Article
Gastroenterology & Hepatology
Yan Xue, Meng Zhang, Tao Li, Feng Liu, Li-Xin Zhang, Xiao-Ping Fan, Bao-Hua Yang, Lei Wang
Summary: In HBeAg-positive CHB patients with HBeAg loss, the consolidation period and HBsAg level at cessation were significant predictors of virological relapse after discontinuation of NAs. Patients with HBeAg seroconversion had lower cumulative relapse rates. Careful monitoring, especially in the early stages after cessation, may lead to a favorable outcome.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Public, Environmental & Occupational Health
Mian Wang, Mingxia Qian, Rongrong Fu, Yiqin Zhang, Xinlan Shen, Dengyuan Yue, Ning Wang, Lei Yang
Summary: This study compared the long-term outcomes between CHB patients who discontinued nucleos(t)ide analogs therapy and those who continued it, revealing that off-therapy patients had a higher risk of ALT flares-up and virological abnormalities. However, there were no significant differences in hyperbilirubinemia, hepatic decompensation, and HCC development between the two groups.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Yachao Tao, Menglan Wang, Juan Liao, Xing Cheng, Min He, Dongmei Zhang, Taoyou Zhou, Jie Chen, Enqiang Chen, Hong Tang
Summary: This study found that serum pgRNA levels were strongly correlated with HBV DNA and HBsAg levels. Low levels of serum pgRNA before treatment may indicate a high probability of HBeAg seroconversion. The baseline serum pgRNA level could serve as a novel predictor for HBeAg seroconversion.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jyun-Yi Wu, Yi-Shan Tsai, Chia-Chen Li, Ming-Lun Yeh, Ching- Huang, Chung-Feng Huang, Jia-Ning Hsu, Meng-Hsuan Hsieh, Yo-Chia Chen, Ta-Wei Liu, Yi-Hung Lin, Po-Cheng Liang, Zu-Yau Lin, Wan-Long Chuang, Ming-Lung Yu, Chia-Yen Dai
Summary: This study aimed to investigate the association between serum miR-125b and liver fibrosis progression in chronic hepatitis B (CHB) patients after nucleos(t)ide analog (NA) treatment. The results showed that baseline miR-125b levels were inversely correlated with the post-treatment FIB-4 index. Age, baseline platelet level, and ALT level were identified as independent predictors of higher FIB-index after 12-month treatment. In patients receiving entecavir (ETV) monotherapy, the alteration of serum miR-125b and age were significantly associated with higher post-treatment FIB-4 index.
Article
Gastroenterology & Hepatology
Jia-Horng Kao, Wen-Juei Jeng, Qin Ning, Tung-Hung Su, Tai-Chung Tseng, Yoshiyuki Ueno, Man-Fung Yuen
Summary: Chronic HBV infection is currently incurable and long-term treatment with NAs can reduce complications, but stopping treatment may lead to virological relapse and adverse outcomes. Close monitoring and personalized follow-up strategies are essential for a safe cessation of NA therapy.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Virology
Shun Kaneko, Masayuki Kurosaki, Toshie Mashiba, Hiroyuki Marusawa, Masahiko Kondo, Yuji Kojima, Yasushi Uchida, Hideki Fujii, Takehiro Akahane, Hitoshi Yagisawa, Atsunori Kusakabe, Haruhiko Kobashi, Takehiko Abe, Hideo Yoshida, Chikara Ogawa, Koichiro Furuta, Nobuharu Tamaki, Keiji Tsuji, Tomomichi Matsushita, Namiki Izumi
Summary: This study aimed to identify the risk factors for HCC development in naive CHB patients treated with current NA. Age, cirrhosis, baseline platelet counts, ALBI score, and AFP one year after NA therapy were found to be independent predictive factors for HCC development. The aMAP and REAL-B scores demonstrated high accuracy in predicting HCC development.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Gastroenterology & Hepatology
Wen-Xiong Xu, Yang-Mei Li, Jian-Guo Li, Yong-Yu Mei, You-Ming Chen, Xue-Jun Li, Chao-Shuang Lin, Hong Deng, Zhi-Xin Zhao, Dong-Ying Xie, Zhi-Liang Gao, Liang Peng
Summary: CHB patients have four types of clinical outcomes after cessation of NA treatment, with different risk factors for relapse that need further exploration. The EOT HBsAg level is independently associated with both virological and clinical relapse.
GASTROENTEROLOGY REPORT
(2021)
Article
Gastroenterology & Hepatology
Florian van Boemmel, Kerstin Stein, Renate Heyne, Joerg Petersen, Peter Buggisch, Christoph Berg, Stefan Zeuzem, Andreas Stallmach, Martin Sprinzl, Eckart Schott, Anita Pathil-Warth, Ulrike von Arnim, Verena Keitel, Juergen Lohmeyer, Karl-Georg Simon, Christian Trautwein, Andreas Trein, Dietrich Hueppe, Markus Cornberg, Frank Lammert, Patrick Ingiliz, Reinhart Zachoval, Holger Hinrichsen, Alexander Zipprich, Hartmuth Klinker, Julian Schulze zur Wiesch, Anett Schmiedeknecht, Oana Brosteanu, Thomas Berg
Summary: Stopping NUC treatment can achieve a higher rate of HBsAg loss compared to continued treatment, especially for patients with end of treatment HBsAg levels <1,000 IU/ml.
JOURNAL OF HEPATOLOGY
(2023)
Article
Immunology
Tong Yu, Miaoqu Zhang, Hanyue Zhang, Jianming Zheng, Chuan Shen, Ning Jiang, Lei Zou, Jing Wang, Yiqi Yu, Qiran Zhang, Shuili Yu, Yanfang Huang, Yuxian Huang, Jiming Zhang, Chao Qiu, Wenhong Zhang, Zhefeng Meng
Summary: Our findings indicate that residual HBV replication persists in chronic hepatitis B patients who have been successfully treated with nucleos(t)ide analogues. It may take many years or even lifelong treatment to effectively eliminate HBV, considering the estimated half-life of cccDNA.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Microbiology
Fa-Da Wang, Jing Zhou, Lan-Qing Li, Meng-Lan Wang, Ya-Cao Tao, Yong-Hong Wang, Dong-Mei Zhang, En-Qiang Chen
Summary: This study aimed to investigate the role of serum pregenomic RNA (pgRNA) and hepatitis B core-related antigen (HBcrAg) at the end of treatment (EOT) in guiding the safe discontinuation of nucleos(t)ide analogs (NAs) in chronic hepatitis B (CHB) patients.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Shi Liu, Rui Deng, Bin Zhou, Xieer Liang, Zhihong Liu, Jie Peng, Jinjun Chen, Yuanping Zhou, Yabing Guo, Yongpeng Chen, Wanying Li, Sheng Shen, Xingyu Lu, Siru Zhao, Xingmei Liao, Hongyan Liang, Yu Lan, Jinlin Hou, Rong Fan, Jian Sun
Summary: High levels of serum HBV RNA are associated with increased risk of hepatocellular carcinoma in chronic hepatitis B patients. Achieving undetectable HBV RNA may be a valuable endpoint of antiviral treatment.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Jin Shang, Huan Liu, Qin Wen, Rili M. Ise, You Tu, Lang Bai, Hong Tang
Summary: In this study, nucleos(t)ide analogue therapy with TDF was found to be more effective than LDT during pregnancy in women with chronic hepatitis B, and showed no evidence of renal toxicity. The use of nucleos(t)ide analogue therapy during pregnancy did not significantly impact the long-term physical development and bone development of children.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Letter
Gastroenterology & Hepatology
Yao-Chun Hsu, Mindie H. Nguyen, Chun-Ying Wu
Summary: This article is linked to papers by Hsu et al. To view these articles, please visit and browse.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Huei-Ru Cheng, Hung-Chih Yang, Su-Ru Lin, Ta-Yu Yang, You-Yu Lin, Tung-Hung Su, Tai-Chung Tseng, Chun-Jen Liu, Jia-Horng Kao
Summary: The diversity of viral quasispecies and the concentration of HBcrAg at the end of treatment can predict virological relapse within 1 year after stopping therapy. Low baseline viral nucleotide diversity and high HBcrAg concentration are associated with a higher risk of relapse.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Infectious Diseases
Guichan Liao, Ziying Liu, Muye Xia, Hongjie Chen, Houji Wu, Bing Li, Tao Yu, Shaohang Cai, Xiaoyong Zhang, Jie Peng
Summary: The significance of circulating soluble PD-1 (sPD-1) in patients with chronic hepatitis B who have discontinued long-term nucleos(t)ide analog (NA) treatment remains unknown. This study aimed to investigate the importance of sPD-1 levels in predicting clinical relapse and HBsAg loss after treatment discontinuation in patients with chronic hepatitis B. The results showed that sPD-1 levels at the end of treatment can be used to predict clinical relapse and HBsAg loss, and may help guide the treatment plan for patients with chronic hepatitis B virus infection.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Cardiac & Cardiovascular Systems
Yinan Wang, Yiming Jia, Qingyun Xu, Ruirui Wang, Lulu Sun, Daoxia Guo, Mengyao Shi, Pinni Yang, Yu Wang, Fanghua Liu, Yonghong Zhang, Zhengbao Zhu
Summary: This study used a two-sample Mendelian randomization (MR) approach to investigate the potential causal effect of myeloperoxidase (MPO) on ischemic stroke, ischemic stroke subtypes, heart failure (HF), and atrial fibrillation (AF). The results suggest that elevated plasma MPO levels may be associated with increased risks of ischemic stroke, cardioembolic stroke, HF, and AF, highlighting the importance of MPO in the development of cardiovascular disease.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Rheumatology
Xing-Bo Mo, Yang-Hua Sun, Long-Fei Wu, Pei He, Rong-Rong Cao, Xin Lu, Yong-Hong Zhang, Fei-Yan Deng, Shu-Feng Lei
Summary: This study identified a novel lncRNA, lnc-RNU12, that is downregulated and genetically associated with rheumatoid arthritis (RA) risk in patients. The results showed that lnc-RNU12 influences the T cell cycle by targeting the genes c-JUN and CCNL2, suggesting its involvement in the pathogenesis of RA.
Article
Clinical Neurology
Zhengbao Zhu, Daoxia Guo, Kaixin Zhang, Pinni Yang, Yiming Jia, Mengyao Shi, Yanbo Peng, Jing Chen, Aili Wang, Tan Xu, Yonghong Zhang, Jiang He
Summary: Plasma osteoprotegerin is associated with poor prognosis of ischemic stroke. High levels of plasma osteoprotegerin are associated with increased risk of death and major disability. Genetically determined high plasma osteoprotegerin is associated with an increased risk of primary outcome.
Article
Clinical Neurology
Shoujiang You, Yucong Bi, Mengyuan Miao, Anran Bao, Jigang Du, Tan Xu, Chun-Feng Liu, Yonghong Zhang, Jiang He, Yongjun Cao, Chongke Zhong
Summary: This study investigated the association between plasma soluble DPP4 (sDPP4) levels and poststroke cognitive impairment (PSCI). The results showed that higher plasma sDPP4 levels were associated with decreased risk of cognitive impairment after noncardioembolic ischemic stroke. Adding sDPP4 to the basic model significantly improved risk reclassification for PSCI. Therefore, plasma sDPP4 levels play an important predictive role in the development of cognitive impairment after noncardioembolic ischemic stroke.
Article
Clinical Neurology
Jigang Du, Yan Wang, Bizhong Che, Mengyuan Miao, Anran Bao, Yanbo Peng, Zhong Ju, Tan Xu, Jiang He, Yonghong Zhang, Chongke Zhong
Summary: This study utilized repeated measures of the National Institutes of Health Stroke Scale (NIHSS) to identify different trajectories of neurological function after stroke and investigated their association with long-term clinical outcomes. The findings revealed that trajectories characterized by persistent severe and moderate neurological impairment were associated with increased risk of cardiovascular events. These results suggest that evaluating the neurological function trajectories of stroke patients through repeated NIHSS measurements can provide additional predictive information and aid in predicting long-term clinical outcomes.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Immunology
Qiongyu Chen, Yan Zhao, Yonghong Zhang, Jianbo Zhang, Wenshu Lu, Chih-Hao Chang, Shisong Jiang
Summary: The human immunodeficiency virus (HIV) is a global pandemic with no cure identified yet. HIV-induced death of lymphocytes involves both necrosis and apoptosis. A pro-apoptotic TNF peptide (P13) inhibits HIV-related cell death and viral transmission, while a pro-necrotic TNF peptide (P16) has little effect. Understanding cell death mechanisms may provide drug targets to reduce CD4(+) cell loss and viral reservoir formation in HIV infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yonghong Zhang, Zhaozhao Liu, Haixiang Sun
Summary: A successful human pregnancy requires the maternal immune system to recognize and tolerate the semi-allogeneic fetus. Dysfunctional maternal-fetal interactions might be associated with the development of pregnancy complications. This review elaborates the interactions between trophoblasts and decidual immune cells, and the role of commensal bacteria in promoting pregnancy progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Zhuo Wang, Wenjie Ge, Yonghong Zhang, Bo Liu, Bin Liu, Shikai Jin, Yuzhu Li
Summary: Animal joint motion is a combination of rotation and translational motion, bringing advantages such as high stability and energy utilization. However, the simple motion characteristic of the hinge joint limits the improvement of the robot's motion performance. In this paper, a new bionic geared five-bar knee joint mechanism based on the kangaroo knee joint is proposed to improve energy utilization and reduce power demand.
BIOENGINEERING-BASEL
(2023)
Article
Clinical Neurology
Bizhong Che, Chongke Zhong, Jigang Du, Mengyuan Miao, Mengyao Shi, Yanbo Peng, Pinni Yang, Daoxia Guo, Jing Chen, Aili Wang, Tan Xu, Yonghong Zhang, Jiang He
Summary: This study aimed to examine the prognostic values of CCL19 and CCL21 in ischemic stroke. The results showed that both CCL19 and CCL21 levels were independently associated with adverse outcomes within 3 months after ischemic stroke, and could improve risk reclassification and discrimination for adverse outcomes.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fanghua Liu, Pinni Yang, Yinan Wang, Mengyao Shi, Ruirui Wang, Qingyun Xu, Yanbo Peng, Jing Chen, Jintao Zhang, Aili Wang, Tan Xu, Yonghong Zhang, Jiang He
Summary: This study investigated the relationship between baseline platelet count and HS-CRP on clinical outcomes in patients with ischemic stroke. The results showed an interaction effect between platelet count and HS-CRP on adverse clinical outcomes. Elevated platelet count was significantly associated with adverse clinical outcomes in patients with high HS-CRP levels. Strategies for anti-inflammatory and antiplatelet therapy should be developed based on platelet and HS-CRP testing results.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Immunology
Yonghong Zhang, Huiyan Wang, Panpan Qiu, Jingwen Jiang, Xuhong Wu, Jie Mei, Haixiang Sun
Summary: Placental trophoblasts play a role in the regulation of regulatory T cells through the PD-1/PD-L1 pathway, and decreased expression of PD-L1 in trophoblasts is associated with Treg deficiency in pregnancy failure. YY1 modulates the expression of PD-L1 in trophoblasts, and elevated levels of NO from M1 macrophages may lead to reduced YY1 expression in recurrent miscarriage.
FRONTIERS IN IMMUNOLOGY
(2023)
Correction
Immunology
Yonghong Zhang, Zhaozhao Liu, Haixiang Sun
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Aerospace
Yonghong Zhang, Chengmin Wang, Shuangquan Tang, You Jiang, Hong Chen, Wenjie Ge
Summary: This study investigates and designs a novel stacked hinge with low stiffness, large rotation angle, high strength, and length-adaptive functionality. A theoretical model for the stiffness of stacked flexure hinges is established based on the large deformation theory of cantilever beams and relevant theories of leaf springs. The model is further modified considering the frictional force to reduce errors. A stiffness-testing experimental platform is designed to verify the correctness of the theoretical model. The stacked flexure hinge is applied to the trailing-edge mechanism of a variable camber wing, achieving the desired deformation and demonstrating feasibility.
Meeting Abstract
Biochemistry & Molecular Biology
Yonghong Zhang
Article
Oncology
Yu Wang, Fanghua Liu, Lulu Sun, Yiming Jia, Pinni Yang, Daoxia Guo, Mengyao Shi, Aili Wang, Guo-Chong Chen, Yonghong Zhang, Zhengbao Zhu
Summary: This study conducted a systematic Mendelian randomization analysis to identify potential causal mediators for breast cancer. The findings suggest that high-density lipoprotein cholesterol (HDL-C) and acetate may play a role in the risk of developing breast cancer. Furthermore, the analysis of side effects indicates that lowering HDL-C may have negative effects on the circulatory system and foreign body injury, while lowering acetate may have negative effects on mental disorders disease.
BREAST CANCER RESEARCH
(2023)