chemical and electrical signals within endothelial cells, evolving into a broader EDH signaling concept. The importance of myoendothelial feedback loop and the bidirectional signaling supported by MEJs help regulate vasoreactivity and optimize blood flow by enabling sinusoidal vasomotion.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Simon Toupance, Stephanie Simonici, Carlos Labat, Chloe Dumoulin, Tsung-Po Lai, Cecile Lakomy, Veronique Regnault, Patrick Lacolley, Francoise Dignat George, Florence Sabatier, Abraham Aviv, Athanase Benetos
Summary: The study found that individuals with longer telomeres have more self-renewing endothelial colony-forming cells. White blood cell telomere length can serve as a surrogate marker for endothelial repair capacity in clinical and laboratory practice, with potential applications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Michael Warkala, Dongying Chen, AnnJosette Ramirez, Ali Jubran, Michael Schonning, Xia Wang, Huaning Zhao, Sophie Astrof
Summary: The development of the fourth pharyngeal arch arteries involves a multistep process with contributions from SHF-derived ECs, remodeling of endothelial plexus into PAAs, and remodeling of PAAs into the aortic arch artery and its major branches. Cell-ECM interactions regulated by integrin alpha 5 beta 1 and Fn1 are essential at each developmental stage.
CIRCULATION RESEARCH
(2021)
Article
Peripheral Vascular Disease
Lauren A. Biwer, Brigett V. Carvajal, Qing Lu, Joshua J. Man, Iris Z. Jaffe
Summary: The study showed that deletion of endothelial MR in obese female animals can improve vascular dilation, and endothelial ER alpha plays a positive role in increasing nitric oxide to rescue vasodilation. MR and ER alpha may compete for striatin binding within endothelial cells to regulate NO.
Article
Physiology
Frederik Boe Hansen, Goncalo Valongueiro Esteves, Susie Mogensen, Judit Prat-Duran, Niels Secher, Bo Lofgren, Asger Granfeldt, Ulf Simonsen
Summary: This study demonstrated enhanced endothelium-dependent vasodilation in middle cerebral arteries 4 hours after cardiac arrest, mediated by potentiated endothelium-derived hyperpolarization and endothelial nitric oxide pathways. In mesenteric arteries, endothelium-dependent vasodilation was comparable between the 2 and 4-hour groups.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Klara Komici, Angelica Perna, Germano Guerra
Summary: Frailty is a clinical condition characterized by a decline in biological reserves, physiological mechanism failure, and vulnerability to stressors. This review focuses on the role of endothelial progenitor cells (EPCs) in frailty, highlighting their impaired function, number, and survival in the elderly. It also discusses the modification of EPCs in age-related diseases such as atherosclerosis, hypertension, and diabetes mellitus. The review concludes by exploring interventions that may restore EPCs expression and function in frail individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)