期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 183, 期 1, 页码 37-49出版社
WILEY-BLACKWELL
DOI: 10.1111/cei.12684
关键词
cell activation; gene regulation; inflammation
类别
资金
- Biotechnology and Biological Sciences Research Council [1128869, 1128490] Funding Source: researchfish
- BBSRC [BBS/E/B/000C0407, BBS/E/B/0000M740, BB/J00152X/1] Funding Source: UKRI
- MRC [G0601618] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/B/0000M740, BBS/E/B/000C0407, BB/J00152X/1] Funding Source: Medline
- Medical Research Council [G0601618] Funding Source: Medline
Sequence-specific RNA binding proteins (RBP) are important regulators of the immune response. RBP modulate gene expression by regulating splicing, polyadenylation, localization, translation and decay of target mRNAs. Increasing evidence suggests that RBP play critical roles in the development, activation and function of lymphocyte populations in the immune system. This review will discuss the post-transcriptional regulation of gene expression by RBP during lymphocyte development, with particular focus on the Tristetraprolin family of RBP.
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